Identifying plausible targets/mechanisms behind adverse events

Identifying possible mechanisms associated with the anaphylactoid reaction observed in rats

This case study outlines how the OFF-X Translatability Dashboard can be used to identify mechanisms potentially associated with the toxicity observed in rats.

During preclinical safety studies, unpredictable toxicities can occur when assessing investigative new molecular entities. Understanding the cause and mechanism behind these toxicities can help
in risk assessment and influence chemical design strategies for risk reduction.

Download the case study to find out more.