Myasthenia Gravis | Treatment Algorithms: Claims Data Analysis | US | 2021


Myasthenia gravis (MG) is a rare neuromuscular disorder caused by specific autoantibodies at the neuromuscular junction, which is characterized by muscle weakness and fatigue. Acetylcholine inhibitors (e.g., pyridostigmine), short- and long-term immunosuppressants, such as prednisone, mycophenolate mofetil, and azathioprine, are the most commonly prescribed agents to manage MG symptoms. However, the MG pipeline is starting to bring novel therapies with unique MOAs to the market, highlighted by the 2017 FDA approval of eculizumab (Soliris). As the MG current treatment landscape continues to evolve, this report offers insights from real-world claims data into prescribing trends in MG to help new players better understand current treatment practices in MG and to define the market niche for their emerging products.


  • What patient shares do key therapies and brands garner by line of therapy in newly diagnosed MG patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed MG patients?
  • How has eculizumab been integrated into the treatment algorithm, and what is its source of business?
  • What percentage of MG patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?
  • What percentage of MG patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
  • What are the product-level compliance and persistency rates among drug-treated patients?


Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.

Markets covered: United States

Key companies: Alexion

Key drugs: eculizumab (Soliris), intravenous and subcutaneous immunoglobulins, pyridostigmine, prednisone

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