Identifying causal genes to be used as drug targets

A top 10 global pharmaceutical company wanted to build its pipeline for identification of causal genes within genome-wide association study (GWAS) loci using Parkinson’s disease as a test case and extending to other indications later. The Clarivate™ Discovery and Translational Sciences consulting team proposed a complementary systems biology approach, leveraging functional gene annotations to directly infer the most likely causal gene in the associated locus.