{"id":390389,"date":"2019-06-28T00:00:00","date_gmt":"2019-06-28T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnemd0005-2019-biopharma-non-alcoholic-steatohepatitis-nash-unmet-need-us-eu-2019\/"},"modified":"2026-04-14T10:25:37","modified_gmt":"2026-04-14T10:25:37","slug":"unnemd0005-2019-biopharma-non-alcoholic-steatohepatitis-nash-unmet-need-us-eu-2019","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnemd0005-2019-biopharma-non-alcoholic-steatohepatitis-nash-unmet-need-us-eu-2019\/","title":{"rendered":"Non-Alcoholic Steatohepatitis (NASH) | Unmet Need | US\/EU | 2019"},"content":{"rendered":"<p><strong>MARKET OUTLOOK<\/strong><\/p>\n<p><abbr title=\"nonalcoholic steatohepatitis\">NASH<\/abbr>\u00a0has the potential to be a large and lucrative therapy market owing to the prevalence of the disease and the lack of approved agents. Patients with\u00a0<abbr title=\"nonalcoholic steatohepatitis\">NASH<\/abbr>\u00a0are at risk of liver fibrosis, cardiovascular disease, and cancer. Currently, physicians are limited to off-label therapies that have limited evidence to support prescribing. Consequently, there is a pressing need for new, effective drug treatments. In this report, hepatologists reveal what attributes drive their prescribing and what they are looking for in terms of efficacy, safety, and delivery from future treatments. Using the Target Product Profile (<abbr title=\"target product profile\">TPP<\/abbr>) simulator, we can establish physicians\u2019 preference for emerging drugs and assess if these drugs can capitalize on the untapped\u00a0<abbr title=\"nonalcoholic steatohepatitis\">NASH<\/abbr>\u00a0space.<\/p>\n<p><strong>QUESTIONS ANSWERED<\/strong><\/p>\n<ul>\n<li>How do hepatologists rate current\u00a0<abbr title=\"nonalcoholic steatohepatitis\">NASH<\/abbr>\u00a0treatment options such as pioglitazone, vitamin E, and metformin?<\/li>\n<li>What drug attributes are key influencers, which have limited impact, and which are hidden opportunities?<\/li>\n<li>What trade-offs across different clinical attributes and price are needed from new\u00a0<abbr title=\"nonalcoholic steatohepatitis\">NASH<\/abbr>\u00a0drugs in order to be preferred over current treatment options?<\/li>\n<li>How could obeticholic acid, elafibranor, and cenicriviroc meet the expectations of physicians treating\u00a0<abbr title=\"nonalcoholic steatohepatitis\">NASH<\/abbr>?<\/li>\n<\/ul>\n<p><strong>PRODUCT DESCRIPTION<\/strong><\/p>\n<p><em>Unmet Need<\/em>\u00a0supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Three market scenarios are profiled in detail by\u00a0<abbr title=\"Decision Resources Group\">DRG<\/abbr>\u00a0experts, and additional customized market scenarios can be evaluated with the corresponding\u00a0<abbr title=\"target product profile\">TPP<\/abbr>\u00a0simulator.<\/p>\n<p><strong>Markets covered:<\/strong>\u00a0United States, United Kingdom, France, Germany.<\/p>\n<p><strong>Primary research:\u00a0<\/strong>Survey of 60 U.S. and 30 European hepatologists and gastroenterologists fielded in April 2019.<\/p>\n<p><strong>Key companies:\u00a0<\/strong>Takeda, Merck KGaA, Intercept, Genfit.<\/p>\n<p><strong>Key drugs:<\/strong>\u00a0Pioglitazone, vitamin E, metformin, ursodeoxycholic acid, statins,\u00a0<abbr title=\"sodium-glucose co-transporter-2\">SGLT-2<\/abbr>\u00a0inhibitors,\u00a0<abbr title=\"glucagon-like peptide\">GLP<\/abbr>-1 receptor agonists.<\/p>\n","protected":false},"template":"","class_list":["post-390389","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-cardiovascular","biopharma-therapy-areas-non-alcoholic-steatohepatitis-nash","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-931"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390389\/revisions"}],"predecessor-version":[{"id":393514,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390389\/revisions\/393514"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=390389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}