{"id":390066,"date":"2021-03-30T00:00:00","date_gmt":"2021-03-30T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/dlsfcg0002-2020-biopharma-unipolar-depression-disease-landscape-and-forecast-g7-2020\/"},"modified":"2026-03-31T10:43:40","modified_gmt":"2026-03-31T10:43:40","slug":"dlsfcg0002-2020-biopharma-unipolar-depression-disease-landscape-and-forecast-g7-2020","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/dlsfcg0002-2020-biopharma-unipolar-depression-disease-landscape-and-forecast-g7-2020\/","title":{"rendered":"Unipolar Depression | Disease Landscape and Forecast | G7 | 2020"},"content":{"rendered":"<p>The unipolar depression market is crowded and highly genericized. The prominent use of SSRIs and, to a lesser extent, SNRIs as early-line treatments contributes to the challenges branded therapies face when entering this market. Newer-to-market brands (e.g., Lundbeck \/ Takeda\u2019s Trintellix \/ Brintellix, Lundbeck \/ Otsuka Pharmaceutical\u2019s Rexulti \/ Rxulti) largely compete for use in treatment-resistant depression (TRD) patients, who make up one-third of the major depressive disorder population. The most recent entrant to the depression market, Janssen\u2019s Spravato, offers the fastest onset of therapeutic effect among the approved therapies\u2014fulfilling a key unmet need\u2014but its use for TRD is constrained by multiple factors. Because of remaining unmet need, physicians will continue to look to emerging therapies\u2014many of which offer novel mechanisms of action\u2014as potential future treatment options in this market.<\/p>\n<p><strong>QUESTIONS ANSWERED:<\/strong><\/p>\n<ul>\n<li>What factors drive and constrain the use of branded antidepressants and atypical antipsychotics? What branded therapy is expected to experience the greatest commercial success during the forecast period?<\/li>\n<li>What clinical role will Spravato (Janssen\u2019s esketamine) play in the treatment of TRD?<\/li>\n<li>Given the crowded, highly genericized unipolar depression market, what is the commercial potential of key emerging therapies for unipolar depression?<\/li>\n<li>What are the greatest areas of unmet need in the treatment of unipolar depression and how are late-phase emerging therapies expected to address these unmet needs?<\/li>\n<\/ul>\n<p><strong>Markets covered: <\/strong>United States, France, Germany, Italy, Spain, United Kingdom, Japan<\/p>\n<p><strong>Primary research: <\/strong>Approximately 15 country-specific interviews with thought-leading psychiatrists and PCPs \/\u00a0GPs; supported by survey data collected for this and other DRG research.<\/p>\n<p><strong>Epidemiology: <\/strong>12-month prevalence of unipolar depression by country, segmented by MDD, minor depression, and dysthymia; diagnosed and drug-treated cases of unipolar depression; 12-month prevalence of MDD by country, segmented by chronic pain status; 12-month prevalence of MDD by country, segmented by treatment-resistant status.<\/p>\n<p><strong>Emerging therapies: <\/strong>Phase III\/preregistration: 5\u00a0drugs. Coverage of select Phase II and Phase I products.<\/p>\n<p><strong>Market forecast features: <\/strong>10-year, annualized, drug-level sales and patient share of key unipolar depression therapies from 2019-2029, segmented by brands \/ generics<\/p>\n<p><strong>Key companies: <\/strong>Allergan, AstraZeneca, Axsome Therapeutics, Fabre-Kramer, Gedeon Richter, GlaxoSmithKline, Janssen, Lundbeck, Otsuka Pharmaceutical, Pfizer, Sage Therapeutics, Shionogi, Sumitomo Dainippon, Sunovion, Takeda<\/p>\n<p><strong>Key drugs: <\/strong>Aripiprazole, bupropion HCl SR\/XR, duloxetine, escitalopram, Latuda (lurasidone), quetiapine IR\/XR, Rexulti \/ Rxulti (brexpiprazole), Spravato (esketamine), Trintellix \/ Brintellix (vortioxetine), venlafaxine IR\u00a0\/\u00a0XR,\u00a0Vraylar \/ Reagila (cariprazine), AXS-05, gepirone ER, SAGE-217 (zuranolone)<\/p>\n","protected":false},"template":"","class_list":["post-390066","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-unipolar-depression","biopharma-date-950"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390066\/revisions"}],"predecessor-version":[{"id":393191,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/390066\/revisions\/393191"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=390066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}