The age-related macular degeneration (AMD) market in the United States is unique given that market penetration of approved branded therapies—Roche / Genentech’s Lucentis, Regeneron’s Eylea, Novartis’s Beovu, Roche’s Vabysmo and Susvimo—has been hampered by the availability of Roche’s Avastin (bevacizumab), frequently compounded and prescribed off-label because of its lower price. Competition facing key brands will further intensify with the launches of Regeneron’s high-dose aflibercept, Kodiak Sciences’ tarcocimab tetrodomer (formerly KSI-301), and AbbVie / Regenxbio’s gene therapy ABBV-RGX-314. These agents potentially offer a dosing advantage over the currently available VEGF inhibitors, addressing a substantial unmet need in this market. In the United States, biosimilars of Lucentis (ranibizumab) began launching in July 2022 and biosimilars of Eylea (aflibercept) are expected to launch in 2024, making it essential to understand how these presumably lower-priced therapies could impact access to premium-priced brands.
Geography: United States
Primary research: Survey of 101 U.S. ophthalmologists, survey of 30 U.S. MCO PDs / MDs
Fingertip formulary: Formulary coverage and restrictions data for wet AMD therapies and Syfovre by commercial plans covering approximately 163.6 million lives and Medicare Part D plans covering 36.7 million lives nationally.
Key drugs covered: Eylea, Lucentis, Vabysmo, Susvimo, Avastin, Byooviz, Cimerli, Avastin, high-dose aflibercept, tarcocimab tetrodomer, ABBV-RGX-314, Syfovre
Reimbursement and contracting.
Access and prescribing.
Opportunities and challenges for emerging therapies.
Disease-specific special topic: the impact of aflibercept biosimilars on the wet AMD market
U.S. Access & Reimbursement provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.