{"id":13886,"date":"2023-11-14T23:28:36","date_gmt":"2023-11-14T14:28:36","guid":{"rendered":"https:\/\/clarivate.com\/ko\/?p=13886"},"modified":"2024-11-06T02:56:53","modified_gmt":"2024-11-06T02:56:53","slug":"innovation-doesnt-always-need-to-be-radical-an-example-in-diabetes","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/ko\/blog\/innovation-doesnt-always-need-to-be-radical-an-example-in-diabetes\/","title":{"rendered":"\ud601\uc2e0\uc774 \ud56d\uc0c1 \uae09\uc9c4\uc801\uc77c \ud544\uc694\ub294 \uc5c6\uc2b5\ub2c8\ub2e4- \ub2f9\ub1e8\ubcd1 \uce58\ub8cc\uc81c\uc758 \uc608"},"content":{"rendered":"

\uc800\ud76c\uc640 \uc77c\ud558\ub294 \ub300\ubd80\ubd84\uc758 \uace0\uac1d\ub4e4\uc740 \uc790\uc0ac \uc81c\ud488\uc774 \ud601\uc2e0\uc801\uc774\ub77c\ub294 \uc810\uc744 \uc54c\ub9ac\uace0 \uc2f6\uc5b4\ud569\ub2c8\ub2e4. \ubb3c\ub860, \uace0\uac1d\uc0ac\ub4e4\uc740 \ud601\uc2e0\uc801\uc785\ub2c8\ub2e4. \uadf8\ub9ac\uace0 \ud601\uc2e0\uc740 \uc911\uc694\ud569\ub2c8\ub2e4. \ud558\uc9c0\ub9cc, \ud658\uc790\uc5d0\uac8c \uc774\uc775\uc774 \ub420 \uacbd\uc6b0\uc5d0\ub9cc \uc911\uc694\ud569\ub2c8\ub2e4. \uc2e4\uc81c\ub85c \uc758\uc57d\ud488\uc5d0 \ub300\ud55c \ud658\uae09 \uacb0\uc815\uc758 \ub9e5\ub77d\uc5d0\uc11c \u2018\ud658\uae09 \uac00\ub2a5\ud55c\u2019\ud601\uc2e0\uc758 \uc815\uc758\ub294 \uc0c8\ub85c\uc6b4 \ubd84\uc790\uc801 \uc2e4\uccb4\uc5d0\uc11c \uac00\uce58\ub098 \ud61c\ud0dd\uc5d0 \ub354 \ucd08\uc810\uc744 \ub9de\ucd94\ub294 \ubc29\ud5a5\uc73c\ub85c \ubc1c\uc804\ud588\uc2b5\ub2c8\ub2e4.<\/a>[1]<\/sup><\/a>\u00a0 \ud558\uc9c0\ub9cc \uc774\ub7f0 \uc810\uc9c4\uc801\uc778 \ubcc0\ud654\ub294 \uc2ec\ud654\uc801\uc778 \ubc1c\uc804\uc744 \uc704\ud55c \uc2dc\uc791\uc810\uc744 \uc81c\uacf5\ud558\ub294 \uae09\uc9c4\uc801\uc778 \u2018\uac8c\uc784 \uccb4\uc778\uc800\u2019\uc5c6\uc774\ub294 \ubd88\uac00\ub2a5\ud560 \uac83\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud658\uc790\uc5d0\uac8c \uc88b\uc740 \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud558\ub294 \uac83\uc740 \uae09\uc9c4\uc801 \ud601\uc2e0\uacfc \uc810\uc9c4\uc801\uc778 \ud601\uc2e0 \ubaa8\ub450\uc5d0 \uc758\uc874\ud569\ub2c8\ub2e4.<\/p>\n

\ub2f9\ub1e8\ubcd1 \uce58\ub8cc\uc81c\ub294 \uc774\ub97c \ubcf4\uc5ec\uc8fc\ub294 \uc644\ubcbd\ud55c \uc608\ub77c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\u00a0 \ube44\ub85d, \ub2f9\ub1e8\ubcd1 \uce58\ub8cc\ubc95\uc740 \uc544\uc9c1 \uc874\uc7ac\ud558\uc9c0\ub294 \uc54a\uc9c0\ub9cc, \uc9c0\ub09c \uc138\uae30 \ub3d9\uc548 \uc810\uc810 \ub354 \ud6a8\uacfc\uc801\uc778 \uc57d\uc744 \uad6c\ud560 \uc218 \uc788\uac8c \ub418\uba74\uc11c \ub2f9\ub1e8\ubcd1\uc740(\ud2b9\ud788 \uc18c\uc544\uae30\ub54c \ub2f9\ub1e8\ubcd1\uc744 \uc9c4\ub2e8\ubc1b\uc744 \uacbd\uc6b0 \uc0ac\ub9dd\ub960\uc774 \ub192\uc558\uc74c) \uc0ac\ud615\uc120\uace0\uc5d0\uc11c \uad00\ub9ac\uac00 \uac00\ub2a5\ud55c \ub9cc\uc131\uc9c8\ud658\uc73c\ub85c \uc5ec\uaca8\uc9c0\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

\uc778\uc290\ub9b0<\/strong>: \uae09\uc9c4\uc801\uc778 \ud601\uc2e0\uc5d0\uc11c \ud45c\uc900 \uce58\ub8cc\uc81c\ub85c<\/strong><\/h3>\n

\ub2f9\ub1e8\ubcd1 \ud658\uc790\ub4e4\uc758 \uc9c8\ubcd1 \uacfc\uc815\uc744 \ubc14\uafbc \ud575\uc2ec\uc801\uc778 \ud601\uc2e0\uc740 1920\ub144\ub300 \uc778\uc290\ub9b0\uc774 \uc57d\ubb3c\ub85c \ud65c\uc6a9\ub41c \uac83\uc785\ub2c8\ub2e4. \uc774\uc804\uc5d0 \ub2f9\ub1e8\ubcd1\uc740 \uce7c\ub85c\ub9ac \uc81c\ud55c\uc73c\ub85c \uad00\ub9ac\ub418\uace0 \uc788\uc5c8\ub294\ub370, \uc774\uac83\uc740 \uc131\uc778\uae30\uc5d0 \uc9c4\ub2e8\ubc1b\uc740 \uc0ac\ub78c\ub4e4(\ud754\ud788 \uc81c 2\ud615 \ub2f9\ub1e8\ubcd1[T2D]\uc73c\ub85c \uc54c\ub824\uc9c4)\uc5d0\uac8c \uc57d\uac04\uc758 \ud61c\ud0dd\uc744 \uc8fc\uae34 \ud588\uc9c0\ub9cc, \uc9c4\ub2e8 \ud6c4 \uba70\uce60 \ub610\ub294 \uba87 \uc8fc \uc774\ub0b4\uc5d0 \uc885\uc885 \uc0ac\ub9dd\ud558\ub294 \uc18c\uc544\uae30 \ub2f9\ub1e8\ubcd1 \uc9c4\ub2e8 \ud658\uc790\ub4e4(\uc81c 1\ud615 \ub2f9\ub1e8\ubcd1[T1D])\uc5d0\uac8c\ub294 \uac70\uc758 \ub3c4\uc6c0\uc774 \ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. [2]<\/sup><\/a>\u00a0\uc778\uc290\ub9b0\uc740 \uce58\ub8cc\uc5d0 \uc811\uadfc\ud560 \uc218 \uc788\ub294 \uc0ac\ub78c\ub4e4\uc774 \uc9c4\ub2e8 \ud6c4 \uc218\ub144 \ub3d9\uc548 \uc0b4\uc218 \uc788\ub294 \uce58\ub8cc\uc635\uc158\uc744 \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc778\uc290\ub9b0\uc774 \ub180\ub77c\uc6b4 \ud601\uc2e0\uc774\uae34 \ud588\uc9c0\ub9cc, \ucc98\uc74c\ubd80\ud130 \uc778\uc290\ub9b0\uc774 \uc624\ub298\ub0a0\ucc98\ub7fc \ud6a8\uacfc\uc801\uc774\uace0 \ub0b4\uc57d\uc131\uc774 \ub6f0\uc5b4\ub098\uba70 \uc624\ub298\ub0a0\ucc98\ub7fc \uc0c1\ub300\uc801\uc73c\ub85c \ud3b8\ub9ac\ud55c \uce58\ub8cc\ubc95\uc740 \uc544\ub2c8\uc5c8\uc2b5\ub2c8\ub2e4. \uc778\uc290\ub9b0\uc740 \ub3d9\ubb3c\uc5d0\uc11c \ucd94\ucd9c\ub418\uba70 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uacfc \uacf5\uae09\ubb38\uc81c\ub85c \uc0ac\uc6a9\uc774 \ubcf5\uc7a1\ud588\uc2b5\ub2c8\ub2e4. [3]<\/sup><\/a>\u00a01960\ub144\ub300\uc640 1970\ub144\ub300\uc5d0 \uc778\uac04\uc758 \uc778\uc290\ub9b0\uacfc \uc7ac\uc870\ud569 \uae30\uc220\uc774 \ub3c4\uc785\ub418\uba74\uc11c \ucd94\uac00\uc801\uc778 \ud601\uc2e0\uc774 \uc774\ub904\uc84c\uc2b5\ub2c8\ub2e4. \uc774 \uae30\uc220\uc740 \uae30\uc874\uc758 \ubcf5\uc7a1\ud55c \ubb38\uc81c\ub97c \ud574\uacb0\ud558\ub294 \ud55c\ud3b8, \uc778\uc290\ub9b0\uc744 \uc811\uadfc\ud558\uae30 \uc27d\uace0 \uc0ac\uc6a9\ud558\uae30 \uc27d\uac8c \ub9cc\ub4e4\uc5c8\uc2b5\ub2c8\ub2e4. [2]<\/sup><\/a>,[3]<\/sup><\/a>\u00a0 \ub2f9\ub1e8\ubcd1 \uce58\ub8cc\uc81c\uc5d0 \ub300\ud55c \uae09\uc9c4\uc801\uc778 \ubcc0\ud654\uc774\ud6c4, \uc77c\ub828\uc758 \uc810\uc9c4\uc801\uc778 \ud601\uc2e0\ub4e4\uc744 \ud1b5\ud574 \uc778\uc290\ub9b0\uc740 \uac1c\uc120\ub41c \uc784\uc0c1\uacb0\uacfc\ub97c \uac16\uac8c \ub418\uc5c8\uc744 \ubfd0 \uc544\ub2c8\ub77c, \uc77c\uc77c\uc8fc\uc0ac \ud69f\uc218\ub97c \ucd5c\uc18c\ud654\ud558\uba74\uc11c \ucd5c\uc801\uc758 \ud608\ub2f9 \uc870\uc808\uc744 \uac00\ub2a5\ucf00\ud558\ub294 \ub2e4\uc591\ud55c \uc791\uc6a9\uae30\uac04\uc744 \uac16\ucd94\uac8c \ub429\ub2c8\ub2e4. [2]<\/sup><\/a> \ud608\ub2f9 \ubaa8\ub2c8\ud130\ub9c1\uc758 \ubc1c\uc804\uacfc \uc778\uc290\ub9b0 \ud39c\uc744 \ud1b5\ud55c \uc778\uc290\ub9b0 \uc804\ub2ec, \uadf8\ub9ac\uace0 \ucd5c\uadfc \ud38c\ud504\uc758 \ubc1c\uc804 \ub4f1\uc73c\ub85c \ub2f9\ub1e8\ubcd1\uc744 \uc553\uace0 \uc788\ub294 \ud658\uc790\ub4e4\uc740 \ubcf4\ub2e4 \ud3b8\ub9ac\ud558\uac8c \uc9c8\ud658\uc744 \uad00\ub9ac\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc778\uc290\ub9b0 \uce58\ub8cc\uc81c\uc758 \uc774\ub7f0 \ubc1c\uc804\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \ud658\uc790\ub4e4\uc774 \uc778\uc290\ub9b0\uc744 \ud1b5\ud574 \ub2f9\ub1e8\ubcd1\uc744 \uce58\ub8cc\ud558\ub294 \uac83\uc5d0 \ub300\ud55c \ubd80\ub2f4\uc740 \uc5ec\uc804\ud788 \uc874\uc7ac\ud558\uba70, \uc774\ub7f0 \ubd80\ub2f4\uc774 \ud658\uc790\ub4e4\uc774 \uc778\uc290\ub9b0\uc744 \ud1b5\ud574 \ub2f9\ub1e8\ubcd1 \uce58\ub8cc\ub97c \uc2dc\uc791\ud558\uace0 \uad00\ub9ac\ud558\ub294 \uac83\uc744 \ubc29\ud574\ud558\uae30\ub3c4 \ud569\ub2c8\ub2e4. [4]<\/sup><\/a><\/p>\n

<\/h3>\n

\uc778\uc290\ub9b0\uc774 \uc804\ubd80\ub294 \uc544\ub2d9\ub2c8\ub2e4<\/strong>.<\/strong><\/h3>\n

\ub2f9\ub1e8\ubcd1 \uce58\ub8cc\uc758 \ud601\uc2e0\uc740 \uc778\uc290\ub9b0\uc5d0\ub9cc \uad6d\ud55c\ub418\uc9c0\ub294 \uc54a\uc2b5\ub2c8\ub2e4. \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790(\ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc57d 90% \ucc28\uc9c0 [5]<\/sup><\/a>)\uc758 \uacbd\uc6b0 \uc778\uc290\ub9b0 \ud544\uc694\uc131\uc744 \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\ub294 \uba87 \uac00\uc9c0 \ucd94\uac00 \uce58\ub8cc \uc635\uc158\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub2f9\ub1e8\ubcd1\uc758 \ub2e4\ub978 \uce58\ub8cc\uc81c\uc778 \uae00\ub8e8\uce74\uace4 \uc720\uc0ac \ud3a9\ud0c0\uc774\ub4dc-1 \uc218\uc6a9\uccb4 \uc791\uc6a9\uc81c(GLP-1 RAs) \ub294 \uc778\uc290\ub9b0 \ud22c\uc5ec \uc804 \uc81c 2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\ub4e4\uc744 \uc704\ud574 \uc0ac\uc6a9\ub420 \uc218 \uc788\uc73c\uba70 \uce58\ub8cc \uacbd\ub85c \ud6c4\ubc18\uc5d0 \uc9c8\ubcd1 \uc870\uc808\uc744 \uac1c\uc120\ud558\uae30 \uc704\ud574 \uc778\uc290\ub9b0\uacfc \ubcd1\uc6a9\ud574 \uc0ac\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.[6]<\/sup><\/a><\/p>\n

GLP-1 RA\ub294 \u00a0\uc810\uc9c4\uc801 \ud601\uc2e0\uc774 \ud658\uc790\uc5d0\uac8c \uc774\uc810\uc744 \uc81c\uacf5\ud558\ub294 \ub610 \ub2e4\ub978 \uc608\uc785\ub2c8\ub2e4. GLP-1 RA \uacc4\uc5f4\ub0b4\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \ud6a8\ub2a5 \ubc0f \uc2ec\ud608\uad00 \ud61c\ud0dd \uc774\uc678\uc5d0\ub3c4, \uacc4\uc5f4 \ub0b4 \uc810\uc9c4\uc801\uc778 \ud601\uc2e0\uc744 \ud1b5\ud574 \ud658\uc790\uc758 \uce58\ub8cc\ubd80\ub2f4\uc744 \uc0c1\ub2f9\ud788 \uc644\ud654\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \ub2f9\ub1e8\ubcd1\uc5d0 \ucd5c\ucd08\ub85c \uc0ac\uc6a9\ub41c \ucd5c\ucd08\uc758GLP-1 RA(\ub2e8\uae30\uac04 \uc791\uc6a9\ud558\ub294 \uc5d0\uc138\ub098\ud0c0\uc774\ub4dc)\ub294 2005\ub144(\ubbf8\uad6d)\/2006\ub144(\uc720\ub7fd)\uc5d0 \ucd9c\uc2dc\ub418\uc5c8\uc73c\uba70 \ud558\ub8e8 2\ud68c \uc8fc\uc0ac\uac00 \ud544\uc694\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uc774\ud6c4\ub85c 1\uc77c 1\ud68c \uc8fc\uc0ac\ub9cc \ud544\uc694\ud55c 2\uac1c\uc758GLP\u20111 RA\uac00 \ucd9c\uc2dc\ub418\uc5c8\uace0, \uadf8 \ub4a4\ub97c \uc774\uc5b4 \uc8fc 1\ud68c \uc8fc\uc0ac\ub9cc \ud544\uc694\ud55c 3\uac1c\uc758GLP-1 RA\uac00 \ucd9c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. (\uadf8\ub9bc 1).[7]<\/sup><\/a>\u00a0\uac00\uc7a5 \ucd5c\uadfc\uc5d0\ub294 \uacbd\uad6c \ud22c\uc5ecGLP-1 RA\uac00 \ucd5c\ucd08\ub85c \ucd9c\uc2dc\ub418\uc5c8\ub294\ub370 \uc774\ub294 \uc790\uac00 \uc8fc\uc0ac \uc758\uc9c0\uc640 \ub2a5\ub825\uc774 \ub354 \uc774\uc0c1GLP-1 RA\uce58\ub8cc\uc758 \uc804\uc81c\uc870\uac74\uc774 \uc544\ub2d8\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. [7]<\/sup><\/a>,[8]<\/sup><\/a>\u00a0\uc774 \ubc1c\uc804\uc740 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc\ubc95\uc5d0 \ub300\ud55c \ud658\uc790\uc758 \uc774\ud574\uc640 \uc900\uc218\ub97c \ud5a5\uc0c1\uc2dc\ucf1c \uce58\ub8cc \uacb0\uacfc\ub97c \uac1c\uc120\ud560 \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uadf8\ub9bc 1: GLP-1 RA \uac1c\ubc1c \uc77c\uc815 [9]<\/sup><\/a>,[10]<\/sup><\/a><\/strong><\/p>\n

\"\"
\n\uc57d\uc5b4: EMA(European Medicines Agency: \uc720\ub7fd\uc758\uc57d\ud488\uccad) US FDA,(United States Food and Drug Administration:\ubbf8\uad6d \uc2dd\ud488 \uc758\uc57d\uad6d)<\/p>\n

<\/h3>\n

\ub2f9\ub1e8\ubcd1\uc758 \ub2e4\uc74c\ub2e8\uacc4\ub294?<\/strong><\/h3>\n

\uc720\uc804\uc790 \ubc0f \uc904\uae30\uc138\ud3ec \uc811\uadfc\ubc95\uc740 \uacb0\uad6d \ub2f9\ub1e8\ubcd1 \uce58\ub8cc\ubc95\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uc744 \uac83\uc785\ub2c8\ub2e4.[2]<\/sup><\/a> \u00a0\uadf8 \ub3d9\uc548 \ub2e8\uacc4\uc801\uc778 \ud601\uc2e0\uc740 \uce58\ub8cc\uc81c\ub97c \uc810\uc810 \ubc1c\uc804\uc2dc\ud0a4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \uc778\uc290\ub9b0\uc744 \ub300\uccb4\ud560 \uc81c\ud615\uc774 \uac1c\ubc1c\ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uba70, \ud55c\uc8fc\uc5d0 \ud55c \ubc88\ub9cc \ud22c\uc5ec\uac00 \ud544\uc694\ud55c \uce58\ub8cc\uc81c\uc640 \uc2ec\uc9c0\uc5b4 \uacbd\uad6c \ud22c\uc5ec\uac00 \uac00\ub2a5\ud55c \uac83\ub4e4\ub3c4 \ud3ec\ud568\ub420 \uac83\uc785\ub2c8\ub2e4. [11]<\/sup><\/a>\u00a0\ub610\ud55c, GLP-1 RA \uacc4\uc5f4\uc758 \uc131\uacf5\uc744 \uae30\ubc18\uc73c\ub85c, \ucd5c\uadfc\uc5d0\ub294 \uc774\uc911 \ud3ec\ub3c4\ub2f9 \uc77c\uc290\ub9b0 \ud2b8\ub85c\ud3f4\ub9ac\ud3a9\ud0c0\uc774\ub4dc \ubc0fGLP-1 RA\uac00 \uc0ac\uc6a9 \uac00\ub2a5 \ud574\uc84c\uc73c\uba70, GLP-1 RA \ub2e8\ub3c5\uc73c\ub85c \ubcf4\ub2e4 \ud070 \uc9c8\ubcd1 \ud1b5\uc81c\ub2a5\ub825\uc744 \ubc1c\ud718\ud560 \uac83\uc785\ub2c8\ub2e4. [12]<\/sup><\/a><\/p>\n

\uce58\ub8cc\ubc95\uc744 \ucc3e\ub294 \ub178\ub825\uc774 \uacc4\uc18d\ub418\ub294 \ub3d9\uc548, \uae09\uaca9\ud55c \ud601\uc2e0\uacfc \uc810\uc9c4\uc801\uc778 \ud601\uc2e0\uc758 \uc870\ud569\uc740 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc5d0 \ub300\ud55c \uc804\ub9dd\uc744 \uacc4\uc18d\ud574\uc11c \uadf9\uc801\uc73c\ub85c \ubcc0\ud654\uc2dc\ud0a4\uace0, \uacb0\uacfc \ubfd0 \uc544\ub2c8\ub77c \uce58\ub8cc\ubd80\ub2f4\ub3c4 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud601\uc2e0\uc5d0\uc11c\uc758 \uae09\uc9c4\uc801 \ub2e8\uacc4\ub294 \ubb3c\ub860 \ud544\uc694\ud558\uc9c0\ub9cc, \uc774\ub7f0 \ub2e8\uacc4\ub97c \ubc14\ud0d5\uc73c\ub85c \ud55c \uc810\uc9c4\uc801 \ud601\uc2e0\uc758 \uc601\ud5a5\uc744 \uacfc\uc18c \ud3c9\uac00\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \uad81\uadf9\uc801\uc73c\ub85c \uc758\uc57d\ud488 \ud658\uae09\uc5d0\uc11c \uac00\uc7a5 \uc911\uc694\ud55c \uac83\uc740 \ud601\uc2e0\uc758 \uc218\uc900\uc774 \uc544\ub2cc \ud658\uc790\uc5d0\uac8c \uc5b4\ub5a4 \uc218\uc900\uc758 \uc774\uc775\uc744 \uc8fc\ub294\uc9c0\uc5d0 \ub2ec\ub824\uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud074\ub798\ub9ac\ubca0\uc774\ud2b8\uc5d0\uc11c\ub294 \ud2b9\ud788 \uc81c\ud488\uc774 \uae30\uc874 \uce58\ub8cc \ud074\ub798\uc2a4\uc5d0 \ucd94\uac00\ub420 \ub54c<\/em>, \ub9c8\ucf13\uc561\uc138\uc2a4\uc640 \uad00\ub828\ub41c \uc774\ud574\uad00\uacc4\uc790\uc5d0\uac8c \uac00\uce58\ub97c \uc785\uc99d\ud558\ub294 \uac83\uc774 \ud56d\uc0c1 \uc26c\uc6b4 \uc77c\uc774 \uc544\ub2c8\ub77c\ub294 \uac83\uc744 \uc54c\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7f0 \uac00\uce58 \uc785\uc99d\uc744 \uc704\ud574\uc11c\ub294 \uc99d\uac70 \uc0dd\uc131 \uacc4\ud68d\uc5d0 \ub300\ud55c \ud1b5\ud569\uc801\uc778 \uc811\uadfc \ubc29\uc2dd\uacfc \ubcc0\ud654\ud558\ub294 \uce58\ub8cc \ud658\uacbd\uc5d0\uc11c \ud2b9\uc815 \ud658\uc790\uad70\uacfc \ubbf8 \ucda9\uc871 \uc694\uad6c\uc5d0 \ub9de\ucd98 \uac00\uce58 \uc81c\uc548\uc5d0 \ub300\ud55c \uac1c\ubc1c\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. <\/em><\/p>\n

\ud074\ub798\ub9ac\ubca0\uc774\ud2b8 \uac00\uce58 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158 \ud300\uc740 \uc99d\uac70<\/em>, \uac00\uce58 \ubc0f \uc561\uc138\uc2a4 \ucee8\uc124\ud305 \ubd80\uc11c\uc758 \uc77c\ubd80\ub85c, \uacac\uace0\ud558\uace0 \uac15\ub825\ud55c \uac00\uce58 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158 \uc790\ub8cc, \ud658\uae09\uacfc \uad00\ub828\ub41c \ubb38\uc11c, \uc774\uc758 \uc81c\uae30 \ucc98\ub9ac\uc790 \ubc0f \uac04\ud589\ubb3c \uac1c\ubc1c\uc744 \uc804\ubb38\uc73c\ub85c \ud569\ub2c8\ub2e4. \ub610\ud55c \ud074\ub798\ub9ac\ubca0\uc774\ud2b8\ub294 \uc8fc\uc694 \uc9c0\ubd88\uc790(\ubcf4\ud5d8\uc0ac \ub4f1)\ubc0f KOL\uc5f0\uad6c, \ub300\ud654\ud615 \ud074\ub77c\ub9ac\uc5b8\ud2b8 \uc6cc\ud06c\uc0f5 \ubc0f \uad50\uc721 \uac1c\ubc1c\uc5d0 \ub300\ud55c \ud48d\ubd80\ud55c \uacbd\ud5d8\uc744 \ubcf4\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2f9\uc0ac\uc758 \uc5ed\ub7c9 \ubc0f \uadc0\uc0ac\uc5d0 \uc774\uac83\uc774 \uc5b4\ub5bb\uac8c \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\ub294\uc9c0 \uc54c\uc544\ubcf4\uace0\uc790 \ud558\uc2e0\ub2e4\uba74\u00a0https:\/\/clarivate.com\/ko\/products\/life-sciences-and-healthcare-consulting-services\/evidence-value-access-consulting\/<\/a><\/u> \ub97c \ubc29\ubb38\ud574\uc8fc\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4. <\/em><\/p>\n

\uc774\ubc88 \uae00\uc740 \uc758\ud559 \uc800\uc220 \ub2f4\ub2f9 \uc218\uc11d \uc774\uc0ac\uc774\uc790 \uc758\ud559 \uc800\uc220\ubd80 \ucc45\uc784\uc790\uc778 <\/em>Sophie Doran\uacfc \uc218\uc11d \uc758\ud559 \uc800\uc220\uac00\uc778 Sophie Streeton\uc5d0 \uc758\ud574 \uc791\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/em><\/p>\n

 <\/p>\n

\ub808\ud37c\ub7f0\uc2a4<\/strong><\/p>\n

[1]<\/sup><\/a>Hofmann et al. A review of current approaches to defining and valuing innovation in health technology assessment. Value in Health. 2021; 24(12):1773-1783.
\n[2]<\/sup><\/a>Buse et al. 100 years on: the impact of the discovery of insulin on clinical outcomes. BMJ Open Diabetes Research and Care. 2021; 9:e002373.
\n[3]<\/sup><\/a>Hirsch et al. The evolution of insulin and how it informs therapy and treatment choices. Endocrine Reviews. 2020; 41:733-755.
\n[4]<\/sup><\/a>Zhu and Harris. Therapeutic inertia in people with type 2 diabetes in primary care: a challenge that just won\u2019t go away. Diabetes Spectrum. 2020; 33(1):44-49.
\n[5]<\/sup><\/a>International Federation of Diabetes. Diabetes Atlas, 10th<\/sup>\u00a02021.
\n[6]<\/sup><\/a>American Diabetes Association. Standards of Medical Care in Diabetes. 2023.
\n[7]<\/sup><\/a>Trujillo et al. GLP-1 receptor agonists: an updated review of head-to-head clinical studies. Therapeutic Advances in Endocrinology and Metabolism. 2021; 12:1-15.
\n[8]<\/sup><\/a>Aroda et al. A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes. Reviews in Endocrine and Metabolic Disorders. 2022; 23:979-994.
\n[9]<\/sup><\/a>Food and Drug Administration. Drug approvals and databases. Available at:\u00a0https:\/\/www.fda.gov\/drugs\/development-approval-process-drugs\/drug-approvals-and-databases<\/a>\u00a0[Accessed November 2023].
\n[10]<\/sup><\/a>European Medicines Agency. Medicines. Available at:\u00a0https:\/\/www.ema.europa.eu\/en\/medicines<\/a>\u00a0[Accessed November 2023].
\n[11]<\/sup><\/a>Rosenstock et al. Weekly icodec vs daily glargine U100 for type 2 diabetes without previous insulin. New England Journal of Medicine. 2023; 389:297-308.
\n[12]<\/sup><\/a>Frias et al. Tirzepatide versus semaglutide once-weekly in patients with type 2 diabetes. New England Journal of Medicine. 2021; 385:503-515<\/p>\n

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