The primary goal of ulcerative colitis (UC) treatment is to induce and maintain remission with few to no clinical symptoms remaining. Conventional therapies (5-ASAs, corticosteroids) are typically used to treat mild to moderate UC, whereas intravenous and subcutaneous tumor necrosis factor-alpha (TNF-α) inhibitors are primarily reserved for moderate to severe disease refractory to conventional treatment or for first-line treatment of the most-severe disease. Takeda’s Entyvio, a cell adhesion molecule (CAM) inhibitor approved for adult UC, offers an alternative treatment option, especially for TNF-α-refractory patients; however, it is not approved for pediatric UC. Still, given the limited treatment options for pediatric UC patients who fail TNF-α inhibitors, physicians may turn to Entyvio for some patients. Indeed, the availability of newer agents will likely make the treatment landscape more complex.
Treatment Algorithms: Claims Data Analysis provides detailed analysis of brand usage across different lines of therapy using real-world patient-level claims data so that clients can accurately assess their source of business and quantify areas of opportunity for increasing their brand share.
Geographies: United States
Real-world data: Longitudinal patient-level claims data analysis
Key drugs covered: Remicade, Humira, Simponi, Entyvio, oral/rectal aminosalicylates, immunosuppressants
Key analysis provided: