{"id":1726,"date":"2020-08-19T10:10:03","date_gmt":"2020-08-19T01:10:03","guid":{"rendered":"https:\/\/clarivate.com\/jp\/blog\/%e5%89%b5%e8%96%ac%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e7%89%b9%e5%ae%9a\/?lang=ja"},"modified":"2020-08-19T10:10:03","modified_gmt":"2020-08-19T01:10:03","slug":"identifying-risks-in-drug-discovery-2","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ja\/blog\/identifying-risks-in-drug-discovery-2\/","title":{"rendered":"\u5275\u85ac\u306b\u304a\u3051\u308b\u30ea\u30b9\u30af\u306e\u7279\u5b9a"},"content":{"rendered":"<div class=\"float-left mr-3\"><span class=\"author vcard\"><img loading=\"lazy\" decoding=\"async\" class=\"avatar avatar-70 wp-user-avatar wp-user-avatar-70 photo alignleft\" src=\"https:\/\/clarivate.com\/cortellis\/wp-content\/uploads\/sites\/4\/2020\/07\/Joshi-Barr-Headshot-BW-150x150.jpg\" alt=\"shivanjali\" width=\"70\" height=\"70\" \/><\/span><\/div>\n<div class=\"float-left author-text\">\n<p class=\"author-name text-uppercase mb-2\"><strong>SHIVANJALI JOSHI-BARR<\/strong><\/p>\n<p class=\"author-title mb-0\">Solution Scientist, Clarivate<\/p>\n<\/div>\n<p>&nbsp;<br \/>\n&nbsp;<br \/>\n&nbsp;<br \/>\n<a href=\"https:\/\/clarivate.com\/cortellis\/article\/identifying-risks-in-drug-discovery\/\">\u82f1\u8a9e\u539f\u6587<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u7b2c\u2160\u76f8\u81e8\u5e8a\u8a66\u9a13\u306b\u53c2\u52a0\u3059\u308b\u6d3b\u6027\u7269\u8cea8\u7a2e\u985e\u306e\u3046\u3061\u3001\u627f\u8a8d\u30fb\u4e0a\u5e02\u3055\u308c\u3066\u3044\u308b\u306e\u306f1\u7a2e\u985e\u306e\u88fd\u54c1\u306e\u307f\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059[1]\u3002\u81e8\u5e8a\u8a66\u9a13\u306e\u6210\u529f\u7387\u304c\u4f4e\u3044\u306e\u306f\u3001\u30d2\u30c8\u3067\u306e\u6709\u52b9\u6027\u306e\u4f4e\u3055\u3084\u3001\u6709\u5bb3\u4e8b\u8c61\u304c\u767a\u751f\u3057\u3066\u958b\u767a\u4e2d\u6b62\u306b\u81f3\u308b\u3053\u3068\u304c\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059[2]\u3002<\/p>\n<p>\u85ac\u7269\u81ea\u4f53\u306e\u56fa\u6709\u306e\u7279\u6027\u3084\u3001\u500b\u3005\u306e\u53cd\u5fdc\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b66\u306e\u5fae\u5999\u306a\u5f79\u5272\u306b\u95a2\u3059\u308b\u77e5\u898b\u306f\u3001\u533b\u85ac\u54c1\u958b\u767a\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u5168\u4f53\u7684\u306a\u6210\u529f\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u30d2\u30f3\u30c8\u306b\u306a\u308a\u5f97\u307e\u3059\u3002\u3053\u306e3\u90e8\u69cb\u6210\u306e\u30d6\u30ed\u30b0\u30b7\u30ea\u30fc\u30ba\u3067\u306f\u3001\u5275\u85ac\u6bb5\u968e\u306e\u5404\u30b9\u30c6\u30c3\u30d7\u304c\u6210\u529f\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u3069\u306e\u3088\u3046\u306b\u91cd\u8981\u3067\u3042\u308b\u304b\u3001\u307e\u305f\u3001\u6bd2\u6027\u8a66\u9a13\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u308b\u30d9\u30b9\u30c8\u30d7\u30e9\u30af\u30c6\u30a3\u30b9\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u65e9\u671f\u6bb5\u968e<\/h2>\n<p>\u898f\u5236\u5f53\u5c40\u304b\u3089\u627f\u8a8d\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u533b\u85ac\u54c1\u306b\u3064\u3044\u3066\u3001\u521d\u671f\u306e\u5275\u85ac\u6bb5\u968e\u306b\u3042\u308b5,000\uff5e10,000\u7a2e\u985e\u306e\u5316\u5b66\u7269\u8cea\u306e\u3046\u3061\u3001\u524d\u81e8\u5e8a\u958b\u767a\u3078\u9032\u3080\u3082\u306e\u306f\u6570\u767e\u7a2e\u985e\u306b\u3059\u304e\u307e\u305b\u3093[2]\u3002 2022\u5e74\u307e\u3067\u306b\u4e16\u754c\u306e\u7814\u7a76\u958b\u767a\u8cbb\u306f920\u5104\u30c9\u30eb\u306b\u9054\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u6700\u3082\u5805\u7262\u3067\u30ea\u30b9\u30af\u306e\u5c11\u306a\u3044\u5019\u88dc\u7269\u8cea\u3092\u81e8\u5e8a\u306b\u9032\u3081\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059[1]\u3002\u305d\u306e\u305f\u3081\u3001\u5275\u85ac\u6bb5\u968e\u3067\u306f\u5b89\u5168\u6027\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306b\u4ee5\u4e0b\u306e\u70b9\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u4fe1\u983c\u6027<\/li>\n<li>\u89e3\u6790<\/li>\n<li>\u30c9\u30e9\u30c3\u30b0\u30c7\u30b6\u30a4\u30f3\u3001\u30c8\u30ea\u30a2\u30fc\u30b8\u3001\u30d2\u30c3\u30c8<\/li>\n<li>\u85ac\u7269\u306e\u518d\u5229\u7528<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u4fe1\u983c\u6027<\/h2>\n<p>\u65e9\u671f\u5275\u85ac\u7814\u7a76\u306e\u57fa\u790e\u3068\u306a\u308b\u306e\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u51fa\u7248\u3055\u308c\u305f\u6587\u732e\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u6bb5\u968e\u3067\u306f\u65e2\u5b58\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u59a5\u5f53\u6027\u3092\u518d\u73fe\u3057\u3001\u5275\u85ac\u53ef\u80fd\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u3084\u75be\u60a3\u9818\u57df\u3092\u7279\u5b9a\u3057\u3066\u5275\u85ac\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u306b\u91cd\u70b9\u304c\u7f6e\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u6982\u5ff5\u5b9f\u8a3c\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u81ea\u4f53\u304c\u56f0\u96e3\u306a\u4f5c\u696d\u3067\u3042\u308b\u4e00\u65b9\u3067\u3001\u7279\u5b9a\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u306a\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u30d5\u30a1\u30fc\u30b9\u30c8\u30a4\u30f3\u30af\u30e9\u30b9\u3092\u76ee\u6307\u3057\u3066\u65b0\u898f\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u8ffd\u6c42\u3057\u3066\u3082\u3001\u305d\u306e\u85ac\u5264\u304c\u526f\u4f5c\u7528\u3092\u4f34\u3046\u5834\u5408\u306b\u306f\u3001\u6642\u9593\u3001\u8cbb\u7528\u3001\u30ea\u30bd\u30fc\u30b9\u3092\u7121\u99c4\u306b\u3057\u3066\u3057\u307e\u3046\u5371\u967a\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u30c7\u30fc\u30bf\u89e3\u6790\u3078\u306e\u7d71\u5408\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/h2>\n<p>\u524d\u81e8\u5e8a\u6bd2\u6027\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u3088\u308a\u7dcf\u5408\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u3001\u8907\u6570\u306eOMICS\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\uff08\u30b2\u30ce\u30df\u30af\u30b9\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u3001\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\u3001\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u5019\u88dc\u85ac\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u6bd2\u6027\u7279\u7570\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3084\u7d4c\u8def\u3092\u7279\u5b9a\u3059\u308b\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u85ac\u5264\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u5168\u4f53\u7684\u306a\u7d4c\u8def\u3084\u30d7\u30ed\u30bb\u30b9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059[3][4]\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u30c9\u30e9\u30c3\u30b0\u30c7\u30b6\u30a4\u30f3\u3001\u30c8\u30ea\u30a2\u30fc\u30b8\u3001\u30ea\u30fc\u30c9\u3078\u306e\u30d2\u30c3\u30c8\u3001\u30ea\u30fc\u30c9\u306e\u6700\u9069\u5316<\/h2>\n<p>\u30ea\u30fc\u30c9\u540c\u5b9a\u306e\u4e3b\u306a\u76ee\u7684\u306f\u3001\u5b9f\u9a13\u7cfb\u3067\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u6709\u3059\u308b\u6700\u9ad8\u52b9\u529b\u306e\u85ac\u5264\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u524d\u81e8\u5e8a\u958b\u767a\u306b\u5411\u3051\u3066\u9032\u5c55\u3059\u308b\u30ea\u30fc\u30c9\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3084\u30cf\u30a4\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u8868\u73fe\u578b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u6226\u7565\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<blockquote><p>\u5358\u5264\u7642\u6cd5\u3084\u4f75\u7528\u7642\u6cd5\u306e\u4e00\u90e8\u3068\u3057\u3066\u4ed6\u306e\u75be\u60a3\u9818\u57df\u3067\u306e\u6709\u52b9\u6027\u3092\u63a2\u308b\u3053\u3068\u306f\u3001\u65b0\u85ac\u5019\u88dc\u767a\u898b\u306e\u305f\u3081\u306b\u6642\u9593\u3068\u8cbb\u7528\u3092\u6295\u8cc7\u3059\u308b\u3053\u3068\u306b\u4ee3\u308f\u308b\u9b45\u529b\u7684\u306a\u9078\u629e\u80a2\u3068\u306a\u308a\u307e\u3059\u3002<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<h2>\u85ac\u7269\u306e\u518d\u5229\u7528<\/h2>\n<p>\u533b\u85ac\u54c1\u958b\u767a\u30b3\u30b9\u30c8\u304c\u4e0a\u6607\u3057\u7d9a\u3051\u308b\u4e2d\u3001\u53e4\u3044\u85ac\u306e\u65b0\u3057\u3044\u7528\u9014\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u306f\u3001\u533b\u85ac\u54c1\u958b\u767a\u8005\u306b\u5e83\u304f\u53d7\u3051\u5165\u308c\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u5b89\u5168\u6027\u3068\u5fcd\u5bb9\u6027\u304c\u5b9f\u8a3c\u3055\u308c\u305f\u304c\u3001\u6709\u52b9\u6027\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u85ac\u5264\u306b\u3064\u3044\u3066\u306f\u3001\u5358\u5264\u7642\u6cd5\u3084\u4f75\u7528\u7642\u6cd5\u306e\u4e00\u90e8\u3068\u3057\u3066\u4ed6\u306e\u75be\u60a3\u9818\u57df\u3067\u306e\u6709\u52b9\u6027\u3092\u63a2\u7d22\u3059\u308b\u3053\u3068\u306f\u3001\u65b0\u85ac\u5019\u88dc\u3092\u767a\u898b\u3059\u308b\u305f\u3081\u306b\u6295\u8cc7\u3057\u305f\u6642\u9593\u3068\u8cbb\u7528\u306b\u4ee3\u308f\u308b\u9b45\u529b\u7684\u306a\u9078\u629e\u80a2\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u5bfe\u5fdc\u3057\u3066\u3001\u5b89\u5168\u6027\u306b\u554f\u984c\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u85ac\u5264\u306f\u3001\u526f\u4f5c\u7528\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u306a\u304c\u3089\u3001\u672c\u6765\u306e\u7528\u9014\u3068\u306f\u7570\u306a\u308b\u7528\u9014\u306b\u518d\u5229\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u30b7\u30ea\u30fc\u30ba\u306e\u30d1\u30fc\u30c82\u3067\u306f\u3001\u88fd\u85ac\u696d\u754c\u304c\u30c8\u30ad\u30b7\u30b3\u30b2\u30ce\u30df\u30af\u30b9\u3001\u30d5\u30a1\u30fc\u30de\u30b3\u30b2\u30ce\u30df\u30af\u30b9\u3001\u30d5\u30a1\u30fc\u30de\u30b3\u30a8\u30d4\u30b2\u30ce\u30df\u30af\u30b9\u3092\u901a\u3058\u3066\u3001\u7279\u5b9a\u306e\u81d3\u5668\u3084\u7279\u5b9a\u306e\u60a3\u8005\u306e\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u533b\u85ac\u54c1\u306e\u5f71\u97ff\u3092\u691c\u8a0e\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/clarivate.com\/cortellis\/campaigns\/how-can-we-improve-identification-of-toxicology-related-risks-in-drug-discovery\/\">\u300cBest practices in toxicology: Current perspectives for enhancing drug safety\u300d\u30ec\u30dd\u30fc\u30c8\u5168\u6587<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>[1] In CMR International Pharmaceutical R&amp;D Factbook. (2019).<br \/>\n[2] Matthews H, Hanison J, Nirmalan N. \u201cOmics\u201d-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives. Proteomes. 2016;4(3).<br \/>\n[3] Holmgren G, Sartipy P, Andersson C, Lindahl A, Synnergren J. Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicological Sciences. 2018;163(1):182-195.<br \/>\n[4] Holmgren G, Synnergren J, Bogest\u00e5l Y, et al. Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2015;328:102-111.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SHIVANJALI JOSHI-BARR Solution Scientist, Clarivate &nbsp; &nbsp; &nbsp; \u82f1\u8a9e\u539f\u6587 &nbsp; \u7b2c\u2160\u76f8\u81e8\u5e8a\u8a66\u9a13\u306b\u53c2\u52a0\u3059\u308b\u6d3b\u6027\u7269\u8cea8\u7a2e\u985e\u306e\u3046\u3061\u3001\u627f\u8a8d\u30fb\u4e0a\u5e02\u3055\u308c\u3066\u3044\u308b\u306e\u306f1\u7a2e\u985e\u306e\u88fd\u54c1\u306e\u307f\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059[1]\u3002\u81e8\u5e8a\u8a66\u9a13\u306e\u6210\u529f\u7387\u304c\u4f4e\u3044\u306e\u306f\u3001\u30d2\u30c8\u3067\u306e\u6709\u52b9\u6027\u306e\u4f4e\u3055\u3084\u3001\u6709\u5bb3\u4e8b\u8c61\u304c\u767a\u751f\u3057\u3066\u958b\u767a\u4e2d\u6b62\u306b\u81f3\u308b\u3053\u3068\u304c\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059[2]\u3002 \u85ac\u7269\u81ea\u4f53\u306e\u56fa\u6709\u306e\u7279\u6027\u3084\u3001\u500b\u3005\u306e\u53cd\u5fdc\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b66\u306e\u5fae\u5999\u306a\u5f79\u5272\u306b\u95a2\u3059\u308b\u77e5\u898b\u306f\u3001\u533b\u85ac\u54c1\u958b\u767a\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u5168\u4f53\u7684\u306a\u6210\u529f\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u30d2\u30f3\u30c8\u306b\u306a\u308a\u5f97\u307e\u3059\u3002\u3053\u306e3\u90e8\u69cb\u6210\u306e\u30d6\u30ed\u30b0\u30b7\u30ea\u30fc\u30ba\u3067\u306f\u3001\u5275\u85ac\u6bb5\u968e\u306e\u5404\u30b9\u30c6\u30c3\u30d7\u304c\u6210\u529f\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u3069\u306e\u3088\u3046\u306b\u91cd\u8981\u3067\u3042\u308b\u304b\u3001\u307e\u305f\u3001\u6bd2\u6027\u8a66\u9a13\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u308b\u30d9\u30b9\u30c8\u30d7\u30e9\u30af\u30c6\u30a3\u30b9\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002 &nbsp; 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