NASH is an increasingly prevalent disease characterized by excess lipid (steatosis) in the liver, resulting in inflammation and eventually liver fibrosis. Ensuing complications can include liver failure and hepatocellular carcinoma, which may necessitate liver transplantation. Consequently, the financial implications of NASH are ever-increasing. Despite a major unmet need, there are currently no drugs approved for NASH in any market; pharmacotherapy is limited to some use of off-label generic drugs, for which there is little evidence of benefit. However, there are now numerous agents in Phase II development or later, with the first launch of an approved agent expected in the next few years. With low diagnosis and treatment rates, novel NASH agents could be priced at a premium and consequently face significant market access challenges, as MCOs look to minimize the impact on their budgets.
U.S. Access & Reimbursement provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.
KEY DRUGS COVERED
Ocaliva (obeticholic acid), cenicriviroc, resmetirom, pioglitazone, metformin, GLP-1 receptor agonists