CDK4\/6 inhibitors (Pfizer\u2019s palbociclib, Novartis\u2019s ribociclib, and Eli Lilly\u2019s abemaciclib) combined with endocrine therapy are central to the treatment of metastatic HR-positive \/ HER2-negative disease, and we expect this class to drive robust sales in the early-stage setting. Novel biomarker-driven therapies (Novartis’s alpelisib, AstraZeneca\u00b4s capivasertib, Roche \/ Chugai Pharmaceutical\u2019s inavolisib, Menarini\u00b4s elacestrant, Eli Lilly\u2019s imlunestrant, and Arvinas \/ Pfizer \/ Rigel\u2019s vepdegestrant) are effective treatment options, and the market will become increasingly crowded with agents seeking to tackle endocrine resistance. HER2-positive breast cancer treatment is rapidly evolving owing to approval and forecast label expansions for agents such as trastuzumab deruxtecan (Daiichi Sankyo \/ AstraZeneca), which has also emerged as a key therapy for the newly defined HER2-low and HER2-ultra-low subgroups. In triple-negative breast cancer, Merck & Co.\u2019s immune checkpoint inhibitor pembrolizumab is the standard of care, while TROP2-targeted agents (Gilead\u2019s sacituzumab govitecan and AstraZeneca \/ Daiichi Sankyo\u2019s datopotamab deruxtecan), have recently moved into the lucrative earlier lines of treatment.<\/p>\n
Questions answered<\/strong><\/p>\n Geography<\/strong>:<\/b> United States, EU5<\/abbr>, Japan<\/p>\n Primary research:<\/b> Country-specific interviews with thought-leading medical oncologists; survey data collected for this and other Clarivate research<\/p>\n Epidemiology:<\/b> Diagnosed incidence of breast cancer by country; histology, stage, and line of therapy, segmented into relevant drug-treatable populations<\/p>\n Forecast:<\/b> 10-year, annualized, drug-level sales and patient share of key breast cancer therapies through 2035, segmented by brands and epidemiological subpopulations<\/p>\n Drug treatments:<\/b> Coverage of select current and emerging therapies<\/p>\n Product description<\/b><\/p>\n Disease Landscape & Forecast offers comprehensive market intelligence with world-class epidemiology, keen insight into current and emerging therapies, and drug forecasts supported by detailed primary and secondary research, enabling you to:<\/p>\n<\/div>\n\n
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