Psoriatic Arthritis | Treatment Algorithms | Claims Data Analysis | US | 2021

Treatment of psoriatic arthritis (PsA) typically begins with conventional disease-modifying antirheumatic drugs (DMARDs), such as methotrexate, and progresses to more-potent biologics or targeted oral therapies as needed. The U.S. market for conventional DMARD-refractory patients is becoming increasingly crowded with multiple efficacious therapies, including six tumor necrosis factor-alpha (TNF-α) inhibitors, the interleukin (IL)-17 inhibitor Cosentyx (Novartis), the IL-12/23 inhibitor Stelara (Janssen), and the first-approved oral targeted PsA therapy, Otezla (Amgen). In addition, the FDA approvals of Xeljanz (Pfizer), an additional oral, first-in-class Janus kinase (JAK) inhibitor, Taltz (Eli Lilly), a second-in-class IL-17 inhibitor, and Tremfya (Janssen), a first-in-class IL-23 inhibitor, have expanded physicians’ treatment armamentarium for PsA, further increasing competition.


  • What patient shares do key therapies and brands garner by line of therapy in newly diagnosed PsA patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed PsA patients?
  • How have Xeljanz and Taltz been integrated into the treatment algorithm, and what are their sources of business?
  • What percentage of PsA patients receive drug therapy within two years of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within two years of diagnosis?
  • What percentage of PsA patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
  • What are the product-level compliance and persistency rates among drug-treated patients?


Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.

Markets covered: United States

Key companies: AbbVie, Amgen, Janssen, Novartis, Eli Lilly, Pfizer

Key drugs: Humira, Enbrel, Remicade, biosimilar infliximab, Cimzia, Simponi, Simponi Aria, Stelara, Cosentyx, Taltz, Orencia, Otezla, Xeljanz, Methotrexate

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