{"id":250292,"date":"2022-12-06T00:00:00","date_gmt":"2022-12-06T00:00:00","guid":{"rendered":"https:\/\/clarivate.com\/products\/research-reports\/report\/dlsfmd0012-2022-biopharma-polycystic-kidney-disease-landscape-forecast\/"},"modified":"2026-03-31T10:35:51","modified_gmt":"2026-03-31T10:35:51","slug":"dlsfmd0012-2022-biopharma-polycystic-kidney-disease-landscape-forecast-disease-landscape-forecast","status":"publish","type":"report","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/report\/dlsfmd0012-2022-biopharma-polycystic-kidney-disease-landscape-forecast-disease-landscape-forecast\/","title":{"rendered":"Polycystic Kidney Disease &#8211; Landscape &#038; Forecast &#8211; Disease Landscape &#038; Forecast"},"content":{"rendered":"<p>Autosomal dominant polycystic kidney disease (<abbr title=\"autosomal dominant polycystic kidney disease\">ADPKD<\/abbr>) is a genetic disorder characterized by the development and progressive enlargement of fluid-filled cysts in the kidneys. Particularly, in the early stages, the disease is often asymptomatic and detectable only through diagnostic imaging of the kidney to reveal cysts. The launch of Otsuka\u2019s Jynarque \/ Jinarc \/ Samsca (tolvaptan) introduced the first disease-specific therapy for <abbr title=\"autosomal dominant polycystic kidney disease\">ADPKD<\/abbr>. Several more therapies for ADPKD are in clinical trials, including Reata Pharmaceutical\u2019s bardoxolone methyl, Galapagos\u2019s GLPG2737, Kadmon\u2019s tesevatinib, and Xortx Therapeutics\u2019 oxypurinol. Some of these therapies are expected to fulfill current unmet needs in the treatment of ADPKD.<\/p>\n<p><strong>Questions answered<\/strong><\/p>\n<ul class=\"round-bullets\">\n<li>What do key opinion leaders think about the emerging therapies bardoxolone methyl, GLPG2737, tesevatinib, and oxypurinol? How will emerging therapies differentiate themselves in an increasingly crowded market?<\/li>\n<li>How will the anticipated genericization of Otsuka\u2019s Jynarque \/ Jinarc \/ Samsca affect the uptake of branded and emerging therapies?<\/li>\n<li>What effect have the discontinuations of Sanofi \/ Genzyme\u2019s venglustat, Regulus Therapeutics\u2019 RGLS-4326, and Palladio Bioscience\u2019s lixivaptan had on the <abbr title=\"autosomal dominant polycystic kidney disease\">ADPKD<\/abbr> therapy market?<\/li>\n<li>What are the key unmet needs in <abbr title=\"autosomal dominant polycystic kidney disease\">ADPKD<\/abbr>, and which therapies likely to fulfill them?<\/li>\n<\/ul>\n<p><strong>Product description<\/strong><\/p>\n<p><em>Disease Landscape &#038; Forecast<\/em> provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.<\/p>\n<p><b>Solution enhancement:<\/b><\/p>\n<p><em>Disease Landscape &#038; Forecast<\/em> introduces a new Drug Pipeline chapter with real-time, global pipeline intelligence content directly from Cortellis. This chapter is updated daily and features interactive figures that can be easily downloaded for detailed analysis or presentations.<\/p>\n","protected":false},"template":"","class_list":["post-250292","report","type-report","status-publish","hentry","report-gateway-biopharma","biopharma-date-960"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/250292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/report"}],"version-history":[{"count":10,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/250292\/revisions"}],"predecessor-version":[{"id":576177,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/report\/250292\/revisions\/576177"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=250292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}