Conventional therapies (5-ASAs, corticosteroids) are typically used to treat mild to moderate pediatric ulcerative colitis (UC), whereas tumor necrosis factor-alpha (TNF-α) inhibitors are primarily reserved for moderate to severe disease that is refractory to conventional treatment or for the first-line treatment of very severe disease. Takeda’s Entyvio, the first cell adhesion molecule (CAM) inhibitor in UC, offers an alternative treatment option, especially for TNF-α-refractory patients. In addition, Pfizer’s Xeljanz is the first Janus kinase (JAK) inhibitor and first oral agent approved (2018) for the treatment of UC. However, these two newer agents are not approved for the treatment of pediatric UC. Given the limited number of therapies available for pediatric patients who fail TNF-α inhibitors, physicians may turn to these agents as a last-line option. Indeed, the availability of these newer agents will likely make the treatment landscape more complex.
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.