{"id":416583,"date":"2023-03-21T00:00:00","date_gmt":"2023-03-21T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnecg0026-2023-biopharma-parkinsons-disease-unmet-need-levodopa-induced-dyskinesia-us-eu-2023\/"},"modified":"2026-04-24T11:21:21","modified_gmt":"2026-04-24T11:21:21","slug":"unnecg0026-2023-biopharma-parkinsons-disease-unmet-need-levodopa-induced-dyskinesia-us-eu-2023","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnecg0026-2023-biopharma-parkinsons-disease-unmet-need-levodopa-induced-dyskinesia-us-eu-2023\/","title":{"rendered":"Parkinson&#8217;s Disease | Unmet Need | Levodopa-Induced Dyskinesia | US\/EU | 2023"},"content":{"rendered":"<p>Levodopa-induced dyskinesia (LID) is a complication stemming from the long-term use of levodopa to treat Parkinson\u2019s disease (PD); it causes abnormal involuntary movements. Surveyed neurologists in the United States estimate that nearly 30% of their PD patients currently experience motor complications and LID, both of which can be disabling and painful and greatly affect patients\u2019 quality of life and activities of daily living. Currently, only a few options are available to treat PD-LID, including amantadine IR, a long-standing generic drug that is not specifically approved for LID and has an unfavorable side-effect profile. In the United States, Supernus\u2019s Gocovri (amantadine ER) is the only FDA-approved treatment for PD-LID; third-to-market Osmolex ER (Supernus) is limited to off-label use. Nevertheless, the treatment of PD-LID is evolving; new research suggests that Supernus\u2019s Xadago has antiglutamatergic properties that may positively impact LID. In addition, the early- and late-phase pipeline is rich with new agents (e.g., dipraglurant [Addex], mesdopetam [IRLAB]). Understanding prescriber perceptions of the available options for PD-LID and the drivers behind prescribers\u2019 clinical decision-making for the indication can help drug developers identify levers for new product positioning and differentiation.<\/p>\n<p><strong>QUESTIONS ANSWERED<\/strong><\/p>\n<ul>\n<li>What clinical endpoints and drug attributes are most influential in prescribing for PD-LID? How do neurologists rate the performance of amantadine, Gocovri, Osmolex ER, and Xadago on these attributes?<\/li>\n<li>What are the prevailing areas of unmet need and opportunity in the treatment of PD-LID?<\/li>\n<li>Based on conjoint analysis and TPP simulation, what trade-offs among efficacy, safety, and price are neurologists willing to make for a hypothetical new drug for PD-LID?<\/li>\n<\/ul>\n<p><strong>PRODUCT DESCRIPTION<\/strong><\/p>\n<p>Provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.<\/p>\n<p><strong>Markets covered:<\/strong> United States, United Kingdom, France, Germany<\/p>\n<p><strong>Primary research: <\/strong>Survey of 61 U.S. and 31 European neurologists fielded in January 2023<\/p>\n<p><strong>Key companies:<\/strong> Supernus<\/p>\n<p><strong>Key drugs:<\/strong>\u00a0amantadine IR, Xadago, Gocovri, Osmolex ER<\/p>\n","protected":false},"template":"","class_list":["post-416583","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-parkinsons-disease","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-975"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/416583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/416583\/revisions"}],"predecessor-version":[{"id":416896,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/416583\/revisions\/416896"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=416583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}