{"id":4613,"date":"2022-02-08T13:13:49","date_gmt":"2022-02-08T04:13:49","guid":{"rendered":"https:\/\/clarivate.com\/ja\/?p=4613"},"modified":"2022-02-08T13:13:49","modified_gmt":"2022-02-08T04:13:49","slug":"innovative-cardiovascular-treatments-top-pharmacotherapy-breakthroughs-at-aha21-2","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ja\/blog\/innovative-cardiovascular-treatments-top-pharmacotherapy-breakthroughs-at-aha21-2\/","title":{"rendered":"\u9769\u65b0\u7684\u306a\u5fc3\u8840\u7ba1\u7cfb\u6cbb\u7642\uff1aAHA21\u3067\u767a\u8868\u3055\u308c\u305f\u85ac\u7269\u7642\u6cd5\u306e\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc"},"content":{"rendered":"<p><a href=\"https:\/\/clarivate.com\/blog\/innovative-cardiovascular-treatments-top-pharmacotherapy-breakthroughs-at-aha21\/\">\u82f1\u8a9e\u539f\u6587\u30b5\u30a4\u30c8<\/a><\/p>\n<p><span style=\"font-size: small\">\u672c\u8a18\u4e8b\u306f\u82f1\u6587\u30d6\u30ed\u30b0\u3092\u65e5\u672c\u8a9e\u306b\u7ffb\u8a33\u518d\u7de8\u96c6\uff08\u4e00\u90e8\u8ffd\u8a18\u3092\u542b\u3080\uff09\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u672c\u8a18\u4e8b\u306e\u6b63\u5f0f\u8a00\u8a9e\u306f\u82f1\u8a9e\u3067\u3042\u308a\u3001\u305d\u306e\u5185\u5bb9\u30fb\u89e3\u91c8\u306b\u3064\u3044\u3066\u306f\u82f1\u8a9e\u304c\u512a\u5148\u3057\u307e\u3059\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u30af\u30e9\u30ea\u30d9\u30a4\u30c8\u306e\u5c02\u9580\u5bb6\u304c\u3001<a href=\"https:\/\/professional.heart.org\/en\/meetings\/scientific-sessions\" target=\"_blank\" rel=\"noopener\">2021 American Heart Association Scientific Sessions (AHA21)<\/a> \u306b\u304a\u3051\u308b\u30db\u30c3\u30c8\u30c8\u30d4\u30c3\u30af\u306b\u3064\u3044\u3066\u3001\u60a3\u8005\u6cbb\u7642\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u95a2\u3059\u308b\u30a4\u30f3\u30b5\u30a4\u30c8\u3092\u4ea4\u3048\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u30d8\u30eb\u30b9\u30b1\u30a2\u5e02\u5834\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u6cbb\u7642\u6cd5\u3092\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u300c<a href=\"https:\/\/clarivate.com\/drugs-to-watch\/\">Drugs to Watch\u2122<\/a>\u300d\u30b7\u30ea\u30fc\u30ba\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u30af\u30e9\u30ea\u30d9\u30a4\u30c8\u306e\u5c02\u9580\u5bb6\u304cAHA21 Scientific Sessions\u3067\u306e\u30c8\u30c3\u30d7\u30d4\u30c3\u30af\u3092\u9078\u3073\u307e\u3057\u305f\u3002\u3053\u306e\u30d0\u30fc\u30c1\u30e3\u30eb\u4f1a\u8b70\u3067\u306f\u30013,600\u4ee5\u4e0a\u306e\u6f14\u984c\u304b\u3089\u7814\u7a76\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u306e\u8a18\u4e8b\u3067\u306f\u30015\u3064\u306e\u6ce8\u76ee\u6f14\u984c\u306e\u5206\u6790\u3068\u3001\u533b\u7642\u7d4c\u55b6\u8005\u306b\u3068\u3063\u3066\u306e\u91cd\u8981\u306a\u30d2\u30f3\u30c8\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>1. EMPEROR-Preserved\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001empagliflozin\u304c50%\u4ee5\u4e0a\u306eHFpEF\u306b\u6709\u52b9<sup>1<\/sup><\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><em>\u99c6\u51fa\u7387\u4f4e\u4e0b\u578b\u5fc3\u4e0d\u5168\uff08HFrEF\uff09\u306b\u5bfe\u3057\u3066\u591a\u304f\u306e\u85ac\u5264\u304c\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001HFpEF\u60a3\u8005\u306b\u304a\u3051\u308b\u6709\u7528\u6027\u306e\u5b9f\u8a3c\u306f\u3001\u533b\u85ac\u54c1\u958b\u767a\u8005\u306b\u3068\u3063\u3066\u56f0\u96e3\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u80cc\u666f\uff1a<\/strong>2021\u5e748\u6708\u3001\u30d9\u30fc\u30ea\u30f3\u30ac\u30fc\u30a4\u30f3\u30b2\u30eb\u30cf\u30a4\u30e0\u3068\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306f\u3001EMPEROR-Preserved\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001HFpEF\uff08\u5de6\u5ba4\u99c6\u51fa\u738740%\u4ee5\u4e0a\uff09\u306e\u6210\u4eba\u60a3\u8005\u306e\u4e88\u5f8c\u306b21%\uff08p&lt;0.001\uff09\u306e\u6709\u610f\u306a\u6539\u5584\u3092\u793a\u3057\u305f\u6700\u521d\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066empagliflozin\uff08Jardiance\uff09\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><strong>AHA21\u3067\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\uff1a<\/strong>EMPEROR-Preserved\u8a66\u9a13\u306e\u30b5\u30d6\u89e3\u6790\u306b\u304a\u3044\u3066\u3001empagliflozin\u306fLVEF\u304c50%\u4ee5\u4e0a\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\uff08\u8a66\u9a13\u8457\u8005\u3089\u306b\u3088\u308c\u3070\u591a\u304f\u306e\u81e8\u5e8a\u533b\u304c\u300c\u771f\u306eHFpEF\u300d\u3068\u8003\u3048\u3066\u3044\u308b\uff09\u306b\u304a\u3044\u3066\u6709\u52b9\u6027\u3092\u793a\u3057\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff08CV\u6b7b\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\uff3bHHF\uff3d\u306e\u8907\u5408\uff09\u306e\u30ea\u30b9\u30af\u309217%\u4f4e\u6e1b\u3057\u307e\u3057\u305f\uff08P = 0.0244\uff09\u3002\u3053\u306e\u6240\u898b\u306f\u3001HF\u306b\u3088\u308b\u5165\u9662\u306e\u6700\u521d\u306e\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u307e\u3067\u306e\u6642\u9593\u304c22%\u77ed\u7e2e\u3055\u308c\u305f\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u307e\u3059\uff08P = 0.0128\uff09\u3002<\/p>\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b\uff1a<\/strong>\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001empagliflozin\u304c50%\u4ee5\u4e0a\u306eHFpEF\u306e\u60a3\u8005\u306b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u51e6\u65b9\u8005\u306bempagliflozin\u304c\u771f\u306eHFpEF\u60a3\u8005\u3092\u542b\u3080HFpEF\u60a3\u8005\u306b\u5bfe\u3059\u308b\u5f37\u529b\u306a\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u3067\u3042\u308b\u3053\u3068\u3092\u78ba\u4fe1\u3055\u305b\u308b\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306e\u5f71\u97ff\u306f\u3001EMPEROR-Preserved\u306e\u7d50\u679c\u304c\u4ed6\u306eSGLT-2\u963b\u5bb3\u5264\u306b\u3082\u9069\u7528\u53ef\u80fd\u3067\u3042\u308b\u3068\u3001\u958b\u696d\u533b\u304c\u3069\u308c\u3060\u3051\u5e83\u304f\u7406\u89e3\u3059\u308b\u304b\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>2. EMPULSE\u306f\u3001\u5165\u9662\u4e2d\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308bempagliflozin\u306e\u6709\u7528\u6027\u3092\u5b9f\u8a3c<sup>2<\/sup><\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><em>\u6025\u6027\u671f\u3067\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5f8c\u3001\u5fc3\u4e0d\u5168\u306e\u6cbb\u7642\u30d1\u30e9\u30c0\u30a4\u30e0\u306b\u304a\u3051\u308bempagliflozin\u306e\u4f4d\u7f6e\u4ed8\u3051\u306f\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3057\u5f97\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u80cc\u666f\uff1a<\/strong>\u904e\u53bb5\u5e74\u9593\u3001\u79c1\u305f\u3061\u306fDAPA-HF\u3084EMPEROR-Preserved\u3001EMPEROR-Reduced\u306a\u3069\u306eSGLT-2\u963b\u5bb3\u5264\u306b\u95a2\u3059\u308b\u8a66\u9a13\u306b\u3088\u308a\u6162\u6027\u5fc3\u4e0d\u5168\u6cbb\u7642\u306e\u9032\u6b69\u3092\u76ee\u306e\u5f53\u305f\u308a\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u30ec\u30ad\u30b7\u30b3\u30f3\u306esotagliflozin\u306eSOLOIST\u8a66\u9a13\u3067\u306f\u3001\u5fc3\u4e0d\u5168\u3067\u5165\u9662\u3057\u305f\u5f53\u521d\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u30d9\u30fc\u30ea\u30f3\u30ac\u30fc\u30a4\u30f3\u30b2\u30eb\u30cf\u30a4\u30e0\u3068\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306eJardiance\uff08empagliflozin\uff09\u306eEMPULSE\u8a66\u9a13\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u72b6\u614b\u3084\u99c6\u51fa\u7387\u306e\u72b6\u614b\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u5165\u9662\u4e2d\u306e\u6025\u6027\u5fc3\u4e0d\u5168\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3057\u305f\u521d\u3081\u3066\u306eSGLT-2\u963b\u5bb3\u5264\u306e\u8a66\u9a13\u3067\u3059\u3002<\/p>\n<p><strong>AHA21\u3067\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\uff1a<\/strong>90\u65e5\u9593\u3068\u3044\u3046\u6bd4\u8f03\u7684\u77ed\u3044\u6642\u9593\u67a0\u306e\u4e2d\u3067\u3001empagliflozin\u3092\u6295\u4e0e\u3057\u305f\u5834\u5408\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u306636%\uff0895% CI: 1.09 to 1.68; P = 0.0054\uff09 \u9ad8\u3044\u78ba\u7387\u3067\u81e8\u5e8a\u52b9\u679c\u3092\u5b9f\u611f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3044\u3044\u307e\u3059\u3002\u307e\u305f\u3001empagliflozin\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u6b7b\u4ea1\u3084\u5fc3\u4e0d\u5168\u306e\u30a4\u30d9\u30f3\u30c8\u3082\u5c11\u306a\u304b\u3063\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <a href=\"https:\/\/eventpilotadmin.com\/web\/page.php?page=IntHtml&amp;project=AHA21&amp;id=6385\" target=\"_blank\" rel=\"noopener\">EMPULSE<\/a>\u306f\u3001SGLT-2\u963b\u5bb3\u5264\u304c\u6025\u6027\u671f\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u3068\u3044\u3046\u4e00\u9023\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u8ffd\u52a0\u3059\u308b\u3082\u306e\u3067\u3059\u3002EMPULSE\u306f\u3001\u3055\u3089\u306b\u8e0f\u307f\u8fbc\u3093\u3067\u3001SGLT-2\u963b\u5bb3\u5264\u3092\u75c5\u9662\u5185\u3067\u4f7f\u7528\u3057\u3001\u75be\u60a3\u7ba1\u7406\u306e\u65e9\u3044\u6bb5\u968e\u3067\u6cbb\u7642\u958b\u59cb\u306e\u30bf\u30a4\u30e0\u30d5\u30ec\u30fc\u30e0\u3092\u30b7\u30d5\u30c8\u3059\u3079\u304d\u3053\u3068\u3092\u5177\u4f53\u7684\u306b\u793a\u3057\u305f\u3082\u306e\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b\uff1a<\/strong>2\u578b\u7cd6\u5c3f\u75c5\u306b\u95a2\u4fc2\u306a\u304f\u767b\u9332\u3055\u308c\u305f\u3053\u3068\u306f\u3001SGLT-2\u963b\u5bb3\u5264\u304c\u672c\u6765\u958b\u767a\u3055\u308c\u305f2\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306b\u52a0\u3048\u3001\u5fc3\u8840\u7ba1\u6cbb\u7642\u85ac\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u4e00\u6b69\u3068\u306a\u308a\u307e\u3059\u3002SGLT-2\u963b\u5bb3\u85ac\u306e\u6cbb\u7642\u958b\u59cb\u304c\u75c5\u9662\u3068\u3044\u3046\u74b0\u5883\u306b\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u308b\u3053\u3068\u3067\u3001\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u9577\u671f\u7ba1\u7406\u306b\u304a\u3044\u3066empagliflozin\u3084\u304a\u305d\u3089\u304f\u4ed6\u306eSGLT-2\u963b\u5bb3\u85ac\u304c\u4f7f\u7528\u3055\u308c\u308b\u7a0b\u5ea6\u304c\u5411\u4e0a\u3059\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>3. \u9593\u8449\u7cfb\u524d\u99c6\u7d30\u80de\u306e\u6a19\u7684\u7d4c\u5fc3\u5185\u6295\u4e0e\u306b\u3088\u308a\u3001\u5168\u8eab\u6027\u708e\u75c7\u3092\u6709\u3059\u308b\u9ad8\u30ea\u30b9\u30af\u306e\u6162\u6027\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308b\u4e0d\u53ef\u9006\u7684\u306a\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u306e\u767a\u75c7\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u6e1b\u5c11<sup>3<\/sup><\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><em>\u30e1\u30bd\u30d6\u30e9\u30b9\u30c8\u306erexlemestrocel-L\uff08Revascor\uff09\u306f\u3001\u5fc3\u4e0d\u5168\u7ba1\u7406\u306b\u610f\u5473\u306e\u3042\u308b\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u6700\u521d\u306e\u5e79\u7d30\u80de\u7642\u6cd5\u3068\u306a\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u80cc\u666f\uff1a<\/strong>2020\u5e7412\u6708\u3001\u30e1\u30bd\u30d6\u30e9\u30b9\u30c8\u306f\u3001\u9032\u884c\u3057\u305f\u6162\u6027\u5fc3\u4e0d\u5168\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u540c\u7a2e\u7d30\u80de\u7642\u6cd5rexlemestrocel-L\u306e\u7b2cIII\u76f8DREAM-HF\u8a66\u9a13\u306e\u30c8\u30c3\u30d7\u30e9\u30a4\u30f3\u7d50\u679c\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u71b1\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3092\u6e1b\u3089\u3059\u3068\u3044\u3046\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u6e80\u305f\u3055\u308c\u306a\u304b\u3063\u305f\u3082\u306e\u306e\u3001\u4e8b\u524d\u306b\u8a2d\u5b9a\u3057\u305f\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308b\u5fc3\u81d3\u6b7b\u306e\u6709\u610f\u306a\u6e1b\u5c11\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><strong>AHA21\u3067\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\uff1a<\/strong>\u3053\u306e\u65b0\u3057\u3044\u89e3\u6790\u3067\u306f\u3001rexlemestrocel-L\u306e\u5358\u56de\u6ce8\u5165\u306f\u3001537\u4eba\u306e\u60a3\u8005\u3059\u3079\u3066\u306b\u304a\u3044\u3066\u3001\u975e\u81f4\u6b7b\u6027MI\u307e\u305f\u306f\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u3092\u542b\u3080\u4e0d\u53ef\u9006\u7684\u75c5\u72b6\u306e\u30ea\u30b9\u30af\u306e65%\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\uff08HR, 0.346; P = 0.001 \uff09\u3002\u5168\u8eab\u6027\u708e\u75c7\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u8840\u6f3f\u4e2d\u9ad8\u611f\u5ea6CRP\u304c2mg\/L\u4ee5\u4e0a\uff09\u3092\u6709\u3059\u308b301\u4eba\u306e\u60a3\u8005\u3067\u306f\u3001\u30ea\u30b9\u30af\u304c79%\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08HR, 0.206; 95% CI, 0.070, 0.611; P = 0.004 \uff09\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306fNYHA\u30af\u30e9\u30b9II\u3068III\u306e\u60a3\u8005\u3067\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u5168\u8eab\u6027\u306e\u708e\u75c7\u304c\u306a\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u708e\u75c7\u3092\u6709\u3059\u308bNYHA\u30af\u30e9\u30b9II\u60a3\u8005\u306b\u304a\u3044\u3066\u3001Rexlemestrocel-L\u306b\u3088\u308aCV\u6b7b\u307e\u3067\u306e\u6642\u9593\u304c80%\u6709\u610f\u306b\u77ed\u7e2e\u3055\u308c\u307e\u3057\u305f\uff08HR, 0.204; 95% CI, 0.068, 0.618; P = 0.005 \uff09\u3002<\/p>\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b\uff1a<\/strong>\u8fd1\u5e74\u306e\u6cbb\u7642\u6cd5\u306e\u9032\u6b69\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5fc3\u4e0d\u5168\u306e\u6b7b\u4ea1\u7387\u306f\u4f9d\u7136\u3068\u3057\u3066\u9ad8\u3044\u6c34\u6e96\u306b\u3042\u308a\u307e\u3059\u3002\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u3068\u3057\u3066\u306f\u3053\u308c\u307e\u3067\u3067\u6700\u5927\u898f\u6a21\u306e\u672c\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001HFrEF\u304a\u3088\u3073\u708e\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u306frexlemestrocel-L\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6709\u671b\u306a\u77e5\u898b\u306f\u3001rexlemestrocel-L\u304c\u5fc3\u4e0d\u5168\u6cbb\u7642\u306e\u30d1\u30e9\u30c0\u30a4\u30e0\u306b\u304a\u3044\u3066\u660e\u78ba\u306a\u4f4d\u7f6e\u3092\u5360\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>4. \u7d4c\u53e3PCSK9\u963b\u5bb3\u5264MK-0616\u306e\u521d\u306e\u30d2\u30c8\u8a66\u9a13\u30c7\u30fc\u30bf\u306b\u3088\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u7cfb\u85ac\u5264\u306b\u52a0\u3048LDL-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e<sup>4<\/sup><\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><em>PCSK9\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u5264\u306f\u6709\u52b9\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u9ad8\u4fa1\u306a\u6ce8\u5c04\u5264\u3067\u3059\u3002\u7d4c\u53e3\u6295\u4e0e\u53ef\u80fd\u306a\u7af6\u5408\u54c1\u306f\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u304a\u3088\u3073\u52d5\u8108\u786c\u5316\u6027\u5fc3\u75be\u60a3\uff08ASCVD\uff09\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u91cd\u8981\u306a\u65b0\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u80cc\u666f\uff1a<\/strong>proprotein convertase subtilisin\/kexin type 9\uff08PCSK9\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u4e00\u6b21\u6cbb\u7642\u306b\u52a0\u3048\u3001\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u304a\u3088\u3073ASCVD\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u3068\u3044\u3046\u70b9\u3067\u91cd\u8981\u306a\u9032\u6b69\u3092\u3082\u305f\u3089\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001PCSK9\u3092\u6a19\u7684\u3068\u3057\u305f\u73fe\u5728\u5229\u7528\u53ef\u80fd\u306a\u6cbb\u7642\u6cd5\uff08\u304a\u3088\u3073\u6700\u65b0\u306e\u6cbb\u7642\u6cd5\uff09\u306f\u3001\u3059\u3079\u3066\u6ce8\u5c04\u306b\u3088\u308b\u6295\u4e0e\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u3053\u306e\u3053\u3068\u306f\u3001\u6cbb\u7642\u6cd5\u306e\u5229\u7528\u3001\u5c0e\u5165\u3001\u304a\u3088\u3073\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306e\u969c\u58c1\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>AHA21\u3067\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\uff1a<\/strong>\u30e1\u30eb\u30af\u306f\u3001PCSK9\u3092\u6a19\u7684\u3068\u3059\u308b\u7d4c\u53e3\u751f\u7269\u5b66\u7684\u5229\u7528\u53ef\u80fd\u306a\u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308bMK-0616\u306e<a href=\"https:\/\/eventpilotadmin.com\/web\/page.php?page=IntHtml&amp;project=AHA21&amp;id=6322\" target=\"_blank\" rel=\"noopener\">\u6700\u521d\u306e\u30d2\u30c8\u3067\u306e\u30c7\u30fc\u30bf<\/a>\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3081\u306e\u88ab\u9a13\u800540\u540d\uff08\u3046\u306185%\u306f\u4e2d\u5f37\u5ea6\u307e\u305f\u306f\u9ad8\u5f37\u5ea6\u306e\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u4e2d\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u7b2cI\u76f8\u53cd\u5fa9\u6295\u4e0e\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001MK-0616\u306f14\u65e5\u5f8c\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u5c11\u306a\u304f\u3068\u308250\uff05\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u6709\u52b9\u6027\u306e\u7a0b\u5ea6\u306f\u3001PCSK9\u3092\u6a19\u7684\u3068\u3059\u308b\u627f\u8a8d\u6e08\u307f\u6ce8\u5c04\u5264\u304a\u3088\u3073\u5b9f\u9a13\u7684\u6ce8\u5c04\u5264\u3067\u89b3\u5bdf\u3055\u308c\u305f\u7bc4\u56f2\u5185\u3067\u3059\u3002<\/p>\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b\uff1a<\/strong>\u7279\u306b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u3088\u3046\u306b\u751f\u6daf\u306b\u308f\u305f\u308b\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u75be\u60a3\u3067\u306f\u3001\u591a\u304f\u306e\u4eba\u304c\u6ce8\u5c04\u5264\u3088\u308a\u3082\u9320\u5264\u306e\u670d\u7528\u3092\u5e0c\u671b\u3057\u3066\u3044\u307e\u3059\u3002\u7d4c\u53e3\u6295\u4e0e\u306e\u8102\u8cea\u7ba1\u7406\u85ac\u306f\u6570\u591a\u304f\u5e02\u8ca9\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u591a\u304f\u306e\u60a3\u8005\u306f\u4f9d\u7136\u3068\u3057\u3066ASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u62b1\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u306b\u306f\u3001\u30a8\u30b9\u30da\u30ea\u30aa\u30f3\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u306e\u7d4c\u53e3\u5264\u3067\u3042\u308bNexletol\uff08\u30d9\u30e0\u30da\u30c9\u9178\uff09\u304a\u3088\u3073Nexlizet\uff08\u30d9\u30e0\u30da\u30c9\u9178\uff0b\u30a8\u30bc\u30c1\u30df\u30d6\uff09\u3001\u3042\u308b\u3044\u306fPCSK9\u3092\u6a19\u7684\u3068\u3057\u305f\u6ce8\u5c04\u5264\u3067\u3042\u308b\u30a2\u30e0\u30b8\u30a7\u30f3\u306eRepatha\uff08evolocumab\uff09\u3001\u30b5\u30ce\u30d5\u30a3\uff0f\u30ea\u30b8\u30a7\u30cd\u30ed\u30f3\u306ePraluent (alirocumab)\u3001\u6b27\u5dde\u3067\u6700\u8fd1\u767a\u58f2\u3055\u308c\u305f\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9\u793e\u306e\u9694\u65e5\u6295\u4e0e\u306eLeqvio (inclisiran)\u304c\u51e6\u65b9\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6cbb\u7642\u30b3\u30b9\u30c8\u3068\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306f\u3001\u52b9\u679c\u7684\u306a\u9577\u671f\u7684\u75be\u75c5\u7ba1\u7406\u3092\u7d99\u7d9a\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u8981\u7d20\u3067\u3042\u308a\u3001\u5f37\u529b\u306a\u7d4c\u53e3\u5264\u306e\u65b0\u3057\u3044\u9078\u629e\u80a2\u306f\u3001\u6ce8\u5c04\u5264\u306e\u7af6\u5408\u54c1\u3088\u308a\u3082\u5e83\u304f\u53d7\u3051\u5165\u308c\u3089\u308c\u3001\u7279\u306b\u30d7\u30e9\u30a4\u30de\u30ea\u30fc\u30b1\u30a2\u533b\u306e\u9593\u3067\u6025\u901f\u306b\u5e02\u5834\u306b\u6d78\u900f\u3057\u3066\u3044\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>5. \u65b0\u898f\u306e\u7d4c\u53e3FXIa\u963b\u5bb3\u5264\u3067\u3042\u308bmilvexian\u306f\u3001\u9759\u8108\u8840\u6813\u585e\u6813\u75c7\uff08VTE\uff09\u306e\u4e88\u9632\u306b\u6709\u671b\u306a\u7d50\u679c\u3092\u793a\u3059<sup>5<\/sup><\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p><em>Milvexian\u306f\u3001\u819d\u95a2\u7bc0\u5f62\u6210\u8853\u5f8c\u306b\u3001\u73fe\u5728\u306eSoC\u3067\u3042\u308b\u30a8\u30ce\u30ad\u30b5\u30d1\u30ea\u30f3\u76ae\u4e0b\u6295\u4e0e\u3068\u6bd4\u8f03\u3057\u3066\u3001\u512a\u308c\u305f\u6709\u52b9\u6027\u3068\u305d\u308c\u306b\u898b\u5408\u3046\u5b89\u5168\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30df\u30eb\u30d9\u30b7\u30a2\u30f3\u306f\u7d4c\u53e3\u6295\u4e0e\u304c\u53ef\u80fd\u3067\u3042\u308b\u3068\u3044\u3046\u5229\u70b9\u3082\u6709\u3057\u3066\u3044\u307e\u3059\u3002<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u80cc\u666f\uff1a<\/strong>\u30e4\u30f3\u30bb\u30f3\u3068\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6\u306f\u3001\u30d5\u30a1\u30fc\u30b9\u30c8\u30a4\u30f3\u30af\u30e9\u30b9\u306e\u7d4c\u53e3FXIa\u963b\u5bb3\u5264\u3068\u306a\u308b\u53ef\u80fd\u6027\u306e\u3042\u308bmilvexian\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002FXIa\u306f\u30c8\u30ed\u30f3\u30d3\u30f3\u751f\u6210\u3092\u5897\u5e45\u3057\u3001\u6b62\u8840\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304b\u3089\u3001FXI\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u8840\u6813\u585e\u6813\u75c7\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><strong>AHA21\u3067\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\uff1a<\/strong>\u819d\u95a2\u7bc0\u7f6e\u63db\u8853\uff08TKR\uff09\u5f8c\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001milvexian\u309225\uff5e400 mg\u306e\u7bc4\u56f2\u30671\u65e51\u56de\u6295\u4e0e\u3057\u305f\u7b2cII\u76f8\u8a66\u9a13\uff08<a href=\"https:\/\/eventpilotadmin.com\/web\/page.php?page=IntHtml&amp;project=AHA21&amp;id=6216\" target=\"_blank\" rel=\"noopener\">AXIOMATIC-TKR<\/a>\uff09\u306e\u30c7\u30fc\u30bf\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u30021\u65e5100 mg\u4ee5\u4e0a\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001\u6a19\u6e96\u6cbb\u7642\u85ac\u3067\u3042\u308benoxaparin\u3068\u6bd4\u8f03\u3057\u3066VTE\u767a\u751f\u7387\u304c\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\uff08\u305d\u308c\u305e\u308c7~11% vs 21%\uff09\u3001\u51fa\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b\uff1a<\/strong>\u73fe\u5728\u306e\u6297\u51dd\u56fa\u85ac\uff08enoxaparin\u306a\u3069\u306e\u65e7\u6765\u306e\u6ce8\u5c04\u5264\u3001rivaroxaban\u306a\u3069\u306e\u65b0\u578b\u7d4c\u53e3\u5264\uff09\u306f\u3001\u5fc3\u623f\u7d30\u52d5\u60a3\u8005\u306b\u304a\u3051\u308bVTE\u4e88\u9632\u3001VTE\u6cbb\u7642\u3001\u8133\u5352\u4e2d\u4e88\u9632\u306a\u3069\u69d8\u3005\u306a\u5834\u9762\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u91cd\u8981\u6027\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u305d\u306e\u6709\u52b9\u6027\u306f\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u307e\u305f\u3001\u91cd\u7be4\u306a\u51fa\u8840\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u3068\u308b\u3053\u3068\u306f\u6297\u51dd\u56fa\u85ac\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3042\u308a\uff0c\u3088\u308a\u512a\u308c\u305f\u30ea\u30b9\u30af\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6301\u3064\u6709\u52b9\u306a\u65b0\u85ac\u304c\uff0c\u81e8\u5e8a\u5bb6\u306b\u8fc5\u901f\u304b\u3064\u5e83\u304f\u53d7\u3051\u5165\u308c\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5bc4\u7a3f\u8005<\/strong><br \/>\n\u3053\u306e\u8a18\u4e8b\u3092\u57f7\u7b46\u3057\u305f\u5faa\u74b0\u5668\u3001\u4ee3\u8b1d\u3001\u814e\u81d3\u3001\u8840\u6db2\u30b0\u30eb\u30fc\u30d7\u306e\u30af\u30e9\u30ea\u30d9\u30a4\u30c8\u5c02\u9580\u5bb6\u306f\u3001Yogesh Shelke M.B.A. (Pharm.), Dwaipayan Chatterjee, M.Pharm., Saptaswa Sen, Ph.D., Gideon Heap, M.Sc., David Rees, Ph.D., Tim Blackstock, M.B. Ch.B. and Graeme Green, Ph.D., M.Sc\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5909\u5316\u306e\u6fc0\u3057\u3044\u5fc3\u81d3\u8840\u7ba1\u306e\u72b6\u6cc1\u3092\u628a\u63e1\u3057\u3001\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u610f\u601d\u6c7a\u5b9a\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/strong><\/p>\n<p><strong>\u30af\u30e9\u30ea\u30d9\u30a4\u30c8\u306e<a href=\"https:\/\/clarivate.com\/products\/research-reports\/disease-landscape-and-forecast\/\">Market Assessment Research\u30ec\u30dd\u30fc\u30c8<\/a>\u3067\u306f\u3001\u4f55\u767e\u3082\u306e\u9069\u5fdc\u75c7\u306b\u95a2\u3059\u308b\u5305\u62ec\u7684\u306a\u30de\u30fc\u30b1\u30c3\u30c8\u30a4\u30f3\u30c6\u30ea\u30b8\u30a7\u30f3\u30b9\u3092\u3054\u5229\u7528\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol style=\"font-size: 14px\">\n<li>Anker SD, et al. EMPEROR-Preserved: Empagliflozin in Heart Failure with a Preserved Ejection Fraction \u226550% &#8211; Results from the EMPEROR-Preserved Clinical Trial. Circulation 2021; 144(suppl1): LBS.05<\/li>\n<li>EMPULSE: Efficacy and Safety of Empagliflozin in Hospitalized Heart Failure Patients: Main Results from the EMPULSE Trial. Circulation 2021; 144(suppl1):05<\/li>\n<li>Perin EC, et al. Randomized Trial of Targeted Transendocardial Delivery of Mesenchymal Precursor Cells in High-Risk Chronic Heart Failure Patients With Reduced Ejection Fraction. Circulation 2021; 144(suppl1): LBS.05<\/li>\n<li>Johns DG, et al. The Clinical Safety, Pharmacokinetics, and LDL-Cholesterol Lowering Efficacy of MK-0616, an Oral PCSK9 Inhibitor. Circulation 2021; 144(suppl1): 06<\/li>\n<li>AXIOMATIC-TKR: Milvexian for Prevention of Venous Thromboembolism after Elective Knee Arthroplasty: The AXIOMATIC-TKR Study. Circulation 2021; 144(suppl1):07<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u82f1\u8a9e\u539f\u6587\u30b5\u30a4\u30c8 \u672c\u8a18\u4e8b\u306f\u82f1\u6587\u30d6\u30ed\u30b0\u3092\u65e5\u672c\u8a9e\u306b\u7ffb\u8a33\u518d\u7de8\u96c6\uff08\u4e00\u90e8\u8ffd\u8a18\u3092\u542b\u3080\uff09\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u672c\u8a18\u4e8b\u306e\u6b63\u5f0f\u8a00\u8a9e\u306f\u82f1\u8a9e\u3067\u3042\u308a\u3001\u305d\u306e\u5185\u5bb9\u30fb\u89e3\u91c8\u306b\u3064\u3044\u3066\u306f\u82f1\u8a9e\u304c\u512a\u5148\u3057\u307e\u3059\u3002 &nbsp; \u30af\u30e9\u30ea\u30d9\u30a4\u30c8\u306e\u5c02\u9580\u5bb6\u304c\u30012021 American Heart Association Scientific Sessions (AHA21) \u306b\u304a\u3051\u308b\u30db\u30c3\u30c8\u30c8\u30d4\u30c3\u30af\u306b\u3064\u3044\u3066\u3001\u60a3\u8005\u6cbb\u7642\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u95a2\u3059\u308b\u30a4\u30f3\u30b5\u30a4\u30c8\u3092\u4ea4\u3048\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002 &nbsp; \u30d8\u30eb\u30b9\u30b1\u30a2\u5e02\u5834\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u6cbb\u7642\u6cd5\u3092\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u300cDrugs to Watch\u2122\u300d\u30b7\u30ea\u30fc\u30ba\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u30af\u30e9\u30ea\u30d9\u30a4\u30c8\u306e\u5c02\u9580\u5bb6\u304cAHA21 Scientific Sessions\u3067\u306e\u30c8\u30c3\u30d7\u30d4\u30c3\u30af\u3092\u9078\u3073\u307e\u3057\u305f\u3002\u3053\u306e\u30d0\u30fc\u30c1\u30e3\u30eb\u4f1a\u8b70\u3067\u306f\u30013,600\u4ee5\u4e0a\u306e\u6f14\u984c\u304b\u3089\u7814\u7a76\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u306e\u8a18\u4e8b\u3067\u306f\u30015\u3064\u306e\u6ce8\u76ee\u6f14\u984c\u306e\u5206\u6790\u3068\u3001\u533b\u7642\u7d4c\u55b6\u8005\u306b\u3068\u3063\u3066\u306e\u91cd\u8981\u306a\u30d2\u30f3\u30c8\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002 &nbsp; &nbsp; 1. EMPEROR-Preserved\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001empagliflozin\u304c50%\u4ee5\u4e0a\u306eHFpEF\u306b\u6709\u52b91 &nbsp; \u99c6\u51fa\u7387\u4f4e\u4e0b\u578b\u5fc3\u4e0d\u5168\uff08HFrEF\uff09\u306b\u5bfe\u3057\u3066\u591a\u304f\u306e\u85ac\u5264\u304c\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001HFpEF\u60a3\u8005\u306b\u304a\u3051\u308b\u6709\u7528\u6027\u306e\u5b9f\u8a3c\u306f\u3001\u533b\u85ac\u54c1\u958b\u767a\u8005\u306b\u3068\u3063\u3066\u56f0\u96e3\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002 &nbsp; \u80cc\u666f\uff1a2021\u5e748\u6708\u3001\u30d9\u30fc\u30ea\u30f3\u30ac\u30fc\u30a4\u30f3\u30b2\u30eb\u30cf\u30a4\u30e0\u3068\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306f\u3001EMPEROR-Preserved\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001HFpEF\uff08\u5de6\u5ba4\u99c6\u51fa\u738740%\u4ee5\u4e0a\uff09\u306e\u6210\u4eba\u60a3\u8005\u306e\u4e88\u5f8c\u306b21%\uff08p&lt;0.001\uff09\u306e\u6709\u610f\u306a\u6539\u5584\u3092\u793a\u3057\u305f\u6700\u521d\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066empagliflozin\uff08Jardiance\uff09\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002 AHA21\u3067\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\uff1aEMPEROR-Preserved\u8a66\u9a13\u306e\u30b5\u30d6\u89e3\u6790\u306b\u304a\u3044\u3066\u3001empagliflozin\u306fLVEF\u304c50%\u4ee5\u4e0a\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\uff08\u8a66\u9a13\u8457\u8005\u3089\u306b\u3088\u308c\u3070\u591a\u304f\u306e\u81e8\u5e8a\u533b\u304c\u300c\u771f\u306eHFpEF\u300d\u3068\u8003\u3048\u3066\u3044\u308b\uff09\u306b\u304a\u3044\u3066\u6709\u52b9\u6027\u3092\u793a\u3057\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff08CV\u6b7b\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\uff3bHHF\uff3d\u306e\u8907\u5408\uff09\u306e\u30ea\u30b9\u30af\u309217%\u4f4e\u6e1b\u3057\u307e\u3057\u305f\uff08P = 0.0244\uff09\u3002\u3053\u306e\u6240\u898b\u306f\u3001HF\u306b\u3088\u308b\u5165\u9662\u306e\u6700\u521d\u306e\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u307e\u3067\u306e\u6642\u9593\u304c22%\u77ed\u7e2e\u3055\u308c\u305f\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u307e\u3059\uff08P = 0.0128\uff09\u3002&#8230;<\/p>\n","protected":false},"author":161,"featured_media":4617,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_links_to":"","_links_to_type":0,"footnotes":""},"categories":[1297,1300,1228],"tags":[],"class_list":["post-4613","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-cortellis","category-life-sciences-healthcare","clarivate-industry-life-sciences-and-healthcare","clarivate-product-biopharma"],"acf":[],"lang":"ja","translations":{"ja":4613},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/4613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/users\/161"}],"replies":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/comments?post=4613"}],"version-history":[{"count":0,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/4613\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media\/4617"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=4613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/categories?post=4613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/tags?post=4613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}