{"id":295535,"date":"2024-04-01T00:00:00","date_gmt":"2024-04-01T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnecg0037-2024-biopharma-post-traumatic-stress-disorder-unmet-need-unmet-need-moderate-to-severe\/"},"modified":"2026-03-31T10:30:34","modified_gmt":"2026-03-31T10:30:34","slug":"unnecg0037-2024-biopharma-post-traumatic-stress-disorder-unmet-need-unmet-need-moderate-to-severe-ptsd-us-eu","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unnecg0037-2024-biopharma-post-traumatic-stress-disorder-unmet-need-unmet-need-moderate-to-severe-ptsd-us-eu\/","title":{"rendered":"Post-Traumatic Stress Disorder &#8211; Unmet Need &#8211; Unmet Need &#8211; Moderate to Severe PTSD (US\/EU)"},"content":{"rendered":"<p>Although multiple guidelines recommend treating post-traumatic stress disorder (<abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr>) with psychotherapy first, such an approach does not suffice for many patients, necessitating the use of pharmacological agents. The need for drug treatment is especially true for moderate and severe cases. Pharmacologic options for <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr> are limited; only two agents are <abbr title=\"Food and Drug Administration\">FDA<\/abbr>-approved, and others are used off-label. Lykos Therapeutics\u2019 <abbr title=\"3,4-methylenedioxymethamphetamine\">MDMA<\/abbr>-assisted psychotherapy has been submitted for <abbr title=\"Food and Drug Administration\">FDA<\/abbr> approval, and Otsuka and Lundbeck reported positive Phase 2 and 3 results for Rexulti in combination with sertraline, suggesting that there may be new options for <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr> management. Our content examines the key drivers of clinical decision-making in moderate to severe <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr> and prescriber perceptions of available treatments, enabling the identification of opportunities within the moderate to severe <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr> therapy market.<\/p>\n<p><strong>Questions answered<\/strong><\/p>\n<ul class=\"round-bullets\">\n<li>Which clinical \/ nonclinical attributes drive psychiatrists\u2019 decision-making in the treatment of moderate to severe <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr>, which have limited impact, and which are hidden opportunities?<\/li>\n<li>How do psychiatrists rate the performance of key current therapies on treatment drivers and goals for moderate to severe <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr>?<\/li>\n<li>What is the relative level of need for improved treatment options in multiple psychiatry indications, including moderate to severe <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr>?<\/li>\n<li>Based on a conjoint analysis and <abbr title=\"Target Product Profile\">TPP<\/abbr> simulation, what trade-offs between efficacy, safety, convenience of administration, and price are psychiatrists willing to make for a hypothetical new therapy to treat moderate to severe <abbr title=\"post-traumatic stress disorder\">PTSD<\/abbr>?<\/li>\n<\/ul>\n<p><strong>Product description<\/strong><\/p>\n<p>Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by Clarivate experts, and additional customized market scenarios can be evaluated with the corresponding <abbr title=\"Target Product Profile\">TPP<\/abbr> Simulator.<\/p>\n<p><strong>Key feature:<\/strong><\/p>\n<p>The Target Product Profile (<abbr title=\"Target Product Profile\">TPP<\/abbr>) Simulator tool allows for customizable market simulations based on conjoint analysis that depicts how physicians make decisions based on actual behavior rather than opinion. Compare up to seven <abbr title=\"Target Product Profile\">TPP<\/abbr>s across multiple disease-specific attributes and price points to gauge which variables influence prescribing behavior.<\/p>\n<p><strong>Markets covered: <\/strong>United States, United Kingdom, France, Germany<\/p>\n<p><strong>Primary research: <\/strong>Survey of 60 U.S. and 32\u00a0European psychiatrists fielded in January 2024<\/p>\n<p><strong>Key companies: <\/strong>Otsuka Pharmaceutical, Lundbeck, Viatris, Apotex<\/p>\n<p><strong>Key drugs: <\/strong>Rexulti, sertraline, paroxetine, venlafaxine, aripiprazole, prazosin<\/p>\n","protected":false},"template":"","class_list":["post-295535","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-psychiatry","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-985"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/295535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/295535\/revisions"}],"predecessor-version":[{"id":295765,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/295535\/revisions\/295765"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=295535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}