{"id":1712,"date":"2020-10-09T08:00:40","date_gmt":"2020-10-08T23:00:40","guid":{"rendered":"https:\/\/clarivate.com\/jp\/blog\/%e8%a3%bd%e8%96%ac%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e9%80%a3%e7%b6%9a%e8%a3%bd%e9%80%a0%e6%b3%95%e3%81%ae%e6%9c%aa%e6%9d%a5\/?lang=ja"},"modified":"2020-10-09T08:00:40","modified_gmt":"2020-10-08T23:00:40","slug":"the-future-of-continuous-manufacturing-in-pharma-2","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ja\/blog\/the-future-of-continuous-manufacturing-in-pharma-2\/","title":{"rendered":"\u88fd\u85ac\u306b\u304a\u3051\u308b\u9023\u7d9a\u88fd\u9020\u6cd5\u306e\u672a\u6765"},"content":{"rendered":"<p><a href=\"https:\/\/clarivate.com\/cortellis\/article\/the-future-of-continuous-manufacturing-in-pharma\/\">\u82f1\u8a9e\u539f\u6587<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><em>\u30d0\u30c3\u30c1\u51e6\u7406\u306f\u3001\u904e\u53bb50\u5e74\u9593\u3001\u88fd\u85ac\u696d\u754c\u3067\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u6a19\u6e96\u7684\u306a\u88fd\u9020\u65b9\u6cd5\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u6700\u8fd1\u306e\u88fd\u9020\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u9023\u7d9a\u88fd\u9020\u3068\u547c\u3070\u308c\u308b\u3088\u308a\u9ad8\u901f\u3067\u52b9\u7387\u7684\u306a\u30d7\u30ed\u30bb\u30b9\u304c\u5b9f\u73fe\u3057\u307e\u3057\u305f\u3002\u3053\u306e2\u3064\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3069\u306e\u3088\u3046\u306b\u6bd4\u8f03\u3055\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u305f\u3001\u898f\u5236\u5f53\u5c40\u306f\u4f55\u3092\u8a00\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306f\u3001\u9023\u7d9a\u88fd\u9020\u3092\u300c\u88fd\u85ac\u696d\u754c\u3092\u8fd1\u4ee3\u5316\u3059\u308b\u305f\u3081\u306e\u4eca\u65e5\u306e\u6700\u3082\u91cd\u8981\u306a\u30c4\u30fc\u30eb\u306e1\u3064\u300d\u3068\u8868\u73fe\u3057\u3001\u305d\u306e\u4f7f\u7528\u3092\u63a8\u5968\u3057\u3001\u6700\u8fd1\u3001\u9023\u7d9a\u88fd\u9020\u306e\u305f\u3081\u306e\u54c1\u8cea\u3078\u306e\u914d\u616e\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c0\u30f3\u30b9\u306e\u8349\u6848\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001<a href=\"https:\/\/clarivate.com\/cortellis\/article\/how-regulation-innovation-quality-and-access-are-inevitably-intertwined\/\">\u696d\u754c\u306e\u5c02\u9580\u5bb6<\/a>\u306e\u9593\u3067\u306f\u3001\u898f\u5236\u5f53\u5c40\u304c\u88fd\u9020\u5206\u91ce\u3067\u306e\u6280\u8853\u9769\u65b0\u306e\u81ea\u7531\u3092\u696d\u754c\u306b\u8a8d\u3081\u308b\u3079\u304d\u3060\u3068\u8003\u3048\u308b\u610f\u898b\u3068\u3001\u898f\u5236\u5f53\u5c40\u304c\u9023\u7d9a\u88fd\u9020\u3092\u652f\u63f4\u3059\u308b\u3053\u3068\u3067\u3001\u9023\u7d9a\u88fd\u9020\u306e\u63a1\u7528\u304c\u5897\u52a0\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u696d\u754c\u306b\u304a\u3051\u308b\u5229\u76ca\u304c\u5897\u5927\u3059\u308b\u3068\u8003\u3048\u308b\u610f\u898b\u306e\u9593\u3067\u3001\u610f\u898b\u304c\u5206\u304b\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u30d0\u30c3\u30c1\u51e6\u7406\u304b\u3089\u306e\u79fb\u884c<\/strong><\/h3>\n<p>50\u5e74\u4ee5\u4e0a\u3082\u524d\u304b\u3089\u3001\u533b\u85ac\u54c1\u306f\u30d0\u30c3\u30c1\u51e6\u7406\/\u88fd\u9020\u3092\u7528\u3044\u3066\u88fd\u9020\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u591a\u6bb5\u968e\u306e\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u6b21\u306e\u6bb5\u968e\u306b\u9032\u3080\u524d\u306b\u5404\u6bb5\u968e\u3092\u5b8c\u4e86\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u672c\u8cea\u7684\u306b\u9577\u3044\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u54c1\u8cea\u691c\u67fb\u306e\u305f\u3081\u306e\u30b9\u30c6\u30c3\u30d7\u9593\u306e\u300c\u4fdd\u7559\u6642\u9593\u300d\u3084\u3001\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u306e\u305f\u3081\u306e\u65bd\u8a2d\u9593\u306e\u6750\u6599\u306e\u8f38\u9001\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u60aa\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6642\u9593\u306e\u304b\u304b\u308b\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u74b0\u5883\u306b\u654f\u611f\u306a\u539f\u6599\u3092\u52a3\u5316\u306e\u30ea\u30b9\u30af\u306b\u3055\u3089\u3057\u3001\u8907\u6570\u306e\u53d6\u308a\u6271\u3044\u30dd\u30a4\u30f3\u30c8\u304c\u3042\u308b\u305f\u3081\u3001\u6c5a\u67d3\u3084\u4eba\u70ba\u7684\u30df\u30b9\u306e\u30ea\u30b9\u30af\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002<\/p>\n<p>\u533b\u85ac\u54c1\u88fd\u9020\u306e\u52b9\u7387\u3068\u54c1\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u52aa\u529b\u3068\u3057\u3066\u3001\u591a\u304f\u306e\u30a2\u30ca\u30ea\u30b9\u30c8\u3084\u533b\u85ac\u54c1\u898f\u5236\u5f53\u5c40\u306f\u3001\u4ed6\u306e\u7523\u696d\u3067\u3059\u3067\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u9023\u7d9a\u88fd\u9020\u3092\u3001\u4ee3\u66ff\u306e\u533b\u85ac\u54c1\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u3068\u3057\u3066\u63d0\u6848\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u9023\u7d9a\u88fd\u9020\u306b\u5bfe\u3059\u308b\u898f\u5236\u5f53\u5c40\u306e\u652f\u63f4<\/strong><\/h3>\n<p>\u8fd1\u5e74\u306e\u88fd\u9020\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u898f\u5236\u5f53\u5c40\u306f\u3001\u88fd\u54c1\u306e\u54c1\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u533b\u85ac\u54c1\u306e\u6b20\u54c1\u3084\u30ea\u30b3\u30fc\u30eb\u306e\u6839\u672c\u7684\u306a\u539f\u56e0\u3092\u7de9\u548c\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u3088\u308a\u8fc5\u901f\u3067\u52b9\u7387\u7684\u306a\u9023\u7d9a\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u3092\u771f\u5263\u306b\u691c\u8a0e\u3059\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u9023\u7d9a\u88fd\u9020\u306f\u3001\u540c\u3058\u65bd\u8a2d\u5185\u3067\u533b\u85ac\u54c1\u3092\u30ce\u30f3\u30b9\u30c8\u30c3\u30d7\u3067\u79fb\u52d5\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u4fdd\u7559\u6642\u9593\u3092\u306a\u304f\u3057\u3001\u30d2\u30e5\u30fc\u30de\u30f3\u30a8\u30e9\u30fc\u306e\u53ef\u80fd\u6027\u3092\u6e1b\u3089\u3057\u3001\u4e00\u8cab\u3057\u305f\u54c1\u8cea\u3092\u78ba\u4fdd\u3057\u3001\u67d4\u8edf\u306a\u5b9f\u884c\u6642\u9593\u306b\u3088\u3063\u3066\u5e02\u5834\u306e\u5909\u5316\u3078\u306e\u8fc5\u901f\u306a\u5bfe\u5fdc\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/p>\n<p>FDA\u306f\u3001\u9023\u7d9a\u88fd\u9020\u306e\u3088\u3046\u306a\u6700\u65b0\u306e\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u3092\u3001\u533b\u85ac\u54c1\u4e0d\u8db3\u3092\u6e1b\u3089\u3059\u305f\u3081\u306e<a href=\"https:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/DrugShortages\/UCM372566.pdf\" target=\"_blank\" rel=\"noopener\">\u6226\u7565\u7684\u306a\u53d6\u308a\u7d44\u307f<\/a>\u306e\u9375\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30b5\u30d7\u30e9\u30a4\u30c1\u30a7\u30fc\u30f3\u304c\u77ed\u304f\u3001\u6df7\u4e71\u3078\u306e\u56de\u5fa9\u529b\u304c\u9ad8\u304f\u3001\u7d99\u7d9a\u7684\u306a\u30a2\u30a6\u30c8\u30d6\u30ec\u30a4\u30af\u306b\u5bfe\u5fdc\u3057\u3066\u30ef\u30af\u30c1\u30f3\u3092\u8fc5\u901f\u306b\u751f\u7523\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u751f\u7523\u898f\u6a21\u3092\u62e1\u5927\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u9ad8\u5ea6\u306a\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u306f\u516c\u8846\u885b\u751f\u306e\u7dca\u6025\u4e8b\u614b\u3078\u306e<a href=\"https:\/\/www.fda.gov\/emergency-preparedness-and-response\/mcm-issues\/advanced-manufacturing\" target=\"_blank\" rel=\"noopener\">\u6e96\u5099\u3068\u5bfe\u5fdc<\/a>\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>2019\u5e742\u6708\u3001FDA\u306f\u533b\u85ac\u54c1\u306e\u7d99\u7d9a\u7684\u306a\u88fd\u9020\u306b\u304a\u3051\u308b\u54c1\u8cea\u3078\u306e\u914d\u616e\u3092\u6982\u8aac\u3057\u305f<a href=\"https:\/\/www.fda.gov\/media\/121314\/download\" target=\"_blank\" rel=\"noopener\">\u30ac\u30a4\u30c0\u30f3\u30b9\u6848<\/a>\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u4e2d\u3067\u3001FDA\u306f\u3001\u65b0\u85ac\u7533\u8acb\uff08NDA\uff09\u3001\u7565\u5f0f\u65b0\u85ac\u7533\u8acb\uff08ANDA\uff09\u3001\u533b\u85ac\u54c1\u30de\u30b9\u30bf\u30fc\u30d5\u30a1\u30a4\u30eb\uff08DMF\uff09\u3001\u751f\u7269\u88fd\u5264\u30e9\u30a4\u30bb\u30f3\u30b9\u7533\u8acb\uff08BLA\uff09\u3001\u304a\u3088\u3073\u975e\u7533\u8acb\u578b\u5bfe\u9762\u8ca9\u58f2\uff08OTC\uff09\u88fd\u54c1\u3067\u63d0\u51fa\u3055\u308c\u308b\u533b\u85ac\u54c1\u7269\u8cea\u304a\u3088\u3073\u3059\u3079\u3066\u306e\u5b8c\u6210\u3057\u305f\u5264\u5f62\u306e\u9023\u7d9a\u88fd\u9020\u3092\u652f\u6301\u3059\u308b\u58f0\u3092\u3042\u3052\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u56fd\u969b\u8abf\u548c\u5354\u8b70\u4f1a\uff08ICH\uff09\u306f\u3001\u30ac\u30a4\u30c0\u30f3\u30b9\u300cQ13 \u533b\u85ac\u54c1\u53ca\u3073\u533b\u85ac\u54c1\u306e\u9023\u7d9a\u88fd\u9020\uff08\u6700\u7d42\u30ac\u30a4\u30c0\u30f3\u30b9\u306e\u63a1\u629e\u306f2021\u5e7411\u6708\u3092\u4e88\u5b9a\uff09\u300d\u3092\u8d77\u8349\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u88fd\u54c1\u306e\u54c1\u8cea\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3067\u304d\u308b\u9023\u7d9a\u88fd\u9020\u306f\u3001FDA \u306e<a href=\"https:\/\/www.fda.gov\/about-fda\/center-drug-evaluation-and-research-cder\/pharmaceutical-quality-21st-century-risk-based-approach-progress-report\" target=\"_blank\" rel=\"noopener\"> QbD\uff08Quality by Design\uff09<\/a>\u69cb\u60f3\u306b\u3082\u5408\u81f4\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001FDA\u306f<a href=\"https:\/\/www.fda.gov\/media\/121314\/download\" target=\"_blank\" rel=\"noopener\">\u9023\u7d9a\u88fd\u9020\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c0\u30f3\u30b9<\/a>\u306e\u4e2d\u3067\u3001&#8221;\u904b\u7528\u4e0a\u306e\u67d4\u8edf\u6027\u306b\u3088\u308a\u3001\u627f\u8a8d\u5f8c\u306e\u898f\u5236\u5f53\u5c40\u3078\u306e\u3044\u304f\u3064\u304b\u306e\u7533\u8acb\u306e\u5fc5\u8981\u6027\u304c\u6e1b\u5c11\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b &#8220;\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u7d99\u7d9a\u7684\u88fd\u9020\u306b\u95a2\u3059\u308b\u696d\u754c\u306e\u898b\u89e3<\/strong><\/h3>\n<p>\u5229\u76ca\u7387\u304c\u4f4e\u4e0b\u3057\u7d9a\u3051\u308b\u4e2d\u3067\u3001\u9023\u7d9a\u88fd\u9020\u306f\u88fd\u85ac\u4f1a\u793e\u306b\u30b3\u30b9\u30c8\u3001\u30ea\u30b9\u30af\u3001\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306e\u524a\u6e1b\u3068\u3044\u3046\u30e1\u30ea\u30c3\u30c8\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002\u9023\u7d9a\u88fd\u9020\u3078\u306e\u79fb\u884c\u306f\u3001\u6b69\u7559\u307e\u308a\u306e\u5411\u4e0a\u3001\u30d5\u30c3\u30c8\u30d7\u30ea\u30f3\u30c8\u306e\u7e2e\u5c0f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u91cf\u306e\u524a\u6e1b\u3001\u5b89\u5b9a\u3057\u305f\u751f\u7523\u3001\u654f\u6377\u6027\u3001\u5ec3\u68c4\u7269\u306e\u524a\u6e1b\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u6f5c\u5728\u7684\u306a\u30e1\u30ea\u30c3\u30c8\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9023\u7d9a\u751f\u7523\u3078\u306e\u79fb\u884c\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u7406\u7531\u304b\u3089\u9045\u308c\u3066\u3044\u307e\u3059\u3002\u7b2c\u4e00\u306b\u3001\u4f01\u696d\u306f\u53e4\u3044\u8a2d\u5099\u3092\u9000\u5f79\u3055\u305b\u3001\u65b0\u3057\u3044\u8a2d\u5099\u3092\u8cfc\u5165\u3057\u3001\u30b9\u30bf\u30c3\u30d5\u3092\u8a13\u7df4\u3057\u3001\u5468\u56f2\u306e\u30a4\u30f3\u30d5\u30e9\u3092\u66f4\u65b0\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u305f\u3081\u3001\u7acb\u3061\u4e0a\u3052\u30b3\u30b9\u30c8\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u4f01\u696d\u306e\u4e2d\u306b\u306f\u3001\u4f4e\u30b3\u30b9\u30c8\u306e\u533b\u85ac\u54c1\u3092\u5927\u91cf\u306b\u6271\u3046\u4ee5\u5916\u306b\u306f\u3001\u9023\u7d9a\u88fd\u9020\u3067\u306f\u5bfe\u5fdc\u3067\u304d\u306a\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u7591\u5ff5\u3092\u62b1\u3044\u3066\u3044\u308b\u4f01\u696d\u3082\u3042\u308a\u307e\u3059\u3002\u5c0f\u30ed\u30c3\u30c8\u306e\u88fd\u54c1\u306e\u5834\u5408\u3001\u5207\u308a\u66ff\u3048\u6642\u306b\u306f\u6d17\u6d44\u3068\u30bb\u30c3\u30c8\u30a2\u30c3\u30d7\u306b\u591a\u5927\u306a\u6642\u9593\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u30a2\u30ca\u30ea\u30b9\u30c8\u3001\u898f\u5236\u5f53\u5c40\u3001\u696d\u754c\u306e\u30ea\u30fc\u30c0\u30fc\u305f\u3061\u306f\u3001\u7d99\u7d9a\u7684\u306a\u88fd\u9020\u304c\u5c06\u6765\u306e\u533b\u85ac\u54c1\u88fd\u9020\u3067\u3042\u308b\u3053\u3068\u306b\u540c\u610f\u3057\u3066\u3044\u307e\u3059\u3002\u4ed6\u306e\u7834\u58ca\u7684\u306a\u6280\u8853\u3068\u540c\u69d8\u306b\u3001\u5c0e\u5165\u306e\u521d\u671f\u6bb5\u968e\u3067\u306f\u30ea\u30bd\u30fc\u30b9\u304c\u96c6\u4e2d\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7d99\u7d9a\u88fd\u9020\u3078\u306e\u52b9\u7387\u7684\u306a\u79fb\u884c\u65b9\u6cd5\u306e\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"https:\/\/clarivate.com\/cortellis\/campaigns\/outlook-2020-regulatory-trends-and-challenges\/\">\u30a6\u30a7\u30d3\u30ca\u30fc &#8220;The future of continuous manufacturing in pharma &#8220;<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u82f1\u8a9e\u539f\u6587 &nbsp; \u30d0\u30c3\u30c1\u51e6\u7406\u306f\u3001\u904e\u53bb50\u5e74\u9593\u3001\u88fd\u85ac\u696d\u754c\u3067\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u6a19\u6e96\u7684\u306a\u88fd\u9020\u65b9\u6cd5\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u6700\u8fd1\u306e\u88fd\u9020\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u9023\u7d9a\u88fd\u9020\u3068\u547c\u3070\u308c\u308b\u3088\u308a\u9ad8\u901f\u3067\u52b9\u7387\u7684\u306a\u30d7\u30ed\u30bb\u30b9\u304c\u5b9f\u73fe\u3057\u307e\u3057\u305f\u3002\u3053\u306e2\u3064\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3069\u306e\u3088\u3046\u306b\u6bd4\u8f03\u3055\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u305f\u3001\u898f\u5236\u5f53\u5c40\u306f\u4f55\u3092\u8a00\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f &nbsp; 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&nbsp; \u30d0\u30c3\u30c1\u51e6\u7406\u304b\u3089\u306e\u79fb\u884c 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