{"id":295534,"date":"2024-04-04T00:00:00","date_gmt":"2024-04-04T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unneon0038-2024-biopharma-acute-lymphoblastic-leukemia-unmet-need-unmet-need-relapsed-or-refractory\/"},"modified":"2026-03-31T10:30:33","modified_gmt":"2026-03-31T10:30:33","slug":"unneon0038-2024-biopharma-acute-lymphoblastic-leukemia-unmet-need-unmet-need-relapsed-or-refractory-philadelphia","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/unneon0038-2024-biopharma-acute-lymphoblastic-leukemia-unmet-need-unmet-need-relapsed-or-refractory-philadelphia\/","title":{"rendered":"Acute Lymphoblastic Leukemia &#8211; Unmet Need &#8211; Unmet Need &#8211; Relapsed or Refractory Philadelphia Chromosome-Negative ALL (US\/EU)"},"content":{"rendered":"<p>Relapsed \/ refractory (<abbr title=\"relapsed\/refractory\">R\/R<\/abbr>) Philadelphia chromosome-negative acute lymphoblastic leukemia (<abbr data-abbreviation-entity=\"6237\" title=\"acute lymphoblastic leukemia\">ALL<\/abbr>) patients have a poor prognosis. No standard of care has been established for relapsed \/ refractory <abbr data-abbreviation-entity=\"6237\" title=\"acute lymphoblastic leukemia\">ALL<\/abbr>, and thus treatment remains a challenge. The mainstay of therapy is chemotherapy such as that used in the first line. The approval of therapies such as Amgen\u2019s Blincyto, Pfizer\u2019s Besponsa, and the <abbr data-abbreviation-entity=\"4751\" title=\"cluster of differentiation\">CD<\/abbr>19-targeted <abbr data-abbreviation-entity=\"5621\" title=\"chimeric antigen receptor\">CAR<\/abbr> T-cell therapies Kymriah (Novartis) and Tecartus (Kite Pharma \/ Gilead Sciences) have expanded the treatment options, but these agents rarely lead to a cure and are associated with potentially severe side effects. Therefore, a strong need remains for more-efficacious and well-tolerated treatments that improve patients\u2019 outcomes.<\/p>\n<p><strong>QUESTIONS ANSWERED<\/strong><\/p>\n<ul class=\"round-bullets\">\n<li>Which attributes most influence prescribers\u2019 decisions for <abbr title=\"relapsed\/refractory\">R\/R<\/abbr> Philadelphia chromosome-negative <abbr data-abbreviation-entity=\"6237\" title=\"acute lymphoblastic leukemia\">ALL<\/abbr>?<\/li>\n<li>How do current therapies such as Blincyto, Besponsa, and <abbr data-abbreviation-entity=\"5621\" title=\"chimeric antigen receptor\">CAR<\/abbr> T-cell agents perform on key treatment drivers and goals for this patient population?<\/li>\n<li>What are the prevailing areas of unmet need and hidden opportunity in the treatment of <abbr title=\"relapsed\/refractory\">R\/R<\/abbr> Philadelphia chromosome-negative <abbr data-abbreviation-entity=\"6237\" title=\"acute lymphoblastic leukemia\">ALL<\/abbr>?<\/li>\n<li>What trade-offs across key clinical attributes and price are acceptable to surveyed hematologist-oncologists for a novel therapy to treat <abbr title=\"relapsed\/refractory\">R\/R<\/abbr> Philadelphia chromosome-negative <abbr data-abbreviation-entity=\"6237\" title=\"acute lymphoblastic leukemia\">ALL<\/abbr>?<\/li>\n<\/ul>\n<p><strong>Markets covered:<\/strong> United States, France, Germany, United Kingdom<\/p>\n<p><strong>Primary research: <\/strong>Survey of 61 U.S. and 30 European hematologist-oncologists fielded in February 2024<\/p>\n<p><strong>Key drugs:<\/strong> Blincyto, Besponsa, Kymriah, Tecartus<\/p>\n<p><strong>PRODUCT DESCRIPTION<\/strong><\/p>\n<p>Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by Clarivate experts, and additional customized market scenarios can be evaluated with the corresponding <abbr data-abbreviation-entity=\"6194\" title=\"Target Product Profile\">TPP<\/abbr> Simulator.<\/p>\n<p><strong>KEY FEATURE<\/strong><\/p>\n<p>The Target Product Profile (<abbr data-abbreviation-entity=\"6194\" title=\"Target Product Profile\">TPP<\/abbr>) Simulator tool allows for customizable market simulations based on conjoint analysis that depicts how physicians make decisions based on actual behavior rather than opinion. Compare up to seven <abbr data-abbreviation-entity=\"6194\" title=\"Target Product Profile\">TPP<\/abbr>s across multiple disease-specific attributes and price points to gauge which variables influence prescribing behavior.<\/p>\n","protected":false},"template":"","class_list":["post-295534","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-acute-lymphoblastic-leukemia","biopharma-therapy-areas-hematological-malignancies","biopharma-therapy-areas-hematology","biopharma-product-unmet-need","biopharma-geography-us","biopharma-date-985"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/295534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/295534\/revisions"}],"predecessor-version":[{"id":295764,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/295534\/revisions\/295764"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=295534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}