{"id":292869,"date":"2024-06-11T00:00:00","date_gmt":"2024-06-11T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/acreop0001-2024-biopharma-dry-and-wet-age-related-macular-degeneration-access-reimbursement-access\/"},"modified":"2026-05-10T11:20:23","modified_gmt":"2026-05-10T11:20:23","slug":"acreop0001-2024-biopharma-dry-and-wet-age-related-macular-degeneration-access-reimbursement-access-reimbursement-age","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/acreop0001-2024-biopharma-dry-and-wet-age-related-macular-degeneration-access-reimbursement-access-reimbursement-age\/","title":{"rendered":"Dry and Wet Age-Related Macular Degeneration &#8211; Access &#038; Reimbursement &#8211; Access &#038; Reimbursement &#8211; Age-Related Macular Degeneration (US)"},"content":{"rendered":"<p>The age-related macular degeneration (<abbr title=\"age-related macular degeneration\">AMD<\/abbr>) therapy market in the United States is unique because the market penetration of approved branded therapies\u2014Roche \/ Genentech\u2019s Lucentis, Regeneron\u2019s Eylea and Eylea <span class=\"abbreviation-guard\">HD<\/span>, Novartis\u2019s Beovu, and Roche\u2019s Vabysmo\u2014and of ranibizumab biosimilars has been hampered by the availability of Roche\u2019s Avastin (bevacizumab), frequently compounded and prescribed off-label because of its lower price. Competition facing key brands will further intensify with the launch of Optea\u2019s sozinibercept and the potential launch of AbbVie \/ Regenxbio\u2019s gene therapy ABBV-RGX-314, as well as biosimilars of Eylea that are expected to launch in the near future. In contrast, the market for geographic atrophy (<abbr title=\"glatiramer acetate\">GA<\/abbr>) is limited to two therapies that launched in the United States in 2023\u2014Apellis\u2019s Syfovre and Astellas\u2019s Izervay\u2014although the <abbr title=\"glatiramer acetate\">GA<\/abbr> pipeline is quite active. This report will help marketers explore how biosimilars could impact access to premium-priced wet <abbr title=\"age-related macular degeneration\">AMD<\/abbr> brands and how the introduction of the first gene therapy with an anticipated high price may affect the market and understand the market access challenges in the new <abbr title=\"glatiramer acetate\">GA<\/abbr> market.<\/p>\n<p><strong>QUESTIONS ANSWERED<\/strong><\/p>\n<ul class=\"BulletListStyle1 SCXP199306607 BCX0 round-bullets\">\n<li>Does coverage of the key <abbr title=\"vascular endothelial growth factor\">VEGF<\/abbr> inhibitors for wet <abbr title=\"age-related macular degeneration\">AMD<\/abbr> differ on <abbr title=\"managed care organization\">MCO<\/abbr>s\u2019 largest Medicare Advantage and commercial insurance plans? To what extent do payers\u2019 cost-control measures impact prescribing of these approved therapies and of Avastin?<\/li>\n<li>How has the availability of biosimilars of Lucentis impacted the brand, and how will the availability of biosimilars of Eylea impact access to and reimbursement of its reference brand? What impact might they have on recently launched therapies such as Vabysmo and Eylea <span class=\"abbreviation-guard\">HD<\/span>?<\/li>\n<li>How do U.S. ophthalmologists use Syfovre and Izervay to treat <abbr title=\"glatiramer acetate\">GA<\/abbr> secondary to <abbr title=\"age-related macular degeneration\">AMD<\/abbr>? How do <abbr title=\"managed care organization\">MCO<\/abbr>s cover these agents?<\/li>\n<li>Do ophthalmologists expect to prescribe therapies in late-phase development to their Medicare and commercially insured wet <abbr title=\"age-related macular degeneration\">AMD<\/abbr> patients? How do payers expect to cover these therapies, and how will those decisions affect prescribing?<\/li>\n<\/ul>\n<p><strong>CONTENT HIGHLIGHTS<\/strong><\/p>\n<p><strong>Geography:<\/strong> United States<\/p>\n<p><strong>Primary research:<\/strong> Survey of 100 U.S. ophthalmologists; survey of 30 U.S. <abbr title=\"managed care organization\">MCO <\/abbr><abbr title=\"pharmacy director\">PD<\/abbr>s \/ <abbr title=\"medical director\">MD<\/abbr>s<\/p>\n<p><strong>Fingertip formulary: <\/strong>Formulary coverage and restrictions data for wet <abbr title=\"age-related macular degeneration\">AMD<\/abbr> therapies and Syfovre by commercial plans covering approximately 160.8 million lives and Medicare Part D plans covering 26.0 million lives nationally.<\/p>\n<p><strong>Key drugs covered: <\/strong>Eylea, Lucentis, Beovu,<strong> <\/strong>Vabysmo, Susvimo<strong>, <\/strong>Avastin,<strong> <\/strong>Byooviz, Cimerli, Eylea <span class=\"abbreviation-guard\">HD<\/span>, ABBV-RGX-314, sozinibercept, Syfovre, Izervay<\/p>\n<p><strong>Content highlights:<\/strong><\/p>\n<p>Reimbursement and contracting.<\/p>\n<p>Access and prescribing.<\/p>\n<p>Opportunities and challenges for emerging therapies.<\/p>\n<p>Disease-specific special topic: the impact of aflibercept biosimilars on the wet <abbr title=\"age-related macular degeneration\">AMD<\/abbr> therapy market<\/p>\n<p><strong>PRODUCT DESCRIPTION<\/strong><\/p>\n<p><em>U.S. Access &#038; Reimbursement <\/em>provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.<\/p>\n","protected":false},"template":"","class_list":["post-292869","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-therapy-areas-age-related-macular-degeneration","biopharma-therapy-areas-ophthalmology","biopharma-geography-us","biopharma-date-985"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/292869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":10,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/292869\/revisions"}],"predecessor-version":[{"id":575951,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/292869\/revisions\/575951"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=292869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}