Tumor necrosis factor-alpha (TNF-α) inhibitors (e.g., AbbVie’s Humira, Amgen’s Enbrel) and Janssen’s interleukin (IL)-12/23 inhibitor Stelara have been leading the U.S. psoriasis biologics market, but the approval of novel, effective therapies has started changing the landscape as newer biologics gain greater acceptance from treating physicians. Novartis’s IL-17 inhibitor Cosentyx and Amgen’s oral phosphodiesterase (PDE)-4 inhibitor Otezla have successfully carved out space in the treatment algorithm. More-effective biologics—AbbVie’s Skyrizi, Janssen’s Tremfya, and Eli Lilly’s Taltz—are threatening TNF-α inhibitors’ first-line dominance. Given the recent entry of biosimilars and the late-phase development of an IL-17 A/F dual inhibitor, an oral tyrosine kinase 2 (TYK2) inhibitor, and two novel topical therapies, marketers of psoriasis therapies must learn how to navigate this increasingly competitive market.
U.S. Access & Reimbursement provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.
Key Drugs: Bimekizumab, Cimzia, Cosentyx, deucravacitinib, Enbrel, Humira, Ilumya, Inflectra, Otezla, Remicade, Remsima (SC), Renflexis, roflumilast (topical), Siliq, Skyrizi, Stelara, Tremfya, tapinarof.
Key Companies: AbbVie, Amgen, Arcutis, Bristol-Myers Squibb, Dermavant, Eli Lilly, Janssen, Merck, Pfizer, Novartis, UCB.