{"id":425714,"date":"2024-04-12T00:00:00","date_gmt":"2024-04-12T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unneim0009-2024-biopharma-ulcerative-colitis-unmet-need-moderate-to-severe-us-eu-2024\/"},"modified":"2026-03-31T10:30:26","modified_gmt":"2026-03-31T10:30:26","slug":"unneim0009-2024-biopharma-ulcerative-colitis-unmet-need-moderate-to-severe-us-eu-2024","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unneim0009-2024-biopharma-ulcerative-colitis-unmet-need-moderate-to-severe-us-eu-2024\/","title":{"rendered":"Ulcerative Colitis | Unmet Need | Moderate to Severe | US\/EU | 2024"},"content":{"rendered":"<p>TNF-alpha inhibitors (Johnson &#038; Johnson Innovative Medicine&#8217;s Remicade, AbbVie\u2019s Humira), a CAM inhibitor (Takeda\u2019s Entyvio), and an IL-12\/23 inhibitor (Johnson &#038; Johnson Innovative Medicine&#8217;s Stelara) are the mainstays of treatment for UC. However, these agents have safety risks and efficacy limitations. Newer alternatives, such as JAK inhibitors (Pfizer\u2019s Xeljanz and AbbVie\u2019s Rinvoq), an IL-23 inhibitor (Eli Lilly\u2019s Omvoh), and S1P-R modulators (BMS\u2019s Zeposia and Pfizer\u2019s Velsipity) have expanded the treatment options, but significant unmet need remains for patients whose UC is refractory to these therapies. Although several agents with novel mechanisms of action are poised to enter market over the next several years, their ability to fulfill these unmet needs remains to be seen.<\/p>\n<p><strong><strong>QUESTIONS <\/strong><strong>ANSWERED<\/strong><\/strong><\/p>\n<ul>\n<li>What are the treatment drivers and goals in moderate to severe UC?<\/li>\n<li>How do current therapies perform on treatment drivers and goals for moderate to severe UC?<\/li>\n<li>In addition to efficacy, which drug attributes most strongly influence physician prescribing behaviors, and which have a limited impact?<\/li>\n<li>What are the prevailing areas of unmet need and hidden opportunity in the treatment of moderate to severe UC?<\/li>\n<li>What trade-offs across clinical attributes and prices are acceptable to U.S. and European gastroenterologists for a hypothetical new UC drug?<\/li>\n<\/ul>\n<p><strong><strong>PRODUCT <\/strong><strong>DESCRIPTION<\/strong><\/strong><\/p>\n<p>Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by Clarivate experts, and additional customized market scenarios can be evaluated with the corresponding TPP Simulator.<\/p>\n<p><strong>KEY FEATURE<\/strong><\/p>\n<p>The Target Product Profile (TPP) Simulator tool allows for customizable market simulations based on conjoint analysis that depicts how physicians make decisions based on actual behavior rather than opinion. Compare up to seven TPPs across multiple disease-specific attributes and price points to gauge which variables influence prescribing behavior.<\/p>\n<p><strong>Markets covered:<\/strong> United States, United Kingdom, France, Germany.<\/p>\n<p><strong>Primary research: <\/strong>Survey of 60 U.S. and 30 European gastroenterologists fielded in February 2024.<\/p>\n<p><strong>Key companies:<\/strong> AbbVie, Johnson &#038; Johnson Innovative Medicine, Pfizer, Takeda, UCB, BMS.<\/p>\n<p><strong>Key drugs:<\/strong> Humira, Remicade, Entyvio, Xeljanz, Stelara, Zeposia, Rinvoq, adalimumab biosimilars, infliximab biosimilars.<\/p>\n","protected":false},"template":"","class_list":["post-425714","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-ulcerative-colitis","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-985"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/425714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":2,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/425714\/revisions"}],"predecessor-version":[{"id":575973,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/425714\/revisions\/575973"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=425714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}