{"id":15441,"date":"2024-09-11T16:59:02","date_gmt":"2024-09-11T07:59:02","guid":{"rendered":"https:\/\/clarivate.com\/ko\/?p=15441"},"modified":"2024-11-06T02:56:27","modified_gmt":"2024-11-06T02:56:27","slug":"early-diagnosis-in-alzheimers-disease-a-first-step-towards-better-care","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ko\/blog\/early-diagnosis-in-alzheimers-disease-a-first-step-towards-better-care\/","title":{"rendered":"\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \uc870\uae30\uc9c4\ub2e8:\ub354 \ub098\uc740 \uce58\ub8cc\ub97c \uc704\ud55c \uccab\uac78\uc74c"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-15451 alignleft\" src=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/cricci_avatar-70x70-1.jpg\" alt=\"\" width=\"102\" height=\"102\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/cricci_avatar-70x70-1.jpg 70w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/cricci_avatar-70x70-1-40x40.jpg 40w\" sizes=\"auto, (max-width: 102px) 100vw, 102px\" \/><\/p>\n<p><strong>Clara Ricci<\/strong><\/p>\n<p><strong>\uc120\uc784\uc758\ud559\uc791\uac00<\/strong><\/p>\n<p><strong>\ud074\ub798\ub9ac\ubca0\uc774\ud2b8<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>9\uc6d4\uc740 \u00a0<a href=\"https:\/\/www.alzint.org\/get-involved\/world-alzheimers-month\/\" target=\"_blank\" rel=\"noopener\">\uc138\uacc4 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ub2ec<\/a>\uc785\ub2c8\ub2e4. \uc138\uacc4 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ub2ec\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uc5f0\uad6c\uc640 \uad00\ub828\ub41c \uc81c\uc57d\ud68c\uc0ac\ub4e4\uc758 \uc9c0\uc6d0\uc744 \ubc1b\uc544 \uad6d\uc81c \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ud611\ud68c\uac00 \uc8fc\ub3c4\ud558\ub294 \uae00\ub85c\ubc8c \ucea0\ud398\uc778\uc785\ub2c8\ub2e4. \ubcf8 \ucea0\ud398\uc778\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc57d 4\uc5b5 1,600\ub9cc\uba85\uc774 \uc54c\uace0 \uc788\ub294 \uce58\ub9e4\uc5d0 \ub300\ud55c \uc778\uc2dd\uc744 \ub192\uc774\uace0 \ubaa8\ub4e0 \uc720\ud615\uc758 \uce58\ub9e4\uc5d0 \ub300\ud574 \uc9c0\uc18d\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\uace0 \uc788\ub294 \ub099\uc778\uc744 \uc5c6\uc560\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4.<\/p>\n<p>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0 \ub300\ud55c \uc644\uce58\ubc95\uc740 \uc5c6\uc9c0\ub9cc, \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc774 \ud658\uc790\uc758 \uae30\ub2a5\uacfc \uc0b6\uc758 \uc9c8\uc744 \uc800\ud558\uc2dc\ud0a4\ub294 \uc2dc\uac04\uc744 \uc9c0\uc5f0\uc2dc\ud0a4\uba70,\uac04\ubcd1\uc778\uc5d0\uac8c \uc8fc\ub294 \ubd80\ub2f4\uc744 \uc644\ud654\ud560 \uc218 \uc788\ub294 \uac1c\uc778 \ub9de\ucda4\ud615\uc758 \ubcf5\ud569\uce58\ub8cc\uc640 \uc9c0\uc6d0\uc740 \uac00\ub2a5\ud569\ub2c8\ub2e4.(Emblad, 2021; Bayly, 2021; Xiang, 2024). \uc774\uc6a9 \uac00\ub2a5\ud55c \uce58\ub8cc \ud6a8\uacfc\ub97c \uadf9\ub300\ud654\ud558\ub824\uba74 \uc801\uc2dc\uc758 \uc815\ud655\ud55c \uc9c4\ub2e8\uc774 \uc911\uc694\ud558\uc9c0\ub9cc, \uc774 \ubcd1\uc744 \uc9c4\ub2e8\ubc1b\ub294 \uc5ec\uc815\uc740 \uae38\uace0 \ubcf5\uc7a1\ud558\uba70, \ube44\uc6a9\ub3c4 \ub9ce\uc774 \ub4ed\ub2c8\ub2e4. (Alzheimer&#8217;s Disease International, 2021; Chiari, 2022; Juganavar, 2023).<\/p>\n<p>\ubcf8 \uae00\uc5d0\uc11c\ub294 \uc54c\uce20\ud558\uc774\uba38 \uc870\uae30\uc9c4\ub2e8\uc5d0 \uad00\ub828\ub41c \uc5b4\ub824\uc6c0\uacfc \uc81c\uc57d\ud68c\uc0ac\ub4e4\uc774 \uc774 \uc9c8\ud658\uc758 \uc601\ud5a5\uc744 \ubc1b\ub294 \ud658\uc790\ub97c \uc9c0\uc6d0\ud560 \uc218 \uae30\ud68c\uc5d0 \uad00\ud574 \uc0b4\ud3b4\ubcf4\uaca0\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<h3>\uc54c\uce20\ud558\uc774\uba38\ub780?<\/h3>\n<p>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc740 \uc804\uc784\uc0c1 \ubb34\uc99d\uc0c1 \ub2e8\uacc4\ubd80\ud130 \uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560(MCI), \uc784\uc0c1\uc801\uc73c\ub85c \uba85\ubc31\ud55c \uce58\ub9e4\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \uc5f0\uc18d\uc801\uc73c\ub85c \uc9c4\ud589\ub418\ub294, \ubd80\ub2f4\uc2a4\ub7fd\uace0 \uc0dd\uba85\uc744 \uc81c\ud55c\ud558\uba70 \uad81\uadf9\uc801\uc73c\ub85c \uce58\uba85\uc801\uc778 \uc2e0\uacbd \ud1f4\ud589\uc131 \uc9c8\ud658\uc785\ub2c8\ub2e4(Gustavsson, 2022; Anon., 2024). \uc54c\uce20\ud558\uc774\uba38\ub294 \ubcf5\uc7a1\ud55c \ubcd1\ud0dc\uc0dd\ub9ac\ub97c \uac16\uace0 \uc788\uc73c\uba70, \uc544\ubc00\ub85c\uc774\ub4dc-\u03b2(A\u03b2) \ud50c\ub77c\ud06c\uc758 \uc138\ud3ec \uc678 \uce68\ucc29\uacfc \ud0c0\uc6b0 \ub2e8\ubc31\uc9c8\uc758 \uc2e0\uacbd\uc12c\uc720 \uc5c9\ud0b4(NFT) \ud615\uc131 \ub4f1 \ub2e4\uc591\ud55c \uae30\uc804\uc774 \uad00\uc5ec\ud574 \uc9c4\ud589\uc131 \uc2e0\uacbd\uc138\ud3ec \uc190\uc2e4\uacfc \uc704\ucd95\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4(Counts, 2017).<\/p>\n<p>A\u03b2 \uce68\ucc29\uc740 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uae30 20\ub144 \uc774\uc0c1 \uc804\uc5d0 \uc2dc\uc791\ub420 \uc218 \uc788\uc73c\uba70(Gordon, 2018), NTF\ucd95\ucc99\uc740 \uc778\uc9c0 \uae30\ub2a5\uc774 \uc815\uc0c1\uc73c\ub85c \ubcf4\uc774\ub294 \uc804\uc784\uc0c1 \ub2e8\uacc4(Counts, 2017)\uc5d0\uc11c \uc2dc\uc791\ub429\ub2c8\ub2e4. (Anon., 2024). \uacbd\ub3c4 \uc778\uc9c0\uc7a5\uc560(MCI)\ub2e8\uacc4\uc5d0\uc11c\ub294 \ubbf8\uc138\ud55c \uc778\uc9c0 \uc99d\uc0c1\uc774 \ubc1c\uc0dd\ud558\uc9c0\ub9cc, \uc54c\uc544\ucc28\ub9ac\uc9c0 \ubabb\ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. (Anon., 2024). \uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560 \ud658\uc790\uc758 \uc57d 43%\uac00 5\ub144 \uc774\ub0b4\uc5d0 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc73c\ub85c \uc778\ud55c \uce58\ub9e4\ub85c \ubc1c\uc804\ud569\ub2c8\ub2e4(Roberts, 2014)(\uadf8\ub9bc 1). \uce58\ub9e4\uac00 \uc2ec\ud574\uc9c0\uba74 \ubcf4\ub2e4 \ub9ce\uc740 \uad00\ub9ac\uac00 \ud544\uc694\ud558\uba70, \uc54c\uce20\ud558\uc774\uba38 \ud658\uc790\uc758 \uc8fc\uc694 \uc0ac\ub9dd \uc6d0\uc778\uc778 \uc695\ucc3d, \uac10\uc5fc, \uc5f0\ud558\uace4\ub780, \uc601\uc591\uc2e4\uc870, \ud761\uc778\uc131 \ud3d0\ub834\uacfc \uac19\uc740 \ud569\ubcd1\uc99d\uc774 \ubc1c\uc0dd\ud569\ub2c8\ub2e4(Anon., 2024).<\/p>\n<p><strong>\uadf8\ub9bc<\/strong><strong> 1. AD<\/strong><strong>\uc5f0\uc18d\uccb4<\/strong> <strong>\uc804\ubc18\uc5d0<\/strong> <strong>\uac78\uce5c<\/strong> <strong>\ubc14\uc774\uc624\ub9c8\ucee4<\/strong> <strong>\ubc0f<\/strong> <strong>\uc784\uc0c1\uc801<\/strong> <strong>\ubcc0\ud654<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-15442 size-large\" src=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-1024x609.jpg\" alt=\"\" width=\"640\" height=\"381\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-1024x609.jpg 1024w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-300x178.jpg 300w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-768x457.jpg 768w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-1536x914.jpg 1536w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-2048x1218.jpg 2048w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture1-scaled-1-1-67x40.jpg 67w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p>Counts et al, 2017 (10) \uc5d0\uc11c \uc218\uc815\ub428<br \/>\n\uc57d\uc5b4:AD-Alzheimer\u2019s disease \uc54c\uce20\ud558\uc774\uba38\ubcd1; MCI-mild cognitive impairment \uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560<\/p>\n<h3><\/h3>\n<p>&nbsp;<\/p>\n<h3>\uc54c\uce20\ud558\uc774\uba38\ubcd1 \uc870\uae30 \uc9c4\ub2e8: \uc65c \ud544\uc694\ud560\uae4c\uc694?<\/h3>\n<p>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0 \ub300\ud55c \uce58\ub8cc\uc81c\uac00 \uc5c6\ub2e4\uba74 \uc65c \uc870\uae30\uc9c4\ub2e8\uc774 \uc911\uc694\ud560\uae4c\uc694?<\/p>\n<p>\uccab\uc9f8, \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ud658\uc790\uac00 \ub3c5\ub9bd\uc131\uacfc \uc0b6\uc758 \uc9c8\uc744 \ub354 \uc624\ub798 \uc720\uc9c0\ud560 \uc218 \uc788\ub3c4\ub85d \uac1c\uc778 \ub9de\ucda4\ud615 \ucf00\uc5b4 \uacc4\ud68d\uc744 \uc54c\ub9ac\uae30 \uc704\ud574\uc11c\uc785\ub2c8\ub2e4. \uc774\ub294 \uc9c8\ubcd1\uc758 \uc9c4\ud589 \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uac04\ubcd1 \ud30c\ud2b8\ub108\uc758 \ubd80\ub2f4\uc744 \ub35c\uc5b4\uc90d\ub2c8\ub2e4(Bayly, 2021). \uac1c\uc778 \ub9de\ucda4\ud615 \uce58\ub8cc\ub294 \uc778\uc9c0 \ubc0f \ube44\uc778\uc9c0 \uc99d\uc0c1\uc744 (\uc77c\uc2dc\uc801\uc73c\ub85c) \uc644\ud654\ud558\uae30 \uc704\ud55c \uc57d\ub9ac\ud559\uc801 \ubc0f \ube44 \uc57d\ub9ac\ud559\uc801 \uac1c\uc785\uacfc \uc54c\uce20\ud558\uc774\uba38\uc758 \uc9c4\ud589\uc744 \ub2a6\ucd9c \uc218 \uc788\ub294 DMT(\uc9c8\ubcd1 \uc218\uc815 \uc694\ubc95)\uc5d0 \uc758\uc874\ud569\ub2c8\ub2e4(\uc54c\uce20\ud558\uc774\uba38 \ud611\ud68c, nd; Emblad, 2021; Xiang, 2024). \ud604\uc7acFDA\uc5d0\uc11c \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\ud55c 8\uac1c \uc57d\ubb3c \uc911 6\uac1c\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc73c\ub85c \uc778\ud55c \uacbd\uc99d\uc5d0\uc11c \uc911\uc99d \uce58\ub9e4 \ud658\uc790\uc5d0\uac8c \uc0ac\uc6a9\ud558\ub294 \uc99d\uc0c1 \uc644\ud654 \uc57d\ubb3c\uc774\uba70, 2\uac1c\ub294 \uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560 \ub610\ub294 \uacbd\uc99d \uce58\ub9e4\ub97c \uc704\ud55c DMT\uc785\ub2c8\ub2e4(\uc54c\uce20\ud558\uc774\uba38 \ud611\ud68c, nd; \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d, 2023\ub144 \ubc0f 2024\ub144).<\/p>\n<p>\ud655\uc9c4 \uc9c4\ub2e8\uc774 \ub0b4\ub824\uc9c0\uba74 \uc54c\uce20\ud558\uc774\uba38 \ud658\uc790\uc640 \uac04\ubcd1\uc778\uc740 \ubc95\uc801, \uc7ac\uc815\uc801 \uc9c0\uc6d0\ubfd0 \uc544\ub2c8\ub77c \uc2e4\uc9c8\uc801\uc774\uace0 \uc815\uc11c\uc801\uc778 \uc9c0\uc6d0\uc744 \ubc1b\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38 \uc9c4\ub2e8\uc744 \ubc1b\uc740 \uc0ac\ub78c\uc740 \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ub4f1\ub85d\ud560 \uc790\uaca9\uc774 \uc8fc\uc5b4\uc9c0\uac8c \ub420 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<h3><\/h3>\n<p>&nbsp;<\/p>\n<h3>\uc54c\uce20\ud558\uc774\uba38 \uc9c4\ub2e8\uacfc \uad00\ub828\ub41c \ud604\uc7ac \ub2f9\uba74\uacfc\uc81c<\/h3>\n<p>\uc54c\uce20\ud558\uc774\uba38 \ud658\uc790\uc640 \uac04\ubcd1\uc778\uc740 \uae34 \uc5ec\uc815\uc744 \uac70\uce58\uac8c \ub418\uba70 \uadf8 \uc5ec\uc815\uc5d0\ub294 \ub9ce\uc740 \uc7a5\uc560\ubb3c\uc774 \ub3c4\uc0ac\ub9ac\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \ub300\uc911\uacfc \uc758\ub8cc \uc11c\ube44\uc2a4 \uc81c\uacf5\uc790 \ubaa8\ub450\uc758 \ub099\uc778\uacfc \uc778\uc2dd \ubd80\uc871\uc774 \uc9c4\ub2e8\uc5d0 \uc788\uc5b4 \uc8fc\uc694 \uc7a5\uc560\ubb3c\ub85c \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4. (Alzheimer&#8217;s Disease International, 2021) \uacfc\uc18c\uc9c4\ub2e8, \uc624\uc9c4, \ub290\ub9b0 \uc9c4\ub2e8\uc774 \ud754\ud788 \ubc1c\uc0dd\ud558\uba70 (Lang, 2017; Alzheimer&#8217;s Disease International, 2021; Chairi, 2022; Gj\u00f8ra, 2024), \uc774\ub294 \uc885\uc885 \uce58\ub8cc \uc9c0\uc5f0\uc73c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \uc2e4\uc81c\ub85c \uc9c4\ub2e8\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ud6c4\uae30 \ub2e8\uacc4\uc5d0\uc11c \uc774\ub8e8\uc5b4\uc9c0\uba70 \uc784\uc0c1 \uac80\uc0ac, \ubcd1\ub825 \ud3c9\uac00, \uc778\uc9c0 \ud14c\uc2a4\ud2b8, \ub1cc \uc601\uc0c1 \uae30\ubc95 \ub4f1 \uc5ec\ub7ec \ubd84\uc57c\uc758 \uc885\ud569\uc801\uc778 \uac80\uc0ac\ub97c \uae30\ubc18\uc73c\ub85c \ud569\ub2c8\ub2e4. (Juganavar, 2023).<\/p>\n<p>\ucd5c\uadfc \uc2e0\uacbd \uc601\uc0c1 \ubc0f \ubc14\uc774\uc624\ub9c8\ucee4 \ubd84\uc11d\uc758 \ubc1c\uc804\uc740 \ub354 \ube60\ub974\uace0 \uc815\ud655\ud55c \uc9c4\ub2e8\uc744 \uac00\ub2a5\ud558\uac8c \ud560 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud604\uc7ac\uc758 \ub3c4\uad6c\ub4e4\uc740 \uad11\ubc94\uc704\ud55c \uc784\uc0c1\uc801 \uc0ac\uc6a9\uc5d0 \uc788\uc5b4\uc11c\ub294 \ud55c\uacc4\ub97c \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. (\ud45c 1). \uc608\ub97c \ub4e4\uc5b4, \uc544\ubc00\ub85c\uc774\ub4dc \uc591\uc804\uc790 \ubc29\ucd9c \ub2e8\uce35\ucd2c\uc601(PET)\uacfc \ub1cc\ucc99\uc218\uc561(CSF) \uae30\ubc18 \uac80\uc0ac\ub294 \uc774\uc804 PET \ub610\ub294 \uc778\uc9c0 \uac80\uc0ac\ub9cc \uc2dc\ud589\ud560 \ub54c\ubcf4\ub2e4 \uc624\uc9c4\uc728\uc744 \ub0ae\ucd94\uc9c0\ub9cc(Rabinovici, 2019; Esquivel, 2022), \uc774\ub97c \uc0ac\uc6a9\ud558\ub824\uba74 \uc804\ubb38 \uc13c\ud130\uc640 \uc778\ub825\uc774 \ud544\uc694\ud558\uace0 \uc0c1\ub2f9\ud55c \ube44\uc6a9\uc774 \ubc1c\uc0dd\ud569\ub2c8\ub2e4(Juganavar, 2023). \uc2e0\uacbd \uc601\uc0c1 \ubc0f \ubc14\uc774\uc624\ub9c8\ucee4 \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \ud608\uc561 \uac80\uc0ac\uc640 \uba38\uc2e0\ub7ec\ub2dd \ubaa8\ub378\uc740 \ucd5c\uc801\uc758 \ube44\uce68\uc2b5\uc801 \uc9c4\ub2e8 \ub3c4\uad6c\ub97c \ucc3e\ub294 \ub370 \uc788\uc5b4 \ud55c \uac78\uc74c \ub354 \ub098\uc544\uac04 \uac83\uc73c\ub85c, \ub2e4\ub978 \uc9c4\ub2e8 \uac80\uc0ac\ubcf4\ub2e4 \ub354 \ube60\ub974\uace0 \uc800\ub834\ud558\uba70 \uc811\uadfc\uc131\uc774 \ub192\uc740 \uc635\uc158\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4(Juganavar, 2023; Anon., 2024; Quanterix, 2024). \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uae30\uc220\uc740 \uc784\uc0c1\uc5d0\uc11c \uc77c\uc0c1\uc801\uc73c\ub85c \uad6c\ud604\ub418\uae30 \uc804\uc5d0 \ucd94\uac00\uc801\uc778 \uac80\uc99d\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n<p><strong>\ud45c<\/strong><strong> 1. <\/strong><strong>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0<\/strong> <strong>\uc0ac\uc6a9\ub418\ub294<\/strong> <strong>\uc9c4\ub2e8\ub3c4\uad6c<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-15443 size-large\" src=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-805x1024.jpg\" alt=\"\" width=\"640\" height=\"814\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-805x1024.jpg 805w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-236x300.jpg 236w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-768x977.jpg 768w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-1208x1536.jpg 1208w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-1610x2048.jpg 1610w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1-31x40.jpg 31w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2024\/09\/Alzheimer-Picture2-1.jpg 1946w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<h3><\/h3>\n<p>&nbsp;<\/p>\n<h3>\uc81c\uc57d \ud68c\uc0ac\ub4e4\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \uc601\ud5a5\uc744 \ubc1b\ub294 \uc0ac\ub78c\ub4e4\uc744 \uc9c0\uc6d0\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/h3>\n<p>\ucd5c\uadfc \uc218\uc2ed \ub144 \ub3d9\uc548 \ub9ce\uc740 \uc9c4\uc804\uc774 \uc788\uc5c8\uc9c0\ub9cc, \uc54c\uce20\ud558\uc774\uba38\ub97c \uc870\uae30\uc5d0 \uc815\ud655\ud558\uac8c \uc9c4\ub2e8\ud558\uace0 \uc774 \uc9c8\ud658\uc758 \uc601\ud5a5\uc744 \ubc1b\ub294 \uc0ac\ub78c\ub4e4\uc744 \uc9c0\uc6d0\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc544\uc9c1 \ub0a8\uc544\uc788\ub294 \uc7a5\ubcbd\uc744 \ud5c8\ubb3c\uae30 \uc704\ud55c \ubcf4\ub2e4 \ub9ce\uc740 \ub178\ub825\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc9c8\ubcd1 \uc778\uc2dd\ubd80\ud130 \uc758\uc57d\ud488 \uac1c\ubc1c\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \ubaa8\ub4e0 \uc218\uc900\uc758 \uc758\ub8cc \uc11c\ube44\uc2a4 \uc81c\uacf5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub294 \uc9c0\uc2dd\uacfc \uc790\uc6d0\uc744 \ubcf4\uc720\ud55c \uc81c\uc57d \ud68c\uc0ac\ub294 \uc5ec\ub7ec \uac00\uc9c0 \ubc29\ubc95\uc73c\ub85c \uae30\uc5ec\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4:<\/p>\n<ul>\n<li><strong>\uc758\ub8cc\uc804\ubb38\uac00\uc640<\/strong> <strong>\ub300\uc911<\/strong> <strong>\uad50\uc721<\/strong><strong>:<\/strong>\u00a0\uc774\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \uad00\ub828\ub41c \ub099\uc778\uacfc \uc778\uc2dd \ubd80\uc871\uc744 \uadf9\ubcf5\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5f4\uc1e0\uac00 \ub420 \uac83\uc785\ub2c8\ub2e4. \ud2b9\uc815 \ub300\uc0c1\uc744 \ud0c0\uac9f\uc73c\ub85c \ud55c \ud6a8\uacfc\uc801\uc778 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158 \uc790\ub8cc\ub294 \uc54c\uce20\ud558\uc774\uba38 \ud658\uc790\uac00 \uc9c4\ub2e8\uacfc \uce58\ub8cc \uacfc\uc815\uc5d0\uc11c \uacaa\ub294 \uc5b4\ub824\uc6c0\uacfc \ud544\uc694\ub97c \uc774\ud574\uad00\uacc4\uc790\uc5d0\uac8c \uc54c\ub9ac\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li><strong>\ube44\uce68\uc2b5\uc801\uc774\uace0<\/strong> <strong>\ube44\uc6a9\uc774<\/strong> <strong>\uc800\ub834\ud558\uba70<\/strong> <strong>\ube60\ub978<\/strong> <strong>\ubc14\uc774\uc624\ub9c8\ucee4<\/strong> <strong>\uae30\ubc18<\/strong> <strong>\uac80\uc0ac\uc5d0<\/strong> <strong>\ub300\ud55c<\/strong> <strong>\uc5f0\uad6c<\/strong> <strong>\uc790\uae08\uc744<\/strong> <strong>\uc9c0\uc6d0<\/strong><strong>:<\/strong>\u00a0\uc774\ub7ec\ud55c \uac80\uc0ac\ub294 \uc0dd\ub9ac\uc801 \ubc1c\ubcd1\uc5d0\uc11c \uc9c4\ub2e8 \ubc0f \uc801\uc808\ud55c \uce58\ub8cc \uc81c\uacf5\uae4c\uc9c0\uc758 \uc2dc\uac04\uc744 \ub2e8\ucd95\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. 2022\ub144 \ubbf8\uad6d FDA\ub294 A\u03b240\/A\u03b242 \uac80\ucd9c\uc744 \uae30\ubc18\uc73c\ub85c \ud55c \ucd5c\ucd08\uc758 CSF \uc9c4\ub2e8 \ud14c\uc2a4\ud2b8\ub97c \uc2b9\uc778\ud588\uc73c\uba70(\ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d, nd), 2024\ub144\uc5d0\ub294 \ud608\uc7a5 \ub610\ub294 \ud608\uc561\uc5d0\uc11c p-tau217 \uc218\uc900\uc744 \uce21\uc815\ud558\ub294 \ub450 \uac00\uc9c0 \uc0c8\ub85c\uc6b4 \uac80\uc0ac\uc5d0 \ub300\ud574 \ud601\uc2e0 \uae30\uae30(Breakthrough Device) \uc9c0\uc815\uc744 \ubd80\uc5ec\ud588\uc2b5\ub2c8\ub2e4. (Quanterix, 2024\ub144; Roche Diagnostics, 2024\ub144). \uc774\ub7ec\ud55c \uac80\uc0ac\ub294 \ub2e4\ub978 \uc9c4\ub2e8 \ud3c9\uac00\uc640 \ud568\uaed8 \uc0ac\uc6a9\ud558\uba74 \uc9c4\ub2e8\uc758 \uc815\ud655\uc131\uc744 \ub192\uc774\uace0 \uc2e0\uc18d\ud55c \uc784\uc0c1 \uc758\uc0ac\uacb0\uc815\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li><strong>\ubcf4\ub2e4<\/strong> <strong>\uc2dc\uc758\uc801\uc808\ud558\uace0<\/strong> <strong>\uc815\ud655\ud55c<\/strong> <strong>\uc9c4\ub2e8<\/strong> <strong>\uae30\uc220<\/strong> <strong>\ud65c\uc6a9<\/strong><strong>: <\/strong>\uc7a0\uc7ac\uc801\uc778 \uc784\uc0c1\uc2dc\ud5d8 \ucc38\uac00\uc790\ub97c \ubcf4\ub2e4 \ud6a8\uc728\uc801\uc73c\ub85c \uc120\ubcc4\ud558\uc5ec \uc784\uc0c1\uc2dc\ud5d8 \uaddc\ubaa8\ub97c \ub298\ub9ac\uace0 \ud53c\ud5d8\uc790 \ud2b9\uc131\uc774 \uc2e4\uc81c \uc54c\uce20\ud558\uc774\uba38 \ud658\uc790 \uc9d1\ub2e8\uc744 \ub354 \uc798 \ub300\ud45c\ud558\ub3c4\ub85d \ud558\uc5ec \uc5f0\uad6c\uc758 \ud1b5\uacc4\uc801 \ud798\uacfc \uacb0\uacfc\uc758 \uc77c\ubc18\ud654 \uac00\ub2a5\uc131\uc744 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li><strong>\uc2e0\uc57d<\/strong> <strong>\uac1c\ubc1c\uc5d0<\/strong> <strong>\ub300\ud55c<\/strong> <strong>\uc9c0\uc18d\uc801\uc778<\/strong> <strong>\ud22c\uc790<\/strong><strong>: <\/strong>\uc54c\uce20\ud558\uc774\uba38 \uc9c4\ud589\uc744 \uc9c0\uc5f0\uc2dc\ud0a4\uace0 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub294 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc \uc635\uc158\uc758 \uac00\uc6a9\uc131\uc744 \uac00\uc18d\ud654\ud558\ub294 \uac83\uc774 \uc5ec\uae30\uc11c\uc758 \ud575\uc2ec\uc785\ub2c8\ub2e4. \uc9c0\ub09c 20\ub144\uac04 \uc54c\uce20\ud558\uc774\uba38 \uc784\uc0c1\uc2dc\ud5d8\uc758 \uc2e4\uc801\uc740 \uc2e4\ub9dd\uc2a4\ub7fd\uc9c0\ub9cc(Jain, 2022), \uc2e4\ud328\ub97c \ud1b5\ud574 \ubcd1\ub9ac \uc0dd\ub9ac\ud559\uc758 \uae30\uc804\uc744 \ubc1d\ud788\ub294 \ub370 \uae30\uc5ec\ud588\uace0, \ucd5c\ucd08\uc758 \uc2b9\uc778\ub41c DMT\uac00 \uac1c\ubc1c\ub418\uace0 \ud5a5\ud6c4 \uce58\ub8cc\ubc95 \uac1c\ubc1c\uc5d0 \ub3c4\uc6c0\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/li>\n<\/ul>\n<h3><\/h3>\n<p>&nbsp;<\/p>\n<h3>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0 \uac78\ub9b0 \ubaa8\ub4e0 \uc0ac\ub78c\uc744 \uc704\ud55c \ub354 \ub098\uc740 \ubbf8\ub798\ub97c \ud5a5\ud574<\/h3>\n<p>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc740 \uc784\uc0c1 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uae30 \uc218\uc2ed \ub144 \uc804\ubd80\ud130 \uc870\uc6a9\ud788 \uc9c4\ud589\ub429\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ud658\uc790\uac00 \uc801\uc808\ud55c \uce58\ub8cc\ub97c \ubc1b\uc544 \uc2e0\uacbd \uae30\ub2a5\uacfc \uac74\uac15\uc744 \ucd5c\ub300\ud55c \uc624\ub7ab\ub3d9\uc548 \ubcf4\uc874\ud558\uace0 \uac04\ubcd1\uc778\uc758 \uac74\uac15\uc744 \uc720\uc9c0\ud558\ub824\uba74 \uc870\uae30 \uc9c4\ub2e8\uc774 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \ucd5c\uadfc \ubc14\uc774\uc624\ub9c8\ucee4 \ubc0f \uc601\uc0c1 \uc5f0\uad6c\uc758 \ubc1c\uc804\uc73c\ub85c \uc54c\uce20\ud558\uc774\uba38 \uc9c4\ub2e8\uc774 \uac04\uc18c\ud654\ub418\uc5c8\uc73c\uba70, DMT\uc5d0 \ub300\ud55c \uc811\uadfc\uc131\uc774 \ub192\uc544\uc9d0\uc5d0 \ub530\ub77c \uac00\uae4c\uc6b4 \ubbf8\ub798\uc5d0 \uc99d\uac00\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\ub294 \uc120\ubcc4, \ubaa8\ub2c8\ud130\ub9c1 \ubc0f \uce58\ub8cc \uc218\uc694\ub97c \ud574\uacb0\ud560 \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4(Alzheimer&#8217;s Disease International, 2021). \ubcf4\ub2e4 \uc815\ud655\ud558\uace0 \uc870\uae30 \uc9c4\ub2e8\uc774 \uac00\ub2a5\ud574\uc9c0\uba74 \ub9de\ucda4\ud615 \uce58\ub8cc, \uc9c0\uc6d0 \ubc0f \uce58\ub8cc\uc5d0 \ub300\ud55c \uc811\uadfc\uc131\uc774 \ud655\ub300\ub418\uc5b4 \ub354 \ub9ce\uc740 \uc54c\uce20\ud558\uc774\uba38 \ud658\uc790\uc640 \uac04\ubcd1 \uc778\uc774 \uacc4\ud68d\uc744 \uc138\uc6b8 \uc218 \uc788\uac8c \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n<p>\ud074\ub798\ub9ac\ubca0\uc774\ud2b8\uc758 \uac00\uce58 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158 \ud300\uc740 \uc0dd\uba85\uacfc\ud559 \uae30\uc5c5\uc774 \ud601\uc2e0\uc801\uc778 \uc758\ub8cc \uae30\uc220\uc758 \uc774\uc810\uc744 \uba85\ud655\ud558\uace0 \ud6a8\uacfc\uc801\uc73c\ub85c \uc2dc\uc7a5 \uc811\uadfc \uc774\ud574\uad00\uacc4\uc790\uc5d0\uac8c \uc804\ub2ec\ud560 \uc218 \uc788\ub3c4\ub85d \uc9c0\uc6d0\ud569\ub2c8\ub2e4. \ud074\ub798\ub9ac\ubca0\uc774\ud2b8\ub294 \ubcf4\ud5d8\uc0ac \uac00\uce58 \uc2a4\ud1a0\ub9ac, \uae00\ub85c\ubc8c \uac00\uce58 \uc11c\ub958, \uc774\uc758 \uc81c\uae30 \ucc98\ub9ac \ubc0f \ucd9c\ud310\ubb3c \ub4f1 \uac15\ub825\ud558\uace0 \uc124\ub4dd\ub825 \uc788\ub294 \uac00\uce58 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158 \uc790\ub8cc\ub97c \uc804\ubb38\uc801\uc73c\ub85c \uac1c\ubc1c\ud569\ub2c8\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc744 \ube44\ub86f\ud55c \ub2e4\uc591\ud55c \uc9c8\ubcd1\uc5d0 \ub300\ud55c \ube44\uc784\uc0c1\uc801 \uce21\uba74(\uc608: \uc801\uc808\ud55c \uc9c4\ub2e8 \ubc0f \uce58\ub8cc\uc5d0 \ub300\ud55c \uc7a5\ubcbd \uc2dd\ubcc4)\uacfc \uad00\ub828\ub41c \uc9c0\uc2dd \uaca9\ucc28\ub97c \ud574\uc18c\ud558\uace0 \uc81c\ud488 \uc5ec\uc815 \uc804\ubc18\uc5d0 \uac78\uccd0 \uace0\uac1d\uc744 \uc9c0\uc6d0\ud55c \ud3ed\ub113\uc740 \uacbd\ud5d8\uc744 \ubcf4\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2f9\uc0ac\uc758 \uc5ed\ub7c9\uacfc \uc9c0\uc6d0 \ubc29\ubc95\uc5d0 \ub300\ud574 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\ub824\uba74 <a href=\"https:\/\/clarivate.com\/ko\/products\/life-sciences-and-healthcare-consulting-services\/\">\uc5ec\uae30<\/a>\ub97c \ud1b5\ud574 \ubb38\uc758\uc8fc\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\ucc38\uc870\ubb38\ud5cc<\/strong><\/p>\n<ol>\n<li>Alzheimer\u2019s Association, n.d. FDA-Approved Treatments for Alzheimer\u2019s. [Online] Available at:\u00a0<a href=\"https:\/\/www.alz.org\/media\/Documents\/alzheimers-dementia-fda-approved-treatments-for-alzheimers-ts.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.alz.org\/media\/Documents\/alzheimers-dementia-fda-approved-treatments-for-alzheimers-ts.pdf<\/a>\u00a0[Accessed 29 August 2024].<\/li>\n<li>Alzheimer\u2019s Disease International, 2021. World Alzheimer Report 2021. [Online] Available at:\u00a0<a href=\"https:\/\/www.alzint.org\/resource\/world-alzheimer-report-2021\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.alzint.org\/resource\/world-alzheimer-report-2021\/<\/a>\u00a0[Accessed 29 August 2024].<\/li>\n<li>Anon., 2024. 2024 Alzheimer\u2019s disease facts and figures. Alzheimer\u2019s &amp; Dementia, 20(5), pp. 3708-3821.<\/li>\n<li>Bayly, M., 2021. Does early-stage intervention improve caregiver well-being or their ability to provide care to persons with mild dementia or mild cognitive impairment? A systematic review and meta-analysis. Psychology and Aging, 36(7), pp. 834-854.<\/li>\n<li>Chiari, A., 2022. How long does it take to diagnose young-onset dementia? A comparison with late-onset dementia. Neurological Sciences, 43(8), pp. 4729-4734.<\/li>\n<li>Counts, S. E., 2017. Biomarkers for the Early Detection and Progression of Alzheimer\u2019s Disease. Neurotherapeutics, 14(1), pp. 35-53.<\/li>\n<li>Emblad, S. Y. M., 2021. Creative Art Therapy as a Non-Pharmacological Intervention for Dementia: A Systematic Review. Journal of Alzheimer\u2019s Disease Reports, 5(1), pp. 353-364.<\/li>\n<li>Esquivel, R. N., 2022. Reducing misdiagnosis of Alzheimer\u2019s Disease pathology utilizing CSF and amyloid PET. Alzheimer\u2019s &amp; Dementia, 18(S5).<\/li>\n<li>Gj\u00f8ra, L., 2024. Prevalence and Determinants of Diagnosed Dementia: A Registry Linkage Study Linking Diagnosis of Dementia in the Population-Based HUNT Study to Registry Diagnosis of Dementia in Primary Care and Hospitals in Norway. Journal of Alzheimer\u2019s Disease, 99(1), pp. 363-375.<\/li>\n<li>Gordon, B. A., 2018. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer\u2019s disease: a longitudinal study. The Lancet Neurology, 17(3), pp. 241-250.<\/li>\n<li>Gustavsson, A., 2022. Global estimates on the number of persons across the Alzheimer\u2019s disease continuum. Alzheimer\u2019s &amp; Dementia, 19(2), pp. 658-670.<\/li>\n<li>Jain, R., 2022. A review of therapeutic failures in late-stage clinical trials. Expert Opinion on Pharmacotherapy, 24(3), pp. 389-399.<\/li>\n<li>Juganavar, A., 2023. Navigating Early Alzheimer\u2019s Diagnosis: A Comprehensive Review of Diagnostic Innovations. Cureus, 15(9).<\/li>\n<li>Lang, L., 2017. 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