{"id":15497,"date":"2024-09-25T15:39:51","date_gmt":"2024-09-25T06:39:51","guid":{"rendered":"https:\/\/clarivate.com\/ko\/?p=15497"},"modified":"2024-11-06T02:56:25","modified_gmt":"2024-11-06T02:56:25","slug":"aiming-for-magic-bullets-in-medicine-are-we-shooting-ourselves-in-the-foot-2","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ko\/blog\/aiming-for-magic-bullets-in-medicine-are-we-shooting-ourselves-in-the-foot-2\/","title":{"rendered":"\uc758\ud559\ubd84\uc57c \u2018\ub9c8\ubc95\uc758 \ucd1d\uc54c\u2019\uc744 \ub178\ub9ac\ub2e4: \uc2a4\uc2a4\ub85c \ubc1c\ub4f1\uc744 \ucc0d\ub294 \uc77c\uc77c\uae4c\uc694?"},"content":{"rendered":"

\"\"<\/p>\n

Eleanor Ward<\/strong><\/p>\n

\uc758\ud559\uc804\ubb38 \uc791\uac00<\/strong><\/p>\n

\ud074\ub798\ub9ac\ubca0\uc774\ud2b8<\/strong><\/p>\n

 <\/p>\n

\ubaa8\ub4e0 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \ub2e8 \ud558\ub098\uc758 \uce58\ub8cc\uc81c\ub97c \ucc3e\ub294 \uac83\uc740 \uc815\ub9d0 \uba4b\uc9c4 \uc77c\uc774\uaca0\uc8e0? \ud574\ub85c\uc6b4 \ubd80\uc791\uc6a9 \uc5c6\uc774 \uc9c8\ubcd1\uc744 \ube60\ub974\uace0 \uc644\ubcbd\ud558\uac8c \uce58\ub8cc\ud560 \uc218 \uc788\ub294<\/a>[1]<\/sup><\/a>\u00a0 \uc774\ub978\ubc14 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019 \uce58\ub8cc\uc81c\ub294 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc758 \uafc8\uc785\ub2c8\ub2e4.<\/a>[2]<\/sup><\/a>\u00a0 \ud558\uc9c0\ub9cc, \uc120\ud0dd\uc801\uc778 \ub3c5\uc131\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \ub2e4\ub978 \uc720\ub9dd\ud55c \uce58\ub8cc\ubc95\uc744 \ud76c\uc0dd\ud558\uba74\uc11c\uae4c\uc9c0 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uce58\ub8cc\uc81c \ucc3e\ub2e4 \ubcf4\ub2c8 \ub2e4\ub978 \uc911\uc694\ud55c \ud601\uc2e0\uc774 \uac04\uacfc\ub418\uace0 \uc788\uc9c0\ub294 \uc54a\uc744\uae4c\uc694?<\/p>\n

<\/h3>\n

\uc758\ud559<\/strong> \ucd5c\ucd08\uc758<\/strong> \u2018<\/strong>\ub9c8\ubc95<\/strong> \ucd1d\uc54c<\/strong>\u2019 <\/strong>\uce58\ub8cc\uc81c<\/strong><\/h3>\n

\uc911\uac1c \uc5f0\uad6c\uc640 \uc815\ubc00 \uc758\ud559\uc758 \uae30\ubcf8 \uc6d0\ub9ac\ub294 \ud604\ub300 \ud654\ud559 \uc694\ubc95\uc758 \uc544\ubc84\uc9c0\ub85c \ub110\ub9ac \uc54c\ub824\uc9c4Paul Ehrlich\uc640 \uac19\uc740 \uacfc\ud559\uc790\ub4e4\uc758 \uc5f0\uad6c\uc5d0\uc11c \ube44\ub86f\ub418\uc5c8\uc2b5\ub2c8\ub2e4. 1897\ub144Ehrlich\ub294 \ud2b9\uc815 \uc138\ud3ec\uac00 \ud45c\uba74\uc5d0 \ud2b9\uc815\uc778\uc2dd\uacfc \uad00\ub828\ub41c \u2018\uc218\uc6a9\uccb4\u2019\ub77c\uace0 \ubd88\ub9ac\ub294 \uc77c\ub828\uc758 \uacc1\uc0ac\uc2ac\uc744 \ub178\ucd9c\ud55c\ub2e4\uace0 \ub9d0\ud588\uc2b5\ub2c8\ub2e4. <\/a>[3]<\/sup><\/a><\/a>[4]<\/sup><\/a>\u00a0Ehrlich \uc640 \ud300\uc740 \uc774\ud6c4 \uc815\uc0c1\uc801\uc778 \uc219\uc8fc\uc138\ud3ec\uc5d0\ub294 \uc601\ud5a5\uc744 \uc8fc\uc9c0 \uc54a\uace0 \ub9e4\ub3c5\uc758 \uc6d0\uc778 \uade0\uc778 Treponema pallidum \ubc15\ud14c\ub9ac\uc544\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \ucd5c\ucd08\uc758 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019 \uc758\uc57d\ud488\uc778 \uc544\ub974\uc2a4\ud398\ub098\ubbfc(Salvarsan\u00ae)\uc744 \uac1c\ubc1c\ud588\uc2b5\ub2c8\ub2e4[3]<\/sup><\/a><\/p>\n

 <\/p>\n

\ud558\uc9c0\ub9cc, \ucd5c\ucd08\uc758 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019 \uc758\uc57d\ud488\uc740 \uc644\ubcbd\ud55c \uc57d\uc774 \uc544\ub2c8\uc5c8\uc2b5\ub2c8\ub2e4. \uce58\ub8cc\uc5d0 \ub300\ud55c \ub0b4\uc131\uc774 \ubc1c\uc0dd\ud588\uace0 \ubaa8\ub4e0spirochetes (\ub098\uc120\ud615 \ubc15\ud14c\ub9ac\uc544 \uadf8\ub8f9)\ub97c \uc81c\uac70\ud558\uae30 \uc704\ud574 \uc870\uc885 \uc218\uc740 \ub610\ub294 \ube44\uc2a4\ubb34\ud2b8\uc640 \ubcd1\uc6a9 \uce58\ub8cc\uac00 \ud544\uc694\ud588\uc2b5\ub2c8\ub2e4. [3]<\/sup><\/a>\u00a0\ud658\uc790\ub4e4\uc740 \uae34 \uae30\uac04 \ub3d9\uc548 \uc5ec\ub7ec \ubc88\uc758 \uc8fc\uc0ac\uac00 \ud544\uc694\ud588\uc73c\uba70, \ubb3c\uc5d0 \ub179\uc9c0 \uc54a\ub294arsphenamide \uc81c\uc81c \ubb38\uc81c\ub3c4 \ubc1c\uc0dd\ud588\uc2b5\ub2c8\ub2e4. \uc774\ud6c4, \ub124\uc624\uc544\ub974\uc2a4\ud398\ub098\ubbfc(Neosalvarsan\u00ae)\uacfc \uc625\uc18c\ud398\ub098\ub974\uc2e0(Mapharsen\u00ae) \ub4f1 \ub2e4\ub978 \ud45c\uc801 \uce58\ub8cc\ubc95\ub4e4\uc774 \ub4f1\uc7a5\ud588\uc9c0\ub9cc, \uc5ec\uc804\ud788 \ub2e4\ub978 \ub3c4\uc804\uacfc\uc81c\ub4e4\uc774 \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

\uadf8\ub9bc 1: \ub9e4\ub3c5 \ud45c\uc801 \uce58\ub8cc\ubc95\uc758 \ubc1c\uc804<\/strong><\/p>\n

\"\"<\/p>\n

\ucd9c\ucc98: Valent P \uc678, 2016;[3]<\/sup><\/a>\u00a0Strebhardt K \uc678 2008.[4]<\/sup><\/a><\/p>\n

<\/h3>\n

\uc81c\uc57d<\/strong> \uac1c\ubc1c\uc5d0\uc11c<\/strong> \u2018<\/strong>\ub9c8\ubc95<\/strong> \ucd1d\uc54c<\/strong>\u2019<\/strong>\uac1c\ub150\uc740<\/strong> \uc5bc\ub9c8\ub098<\/strong> \ud604\uc2e4\uc801\uc77c\uae4c\uc694<\/strong>?<\/strong><\/h3>\n

\uc774\ud6c4 \ub2e4\ub978 \ud601\uc2e0\uc801\uc778 \uc758\ud559\uae30\uc220\ub4e4\ub3c4 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\ub85c \ubd88\ub9ac\uae34 \ud588\uc9c0\ub9cc, \uc644\uc804\ud55c \uce58\ub8cc\ubc95\uc744 \uc81c\uacf5\ud558\uc9c0\ub294 \ubabb\ud588\uc2b5\ub2c8\ub2e4. \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc774\ub77c\ub294 \uac1c\ub150\uc740 20\uc138\uae30 \uc911\ubc18\uc5d0 \ud56d\uc0dd\uc81c\uc640 \uc778\uc290\ub9b0\uc758 \uac1c\ubc1c\ub85c \uc778\uae30\ub97c \uc5bb\uc5c8\ub294\ub370, \uc774\ub294 \uc758\ud559\uc758 \ud310\ub3c4\ub97c \ubc14\uafb8\uae34 \ud588\uc9c0\ub9cc \uc644\ubcbd\ud558\uc9c0\ub294 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ud398\ub2c8\uc2e4\ub9b0\uc5d0 \ub300\ud55c \ud56d\uade0\uc81c \ub0b4\uc131 \ubc1c\uc0dd\uc774 \ub098\ud0c0\ub0ac\uc73c\uba70, \uc778\uc290\ub9b0 \uce58\ub8cc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc5d0\uac8c\uc11c \ud569\ubcd1\uc99d\uc774 \ubc1c\uc0dd\ud558\ub294 \ub4f1\uc758 \ud55c\uacc4\uac00 \ub4dc\ub7ec\ub0ac\uc2b5\ub2c8\ub2e4. <\/a>[5]<\/sup><\/a><\/p>\n

\u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc740 \uc9c8\ubcd1\uc758 \uc885\ub958\uc5d0 \ub530\ub77c \ub2e4\ub974\uac8c \uc801\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9ce\uc740 \uacbd\uc6b0, \ud658\uc790\ub4e4\uc740 \ub2e8\uc77c \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\ub85c \ud574\uacb0\ud560 \uc218 \uc5c6\ub294 \uc5ec\ub7ec\uac00\uc9c0 \uc7a5\uae30 \uc9c8\ud658\uc744 \uc553\uace0 \uc788\uc2b5\ub2c8\ub2e4. [5]<\/sup><\/a>\u00a0\ub354\uc6b1\uc774 \ub2f9\ub1e8\ubcd1\uc774\ub098 \uc2ec\uc7a5\ubcd1\uacfc \uac19\uc774 \ub9ce\uc740 \uc9c8\ubcd1\uc740 \uc720\uc804\uc801, \uc0dd\ud65c\uc2b5\uad00\uc801, \ud658\uacbd\uc801 \uc694\uc778\uac04\uc758 \ubcf5\uc7a1\ud55c \uc0c1\ud638 \uc791\uc6a9\uc744 \ud3ec\ud568\ud569\ub2c8\ub2e4. \ub610\ud55c \ud658\uc790 \uac04\uc758 \ubcc0\ub3d9\uc131\ub3c4 \uace0\ub824\ud574\uc57c \ud558\ub294\ub370, \uac1c\uc778\uc758 \uae30\uc800 \uac74\uac15\uc0c1\ud0dc, \ub098\uc774, \uc131\ubcc4\uc5d0 \ub530\ub77c \uce58\ub8cc\uc5d0 \ub300\ud55c \ubc18\uc751\uc774 \ub2e4\ub97c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubcd1\uc758 \uc6d0\uc778\uc774 \ubd88\ubd84\uba85\ud558\uac70\ub098 \ubcf5\uc7a1\ud55c \uacbd\uc6b0, \ub610\ub294 \uc5b4\ub5a4 \ud658\uc790\uac00 \ud574\ub2f9 \uc9c8\ud658\uc744 \uc553\uace0 \uc788\ub294\uc9c0\ub97c \uc77c\uad00\ub418\uac8c \ud310\ub2e8\ud558\uae30 \uc5b4\ub824\uc6b4 \uacbd\uc6b0\uc5d0\ub294 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc811\uadfc\ubc95\uc740 \ud604\uc2e4\uc801\uc774\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. [5]<\/sup><\/a> \ub2e4\uc6d0\uc131 \uc9c8\ud658\uc73c\ub85c \uc5ec\uaca8\uc9c0\ub294 \uc6b0\uc6b8\uc99d\uc774\ub098 \uc870\ud604\ubcd1\uacfc \uac19\uc740 \uc911\ucd94 \uc2e0\uacbd\uacc4 \uc9c8\ud658\uc758 \uacbd\uc6b0, \ub2e8\uc77c \ubd84\uc790 \ud45c\uc801\uc5d0 \uc120\ud0dd\uc801\uc778 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud558\ub824\ub294 \ub178\ub825\uc740 \ub300\ubd80\ubd84 \uc2e4\ud328\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7f4 \ub54c\ub294 \uc5ec\ub7ec \ubd84\uc790 \ud45c\uc801\uacfc \uc0c1\ud638\uc791\uc6a9\ud558\ub294 \u2018\ub9c8\ubc95 \uc0b0\ud0c4\ucd1d\u2019\u2014 \uc989, \ub2e4\uc218\uc758 \ud45c\uc801\uc5d0 \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\uc744 \uac1c\ubc1c\ud558\ub294 \uc811\uadfc \ubc29\uc2dd\uc774 \uc81c\uc548\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. [6]<\/sup><\/a><\/p>\n

\ub9ce\uc740 \ubcd1\ub9ac\ud559\uc801 \ud45c\uc801\uc774 \uc5ec\ub7ec \uc0dd\ub9ac\uc801 \uae30\ub2a5\uc744 \uac00\uc9c0\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0 \ub9e4\uc6b0 \ud2b9\uc815\ud55c \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc774 \uc5ec\ub7ec \uc138\ud3ec \uacbd\ub85c\uc5d0 \ub3d9\uc2dc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uccd0 \uc758\ub3c4\ud558\uc9c0 \uc54a\uc740 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. <\/a>[7]<\/sup><\/a>\u00a0\ud45c\uc801 \ub2e8\ubc31\uc9c8\uc740 \ub610\ud55c \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac\uc801 \uae30\ub2a5\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\uacfc \uc720\uc0ac\ud55c \ud65c\uc131\uc601\uc5ed\uc744 \uac00\uc9c8 \uc218 \uc788\uc5b4 \uc758\ub3c4\ud558\uc9c0 \uc54a\uac8c \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.[7]<\/sup><\/a>\u00a0\uc911\uc694\ud55c \uc0dd\ubb3c\ud559\uc801 \uacbd\ub85c\uc758 \uc911\ubcf5\uc740 \uacbd\ub85c\uc5d0\uc11c \ub2e8\uc77c \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc758 \uc720\uc6a9\uc131\uc744 \uc81c\ud55c\ud558\uace0 \uc774\ub97c \ubcf4\uc644\ud558\ub294 \ubc31\uc5c5 \ub610\ub294 \uc911\ubcf5 \uc2dc\uc2a4\ud15c\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc2b5\ub2c8\ub2e4.[7]<\/sup><\/a><\/p>\n

\ud558\ub098\uc758 \ud2b9\uc815 \uc9c8\ubcd1 \uacbd\ub85c\uc5d0 \uc791\uc6a9\ud558\ub294 \uace0\ub3c4\ub85c \uc120\ud0dd\uc801\uc778 \uce58\ub8cc\uc6a9 ‘\ub9c8\ubc95\uc758 \ucd1d\uc54c’\uc744 \ucc3e\ub294 \ub370 \uc6b0\uc120\uc21c\uc704\ub97c \ub450\ub2e4 \ubcf4\uba74 \uc5ec\ub7ec \ubd84\uc790 \ud45c\uc801\uc5d0 \uc791\uc6a9\ud558\ub294 \ub2e4\ubaa9\uc801 \uc57d\ubb3c\uc774 \uac04\uacfc\ub420 \uc704\ud5d8\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\ubaa9\uc801 \uc57d\ubb3c\uc740 \ubd80\uc791\uc6a9 \uc704\ud5d8\uc774 \ub354 \ud06c\ub2e4\uace0 \uc778\uc2dd\ub420 \uc218 \uc788\uc9c0\ub9cc, \uc0ac\uc2e4 \uad11\ubc94\uc704\ud55c \uce58\ub8cc \ud6a8\uacfc\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4 Aspirin (\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0)\uc740 \uc2dc\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc81c(COX) \ub3d9\uc885 \ud6a8\uc18c\uc778 COX-1\uacfc COX-2\ub97c \uc5b5\uc81c\ud558\uace0 \uc5fc\uc99d\uc774 \uc788\ub294 \ubaa8\ub4e0 \ubd80\uc704\uc5d0 \uc791\uc6a9\ud569\ub2c8\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc740 \ub610\ud55c \ud608\uc561\uc744 \ubb3d\uac8c\ud558\uace0 \ud608\uc18c\ud310 \uc751\uc9d1\uc744 \uc904\uc5ec \uc2ec\ud608\uad00 \uc9c8\ud658\uacfc \uc790\uac04\uc804\uc99d\uc744 \uc608\ubc29\ud558\uace0 \ud56d\uc5fc \ud6a8\uacfc\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. [7]<\/sup><\/a> \u00a0\ub530\ub77c\uc11c \uc720\ub9dd\ud55c \uc57d\ubb3c\uc774 \ub2e8\uc77c \ud45c\uc801\uc5d0 \uc791\uc6a9\ud558\uc9c0 \uc54a\ub294\ub2e4\uace0 \ud574\uc11c \ubb34\uc2dc\ud558\uc9c0 \uc54a\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4.<\/p>\n

<\/h3>\n

\u2018<\/strong>\ub9c8\ubc95<\/strong> \ucd1d\uc54c<\/strong>\u2019<\/strong>\uc774<\/strong> \uc554\uce58\ub8cc\uc758<\/strong> \ubbf8\ub798\uc77c\uae4c\uc694<\/strong>?<\/strong><\/h3>\n

\uacfc\ud559\uc790\ub4e4\uc740 \uc624\ub7ab\ub3d9\uc548 \uc554\uc5d0 \ub300\ud55c \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc744 \ucc3e\uae30 \uc704\ud574 \ub178\ub825\ud574\uc654\uc2b5\ub2c8\ub2e4. \uadf8 \uc911 \ud558\ub098\uc758 \uc131\uacf5 \uc0ac\ub840\ub85c imatinib\uc744 \ub4e4 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc57d\ubb3c\uc740 \ub9cc\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1(CML)\uc758 \ubcd1\ub9ac\ud559\uc801 \uacfc\uc815\uc5d0 \uad00\uc5ec\ud558\ub294 \ubd84\uc790\uc801 \ub3d9\uc778\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \ub2e8\uc77c \uc57d\uc81c\uc785\ub2c8\ub2e4. CML\uc5d0\uc11c\ub294 9\ubc88\uacfc 22\ubc88 \uc5fc\uc0c9\uccb4 \uac04\uc758 \uc0c1\ud638 \uc804\uc704\uac00 \ubc1c\uc0dd\ud558\uc5ec, \ud544\ub77c\ub378\ud53c\uc544 \uc5fc\uc0c9\uccb4\ub77c\uace0 \uc54c\ub824\uc9c4 \ub2e8\ucd95\ub41c 22\ubc88 \uc5fc\uc0c9\uccb4\uac00 \ud615\uc131\ub429\ub2c8\ub2e4.[8]<\/sup><\/a>\u00a0\uc774 \uc804\uc704\uc758 \ube0c\ub808\uc774\ud06c\ud3ec\uc778\ud2b8\ub294 BCR-ABL1\uc774\ub77c\ub294 \uc735\ud569 \uc720\uc804\uc790\ub97c \uc0dd\uc131\ud558\ub294\ub370, \uc774\ub294 \uac74\uac15\ud55c \uc138\ud3ec\uc5d0\ub294 \uc874\uc7ac\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. BCR-ABL1 \uc735\ud569 \uc720\uc804\uc790\ub294 \ube44\uc815\uc0c1\uc801\uc778 \ub2e8\ubc31\uc9c8(BCR-ABL1)\uc744 \uc0dd\uc131\ud558\uba70, \uc774 \ub2e8\ubc31\uc9c8\uc740 \uc9c0\uc18d\uc801\uc73c\ub85c \uac15\ud654\ub41c \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc81c \ud65c\uc131\uc744 \ub098\ud0c0\ub0b4\uc5b4 \uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \uc720\uc9c0\ud558\uace0 \ubd84\ud654\ub97c \uc5b5\uc81c\ud558\uba70, \uc138\ud3ec \uc0ac\uba78\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc744 \ubd80\uc5ec\ud569\ub2c8\ub2e4.[8]<\/sup><\/a>\u00a0imatinib\uc740 \ubc14\ub85c \uc774 \ub2e8\ubc31\uc9c8\uc744 \uc5b5\uc81c\ud558\ub294 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.[8]<\/sup><\/a><\/p>\n

2017\ub144 imatinib\uc5d0 \ub300\ud55c \uc911\ucd94\uc801\uc778 3\uc0c1 \uc784\uc0c1\uc2dc\ud5d8(IRIS \uc2dc\ud5d8)\uc5d0 \ub530\ub974\uba74 1\ucc28 imatinib\uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\uc758 10\ub144 \uc804\uccb4 \uc0dd\uc874\uc728\uc740 83.3%\uc600\uc73c\uba70, 82.8%\uc758 \ud658\uc790\uac00 \uc138\ud3ec\uc720\uc804\ud559\uc801 \uc644\uc804\ubc18\uc751\uc744 \ubcf4\uc778 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. [9]<\/sup><\/a>\u00a0 \uc784\uc0c1\uc2dc\ud5d8 \ucd08\uae30\uc5d0 \ubb34\uc791\uc704\ub85c \ubc30\uc815\ub418\uc5b4 \uc778\ud130\ud398\ub860 \uc54c\ud30c+\uc2dc\ud0c0\ub77c\ube48 \uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\ub4e4 \uc0ac\uc774\uc5d0\uc11c \uad50\ucc28 \uce58\ub8cc \ube44\uc728\uc774 \ub192\uc558\uae30 \ub54c\ubb38\uc5d0(\ud658\uc790\uc758 65.6%, \uad50\ucc28 \uce58\ub8cc \uc804 \uce58\ub8cc \uae30\uac04 \uc911\uc559\uac12: 0.8\ub144), IRIS\uc758 \ucd5c\uc885 \ubd84\uc11d\uc5d0\uc11c\ub294 \ubb34\uc791\uc704\ub85c \ubc30\uc815\ub418\uc5b4 imatinib \uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\ub4e4\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdc4\uc2b5\ub2c8\ub2e4. imatinib\uce58\ub8cc \uc804\uc5d0\ub294 CML \ud658\uc790\uc758 30%\ub9cc\uc774 \uc9c4\ub2e8 \ud6c4 5\ub144 \uc774\uc0c1 \uc0dd\uc874\ud588\uc2b5\ub2c8\ub2e4.[10]<\/sup><\/a>\u00a0\uc774\uc81c imatinib\uce58\ub8cc 2\ub144 \ud6c4 \uad00\ud574 \uc0c1\ud0dc\uc5d0 \uc788\ub294 \ud544\ub77c\ub378\ud53c\uc544 \uc5fc\uc0c9\uccb4 \uc591\uc131 CML \ud658\uc790\uc758 \uae30\ub300 \uc218\uba85\uc740 \uc554\uc774 \uc5c6\ub294 \uc0ac\ub78c\uacfc \ub3d9\uc77c\ud569\ub2c8\ub2e4.[11]<\/sup><\/a>[12]<\/sup><\/a><\/p>\n

\ud558\uc9c0\ub9cc \ubaa8\ub4e0 \uc554\uc774 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\ub85c \uaca8\ub0e5\ud560 \uc218 \uc788\ub294 \uc798 \uc815\uc758\ub41c \ubd84\uc790 \ud45c\uc801\uc774\ub098 \uc8fc\ub3c4\uc801 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c0\uace0 \uc788\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4. \uc801\uc808\ud55c \ud45c\uc801 \uce58\ub8cc\uac00 \uac00\ub2a5\ud55c \uacbd\uc6b0\uc5d0\ub3c4, \ud574\ub2f9 \uce58\ub8cc\uc758 \ud61c\ud0dd\uc744 \ubc1b\uc744 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \ud658\uc790\ub97c \uc2dd\ubcc4\ud558\uae30 \uc704\ud55c \uc815\ud655\ud55c \ubc14\uc774\uc624\ub9c8\ucee4\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \ub610\ud55c \uc885\uc591\uc758 \uc774\uc9c8\uc131\uc740 \ud070 \uc7a5\ubcbd\uc774 \ub429\ub2c8\ub2e4. \ub2e8\uc77c \ud45c\uc801 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc774 \ubaa8\ub4e0 \uc554 \uc138\ud3ec\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud558\uc9c0 \ubabb\ud560 \uc218\ub3c4 \uc788\uae30 \ub54c\ubb38\uc5d0, \uc774 \uacbd\uc6b0\uc5d0\ub294 \uc5ec\ub7ec \uce58\ub8cc\ubc95\uc744 \ubcd1\ud589\ud574\uc57c \ud560 \ud544\uc694\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacbd\uc6b0 \uc5ec\ub7ec \uac00\uc9c0 \uce58\ub8cc\ubc95\uc744 \uc870\ud569\ud574\uc57c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc554\uc138\ud3ec\ub294 \uc57d\ubb3c \ud45c\uc801\uc758 \ub3cc\uc5f0\ubcc0\uc774, \uc57d\ubb3c \uc720\ucd9c \ud38c\ud504\uc758 \uc0c1\ud5a5 \uc870\uc808 \ub610\ub294 \ub300\uccb4 \uc2e0\ud638 \uacbd\ub85c\uc758 \ud65c\uc131\ud654\ub97c \ud1b5\ud574 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \ud45c\uc801 \uce58\ub8cc\uc5d0 \ub300\ud55c \ub0b4\uc131\uc744 \uac1c\ubc1c\ud558\uc5ec \uce58\ub8cc\uc5d0 \ub300\ud55c \ubc18\uc751 \uae30\uac04\uc744 \uc81c\ud55c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. CML\uc5d0\uc11c imatinib\uc758 \ub180\ub77c\uc6b4 \uc131\uacf5\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ub0b4\uc131\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc2b5\ub2c8\ub2e4.[13]<\/sup><\/a> \uc2e4\uc81c\ub85c \uc57d 17%\uc758 \ud658\uc790\uac00 5\ub144 \ub3d9\uc548 imatinib\uc5d0 \ub0b4\uc131\uc774 \uc0dd\uae41\ub2c8\ub2e4. [14]<\/sup><\/a><\/p>\n

 <\/p>\n

\uc81c\uc57d\uc0b0\uc5c5<\/strong> \ud601\uc2e0<\/strong>: \u00a0<\/strong>\uc55e\uc73c\ub85c<\/strong> \uc6b0\ub9ac\ub294<\/strong> \uc5b4\ub514\ub85c<\/strong> \uac00\uc57c\ud560\uae4c\uc694<\/strong>?<\/strong><\/h3>\n

\u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019 \uac1c\ub150\uc740 \ub9e4\ub825\uc801\uc774\uc9c0\ub9cc, \uc2e4\uc81c\ub85c \ud574\ub85c\uc6b4 \ubd80\uc791\uc6a9 \uc5c6\uc774 \uce58\ub8cc \ud6a8\uacfc\uac00 \uc788\ub294 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc5ed\ud560\uc744 \ud558\ub294 \uce58\ub8cc\ubc95\uc740 \uac70\uc758 \uc5c6\uc2b5\ub2c8\ub2e4. \uc77c\ubd80 \uc9c8\ubcd1 \uce58\ub8cc\uc5d0\uc11c \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019\uc740 \ud601\uc2e0\uc801\uc778 \ubcc0\ud654\ub97c \uac00\uc838\uc654\uc9c0\ub9cc, \ubaa8\ub4e0 \uc9c8\ud658\uc5d0\uc11c \uc774\uac83\uc774 \uc801\uc6a9\ub418\uc9c0\ub294 \uc54a\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud55c\uacc4\ub97c \uc778\uc815\ud558\uace0 \ub2e4\ub978 \uce58\ub8cc\ubc95\ub3c4 \uc5ec\uc804\ud788 \uac00\uce58\uac00 \uc788\uc74c\uc744 \uc778\uc2dd\ud568\uc73c\ub85c\uc368 \uc57d\ubb3c\uc744 ‘\ub9c8\ubc95\uc758 \ucd1d\uc54c’\ub85c\uc11c\uc758 \uae30\ub2a5\ub9cc\uc73c\ub85c \ud310\ub2e8\ud558\uc9c0 \uc54a\uace0 \uc0c8\ub85c\uc6b4 \uae30\ud68c\uac00 \ub098\ud0c0\ub0a0 \ub54c\ub9c8\ub2e4 \uc774\ub97c \ud3ec\ucc29\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

\ud074\ub798\ub9ac\ubca0\uc774\ud2b8\uc5d0\uc11c\ub294<\/em> \uace0\uac1d\uc774<\/em> \ub9c8\ucf13<\/em> \uc561\uc138\uc2a4<\/em> \ubaa9\ud45c\ub97c<\/em> \ub2ec\uc131\ud558\ub294<\/em> \ub370<\/em> \ub3c4\uc6c0\uc744<\/em> \uc8fc\ub294<\/em> \uac15\ub825\ud558\uace0<\/em> \uc124\ub4dd\ub825<\/em> \uc788\ub294<\/em> \uac00\uce58<\/em> \ucee4\ubba4\ub2c8\ucf00\uc774\uc158<\/em> \uc790\ub8cc\ub97c<\/em> \uac1c\ubc1c\ud558\ub294<\/em> \ub370<\/em> \uc804\ubb38\ud654\ub418\uc5b4<\/em> \uc788\uc2b5\ub2c8\ub2e4<\/em>. <\/em>\uc800\ud76c\uc758<\/em> \uace0\ub3c4\ub85c<\/em> \ud6c8\ub828\ub41c<\/em> \uac00\uce58<\/em> \ucee4\ubba4\ub2c8\ucf00\uc774\uc158<\/em> \uc804\ubb38\uac00\ub4e4\uc740<\/em> \uc9c8\ubcd1\uc758<\/em> \uc6d0\uc778\uacfc<\/em> \ubcd1\ub9ac\ud559<\/em>, <\/em>\uadf8\ub9ac\uace0<\/em> \uace0\uac1d<\/em> \uc81c\ud488\uc758<\/em> \uc791\uc6a9<\/em> \uba54\ucee4\ub2c8\uc998\uc744<\/em> \uae4a\uc774<\/em> \uc788\uac8c<\/em> \ubd84\uc11d\ud560<\/em> \uc218<\/em> \uc788\ub294<\/em> \uacfc\ud559\uc801<\/em> \ud1b5\ucc30\ub825\uc744<\/em> \ubcf4\uc720\ud558\uace0<\/em> \uc788\uc5b4<\/em>, <\/em>\uac00\uce58<\/em> \ucc28\ubcc4\uc810\uc744<\/em> \uc2dd\ubcc4\ud558\uace0<\/em> \uc804\ub2ec\ud560<\/em> \uc218<\/em> \uc788\uc2b5\ub2c8\ub2e4<\/em>.<\/em><\/p>\n

\ub354<\/em> \uc790\uc138\ud55c<\/em> \uc815\ubcf4\ub098<\/em> \uc800\ud76c<\/em> \ud300\uc758<\/em> \uba64\ubc84\uc640\uc758<\/em> \uc0c1\ub2f4\uc744<\/em> \uc6d0\ud558\uc2dc\uba74<\/em> \uc5b8\uc81c\ub4e0\uc9c0<\/em> \uc5f0\ub77d\ud574 \uc8fc\uc2ed\uc2dc\uc624.<\/a><\/em><\/p>\n

\ubcf8<\/em> \uae00\uc740<\/em> \uc758\ud559\uc791\uac00\uc778<\/em> Eleanor Ward<\/em>\uc5d0<\/em> \uc758\ud574<\/em> \uc791\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4<\/em>.<\/em><\/p>\n

 <\/p>\n

\ucc38\uace0 \uc790\ub8cc:<\/strong><\/p>\n

<\/a>[1]<\/sup><\/a>Collins. Definition of \u2018magic bullet\u2019. Accessed May 2024. Available online at: [https:\/\/www.collinsdictionary.com\/dictionary\/english\/magic-bullet#:~:text=In%20medicine%2C%20a%20magic%20bullet,%5Binformal%5D<\/a>].
\n<\/a>[2]<\/sup><\/a>Merriam-Webster. Magic bullet dictionary entry. Accessed May 2024. Available online at: [https:\/\/www.merriam-webster.com\/dictionary\/magic%20bullet#dictionary-entry-1<\/a>]. 2024.
\n<\/a>[3]<\/sup><\/a>Valent P, Groner B, Schumacher U, Superti-Furga G, Busslinger M, Kralovics R, et al. Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. Journal of Innate Immunity. 2016;8(2):111-20.
\n<\/a>[4]<\/sup><\/a>Strebhardt K, Ullrich A. Paul Ehrlich\u2019s magic bullet concept: 100 years of progress. Nature Reviews Cancer. 2008 2008\/06\/01;8(6):473-80.
\n<\/a>[5]<\/sup><\/a>Richard Smith. The case for medical nihilism and \u201cgentle medicine\u201d. Accessed March 2024. Available online at: [https:\/\/blogs.bmj.com\/bmj\/2018\/06\/04\/richard-smith-the-case-for-medical-nihilism-and-gentle-medicine\/<\/a>].
\n<\/a>[6]<\/sup><\/a>Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Reviews Drug Discovery. 2004 2004\/04\/01;3(4):353-9.
\n<\/a>[7]<\/sup><\/a>Mencher SK, Wang LG. Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin Pharmacol. 2005 Apr 26;5:3.
\n<\/a>[8]<\/sup><\/a>Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, et al. The Philadelphia chromosome in leukemogenesis. Chin J Cancer. 2016 May 27;35:48.
\n<\/a>[9]<\/sup><\/a>Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP, et al. Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia. N Engl J Med. 2017 Mar 9;376(10):917-27.
\n<\/a>[10]<\/sup><\/a>Pray, L. (2008) Gleevec: the Breakthrough in Cancer Treatment. Nature Education 1(1):37.
\n<\/a>[11]<\/sup><\/a>National Cancer Institute. How Imatinib Transformed Leukemia Treatment and Cancer Research. Accessed March 2024. Available online at: [https:\/\/www.cancer.gov\/research\/progress\/discovery\/gleevec<\/a>]. 2018.
\n<\/a>[12]<\/sup><\/a>Leukemia & Lymphoma Society. FDA Approves First Targeted Treatment for Newly Diagnosed Leukemia Subtype. Accessed April 2024. Available online at: [https:\/\/www.lls.org\/news\/fda-approves-first-targeted-treatment-newly-diagnosed-leukemia-subtype<\/a>]. 2024.
\n<\/a>[13]<\/sup><\/a>Bitencourt R, Zalcberg I, Louro ID. Imatinib resistance: a review of alternative inhibitors in chronic myeloid leukemia. Rev Bras Hematol Hemoter. 2011;33(6):470-5.
\n<\/a>[14]<\/sup><\/a>Druker BJ, Guilhot F, O\u2019Brien SG, Gathmann I, Kantarjian H, Gattermann N, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006 Dec 7;355(23):2408-17.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Eleanor Ward \uc758\ud559\uc804\ubb38 \uc791\uac00 \ud074\ub798\ub9ac\ubca0\uc774\ud2b8   \ubaa8\ub4e0 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \ub2e8 \ud558\ub098\uc758 \uce58\ub8cc\uc81c\ub97c \ucc3e\ub294 \uac83\uc740 \uc815\ub9d0 \uba4b\uc9c4 \uc77c\uc774\uaca0\uc8e0? \ud574\ub85c\uc6b4 \ubd80\uc791\uc6a9 \uc5c6\uc774 \uc9c8\ubcd1\uc744 \ube60\ub974\uace0 \uc644\ubcbd\ud558\uac8c \uce58\ub8cc\ud560 \uc218 \uc788\ub294[1]\u00a0 \uc774\ub978\ubc14 \u2018\ub9c8\ubc95 \ucd1d\uc54c\u2019 \uce58\ub8cc\uc81c\ub294…<\/p>\n","protected":false},"author":207,"featured_media":15500,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_links_to":"","_links_to_type":0,"footnotes":""},"categories":[1315,1544],"tags":[1836,1401],"class_list":["post-15497","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life-sciences-healthcare","category-evidence-value-and-access","tag-market-access","tag-pharmaceutical","clarivate-industry-life-sciences-and-healthcare"],"acf":[],"lang":"ko","translations":{"ko":15497},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/15497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/users\/207"}],"replies":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/comments?post=15497"}],"version-history":[{"count":1,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/15497\/revisions"}],"predecessor-version":[{"id":329664,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/15497\/revisions\/329664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media\/15500"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=15497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/categories?post=15497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/tags?post=15497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}