{"id":581264,"date":"2025-04-21T00:00:00","date_gmt":"2025-04-21T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnecg0014-2025-biopharma-alzheimers-disease-unmet-need-agitation-in-alzheimers-disease-us-eu-2025\/"},"modified":"2026-05-10T11:17:08","modified_gmt":"2026-05-10T11:17:08","slug":"unnecg0014-2025-biopharma-alzheimers-disease-unmet-need-agitation-in-alzheimers-disease-us-eu-2025","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnecg0014-2025-biopharma-alzheimers-disease-unmet-need-agitation-in-alzheimers-disease-us-eu-2025\/","title":{"rendered":"Alzheimer&#8217;s Disease | Unmet Need | Agitation in Alzheimer&#8217;s Disease | US EU | 2025"},"content":{"rendered":"<p>Agitation affects most Alzheimer\u2019s disease (AD) patients and comprises a constellation of disruptive symptoms for patients and their families, which may contribute to nursing home placement. Agitation is commonly treated with off-label atypical antipsychotics, in spite of safety warnings they carry related to elevated risk of death in elderly dementia patients. In 2023, Lundbeck \/ Otsuka\u2019s Rexulti (brexpiprazole) became the first FDA-approved drug to treat agitation associated with AD. Other novel agents are also emerging as potential treatments (e.g., Axsome\u2019s Auvelity). Understanding the drivers of clinical decision-making in agitation and prescriber perceptions of the risk \/ benefit profiles of today\u2019s approved brand and off-label generic options will help identify opportunities for new product positioning and differentiation in this evolving market.<\/p>\n<p><strong>QUESTIONS ANSWERED<\/strong><\/p>\n<ul>\n<li>What are the most important treatment drivers and goals for prescribers in agitation in AD?<\/li>\n<li>What attributes drive decision-making in agitation in AD, which have limited impact, and which are hidden opportunities?<\/li>\n<li>How do Rexulti and off-label agents perform on these attributes?<\/li>\n<li>Based on a conjoint analysis and TPP simulation, what trade-offs across key clinical attributes and price are neurologists willing to make for a hypothetical new drug to treat agitation in AD?<\/li>\n<\/ul>\n<p><strong>PRODUCT DESCRIPTION<\/strong><\/p>\n<p>Unmet Need offers insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities, enabling you to:<\/p>\n<ul>\n<li>Evaluate clinical and nonclinical product attributes that influence treatment decisions through physicians\u2019 weightings and analysis of stated vs. derived importance<\/li>\n<li>Pinpoint areas of high unmet need by assessing current drug performance against key attributes and treatment drivers<\/li>\n<li>Analyze market scenarios for different target product profiles using the TPP Simulator<\/li>\n<\/ul>\n<p><strong>Markets covered:<\/strong> United States, United Kingdom, France, Germany<\/p>\n<p><strong>Primary research: <\/strong>Survey of 60 U.S. and 30 European neurologists fielded in February 2025<\/p>\n<p><strong>Key companies:<\/strong> Otsuka \/ Lundbeck<\/p>\n<p><strong>Key drugs:<\/strong> Rexulti, quetiapine, risperidone, olanzapine, aripiprazole, citalopram, gabapentin<\/p>\n<p><strong>Key feature <\/strong><\/p>\n<p>Target Product Profile (TPP) simulator tool allows for customizable market simulations based on conjoint analysis. Compare up to seven TPPs across multiple disease-specific attributes and price points to gauge which variables influence prescribing behavior.<\/p>\n","protected":false},"template":"","class_list":["post-581264","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-alzheimers-disease","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-2297"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/581264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/581264\/revisions"}],"predecessor-version":[{"id":581356,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/581264\/revisions\/581356"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=581264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}