Owing to the various etiologies of the disease and differences in presentation, management of FSGS needs to be individualized. As the nephrotic syndrome increases the risk of worse outcomes, RAAS inhibitors are often initiated to reduce proteinuria and diuretics are commonly used for symptomatic benefit. Corticosteroid and immunosuppressive therapy (calcineurin inhibitors and antiproliferative agents) is also considered in FSGS associated with clinical features of the nephrotic syndrome. Immunosuppressive agents typically find use in patients for whom use of high-dose corticosteroid treatment is a concern, or where patients fail to respond to corticosteroid treatment. Using longitudinal claims data analysis, we demonstrate how FSGS is being treated in the United States and provide insights into what is driving prescribing practices.
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.