As the prevalence of chronic pain associated with numerous indications (e.g., osteoarthritis, cancer) and of idiopathic origin (e.g., chronic back pain) continues to increase in the United States, obtaining favorable market access and reimbursement for branded analgesics will become increasingly challenging. The current analgesic market contains a wide variety of well-entrenched and established therapeutic options across several drug classes, frequently available in generic forms, and continues to see entry of new analgesics that are most often either abuse-deterrent formulations of existing opioid analgesics or reformulations of existing products. Despite the quantity of analgesic options available, surveyed payers and physicians are united in their acknowledgement of the continuing clinical shortcomings of many therapies and in their support for new analgesics. Emerging analgesics that are able to differentiate from current products on clinical factors and are able to present persuasive pharmacoeconomic data will be most likely to obtain favorable market access/reimbursement conditions from MCOs, which will then facilitate use among prescribers who are particularly sensitive to the impact of cost-sharing on their chronic pain patients.
Markets covered: United States.
Methodology: Surveys of 143 PCPs and pain specialists and 30 managed care company officials, including 15 pharmacy directors and 15 medical directors, in January 2017.
Indication coverage: Chronic pain.
Key drugs covered: Celebrex, Cymbalta, Hysingla ER, Lyrica, Nucynta ER, OxyContin, Targiniq ER, Zohydro ER, cebranopadol, tanezumab.
Key companies mentioned: Acorda, Depomed, Eli Lilly, Endo, Grünenthal, Horizon, Janssen, NeurogesX, Pernix, Pfizer, Purdue, Zogenix.