{"id":296012,"date":"2025-04-01T00:00:00","date_gmt":"2025-04-01T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unneim0015-2024-biopharma-chronic-obstructive-pulmonary-disease-unmet-need-unmet-need-severe-to-very\/"},"modified":"2026-03-31T10:26:38","modified_gmt":"2026-03-31T10:26:38","slug":"unneim0015-2025-biopharma-chronic-obstructive-pulmonary-disease-unmet-need-unmet-need-severe-to-very-severe-chronic","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unneim0015-2025-biopharma-chronic-obstructive-pulmonary-disease-unmet-need-unmet-need-severe-to-very-severe-chronic\/","title":{"rendered":"Chronic Obstructive Pulmonary Disease &#8211; Unmet Need &#8211; Unmet Need &#8211; Severe to Very Severe Chronic Obstructive Pulmonary Disease | US\/EU"},"content":{"rendered":"<p>The severe to very severe chronic obstructive pulmonary disease (COPD) drug market is becoming increasingly crowded as several LAMAs, LABA\/ICSs, LABA\/LAMAs, LABA\/LAMA\/ICSs, and, most recently, the PDE-3\/PDE-4 inhibitor Ohtuvayre and the IL-4\/IL-13 inhibitor Dupixent compete in the maintenance drug space. Unfortunately, none of these agents can reverse the progression of COPD or repair lung tissue; instead, current drug treatment focuses on improving breathing and reducing inflammation. Although inhaled medications can reduce the burden of COPD by easing its symptoms, patients\u2019 quality of life still suffers, and the disease remains one of the leading causes of death worldwide. Thus, significant unmet need remains for more-effective or disease-modifying therapies, especially for those patients with more-severe COPD whose symptoms are not adequately controlled with available therapies.<\/p>\n<p><strong>Questions answered<\/strong><\/p>\n<ul class=\"BulletListStyle1 SCXW222684411 BCX0 round-bullets\">\n<li>Which drug attributes most influence pulmonologists\u2019 prescribing decisions for COPD, which have limited impact, and which are hidden opportunities?<\/li>\n<li>How do current therapies, such as BI\u2019s Spiriva and Stiolto, GSK\u2019s Anoro and Trelegy, AstraZeneca\u2019s Symbicort, Sanofi \/ Regeneron\u2019s Dupixent, and Verona\u2019s Ohtuvayre perform on these measures?<\/li>\n<li>What trade-offs across different clinical \/ nonclinical attributes and price are acceptable to U.S. and European pulmonologists for a hypothetical new COPD drug?<\/li>\n<\/ul>\n<p><strong>Product description<\/strong><\/p>\n<p>Unmet Need offers insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities, enabling you to:<\/p>\n<ul class=\"BulletListStyle1 SCXW222684411 BCX0 round-bullets\">\n<li>Evaluate clinical and nonclinical product attributes that influence treatment decisions through physicians\u2019 weightings and analysis of stated vs. derived importance.<\/li>\n<li>Pinpoint areas of high unmet need by assessing current drug performance against key attributes and treatment drivers.<\/li>\n<li>Analyze market scenarios for different target product profiles using the TPP Simulator.<\/li>\n<\/ul>\n<div>\n<p style=\"\"><strong>Geography:<\/strong> United States, France, Germany, United Kingdom<\/p>\n<\/div>\n<div><strong>Primary research:<\/strong> Survey of 60 U.S. and 30 European pulmonologists<\/div>\n<div><\/div>\n<div><strong>Key drugs covered:<\/strong> Dupixent, Anoro, Spiriva, Symbicort, Trelegy, Ohtuvayre<\/div>\n<div>\n<p style=\"\"><strong>Key analyses:<\/strong> Importance of clinical and nonclinical product attributes to physicians; Assessment of current drug performance against treatment drivers and goals;\u00a0Physician perceptions of unmet needs in the indication and related indications; Remaining drug development opportunities<\/p>\n<\/div>\n<div><strong>Key feature:<\/strong> Target Product Profile (TPP) simulator tool allows for customizable market simulations based on conjoint analysis. Compare up to seven TPPs across multiple disease-specific attributes and price points to gauge which variables influence prescribing behavior.<\/div>\n","protected":false},"template":"","class_list":["post-296012","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-chronic-obstructive-pulmonary-disease","biopharma-therapy-areas-respiratory","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-2297"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/296012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":3,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/296012\/revisions"}],"predecessor-version":[{"id":575805,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/296012\/revisions\/575805"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=296012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}