{"id":583928,"date":"2026-03-27T12:59:18","date_gmt":"2026-03-27T12:59:18","guid":{"rendered":"https:\/\/clarivate.com\/life-sciences-healthcare\/?p=583839"},"modified":"2026-07-17T09:57:08","modified_gmt":"2026-07-17T09:57:08","slug":"balancing-the-promise-of-targeted-protein-degradation-with-real-world-safety-insights","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ko\/blog\/balancing-the-promise-of-targeted-protein-degradation-with-real-world-safety-insights\/","title":{"rendered":"\ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574(TPD)\uc758 \uac00\ub2a5\uc131\uacfc \uc2e4\uc81c \uc548\uc804\uc131 \uc778\uc0ac\uc774\ud2b8\uc758 \uade0\ud615"},"content":{"rendered":"

\ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574(Targeted Protein Degradation, TPD)\ub294 \ud559\uc220\uc801 \uac1c\ub150\uc744 \ub118\uc5b4 \uc784\uc0c1\uc801\uc73c\ub85c \uac80\uc99d\ub41c \uce58\ub8cc \uc804\ub7b5\uc73c\ub85c \ube60\ub974\uac8c \uc790\ub9ac \uc7a1\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc9c8\ubcd1\uc744 \uc720\ubc1c\ud558\ub294 \ub2e8\ubc31\uc9c8\uc758 \ud65c\uc131\uc744 \ub2e8\uc21c\ud788 \uc5b5\uc81c\ud558\ub294 \ub370 \uadf8\uce58\uc9c0 \uc54a\uace0 \ub2e8\ubc31\uc9c8 \uc790\uccb4\ub97c \uc81c\uac70\ud568\uc73c\ub85c\uc368, \uae30\uc874\uc5d0\ub294 Undruggable(\uae30\uc874 \uc57d\ubb3c\ub85c\ub294 \ud45c\uc801\ud654\uac00 \uc5b4\ub824\uc6b4)\uc73c\ub85c \uc5ec\uaca8\uc84c\ub358 \ud45c\uc801\uae4c\uc9c0 \uce58\ub8cc \ub300\uc0c1\uc73c\ub85c \ud655\uc7a5\ud560 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc81c\uc57d\u00b7\ubc14\uc774\uc624 \uae30\uc5c5\uc758 \uc2e0\uc57d \uac1c\ubc1c\uc790\uc5d0\uac8c TPD\ub294 \ub192\uc740 \ud6a8\ub2a5\uacfc \uc6b0\uc218\ud55c \uc120\ud0dd\uc131\uc744 \uae30\ub300\ud560 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc811\uadfc\ubc95\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub2e8\ubc31\uc9c8\uc744 \ube44\uac00\uc5ed\uc801\uc73c\ub85c \uc81c\uac70\ud55c\ub2e4\ub294 \ud2b9\uc131\uc740 \uac1c\ubc1c \ucd08\uae30\ubd80\ud130 \ubc18\ub4dc\uc2dc \uac80\ud1a0\ud574\uc57c \ud560 \uc0c8\ub85c\uc6b4 \uc548\uc804\uc131 \uacfc\uc81c\ub97c \ud568\uaed8 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac TPD\uc758 \uc804\uc784\uc0c1 \uc548\uc804\uc131 \ud3c9\uac00 \uc804\ub7b5\uc740 \uc544\uc9c1 \ubc1c\uc804 \ub2e8\uacc4\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc0c8\ub85c\uc6b4 \uc791\uc6a9\uae30\uc804, \ubcf5\uc7a1\ud55c \ubd84\uc790 \uad6c\uc870, \uadf8\ub9ac\uace0 \ube60\ub974\uac8c \ud655\ub300\ub418\ub294 \uc784\uc0c1 \uacbd\ud5d8\uc744 \uace0\ub824\ud558\uba74 \uae30\uc874 \ub3c5\uc131\ud3c9\uac00\ub9cc\uc73c\ub85c\ub294 \ucda9\ubd84\ud558\uc9c0 \uc54a\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ub300\uaddc\ubaa8 \ud658\uc790\uc5d0\uac8c \ud22c\uc5ec\ub418\uae30 \uc804\uc5d0 \uc7a0\uc7ac\uc801\uc778 \uc704\ud5d8\uc744 \uc608\uce21\ud558\uace0 \uac1c\ubc1c \ub9ac\uc2a4\ud06c\ub97c \uc904\uc77c \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ub370\uc774\ud130 \uae30\ubc18 \uc811\uadfc\ubc95\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\ucd5c\uadfc \uc784\uc0c1 \uac1c\ubc1c \uc911\uc778 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\ub97c \uccb4\uacc4\uc801\uc73c\ub85c \ubd84\uc11d\ud55c \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc811\uadfc\ubc95\uc5d0\uc11c \uc5b4\ub5a4 \uc548\uc804\uc131 \uc704\ud5d8\uc774 \ub098\ud0c0\ub098\uace0 \uc788\ub294\uc9c0, \uadf8\ub9ac\uace0 \uae30\uc874\uc758 \uc0dd\ubb3c\ud559 \ubc0f \uc720\uc804\ud559\uc801 \uc9c0\uc2dd\uc744 \ud65c\uc6a9\ud574 \uc774\ub97c \uc5b4\ub5bb\uac8c \ud574\uc11d\ud560 \uc218 \uc788\ub294\uc9c0\ub97c \ubcf4\uc5ec\uc8fc\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc784\uc0c1 \uac1c\ubc1c\uc774 \ube60\ub974\uac8c \ud655\ub300\ub418\ub294 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c<\/strong><\/h3>\n

\ud604\uc7ac \uac1c\ubc1c \uc911\uc778 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\ub97c \ubd84\uc11d\ud55c \uacb0\uacfc, TPD \ubd84\uc57c\uac00 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \ub3d9\uc2dc\uc5d0 \ud601\uc2e0\uc774 \uc18c\uc218\uc758 \ud575\uc2ec \uc0dd\ubb3c\ud559\uc801 \ud45c\uc801\uc5d0 \uc9d1\uc911\ub418\uace0 \uc788\uc74c\uc744 \ud655\uc778\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\ud604\uc7ac 80\uac1c \uc774\uc0c1\uc758 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\uac00 \uc784\uc0c1 \uac1c\ubc1c \ub2e8\uacc4\uc5d0 \uc788\uc73c\uba70, \ucd08\uae30 \uc784\uc0c1 1\uc0c1\ubd80\ud130 \ud5c8\uac00 \uc2e0\uccad \uc9c1\uc804 \ub2e8\uacc4\uae4c\uc9c0 \ud3ed\ub113\uac8c \ubd84\ud3ec\ud574 \uc788\uc2b5\ub2c8\ub2e4. \ub300\ubd80\ubd84\uc740 \ud56d\uc554 \ubd84\uc57c\ub97c \ub300\uc0c1\uc73c\ub85c \uac1c\ubc1c\ub418\uace0 \uc788\uc9c0\ub9cc, \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc744 \ube44\ub86f\ud55c \ub2e4\uc591\ud55c \uc9c8\ud658 \uc601\uc5ed\uc73c\ub85c \uc801\uc6a9 \ubc94\uc704\uac00 \uc810\ucc28 \ud655\ub300\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac \uc784\uc0c1 \uac1c\ubc1c\uc740 \uc548\ub4dc\ub85c\uac90 \uc218\uc6a9\uccb4(AR),\uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uc6a9\uccb4(ER),\ube0c\ub8e8\ud1a4 \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c(BTK),IKAROS \uacc4\uc5f4 \ub2e8\ubc31\uc9c8 \ubc0f GSPT\uc640 \uac19\uc7405\uac00\uc9c0 \ud575\uc2ec \ud45c\uc801\uc5d0 \uc9d1\uc911\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc774\ub4e4 \ub2e8\ubc31\uc9c8\uc740 \uc9c8\ud658 \ubc1c\uc0dd\uc5d0 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud558\uba74\uc11c\ub3c4 \uae30\uc874\uc5d0\ub294 \uce58\ub8cc\uac00 \uc5b4\ub824\uc6e0\ub358 \ud45c\uc801\uc785\ub2c8\ub2e4. \ub610\ud55c \ub3d9\uc77c\ud55c \ud45c\uc801\uc744 \uaca8\ub0e5\ud558\ub294 \uae30\uc874 \uc800\ud574\uc81c(inhibitor)\ub098 \uae38\ud56d\uc81c(antagonist)\uc640 \ube44\uad50\ud560 \uc218 \uc788\ub2e4\ub294 \uc810\uc5d0\uc11c, \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\uc758 \uc548\uc804\uc131\uacfc \ud2b9\uc131\uc744 \uc774\ud574\ud558\ub294 \uc911\uc694\ud55c \uae30\uc900\uc774 \ub429\ub2c8\ub2e4.<\/p>\n

\uc774\uc0c1\ubc18\uc751\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \ucd08\uae30 \uc548\uc804\uc131 \uc2e0\ud638<\/strong><\/h3>\n

\uae30\uc874 \uc800\ud574\uc81c\uc640 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\uc5d0\uc11c \ubcf4\uace0\ub41c \uc774\uc0c1\ubc18\uc751\uc744 \ube44\uad50\ud558\uba74 TPD\uc758 \uc548\uc804\uc131 \ud2b9\uc131\uc774 \uae30\uc874 \uce58\ub8cc\uc81c\uc640 \uc5b4\ub5bb\uac8c \uc720\uc0ac\ud558\uac70\ub098 \ub2e4\ub978\uc9c0\ub97c \ud30c\uc545\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. BTK, AR, ER\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc57d\ubb3c\uc744 \ube44\uad50\ud55c \uacb0\uacfc, \uac00\uc7a5 \ud754\ud558\uac8c \ubcf4\uace0\ub418\ub294 \uc774\uc0c1\ubc18\uc751\uc740 \ub450 \uce58\ub8cc \ubc29\uc2dd\uc5d0\uc11c \uc0c1\ub2f9 \ubd80\ubd84 \uacf5\ud1b5\uc801\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub300\ud45c\uc801\uc73c\ub85c \ud608\uc561\uacc4 \uc774\uc0c1\ubc18\uc751, \uc704\uc7a5\uad00 \uc9c8\ud658, \ud53c\ubd80 \ubc0f \ud53c\ud558\uc870\uc9c1 \uc774\uc0c1\ubc18\uc751 \ub4f1\uc774 \uc774\uc5d0 \ud574\ub2f9\ud569\ub2c8\ub2e4. \uc774\ub294 TPD \uc790\uccb4\uc758 \ub3c5\uc131\uc774\ub77c\uae30\ubcf4\ub2e4 \ud574\ub2f9 \ud45c\uc801\uc758 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc744 \ubc18\uc601\ud558\ub294 \uacb0\uacfc\ub85c \ud574\uc11d\ub429\ub2c8\ub2e4.<\/p>\n

\ubc18\uba74 \uc77c\ubd80 \ucc28\uc774\uc810\ub3c4 \uad00\ucc30\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.\uc608\ub97c \ub4e4\uc5b4 BTK \ubd84\ud574\uc81c\uc5d0\uc11c\ub294 \uc77c\ubd80 BTK \uc800\ud574\uc81c\uc5d0\uc11c \ubcf4\uace0\ub41c \uac04\ub2f4\ub3c4\uacc4 \uc9c8\ud658\uc774 \uc544\uc9c1 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub610\ud55c AR \ubd84\ud574\uc81c\uc5d0\uc11c\ub294 \uae30\uc874 AR \uae38\ud56d\uc81c\uc5d0\uc11c \ub098\ud0c0\ub0ac\ub358 \uc815\uc2e0\uacfc\uc801 \uc774\uc0c1\ubc18\uc751\uc774 \ud604\uc7ac\uae4c\uc9c0\ub294 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub2e4\ub9cc \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \uc544\uc9c1 \uc81c\ud55c\ub41c \ud658\uc790 \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \ucd08\uae30 \uad00\ucc30\uc774\ub77c\ub294 \uc810\uc744 \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4. \ud604\uc7ac\uae4c\uc9c0 \uc548\uc804\uc131 \ubb38\uc81c\uac00 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\ub2e4\uace0 \ud574\uc11c \uc7a5\uae30\uc801\uc778 \uc548\uc804\uc131\uc774 \ud655\ubcf4\ub410\ub2e4\uace0 \ub2e8\uc815\ud560 \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4. \uc55e\uc73c\ub85c \ub354 \ub9ce\uc740 \ud658\uc790\uc640 \ub2e4\uc591\ud55c \uc9d1\ub2e8\uc744 \ub300\uc0c1\uc73c\ub85c \uc784\uc0c1\uc774 \ud655\ub300\ub418\uba74 \ub4dc\ubb3c\uac70\ub098 \uc9c0\uc5f0\uc131 \uc774\uc0c1\ubc18\uc751\uc774 \uc0c8\ub86d\uac8c \ud655\uc778\ub420 \uac00\ub2a5\uc131\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\"\"<\/p>\n

\uc720\uc804\ud559\uacfc \uc0dd\ubb3c\ud559\uc744 \ud65c\uc6a9\ud55c \uc704\ud5d8 \uc608\uce21<\/strong><\/h3>\n

\ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\uc758 \uc548\uc804\uc131\uc744 \uc774\ud574\ud558\ub294 \uac00\uc7a5 \uac15\ub825\ud55c \ub3c4\uad6c \uc911 \ud558\ub098\ub294 \uae30\uc874 \ub3c5\uc131\uc2dc\ud5d8\uc774 \uc544\ub2c8\ub77c \uc720\uc804\ud559\uc801 \uc815\ubcf4\uc785\ub2c8\ub2e4. \ud2b9\ud788 \uc0ac\ub78c\uc758 \uae30\ub2a5\uc0c1\uc2e4(loss-of-function, LoF) \ubcc0\uc774\uc640 \uc720\uc804\uc790 \uacb0\uc190(Knockout, KO) \ubaa8\ub378, \ud2b9\ud788 \uc778\uac04\ud654 \ubaa8\ub378(humanized systems)\uc740 \uc7a5\uae30\uac04 \ub2e8\ubc31\uc9c8\uc774 \uc81c\uac70\ub41c \uc0c1\ud0dc\ub97c \ubaa8\uc0ac\ud560 \uc218 \uc788\uc5b4 \uc9c0\uc18d\uc801\uc778 \ud45c\uc801 \ubd84\ud574\uac00 \uc778\uccb4\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc774\ud574\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

BTK\ub294 \ub300\ud45c\uc801\uc778 \uc0ac\ub840\uc785\ub2c8\ub2e4. X-\uc5f0\uad00 \ubb34\uac10\ub9c8\uae00\ub85c\ubd88\ub9b0\ud608\uc99d(X-linked agammaglobulinemia)\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 BTK \uae30\ub2a5\uc0c1\uc2e4\uc740 B\uc138\ud3ec \uc2e0\ud638 \uc804\ub2ec\uc5d0 \uc2ec\uac01\ud55c \uc7a5\uc560\ub97c \uc77c\uc73c\ud0a4\uba70 \uac10\uc5fc \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uacfc \uc77c\uce58\ud558\uac8c BTK \uc800\ud574\uc81c\uc640 BTK \ubd84\ud574\uc81c \ubaa8\ub450 \uc784\uc0c1\uc5d0\uc11c \uac10\uc5fc \uad00\ub828 \uc774\uc0c1\ubc18\uc751 \uc704\ud5d8\uc774 \uc99d\uac00\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc720\uc804\ud559\uc801 \uadfc\uac70\uc640 \uc57d\ub9ac\ud559\uc801 \ub370\uc774\ud130\uac00 \uc77c\uce58\ud55c\ub2e4\ub294 \uc810\uc740 \uc774\ub7ec\ud55c \uc774\uc0c1\ubc18\uc751\uc774 \ud45c\uc801 \uc790\uccb4(On-target effect)\uc5d0\uc11c \ube44\ub86f\ub41c \uc608\uce21 \uac00\ub2a5\ud55c \uacb0\uacfc\uc784\uc744 \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4.<\/p>\n

AR\uacfc ER\ucc98\ub7fc \ud638\ub974\ubaac\uc5d0 \uc758\ud574 \ud65c\uc131\ud654\ub418\ub294 \uc804\uc0ac\uc778\uc790\ub294 \ub610 \ub2e4\ub978 \uc911\uc694\ud55c \uc0ac\ub840\uc785\ub2c8\ub2e4.\uc774\ub4e4 \uc218\uc6a9\uccb4\ub294 \ub300\uc0ac\uc640 \uc0dd\uc2dd \uae30\ub2a5 \uc870\uc808\uc5d0 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \uc218\ud589\ud558\uba70, AR \ub610\ub294 ER\uc758 \ubd84\ud574\ub294 \uc720\ubc29 \uad00\ub828 \uc774\uc0c1\ubc18\uc751, \uc2dd\uc695 \ubcc0\ud654, \ub300\uc0ac \uc774\uc0c1 \ub4f1\uacfc \uc5f0\uad00\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774 \uc5ed\uc2dc \uc0c8\ub85c\uc6b4 \ub3c5\uc131\uc774 \uc544\ub2c8\ub77c \ud574\ub2f9 \ud45c\uc801\uc758 \uc54c\ub824\uc9c4 \uc0dd\ubb3c\ud559\uc801 \uae30\ub2a5\uc744 \ubc18\uc601\ud558\ub294 \uacb0\uacfc\uc785\ub2c8\ub2e4.<\/p>\n

TPD\uc758 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc744 \ubc18\uc601\ud55c \uc804\uc784\uc0c1 \uc548\uc804\uc131 \uc804\ub7b5<\/strong><\/h3>\n

TPD \ud504\ub85c\uadf8\ub7a8\uc744 \uac1c\ubc1c\ud558\ub294 \uae30\uc5c5\uc774\ub77c\uba74 \uc804\uc784\uc0c1 \uc548\uc804\uc131 \uc804\ub7b5\uc744 \uc218\ub9bd\ud560 \ub54c \ud45c\uc801\uc758 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131, \uc720\uc804\ud559\uc801 \uc815\ubcf4, \uadf8\ub9ac\uace0 \uae30\uc874 \uc784\uc0c1 \uacbd\ud5d8\uc744 \ud568\uaed8 \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4. \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\ub97c \uc644\uc804\ud788 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \ubc29\uc2dd\uc73c\ub85c \uc811\uadfc\ud558\uae30\ubcf4\ub2e4\ub294 \uae30\uc874 \uce58\ub8cc\uc81c\uc640 \ube44\uad50\ud558\uba74\uc11c \ube44\uac00\uc5ed\uc801\uc778 \ub2e8\ubc31\uc9c8 \uc81c\uac70\uac00 \uae30\uc874 \uc704\ud5d8\uc744 \uc99d\ud3ed\uc2dc\ud0a4\ub294\uc9c0, \ubc1c\uc0dd \uc2dc\uc810\uc744 \ubcc0\ud654\uc2dc\ud0a4\ub294\uc9c0, \ub610\ub294 \uc0c8\ub85c\uc6b4 \uc548\uc804\uc131 \uc774\uc288\ub97c \ucd08\ub798\ud558\ub294\uc9c0\ub97c \ud3c9\uac00\ud558\ub294 \uac83\uc774 \ub354\uc6b1 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4.<\/p>\n

\uc774\ub97c \uc704\ud574\uc11c\ub294 \uae30\uc874 \uc800\ud574\uc81c\uc758 \uc784\uc0c1 \ub370\uc774\ud130,\uc0ac\ub78c\uc758 \uc720\uc804\ud559\uc801 \uc815\ubcf4, \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c(Pathway) \uc0dd\ubb3c\ud559,\ucd95\uc801\ub418\uace0 \uc788\ub294 TPD \ud2b9\uc774\uc801 \uc548\uc804\uc131 \ub370\uc774\ud130\uc640 \uac19\uc740 \ub2e4\uc591\ud55c \uadfc\uac70\ub97c \ud1b5\ud569\uc801\uc73c\ub85c \ud65c\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ubc88 \ubd84\uc11d\uc5d0\uc11c\ub294 OFF-X Translational Safety Intelligence<\/strong><\/a>\ub97c \ud65c\uc6a9\ud574 \uc8fc\uc694 \ud45c\uc801\uc5d0\uc11c \uc800\ud574\uc81c\uc640 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\uc758 \uc774\uc0c1\ubc18\uc751\uc744 \uccb4\uacc4\uc801\uc73c\ub85c \ube44\uad50\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc811\uadfc\ubc95\uc740 \uc11c\ub85c \ub2e4\ub978 \uce58\ub8cc \ubc29\uc2dd\uacfc \uc0dd\ubb3c\ud559\uc801 \uae30\uc804\uc744 \uc885\ud569\uc801\uc73c\ub85c \ube44\uad50\ud558\uba74\uc11c \uc548\uc804\uc131 \uc2e0\ud638\ub97c \ubcf4\ub2e4 \uc815\ud655\ud558\uac8c \ud574\uc11d\ud560 \uc218 \uc788\ub3c4\ub85d \uc9c0\uc6d0\ud569\ub2c8\ub2e4.<\/p>\n

\uc778\uc0ac\uc774\ud2b8\ub97c \uc2e4\ud589\uc73c\ub85c \uc5f0\uacb0\ud558\uae30<\/strong><\/h3>\n

\ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574\ub294 \uc2e0\uc57d \uac1c\ubc1c\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \ubc14\uafc0 \uc7a0\uc7ac\ub825\uc744 \uc9c0\ub2c8\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uac00\ub2a5\uc131\uc744 \ud604\uc2e4\ub85c \ub9cc\ub4e4\uae30 \uc704\ud574\uc11c\ub294 \uc0dd\ubb3c\ud559\uc801 \uadfc\uac70\uc5d0 \uae30\ubc18\ud55c \uccb4\uacc4\uc801\uc778 \uc704\ud5d8 \ud3c9\uac00\uac00 \ud544\uc218\uc801\uc785\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac\uae4c\uc9c0\uc758 \ub370\uc774\ud130\ub294 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc81c\uac00 \ub3d9\uc77c\ud55c \ud45c\uc801\uc744 \uaca8\ub0e5\ud558\ub294 \uae30\uc874 \uc800\ud574\uc81c\uc640 \ub9ce\uc740 \uc548\uc804\uc131 \ud2b9\uc131\uc744 \uacf5\uc720\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uc77c\ubd80 \ub3c5\uc131 \ud504\ub85c\ud30c\uc77c\uc5d0\uc11c\ub294 \ucc28\uc774\ub97c \ubcf4\uc77c \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ucc28\uc774\ub97c \uba85\ud655\ud788 \uaddc\uba85\ud558\uae30 \uc704\ud574\uc11c\ub294 \ud5a5\ud6c4 \ub354 \ub9ce\uc740 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \ub300\uaddc\ubaa8 \uc784\uc0c1 \ub370\uc774\ud130\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac \uc2dc\uc810\uc5d0\uc11c \uc2e0\uc57d \uac1c\ubc1c\uc790\uc5d0\uac8c \uac00\uc7a5 \uc911\uc694\ud55c \uba54\uc2dc\uc9c0\ub294 \ubd84\uba85\ud569\ub2c8\ub2e4. \ube44\uad50 \uc57d\ub9ac\ud559\uc801 \ubd84\uc11d\uacfc \uc720\uc804\ud559 \ubc0f \uc0dd\ubb3c\ud559\uc801 \uc778\uc0ac\uc774\ud2b8\ub97c \ud568\uaed8 \ud65c\uc6a9\ud558\uba74 \uc7a0\uc7ac\uc801\uc778 \uc548\uc804\uc131 \uc704\ud5d8\uc744 \ubcf4\ub2e4 \ud6a8\uacfc\uc801\uc73c\ub85c \uc608\uce21\ud558\uace0, \ub354 \ud569\ub9ac\uc801\uc778 \uc804\uc784\uc0c1 \uac1c\ubc1c \uc804\ub7b5\uc744 \uc218\ub9bd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.OFF-X Translational Safety Intelligence<\/a>\ub97c \ud1b5\ud574 \ud45c\uc801\ubcc4 \uc704\ud5d8\uc744 \ud3c9\uac00\ud558\uace0, \uc2e0\uc57d \ubc1c\uad74\ubd80\ud130 \uac1c\ubc1c \uc804 \uacfc\uc815\uc5d0 \uac78\uccd0 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc811\uadfc\ubc95\uc758 \uac1c\ubc1c \ub9ac\uc2a4\ud06c\ub97c \uc5b4\ub5bb\uac8c \uc904\uc77c \uc218 \uc788\ub294\uc9c0 \uc0ac\uc774\ud2b8\ub97c \ubc29\ubb38\ud574\uc11c \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694.<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574(TPD)\uc758 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uae30\uc874 \uc800\ud574\uc81c\uc640 \ube44\uad50\ud558\uace0, \uc720\uc804\ud559 \ubc0f Translational Safety Intelligence\ub97c \ud65c\uc6a9\ud55c \uc704\ud5d8 \uc608\uce21\uacfc \uc804\uc784\uc0c1 \uc548\uc804\uc131 \uc804\ub7b5\uc744 \uc0b4\ud3b4\ubcf4\uc138\uc694.<\/p>\n","protected":false},"author":101,"featured_media":583840,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_links_to":"","_links_to_type":0,"footnotes":""},"categories":[2452],"tags":[],"class_list":["post-583928","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biopharma","clarivate-content-type-blog","clarivate-industry-life-sciences-and-healthcare","clarivate-product-family-cortellis","lsh-focus-area-research-and-development"],"acf":[],"lang":"ko","translations":{"ko":583928,"en":583839,"ja":583927},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/583928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/users\/101"}],"replies":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/comments?post=583928"}],"version-history":[{"count":8,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/583928\/revisions"}],"predecessor-version":[{"id":586264,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/583928\/revisions\/586264"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media\/583840"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=583928"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/categories?post=583928"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/tags?post=583928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}