For more than a decade, AbbVie’s Restasis was the only FDA-approved therapy for dry eye disease (DED) until the launch of Novartis’s Xiidra in 2016, followed by Restasis MultiDose, Sun Ophthalmics’ Cequa, Alcon’s Eysuvis, and, more recently, Oyster Point’s Tyrvaya. In addition to these drugs, off-label ophthalmic corticosteroids and antibiotics are often prescribed for DED. Competition has further increased with the launch of the first generics of Restasis in February 2022 and will continue to increase with the expected near-term launch of other late-stage agents, particularly Aldeyra’s ADX-102 and Novaliq’s CyclASol. Because treatment burden plays a critical role in the management of DED, it is important to understand the preferences and expectations of physicians and payers regarding approved and emerging therapies. This report explores drivers of physicians’ and payers’ prescribing and coverage decisions and their receptivity to emerging agents for DED. These preferences dictate prescribing trends and patient access to DED therapies, ultimately shaping the future treatment landscape and market dynamics.
Geography: United States
Primary research: Survey of 100 U.S. ophthalmologists and optometrists, survey of 30 U.S. MCO PDs / MDs
Fingertip formulary: Formulary coverage and restrictions data for DED therapies by commercial plans covering approximately 163.6 million lives and Medicare Part D plans covering 36.7 million lives nationally.
Key drugs covered: Restasis, Restasis MultiDose, Xiidra, Cequa, Klarity-C, Eysuvis, Tyrvaya, CyclASol, NOV03, RGN-259, ADX-102
Reimbursement and contracting.
Access and prescribing.
Opportunities and challenges for emerging therapies.
Disease-specific special topic.
U.S. Access & Reimbursement provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.