DRG epidemiologists estimate that 40% of epilepsy patients experience generalized-onset seizures (GOS). The most commonly prescribed early-line treatments for GOS are older antiepileptic drugs (AEDs), such as valproic acid, levetiracetam, topiramate, and lamotrigine.To date, perampanel is the only third-generation AED approved for generalized epilepsy. Neurologists consider many factors when choosing among the numerous first-, second-, and third-generation AEDs and must make adjustments throughout a patient’s disease course to achieve optimal seizure control. Understanding the evolving journey of epilepsy patients with GOS provides important context about the complex, saturated, and heavily generic drug market that developers of new AEDs will enter, should they pursue an expanded labeling for GOS. For the first time, our 2019 Treatment Algorithms series offers this GOS segmentation, as well as a companion study on partial-onset seizures (POS).
Markets covered: United States
Real-world data: Longitudinal patient-level claims data analysis
Key companies: Eisai, Supernus Pharmaceuticals, Upsher-Smith
Key drugs covered: Fycompa, Trokendi XR, Qudexy XR, clonazepam, phenytoin, levetiracetam, lamotrigine, valproate
Key analysis provided:
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.