Chronic inducible urticaria (CIndU) includes different chronic urticaria subtypes that are inducible by specific triggers. Evidence exists that CIndU appears to be more resistant to standard doses of antihistamines than chronic spontaneous urticaria (CSU), and with only one approved biological therapy targeting CSU—Novartis/Roche’s Xolair—CIndU presents an opportunity for more-effective drug development. Although patient shares of drug classes have been relatively stable over the last year, positive trends among more-recent second-generation antihistamines can be seen with improved efficacy and fewer side effects. Montelukast is a key drug in the CIndU market and a preferred combination agent, consistent with the recommended use of leukotriene receptor antagonists as add-on treatment in the current urticaria treatment guidelines. Biologics such as AbbVie’s Humira and Xolair see off-label use for CIndU patients, underscoring the need for novel therapies in this space.