Rheumatoid arthritis (RA) treatment is typically initiated with cost-effective conventional DMARDs, such as methotrexate. The U.S. market for conventional DMARD-refractory RA patients is crowded with efficacious biologics, including blockbuster tumor necrosis factor alpha (TNF-alpha) inhibitors Amgen’s Enbrel, AbbVie’s Humira, and Janssen’s Remicade, as well as non-TNF-alpha inhibitors such as Bristol-Myers Squibb’s Orencia, Roche’s/Genentech’s Rituxan and Actemra. In addition, Pfizer’s Jak inhibitor Xeljanz, the first targeted oral molecule approved for RA, has been approved for almost five years in the United States and is gaining steady uptake in early lines of therapy.
- What patient share do key therapies and brands garner by line of therapy in newly diagnosed RA patients? What are the quarterly trends in prescribing among recently-treated and new diagnosed RA patients?
- How have non-TNF-alpha inhibitor biologics and Xeljanz been integrated into the treatment algorithm? What proportion of RA patients receive drug therapy within three years of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within three years of diagnosis?
- What percentage of RA patients are treated with monotherapy versus combination therapy? What are the most widely used combination therapies?
- What are the product-level compliance and persistency rates among drug-treated patients with RA?