Hemophilia A patients are a heterogeneous cohort. The tendency to bleed is highly individual, resulting in a complex management landscape. Two core therapeutic approaches are used: (1) prophylaxis, where the aim is to prevent clinically meaningful bleeds through maintaining factor VIII (FVIII) levels and (2) on-demand treatment, where drugs are used at the time of a significant bleed. Various similar FVIII replacement therapies are available (e.g., Takeda’s Advate, Sanofi’s Elocta). However, some patients develop inhibitors (alloantibodies) that can reduce the effectiveness of FVIII replacement. The launch of Genentech’s novel subcutaneous therapy Hemlibra has impacted the hemophilia A +/- inhibitors markets in differing ways. In the noninhibitor space, compelling reasons exist for many hemophilia A patients to remain on FVIII replacement therapies. In contrast, Hemlibra has dramatically altered treatment dynamics in the inhibitor space and has spurred much discussion about its merits in the management of newly diagnosed inhibitor patients.
Geographies: France, Germany, Italy, Spain, United Kingdom.
Primary research: Survey of 217 European hematologists.
Key drugs covered: Advate, Adynovi, Afstyla, Elocta, Esperoct, FEIBA, Hemlibra, Jivi, Kogenate, Kovaltry, Novoeight, NovoSeven, Nuwiq, Recombinate, Refacto.
Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.