{"id":390073,"date":"2021-03-23T00:00:00","date_gmt":"2021-03-23T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/dlsfim0007-2020-biopharma-rheumatoid-arthritis-disease-landscape-and-forecast-g7-2020\/"},"modified":"2026-04-19T23:23:05","modified_gmt":"2026-04-19T23:23:05","slug":"dlsfim0007-2020-biopharma-rheumatoid-arthritis-disease-landscape-and-forecast-g7-2020","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/dlsfim0007-2020-biopharma-rheumatoid-arthritis-disease-landscape-and-forecast-g7-2020\/","title":{"rendered":"Rheumatoid Arthritis | Disease Landscape and Forecast | G7 | 2020"},"content":{"rendered":"<p>The increasingly crowded RA market boasts many targeted agents representing several different drug classes, including blockbuster TNF-\u03b1 inhibitors, five non-TNF-\u03b1 biologics (including the second IL-6 inhibitor Kevzara [Regeneron \/ Sanofi]), and five oral JAK inhibitors\u2014Xeljanz (Pfizer), Olumiant (Eli Lilly), Rinvoq (AbbVie), Jyseleca (Galapagos \/ Gilead \/ Eisai), and Smyraf (Astellas). The TNF-\u03b1 inhibitors are the most widely prescribed biologics for RA that is refractory to conventional DMARDs, and the non-TNF-\u03b1 biologics and JAK inhibitors largely compete for use in the TNF-refractory population. With the recent approval of an additional JAK inhibitor (Gilead \/ Galapagos\u2019s Jyseleca) and biosimilars of several TNF and non-TNF biologics, marketers are facing fierce competition and increasing challenges to gain market share.<\/p>\n<p><strong>Questions answered:<\/strong><\/p>\n<ul>\n<li>What are physicians\u2019 preferred TNF-\u03b1 inhibitors, and what factors are influencing this perception? Given the increasingly fragmented RA market, how likely are physicians to cycle through multiple anti-TNF agents before progressing to a novel MOA?<\/li>\n<li>What are physicians\u2019 perceptions of the currently marketed non-TNF-\u03b1 inhibitor biologics and oral JAK inhibitors, and where do these agents fit in their current treatment approach? Which of these agents has been\/will be the most successful in targeting the TNF-refractory patient segment?<\/li>\n<li>How will the entry of additional novel oral therapies affect the RA treatment algorithm, and in which patient segments and lines of treatment will these therapies most likely be used? How will the entry of biosimilars affect the market sales and patient share of currently marketed RA agents and the entry of emerging therapies?<\/li>\n<\/ul>\n<p><strong>Scope:<\/strong><\/p>\n<p><strong>Markets covered:<\/strong> United States, France, Germany, Italy, Spain, United Kingdom, and Japan.<\/p>\n<p><strong>Primary research:<\/strong> 27 country-specific interviews with thought leaders.<\/p>\n<p><strong>Epidemiology:<\/strong> Number of total, diagnosed, and drug-treated prevalent cases of RA; number of diagnosed prevalent cases of RA by severity.<\/p>\n<p><strong>Emerging therapies: <\/strong>Preregistered \/ registered: 1 drug; Phase III: 2 drugs; coverage of 8 select early-phase pipeline products.<\/p>\n","protected":false},"template":"","class_list":["post-390073","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-rheumatoid-arthritis","biopharma-date-950"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390073","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390073\/revisions"}],"predecessor-version":[{"id":393198,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390073\/revisions\/393198"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=390073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}