Diabetic retinopathy (DR) is an ophthalmic complication of diabetes. In the advanced stages of DR, leaking fluid from abnormal blood vessels can cause the macula to swell, impacting sharp vision in the center of the visual field, a condition known as diabetic macular edema (DME). Several current therapies targeting vascular endothelial growth factor (VEGF) have been shown to improve visual acuity in DME patients. The most frequently used anti-VEGF agents in DME, administered via intravitreal (eye) injections, are Lucentis and Eylea—both approved for the treatment of DME—and off-label compounded Avastin. In addition to the anti-VEGF therapies, two long-acting corticosteroid implants, Ozurdex and Iluvien, were approved in 2014 for the treatment of DME. Additionally, some patients may be treated with intravitreal injections of triamcinolone. Given the competitive DME market, it is essential to understand how DME patients are currently being treated using real-world data.
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