{"id":1196,"date":"2020-01-15T07:57:46","date_gmt":"2020-01-14T23:57:46","guid":{"rendered":"https:\/\/clarivate.com\/tw\/2020\/01\/15\/2019%e5%85%a8%e7%90%83%e7%94%9f%e7%89%a9%e9%86%ab%e8%97%a5%e5%b9%b4%e5%ba%a6%e4%ba%8b%e4%bb%b6%e7%9b%a4%e9%bb%9e\/?lang=zh-hant"},"modified":"2020-01-15T07:57:46","modified_gmt":"2020-01-14T23:57:46","slug":"year-in-review-2019-a-pretty-good-year-for-biopharma","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/zh\/blog\/year-in-review-2019-a-pretty-good-year-for-biopharma\/","title":{"rendered":"2019\u5168\u7403\u751f\u7269\u91ab\u85e5\u5e74\u5ea6\u4e8b\u4ef6\u76e4\u9ede"},"content":{"rendered":"

\u672c\u6587\u7bc0\u9078\u81ea \u79d1\u777f\u552f\u5b89 BioWorld \u5831\u5c0e<\/a>\uff0c\u539f\u6587\u7de8\u8f2f\u70ba\u00a0Anette Breindl, Karen Carey, Michael Fitzhugh, Lee Landenberger, Randy Osborne, Alfred Romann, Cormac Sheridan and Peter Winter<\/em><\/p>\n

 <\/p>\n

\u5c0d\u65bc\u751f\u7269\u88fd\u85e5\u516c\u53f8\u4f86\u8aaa\uff0c2019\u5e74\u53ef\u8b02\u662f\u4e86\u4e0d\u8d77\u7684\u4e00\u5e74\uff1a\u91d1\u878d\u5e02\u5834\u84ec\u52c3\u767c\u5c55\uff0c\u5c24\u5176\u662f\u5275\u6295\u8cc7\u91d1 (venture capital) \u6d41\u5165\u8a72\u9818\u57df\uff0c\u4ea4\u6613\u984d\u9054\u5230\u4e86\u6b77\u53f2\u6700\u9ad8\u6c34\u6e96\uff1b\u8207\u6b64\u540c\u6642\uff0c\u96a8\u8457\u7d30\u80de\u548c\u57fa\u56e0\u7642\u6cd5\u7684\u767c\u5c55\uff0c\u79d1\u5b78\u7684\u7a81\u7834\u5f15\u9818\u4e86\u767c\u5c55\u7684\u65b9\u5411\uff0c\u7b2c\u4e00\u500b\u6210\u529f\u7684\u8de1\u8c61\u51fa\u73fe\u5728CRISPR\u7b49\u65b0\u6280\u8853\u4e0a\uff0c\u4eba\u5011\u671f\u76fc\u5df2\u4e45\u7684\u57fa\u56e0\u7d44\u5b78\u6709\u671b\u6210\u70ba\u91ab\u7642\u4fdd\u5065\u7684\u524d\u6cbf\u9818\u57df\u3002\u4f46\u662f\uff0c\u4e00\u4e9b\u8b66\u793a\u5373\u5c07\u51fa\u73fe……\u85e5\u54c1\u5b9a\u50f9\u7684\u722d\u8ad6\u7e7c\u7e8c\u5347\u6eab\uff0c\u4e26\u8513\u5ef6\u81f3\u7f8e\u570b\u4ee5\u5916\uff0c\u82f1\u570b\u812b\u6b50\u548c\u4e2d\u7f8e\u8cbf\u6613\u6469\u64e6\u7684\u526f\u4f5c\u7528\u958b\u59cb\u986f\u73fe\uff0c\u800c\u9d09\u7247\u985e\u85e5\u7269\u7684\u6e05\u7b97\u4f3c\u4e4e\u7d42\u65bc\u4f86\u81e8\u3002<\/p>\n

\u5728\u6211\u5011\u958b\u59cb\u5c55\u671b2020\u5e74\u4e4b\u524d\uff0c\u5148\u5feb\u901f\u56de\u9867\u4e00\u4e0b2019\u5e74\u751f\u7269\u88fd\u85e5\u884c\u696d\u7684\u4e00\u4e9b\u4e3b\u8981\u8da8\u52e2\u548c\u65b0\u805e\uff0c\u5f9e\u5341\u5e74\u4f86\u5c62\u5c62\u6253\u7834\u7684\u4f75\u8cfc\u8a18\u9304\u958b\u59cb\u3002<\/p>\n

 <\/p>\n

Celgene\u5275\u4e0b\u65b0\u9ad8\u7684\u4f75\u8cfc\u548c\u4ea4\u6613<\/strong><\/h3>\n

2019\u5e74\u7684\u4ea4\u6613\u74b0\u5883\u4e0d\u50c5\u8b93\u524d\u4e00\u5e74\u76f8\u5f62\u898b\u7d40\uff08\u524d\u4e00\u5e74\u672c\u8eab\u5c31\u8868\u73fe\u51fa\u8272\uff09\uff0c\u800c\u4e14\u9084\u8d85\u904e\u4e86\u904e\u53bb10\u5e74\u7684\u6240\u6709\u5e74\u4efd\uff0c\u5275\u4e0b\u4e86\u4ea4\u6613\u6578\u91cf\u548c\u9810\u671f\u50f9\u503c\u7684\u6700\u9ad8\u7d00\u9304\u3002<\/p>\n

\u540c\u6a23\uff0c2019\u5e74\u7684\u5927\u578b\u4f75\u8cfc\u6d3b\u52d5\u4e5f\u975e\u5e38\u5f15\u4eba\u6ce8\u76ee\u30022018\u5e7411\u6708\uff0c\u5fc5\u6cbb\u59a5\u65bd\u8cb4\u5bf6 (Bristol-Myers Squibb Co.) \u4ee5740\u5104\u7f8e\u5143\u6536\u8cfcCelgene Corp.\u7684\u4ea4\u6613\u5b8c\u6210\u5f8c\uff0c2019\u5e74\u6210\u70ba\u8fc4\u4eca\u70ba\u6b62\u751f\u7269\u88fd\u85e5\u4f01\u696d\u4f75\u8cfc\u4ea4\u6613\u50f9\u503c\u6700\u9ad8\u7684\u4e00\u5e74\uff0c\u50c5\u6b21\u65bcActavis plc\u57282015\u5e74\u4ee5770\u5104\u7f8e\u5143\u6536\u8cfcAllergan Inc.\u3002\u53e6\u4e00\u500b\u91cd\u78c5\u4ea4\u6613\u662f\u6b66\u7530\u88fd\u85e5\u6709\u9650\u516c\u53f8 (Takeda Pharmaceutical Co. Ltd.) 2019\u5e741\u6708\u4ee5622.2\u5104\u7f8e\u5143\u6536\u8cfcShire plc\uff0c\u9019\u662f\u7e7c2009\u5e74\u60e0\u6c0f (Wyeth) \u548c\u8f1d\u745e(Pfizer Inc.)\u4ee5680\u5104\u7f8e\u5143\u7684\u50f9\u683c\u5408\u4f75\u5f8c\u7684\u7b2c\u56db\u5927\u4f75\u8cfc\u4ea4\u6613\u3002<\/p>\n

\u4f46\u662f\u5c0d\u65bc\u4e00\u500b\u6709\u845740\u591a\u5e74\u6b77\u53f2\u7684\u884c\u696d\u4f86\u8aaa\uff0c\u6536\u8cfcCelgene\u662f\u4e00\u500b\u6b77\u53f2\u6027\u4e8b\u4ef6\uff0c\u56e0\u70ba\u8a72\u516c\u53f8\u5f9e1986\u5e74\u958b\u59cb\u5c31\u662f\u4e00\u5bb6\u7d14\u7cb9\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5f88\u50cf\u6210\u7acb\u65bc1976\u5e74\u7684\u57fa\u56e0\u6cf0\u514b\u516c\u53f8 (Genentech Inc.)\uff0c\u5f8c\u8005\u57282009\u5e74\u88ab\u7f85\u6c0f\u63a7\u80a1\u516c\u53f8 (Roche Holdings AG) \u4ee5468\u5104\u7f8e\u5143\u7684\u50f9\u683c\u6536\u8cfc\u3002\u9019\u5169\u8d77\u6536\u8cfc\u5206\u5225\u6392\u5728\u751f\u7269\u88fd\u85e5\u516c\u53f8\u6700\u9ad8\u6536\u8cfc\u50f9\u683c\u699c\u7684\u7b2c\u4e8c\u4f4d\u548c\u7b2c\u516d\u4f4d\uff0c\u4f46\u5982\u679c\u56b4\u683c\u5730\u8003\u5bdf\u6536\u8cfc\u751f\u7269\u6280\u8853\u958b\u767c\u5546\u7684\u60c5\u6cc1\uff0c\u5b83\u5011\u5c07\u6392\u5728\u524d\u5169\u4f4d\u30022019\u5e74\u9084\u6709\u53e6\u5916\u5169\u7b46\u5927\u578b\u6536\u8cfc\uff1a\u8f1d\u745e\u88fd\u85e5 (Pfizer) 7\u6708\u4efd\u4ee5114\u5104\u7f8e\u5143\u6536\u8cfcArray Biopharma Inc.\uff0c\u79ae\u4f86\u88fd\u85e5 (Eli Lilly and Co.) 2\u6708\u4efd\u4ee580\u5104\u7f8e\u5143\u6536\u8cfcLoxo Oncology Inc.\u3002\u6839\u64daBioWorld\u7684\u8cc7\u6599\uff0c\u5728\u751f\u7269\u6280\u8853\u516c\u53f8\u7684\u6700\u9ad8\u6536\u8cfc\u50f9\u4e2d\uff0c\u5b83\u5011\u6392\u5728\u7b2c12\u4f4d\u548c\u7b2c20\u4f4d\u3002Celgene\u3001Array\u548cLoxo\u5c08\u6ce8\u65bc\u5c0f\u5206\u5b50\u764c\u75c7\u6cbb\u7642\u548c\u5176\u5b83\u9069\u61c9\u75c7\uff0c\u4f46Celgene\u4e5f\u81f4\u529b\u65bcCAR-T\u7d30\u80de\u6cbb\u7642\u3002<\/p>\n

\u9664\u4e86\u4f75\u8cfc\u4ea4\u6613\uff0cCelgene\u9084\u53c3\u8207\u4e862019\u5e74\u7684\u53e6\u4e00\u7b46\u5de8\u984d\u4ea4\u6613\uff1a\u4ee5134\u5104\u7f8e\u5143\u7684\u50f9\u683c\u5c07\u53e3\u670dPED4 \u6291\u5236\u5291 Otezla\uff08apremilast\uff09\u53ca\u5176\u76f8\u95dc\u8cc7\u7522\u51fa\u552e\u7d66Amgen Inc .\u3002\u5728 BioWorld<\/a> \u548c Cortellis<\/a> \u7684\u8cc7\u6599\u5eab\u4e2d\uff0c\u9019\u662f\u6240\u6709\u975e\u4f75\u8cfc\u4ea4\u6613\u7684\u7b2c\u4e8c\u9ad8\uff0c\u5305\u62ec\u8cc7\u7522\u8cfc\u8cb7\u3001\u6388\u6b0a\u548c\u5408\u4f5c\u30022014\u5e74\uff0c\u8afe\u83ef\u88fd\u85e5(Novartis AG)\u65a5\u8cc7160\u5104\u7f8e\u5143\u6536\u8cfc\u4e86\u845b\u862d\u7d20\u53f2\u514b (Glaxosmithkline plc) \u7684\u816b\u7624\u6cbb\u7642\u696d\u52d9\u3002\u64da\u4e00\u4e9b\u5206\u6790\u5e2b\u7a31\uff0cOtezla\u57282014\u5e74\u7372\u5f97\u4e86FDA\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u6d3b\u52d5\u6027\u4e7e\u766c\u95dc\u7bc0\u708e\u548c\u4e2d\u5ea6\u5230\u91cd\u5ea6\u6591\u584a\u578b\u4e7e\u766c\uff0c\u901a\u904e\u64f4\u5f35\uff0c\u5176\u92b7\u552e\u984d\u53ef\u9054\u5230100\u5104\u7f8e\u5143\u3002<\/p>\n

\u9032\u51652020\u5e74\uff0c\u5176\u4ed6\u4e00\u4e9b\u6f5b\u5728\u7684\u5927\u578b\u4f75\u8cfc\u4ea4\u6613\u53ef\u80fd\u6703\u5b8c\u6210\uff0c\u5305\u62ec\u8afe\u83ef (Novartis) \u4ee597\u5104\u7f8e\u5143\u6536\u8cfcThe Medicines Co.\uff0c\u4ee5\u53ca\u827e\u4f2f\u7dad (Abbvie Inc.)\u4ee5630\u5104\u7f8e\u5143\u6536\u8cfcAllergan plc\u3002\u5169\u5bb6\u516c\u53f8\u6709\u671b\u5728\u65b0\u5e74\u521d\u5b8c\u6210\u4ea4\u6613\u3002<\/p>\n

2019\u5e74\u7684\u4f75\u8cfc\u4ea4\u6613\u6578\u91cf\u70ba166\u7b46\uff0c\u662f\u904e\u53bb10\u5e74\u7684\u6700\u9ad8\u6c34\u6e96\uff0c\u4f75\u8cfc\u50f9\u503c\u70ba2143\u5104\u7f8e\u5143\uff0c\u50c5\u6b21\u65bc2015\u5e74\u76842564\u5104\u7f8e\u5143\uff0c\u4f4d\u5c45\u7b2c\u4e8c\u30022019\u5e74\u7684\u4ea4\u6613\u9054\u5230\u4e8610\u5e74\u4f86\u7684\u6700\u9ad8\u6c34\u6e96\uff0c\u8ddf\u8e641567\u5b97\u4ea4\u6613\u7684\u9810\u8a08\u50f9\u503c1520\u5104\u7f8e\u5143\u3002\u622a\u81f312\u670820\u65e5\uff0c\u5168\u5e74\u5171\u5ba3\u4f48\u4e8637\u7b46\u4ea4\u6613\uff0c\u9810\u8a08\u50f9\u503c\u8d85\u904e10\u5104\u7f8e\u5143\u3002<\/p>\n

 <\/p>\n

\u5438\u5f15\u8cc7\u91d1\u6c92\u6709\u96e3\u5ea6<\/strong><\/h3>\n

\u5118\u7ba12019\u5e74\u5927\u90e8\u5206\u6642\u9593\uff0c\u5c24\u5176\u662f\u7b2c\u4e8c\u548c\u7b2c\u4e09\u5b63\u5ea6\uff0c\u8cc7\u672c\u5e02\u5834\u8868\u73fe\u4e0d\u4f73\uff0c\u4f46\u751f\u7269\u88fd\u85e5\u884c\u696d\u5728\u518d\u6b21\u5438\u5f15\u8cc7\u91d1\u65b9\u9762\u6c92\u6709\u9047\u5230\u4efb\u4f55\u56f0\u96e3\u3002BioWorld\u8cc7\u6599\u986f\u793a\uff0c\u5728\u8ddd\u96e22019\u5e74\u7d50\u675f\u9084\u6709\u4e00\u5929\u7684\u6642\u5019\uff0c\u5168\u7403\u516c\u53f8\u901a\u904e\u516c\u5171\u548c\u79c1\u52df\u7372\u5f97\u4e86\u5927\u7d04575\u5104\u7f8e\u5143\u7684\u6536\u5165\u3002\u9019\u6bd42018\u5e74\u7684\u7e3d\u878d\u8cc7\u984d\u5c11\u4e8690\u5104\u7f8e\u5143\uff0c\u6bd42015\u5e74\u7684684\u5104\u7f8e\u5143\u5c11\u4e86110\u5104\u7f8e\u5143\uff0c\u5728\u884c\u696d\u6b77\u53f2\u4e0a\u7684\u7e3d\u878d\u8cc7\u984d\u4e2d\u7a69\u5c45\u7b2c\u4e09\u4f4d\u3002<\/strong><\/p>\n

\u5305\u62ec\u9996\u6b21\u516c\u958b\u52df\u80a1(IPO)\u5728\u5167\u7684\u516c\u958b\u52df\u80a1\u5df2\u7d93\u5275\u9020\u4e86\u8fd1300\u5104\u7f8e\u5143\u7684\u6536\u5165\uff0c\u5360\u4eca\u5e74\u7e3d\u878d\u8cc7\u984d\u768452%\u3002\u5118\u7ba1\u8a72\u884c\u696d\u666e\u904d\u5b58\u5728\u8ca0\u9762\u60c5\u7dd2\uff0c\u4f46\u5df2\u5b8c\u6210\u7684\u65b0\u751f\u7269\u88fd\u85e5IPO\u6578\u91cf\u8868\u660e\uff0c\u5e02\u5834\u5c0d\u65b0\u767c\u884c\u80a1\u7968\u7684\u9700\u6c42\u4f9d\u7136\u5065\u5eb7\u3002\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u751f\u7269\u88fd\u85e5\u516c\u53f8\u57282019\u5e74\u5171\u9032\u884c\u4e8662\u6b21IPO\uff0c\u878d\u8cc784\u5104\u7f8e\u5143\uff0c\u7565\u4f4e\u65bc2018\u5e74\u7684107\u5104\u7f8e\u5143\uff0c\u4f46\u9818\u5148\u65bcBioWorld\u8cc7\u6599\u5eab\u4e2d2000\u5e74\u4ee5\u4f86\u7684\u6240\u6709\u5176\u4ed6\u5e74\u4efd\u3002\u9019\u4e00\u5e74\u76842\u6708\u30016\u6708\u548c9\u6708\u7684IPO\u878d\u8cc7\u984d\u5747\u5275\u4e0b\u7d00\u9304\uff0c\u4e5f\u53ef\u4ee5\u8aaa\u9019\u662f\u6709\u53f2\u4ee5\u4f86\u6700\u597d\u7684\u7b2c\u4e8c\u5b63\u5ea6\u3002<\/p>\n

2019\u5e74\u521d\uff0c\u5168\u7403\u79c1\u71df\u4f01\u696d\u5275\u9020\u4e86\u65b0\u7684\u7d00\u9304\uff0c\u7b2c\u4e00\u5b63\u5ea6\u5438\u5f15\u4e86\u8d85\u904e46\u5104\u7f8e\u5143\u7684\u6295\u8cc7\u3002\u5118\u7ba1\u7b2c\u4e8c\u5b63\u5ea6\u7684\u4ea4\u6613\u984d\u7565\u6709\u653e\u7de9\uff0c\u7d04\u70ba38\u5104\u7f8e\u5143\uff0c\u4f46\u7b2c\u4e09\u5b63\u5ea6\u53c8\u6709\u6240\u56de\u5347\uff0c\u4ea4\u6613\u984d\u8d85\u904e40\u5104\u7f8e\u5143\u3002\u79c1\u4eba\u878d\u8cc7\u5728\u6700\u5f8c\u4e00\u500b\u5b63\u5ea6\u7e7c\u7e8c\u4fdd\u6301\u5f37\u52c1\u52e2\u982d\uff0c\u4f7f\u4eca\u5e74\u8fc4\u4eca\u7684\u878d\u8cc7\u7e3d\u984d\u9054\u5230\u8fd1160\u5104\u7f8e\u5143\uff0c\u50c5\u6bd42018\u5e74\u5275\u4e0b\u7684\u79c1\u4eba\u878d\u8cc7\u7d00\u9304\u5c1113\u5104\u7f8e\u5143\u3002<\/p>\n

 <\/p>\n

CRISPR\u9032\u5165\u9ec3\u91d1\u6642\u671f<\/strong><\/h3>\n

2019\u5e74\uff0c\u57fa\u56e0\u7de8\u8f2f\u53d6\u5f97\u4e86\u81e8\u5e8a\u548c\u57fa\u790e\u79d1\u5b78\u9032\u5c55\u3002\u81e8\u5e8a\u65b9\u9762\uff0cCRISPR Therapeutics AG\u548cVertex Pharmaceuticals Inc.\u572811\u6708\u5831\u544a\u7a31\uff0c\u7528CRISPR\/Cas9\u7de8\u8f2f\u81ea\u9ad4\u9aa8\u9ad3\u6cbb\u7642\u4f9d\u8cf4\u8f38\u8840\u7684\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u548c\u942e\u72c0\u7d30\u80de\u75c5\u7684\u5169\u540d\u60a3\u8005\uff0c\u5206\u5225\u986f\u793a\u4e86\u6210\u529f\u7684\u690d\u5165\u548c\u75c7\u72c0\u7684\u6539\u5584\u3002\u9019\u4e9b\u8cc7\u6599\u70ba\u57fa\u56e0\u7de8\u8f2f\u7684\u539f\u7406\u63d0\u4f9b\u4e86\u8b49\u64da\u3002\u81ea\u5f9e\u57fa\u56e0\u7de8\u8f2f\u88ab\u9996\u6b21\u63cf\u8ff0\u4ee5\u4f86\uff0c\u4eba\u5011\u5c31\u5df2\u7d93\u8a8d\u8b58\u5230\u5b83\u7684\u8f49\u5316\u6f5b\u529b\uff0c\u5b83\u5c07\u80fd\u5920\u5728\u81e8\u5e8a\u548c\u7814\u7a76\u61c9\u7528\u4e2d\u767c\u63ee\u4f5c\u7528\u3002<\/p>\n

\u8207\u6b64\u540c\u6642\uff0c\u57fa\u790e\u7814\u7a76\u4eba\u54e1\u7e7c\u7e8c\u64f4\u5c55\u57fa\u56e0\u7de8\u8f2f\u7684\u5de5\u5177\u7bb1\u300210\u6708\uff0c\u54c8\u4f5b\u5927\u5b78\u5e03\u7f85\u5fb7\u7814\u7a76\u6240(Broad Institute of Harvard)\u548c\u9ebb\u7701\u7406\u5de5\u5b78\u9662(MIT)\u7684\u7814\u7a76\u4eba\u54e1\u5831\u544a\u4e86prime\u7de8\u8f2f\u6280\u8853\u7684\u767c\u5c55\u3002Prime\u7de8\u8f2f\u6280\u8853\u539f\u5247\u4e0a\u53ef\u4ee5\u7cfe\u6b63\u76ee\u524d\u5df2\u77e5\u7684\u5c0e\u81f4\u57fa\u56e0\u75be\u75c5\u7684\u5927\u7d047.5\u842c\u500b\u57fa\u56e0\u7d44\u8b8a\u5316\u4e2d\u768490%\u3002\u7528\u54c8\u4f5b\u5927\u5b78\u81ea\u7136\u79d1\u5b78\u6559\u6388Thomas Dudley Cabot\u7684\u9996\u5e2d\u7814\u7a76\u54e1David Liu\u7684\u8a71\u8aaa\uff0cprime\u7de8\u8f2f\u52a0\u5165\u4e86CRISPR\u672c\u8eab\u548c\u57fa\u672c\u7de8\u8f2f\u5de5\u5177\uff0c\u53ef\u4ee5\u5be6\u73fe\u300c\u5728\u5206\u5b50\u751f\u547d\u79d1\u5b78\u4e2d\u5b58\u5728\u5df2\u4e45\u7684\u9858\u671b\u300d\uff0c\u6309\u7167\u610f\u9858\u4f86\u7de8\u8f2f\u57fa\u56e0\u7d44\u3002<\/p>\n

\u7576\u7136\uff0c\u4e26\u975e\u6240\u6709CRISPR\u65b0\u805e\u662f\u7a4d\u6975\u7684\uff1a2019\u5e74\u5e95\uff0c\u4e2d\u570b\u79d1\u5b78\u5bb6\u4f55\u5efa\u594e\u88ab\u5224\u8655\u4e09\u5e74\u5f92\u5211\uff0c\u4e26\u7f70\u6b3e300\u842c\u5143\uff08429,421\u7f8e\u5143\uff09\u3002\u4ed6\u975e\u6cd5\u9032\u884c\u4eba\u985e\u80da\u80ce\u57fa\u56e0\u7de8\u8f2f\uff0c\u5c0e\u81f4\u5176\u57fa\u56e0\u907a\u50b3\u6539\u8b8a\u7684\u96d9\u80de\u80ce\u5973\u5b69\u548c\u53e6\u4e00\u500b\u5b30\u5152\u7684\u51fa\u751f\u3002<\/p>\n

 <\/p>\n

\u963f\u8332\u6d77\u9ed8\u75c7\u85e5\u7269\u66d9\u5149\u518d\u73fe<\/strong><\/h3>\n

2019\u5e7410\u6708\uff0c\u7e3d\u90e8\u8a2d\u5728\u7f8e\u570b\u9ebb\u585e\u8af8\u585e\u5ddeCambridge\u7684Biogen\u516c\u53f8\u8868\u793a\uff0c\u6839\u64da\u8207\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u7684\u8ac7\u5224\uff0c\u8a72\u516c\u53f8\u5c07\u5c0b\u6c42\u76e3\u7ba1\u6a5f\u69cb\u6279\u51c6\u6297\u985e\u6fb1\u7c89\u86cb\u767d\u03b2\u6297\u9ad4aducanumab\u5728\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7(AD)\u4e2d\u7684\u61c9\u7528\u3002\u9019\u500b\u6d88\u606f\u8b93\u83ef\u723e\u8857\u5927\u5403\u4e00\u9a5a\u3002\u5118\u7ba1III\u671f\u7814\u7a76Emerge\u548cEngage\u7684\u8cc7\u6599\u8d77\u521d\u4e26\u6c92\u6709\u770b\u8d77\u4f86\u5f88\u6709\u5e0c\u671b\uff0c\u4f46Biogen\u6307\u51faEmerge\u9054\u5230\u4e86\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\uff0c\u986f\u8457\u6e1b\u5c11\u81e8\u5e8a\u6b7b\u4ea1\uff0c\u4e26\u5f15\u7528\u4e86Engage\u7684\u4e00\u90e8\u5206\u60a3\u8005\u7684\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e9b\u60a3\u8005\u4f7f\u7528\u8207\u6771\u4eac\u7684Eisai Co. Ltd.\u5408\u4f5c\u958b\u767c\u7684\u9ad8\u5291\u91cf\u85e5\u7269\u5f8c\uff0c\u8868\u73fe\u826f\u597d\u3002<\/p>\n

\u5177\u9ad4\u4f86\u8aaa\uff0c\u63d0\u4ea4\u7533\u8acb\u7684\u6c7a\u5b9a\u662f\u57fa\u65bcIII\u671f\u7814\u7a76\u7684\u4e00\u500b\u5927\u8cc7\u6599\u96c6\u7684\u65b0\u5206\u6790\uff0c\u8a72\u7814\u7a76\u5728\u6b64\u524d\u9032\u884c\u7684\u7121\u6548\u5206\u6790\u4e4b\u5f8c\u65bc2019\u5e743\u6708\u4e2d\u6b62\u3002\u9032\u4e00\u6b65\u7684\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cAducanumab\u5f9e\u85e5\u7406\u5b78\u548c\u81e8\u5e8a\u8868\u73fe\u5747\u986f\u793a\u80fd\u6709\u6548\u964d\u4f4e\u8166\u985e\u6fb1\u7c89\u86cb\u767d\uff0c\u4e26\u63a7\u5236\u81e8\u5e8a\u9032\u7a0b\u3002\u9019\u662f\u901a\u904e\u9810\u5148\u8a2d\u5b9a\u7684\u4e3b\u8981\u7d42\u9ede\u81e8\u5e8a\u7661\u5446\u75c7\u7b49\u7d1a\u8a55\u5b9a\u7e3d\u548c\u5f97\u51fa\u7684\u3002<\/p>\n

BLA\uff08\u751f\u7269\u88fd\u54c1\u7684\u8a3b\u518a\u7533\u8acb\uff09\u53ef\u80fd\u4e0d\u6703\u90a3\u9ebc\u9059\u9060\u30022019\u5e7412\u6708\u521d\u5728\u8056\u5730\u7259\u54e5\u8209\u884c\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u81e8\u5e8a\u8a66\u9a57\u5e74\u6703\u4e0a\u767c\u4f48\u4e86\u66f4\u591a\u8cc7\u6599\uff0cSVB Leerink\u5206\u6790\u5e2bGeoffrey Porges\u8aee\u8a62\u7684\u5c08\u5bb6\u610f\u898b\u8a8d\u70baEmerge\u300c\u5118\u7ba1\u6709\u524d\u671f\u7684\u7121\u6548\u6027\u5206\u6790\u7d50\u679c\u4e14\u8207Engage\u7d50\u679c\u4e0d\u5b8c\u5168\u4e00\u81f4\uff0c\u4f46\u662f\u6b64\u6b21\u7684\u5206\u6790\u7d50\u679c\u4ee4\u4eba\u4fe1\u670d\u4e14\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u300d\uff0c\u5979\u88dc\u5145\u8aaa\uff1a\u300c\u6839\u64da\u5728FDA\u795e\u7d93\u79d1\u5b78\u90e8\u9580\u7684\u7d93\u9a57\uff0cEngage\u4e2d\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6210\u50cf\u7d50\u679c\u53ef\u9032\u4e00\u6b65\u652f\u6301\u8a72\u5be9\u6279\u3002\u300d<\/p>\n

\u53e6\u4e00\u500b\u56e0\u7d20\u662f\u76e3\u7ba1\u6a5f\u69cb\u5c0d\u65bc\u6279\u51c6\u6539\u5584AD\u7642\u6cd5\u7684\u671f\u5f85\u3002\u300c\u5118\u7ba1\u7e3d\u9ad4\u7684\u57fa\u8abf\u662f\u7a4d\u6975\u7684\uff0c\u4f46\u5c08\u5bb6\u4e5f\u8868\u9054\u4e86\u5979\u7684\u64d4\u6182\uff0cFDA\u5c07\u6700\u7d42\u5be9\u6838Biogen\u5c1a\u672a\u62ab\u9732\u7684\u5168\u90e8\u539f\u59cb\u8cc7\u6599\uff0c\u57fa\u65bc\u6750\u6599\u7684\u4e0d\u540c\u767c\u73fe\uff08\u5118\u7ba1\u53ef\u80fd\u6027\u4e0d\u5927\uff09\u53ef\u80fd\u6703\u7522\u751f\u5c0d\u85e5\u7269\u7684\u4e0d\u5229\u6c7a\u5b9a\u300d\uff0c Porges\u5728\u5831\u544a\u4e2d\u5beb\u9053\u3002\u4ed6\u8aaa\uff0c\u300cBiogen\u8a08\u756b\u57282020\u5e74\u521d\u905e\u4ea4BLA\uff0c\u905e\u4ea4\u6750\u6599\u7684\u95dc\u9375\u5167\u5bb9\u5c07\u9762\u81e8\u6311\u6230\uff0c\u5305\u62ec\u81e8\u5e8a\u8a66\u9a57\u4e2d\u6b62\u548c\u9000\u51fa\u7684\u8a73\u7d30\u63cf\u8ff0\u548c\u8aaa\u660e\uff0c\u7121\u6548\u5206\u6790\u5f8c\u589e\u52a0\u7684\u60a3\u8005\u4eba\u6578\u4ee5\u53ca\u5c0d\u65bc\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u5206\u6790\u53ef\u80fd\u5b58\u5728\u7684\u5206\u6b67\u3002\u300d<\/p>\n

 <\/p>\n

\u4eba\u5de5\u667a\u6167\u6a5f\u5668\u5b78\u7fd2\uff1a\u985b\u8986\u91ab\u7642\u4fdd\u5065\u9818\u57df<\/strong><\/h3>\n

\u70ba\u4e86\u7406\u89e3\u6bcf\u5929\u5728\u885b\u751f\u4fdd\u5065\u7cfb\u7d71\u4e2d\u7522\u751f\u7684\u8cc7\u6599\u6d77\u562f\uff0c\u4e0d\u53ef\u907f\u514d\u7684\u9700\u8981\u65b0\u7684\u5de5\u5177\u3002\u5118\u7ba1\u4ecd\u5728\u767c\u5c55\u4e2d\uff0c\u4eba\u5de5\u667a\u6167\uff0c\u9019\u500b\u5305\u62ec\u6a5f\u5668\u5b78\u7fd2\u3001\u81ea\u7136\u8a9e\u8a00\u8655\u7406\u3001\u5de8\u91cf\u8cc7\u6599\u548c\u6578\u4f4d\u91ab\u7642\u61c9\u7528\u7684\u7e3d\u7a31\uff0c\u5df2\u7d93\u88ab\u61c9\u7528\u65bc\u91ab\u7642\u4fdd\u5065\u7684\u5404\u500b\u65b9\u9762\uff0c\u4e0d\u50c5\u8ddf\u4e0a\u4e86\u6d77\u91cf\u8cc7\u6599\uff0c\u9084\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u8abf\u67e5\uff0c\u4e26\u751f\u6210\u9810\u6e2c\u898b\u89e3\u3002
\n\u6beb\u7121\u7591\u554f\uff0c\u4e0b\u4e00\u6ce2\u7684\u85e5\u7269\u767c\u73fe\u5c07\u7531\u5f37\u5927\u7684\u8d85\u7d1a\u96fb\u8166\u4f86\u5be6\u73fe\uff0c\u9019\u4e9b\u8d85\u7d1a\u96fb\u8166\u904b\u884c\u8907\u96dc\u7684\u6f14\u7b97\u6cd5\uff0c\u70ba\u958b\u767c\u5275\u65b0\u7642\u6cd5\u63d0\u4f9b\u6f5b\u5728\u7684\u65b0\u79d1\u5b78\u65b9\u6cd5\u3002\u4f46\u662f\u5b83\u7684\u5f71\u97ff\u9060\u4e0d\u6b62\u9019\u4e9b\u3002\u4f8b\u5982\uff0c\u9ea5\u80af\u932b\u5168\u7403\u7814\u7a76\u6240 (McKinsey Global Institute)\u4f30\u8a08\uff0c\u904b\u7528\u5de8\u91cf\u8cc7\u6599\u7b56\u7565\u66f4\u597d\u5730\u70ba\u6c7a\u7b56\u63d0\u4f9b\u8cc7\u8a0a\uff0c\u6bcf\u5e74\u53ef\u4ee5\u70ba\u7f8e\u570b\u91ab\u7642\u7cfb\u7d71\u5275\u9020\u9ad8\u90541000\u5104\u7f8e\u5143\u7684\u50f9\u503c\u3002<\/p>\n

\u9019\u5c31\u662f\u70ba\u4ec0\u9ebc\u4eba\u5de5\u667a\u6167\u53ca\u5176\u4f5c\u70ba\u4e00\u7a2e\u91cd\u8981\u5de5\u5177\u65e5\u76ca\u589e\u9577\u7684\u91cd\u8981\u6027\uff0c\u4f7f\u5f97\u5b83\u6210\u70ba2019\u5e74\u7684\u982d\u689d\u65b0\u805e\u4e4b\u4e00\u3002\u5b83\u662f\u5982\u6b64\u91cd\u8981\uff0c\u4ee5\u81f3\u65bc\u4eca\u5e74\u65e9\u4e9b\u6642\u5019\u767c\u4f48\u4e86\u753128\u500b\u5831\u5c0e\u7d44\u6210\u7684BioWorld\u548cBioWorld MedTech\u7cfb\u5217\uff0c\u6df1\u5165\u63a2\u8a0e\u4e86\u4eba\u5de5\u667a\u6167\u5728\u91ab\u7642\u4fdd\u5065\u9818\u57df\u7684\u8da8\u52e2\u3001\u6a5f\u9047\u548c\u6311\u6230\u3002<\/p>\n

\u5df2\u7d93\u6709\u5927\u91cf\u7684\u8b49\u64da\u8868\u660e\uff0c\u4eba\u5de5\u667a\u6167\u7684\u5f71\u97ff\u5e36\u4f86\u4e86\u5f9e\u5be6\u9a57\u5ba4\u5230\u81e8\u5e8a\u7684\u5de8\u5927\u8b8a\u5316\u3002\u4f8b\u5982\uff0c\u5927\u578b\u88fd\u85e5\u516c\u53f8\u8207\u5c08\u6ce8\u65bc\u4eba\u5de5\u667a\u6167\u7684\u516c\u53f8\u5408\u4f5c\uff0c\u5c0b\u6c42\u6a5f\u5668\u5b78\u7fd2\u7684\u5e6b\u52a9\u4ee5\u627e\u5230\u8af8\u5982\u963f\u8332\u6d77\u9ed8\u75c7\u7b49\u75be\u75c5\u7684\u65b0\u85e5\u7269\u9776\u9ede\uff0c\u78ba\u5b9a\u9069\u5408\u81e8\u5e8a\u7814\u7a76\u7684\u60a3\u8005\uff0c\u52aa\u529b\u6539\u5584\u8a66\u9a57\u62db\u52df\uff0c\u6548\u7387\u548c\u6c7a\u7b56\u5236\u5b9a\u5728\u5404\u7a2e\u898f\u6a21\u7684\u516c\u53f8\u4e2d\u9032\u884c\uff0c\u5c0b\u6c42\u63d0\u9ad8\u8271\u96e3\u7684\u81e8\u5e8a\u6210\u529f\u7684\u6a5f\u6703\u3002\u91ab\u9662\u6b63\u5728\u4f7f\u7528\u4eba\u5de5\u667a\u6167\u4f86\u6539\u5584\u91ab\u7642\u8a3a\u65b7\u548c\u5f71\u50cf\u8655\u7406\uff0c\u5f9e\u800c\u53ef\u4ee5\u5c07\u78c1\u5171\u632f\u548cX\u5c04\u7dda\u5716\u50cf\u7684\u5206\u6790\u548c\u89e3\u91cb\u5f9e\u6578\u5c0f\u6642\u6e1b\u5c11\u5230\u6578\u5206\u9418\u3002<\/p>\n

\u5c08\u9580\u5f9e\u4e8b\u91ab\u7642\u4fdd\u5065\u9818\u57df\u7684\u98a8\u96aa\u6295\u8cc7\u516c\u53f8\u4e5f\u8a8d\u8b58\u5230\u4e86\u9019\u4e00\u65b0\u8208\u9818\u57df\u7684\u91cd\u8981\u6027\uff0c\u4e26\u652f\u6301\u65b0\u8208\u751f\u7269\u88fd\u85e5\u516c\u53f8\u4f7f\u7528\u4eba\u5de5\u667a\u6167\u548c\u6a5f\u5668\u5b78\u7fd2\u4f86\u589e\u5f37\u5176\u85e5\u7269\u767c\u73fe\u548c\u958b\u767c\u6d3b\u52d5\u3002\u5728\u904e\u53bb\u7684\u5169\u5e74\u4e2d\uff0c\u9019\u500b\u9818\u57df\u7684\u516c\u53f8\u5df2\u7d93\u5438\u5f15\u4e86\u8d85\u904e10\u5104\u7f8e\u5143\u7684\u8cc7\u91d1\u3002<\/p>\n

 <\/p>\n

\u85e5\u54c1\u5b9a\u50f9\u6210\u70ba\u5168\u7403\u6027\u554f\u984c<\/strong><\/h3>\n

\u52302019\u5e74\uff0c\u85e5\u54c1\u5b9a\u50f9\u6210\u70ba\u5168\u7403\u7bc4\u570d\u5167\u7684\u4e00\u500b\u4e3b\u8981\u554f\u984c\uff0c\u5404\u570b\u653f\u5e9c\u7e7c\u7e8c\u52aa\u529b\u964d\u4f4e\u91ab\u7642\u6210\u672c\uff0c\u958b\u767c\u6700\u65b0\u3001\u6700\u6602\u8cb4\u7684\u57fa\u56e0\u548c\u7d30\u80de\u7642\u6cd5\uff0c\u5c0b\u627e\u7f55\u898b\u75be\u75c5\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u4e26\u61c9\u5c0d\u6297\u751f\u7d20\u8010\u85e5\u6027\u3002<\/p>\n

\u50c5\u5728\u7f8e\u570b\uff0c\u4e00\u5e74\u4e2d\u5c31\u51fa\u73fe\u4e86\u5927\u91cf\u7684\u7acb\u6cd5\u5617\u8a66\u3002\u570b\u6703\u82b1\u4e86\u5e7e\u500b\u6708\u7684\u6642\u9593\u7814\u7a76H.R. 3\uff0c\u5373\u300a\u964d\u4f4e\u85e5\u7269\u6210\u672c\u6cd5\u6848\u300b(Lower Drug Costs Now Act)\uff0c\u76ee\u6a19\u662f\u5f9e2023\u5e74\u958b\u59cb\u7bc0\u77013,450\u5104\u7f8e\u5143\u7684Medicare D\u90e8\u5206\u8655\u65b9\u85e5\u300212\u6708\u4e2d\u65ec\uff0c\u5ddd\u666e\u7e3d\u7d71\u7c3d\u7f72\u4e86\u4e00\u9805\u6cd5\u6848\uff0c\u5141\u8a31\u5f9e\u52a0\u62ff\u5927\u9032\u53e3\u66f4\u4fbf\u5b9c\u7684\u85e5\u7269\u2014\u2014\u5118\u7ba1\u52a0\u62ff\u5927\u6b63\u5728\u53cd\u64ca\u3002\u8207\u6b64\u540c\u6642\uff0c\u964d\u4f4e\u85e5\u54c1\u50f9\u683c\u7684\u52aa\u529b\u5c0e\u81f4\u5411FDA\u63d0\u4ea4ANDAs\u7684\u6578\u91cf\u6fc0\u589e\u3002<\/p>\n

\u52a0\u62ff\u5927\u901a\u904e\u66f4\u6539\u85e5\u54c1\u50f9\u683c\u6bd4\u8f03\u570b\u5bb6\u7684\u65b9\u5f0f\u4f86\u6539\u8b8a\u85e5\u54c1\u5b9a\u50f9\u7684\u65b9\u6cd5\uff0c\u56e0\u6b64\u5c08\u5229\u85e5\u54c1\u50f9\u683c\u5be9\u67e5\u59d4\u54e1\u6703\uff08PMPRB\uff09\u4e0d\u518d\u5c07\u85e5\u54c1\u50f9\u683c\u8207\u7f8e\u570b\u548c\u745e\u58eb\u9032\u884c\u6bd4\u8f03\uff0c\u9019\u5169\u500b\u570b\u5bb6\u7684\u85e5\u54c1\u6700\u70ba\u6602\u8cb4\u3002<\/p>\n

\u5728\u82f1\u570b\u548c\u6b50\u6d32\uff0c\u6709\u95dc\u662f\u5426\u5141\u8a31Vertex\u88fd\u85e5\u516c\u53f8 (Vertex Pharmaceuticals Inc.) \u7684\u56ca\u6027\u7e96\u7dad\u5316\u85e5\u7269\uff08\u5305\u62ecTrikafta\uff09\u8cbb\u7528\u5831\u92b7\u7684\u722d\u8ad6\u6b63\u5728\u9032\u884c\uff0c\u9019\u5c31\u662f\u6311\u6230\u7684\u4e00\u500b\u4f8b\u8b49\u3002Trikafta\u7684\u5b9a\u50f9\u70ba\u6bcf\u5e74311,503\u7f8e\u5143\uff0c\u4e26\u5c07\u65bc2020\u5e74\u4e0a\u5e02\u3002\u5728\u6b50\u6d32\uff0c\u5982\u4f55\u8655\u7406\u7d30\u80de\u548c\u57fa\u56e0\u6cbb\u7642\u7684\u5831\u92b7\u554f\u984c\uff0c\u4ee5\u53ca\u70ba\u975e\u5e38\u6602\u8cb4\u7684\u4e00\u6b21\u6027\u6cbb\u7642\u5236\u5b9a\u4ed8\u6b3e\u65b9\u6848\u65b9\u9762\uff0c\u53d6\u5f97\u4e86\u4e00\u4e9b\u9032\u5c55\u3002\u6fb3\u6d32\u4e5f\u5728\u52aa\u529b\u722d\u53d6\u9019\u4e9b\u65b0\u8208\u7642\u6cd5\u7684\u5831\u92b7\u3002<\/p>\n

2019\u5e749\u6708\uff0c\u4e2d\u570b\u64f4\u5927\u4e86\u4e00\u9805\u964d\u4f4e\u5168\u570b\u5b78\u540d\u85e5\u6210\u672c\u7684\u8a66\u9ede\u8a08\u756b\u3002\u4e2d\u570b\u63a1\u53d6\u62db\u6a19\u65b9\u5f0f\uff0c\u5411\u653f\u5e9c\u91ab\u9662\u63d0\u4f9b\u5217\u5165\u570b\u5bb6\u5831\u92b7\u6e05\u55ae\u7684\u85e5\u54c1\u3002\u4e2d\u570b\u5e0c\u671b\u901a\u904e\u524a\u6e1b\u4f4e\u6210\u672c\u5b78\u540d\u85e5\u7684\u958b\u652f\uff0c\u70ba\u65b0\u578b\u6cbb\u7642\u63d0\u4f9b\u8cc7\u91d1\u3002\u9577\u671f\u4ee5\u4f86\uff0c\u4e2d\u570b\u7684\u85e5\u54c1\u958b\u92b7\u9060\u9060\u9ad8\u65bc\u5176\u5b83\u5927\u591a\u6578\u5730\u5340\u3002<\/p>\n

\u65e5\u672c\u4e5f\u5728\u52aa\u529b\u964d\u4f4e\u85e5\u7269\u6210\u672c\uff0c\u5176\u52aa\u529b\u91cd\u9ede\u662f\u9f13\u52f5\u4f7f\u7528\u5b78\u540d\u85e5\u3002\u653f\u5e9c\u5e0c\u671b2020\u5e74\uff0c\u5176950\u5104\u7f8e\u5143\u7684\u85e5\u54c1\u5e02\u5834\u4e2d80\uff05\u662f\u5b78\u540d\u85e5\u3002<\/p>\n

 <\/p>\n

\u9d09\u7247\u985e\u85e5\u7269\u5371\u6a5f\u5e2d\u6372\u6cd5\u5ead<\/strong><\/h3>\n

2018\u5e74\uff0c\u7f8e\u570b\u76e3\u7ba1\u6a5f\u69cb\u548c\u885b\u751f\u5b98\u54e1\u6372\u5165\u4e86\u9d09\u7247\u985e\u85e5\u7269\u7684\u722d\u8ad6\uff0c\u5f15\u767c\u4e86\u4eca\u5e74\u7684\u6230\u722d\u3002\u90a3\u6642\uff0c\u6cd5\u9662\u6210\u529f\u7684\u4f54\u64da\u4e86\u821e\u81fa\u4e2d\u5fc3\uff0c\u5e7e\u5bb6\u5927\u516c\u53f8\u8abf\u67e5\u4e86\u60c5\u6cc1\u4e4b\u5f8c\u6c7a\u5b9a\u548c\u89e3\uff0c\u800c\u4e0d\u662f\u5192\u96aa\u6253\u4e00\u5834\u66e0\u65e5\u6301\u4e45\u7684\u5b98\u53f8\u3002<\/p>\n

\u5728Cuyahoga\u548cSummit\u7b49\u7e23\u8207Purdue Pharma\u4e4b\u9593\u5f15\u4eba\u6ce8\u76ee\u7684Track 1\u9d09\u7247\u985e\u85e5\u7269\u6848\u4ef6\u4e2d\uff0cPurdue Pharma\u65bc2019\u5e749\u6708\u4e2d\u65ec\u7533\u8acb\u7834\u7522\uff0c\u5728\u539f\u5247\u4e0a\u9054\u6210\u4e86\u5354\u8b70\u548c\u89e3\uff0c\u89e3\u6c7a\u4e86\u7f8e\u570b\u57ce\u5e02\u548c\u7e23\u4ee5\u53ca20\u591a\u500b\u5dde\u548c\u5730\u5340\u63d0\u51fa\u7684\u8d85\u904e2,000\u591a\u500b\u8207\u9d09\u7247\u985e\u85e5\u7269\u6709\u95dc\u7684\u8a34\u8a1f\u3002\u70ba\u6b64\uff0c\u9054\u6210\u4e86\u4e00\u9805100\u5104\u7f8e\u5143\u7684\u548c\u89e3\u5354\u5b9a\uff0c\u8981\u6c42\u5c07Purdue\u7684\u8cc7\u7522\u653e\u5165\u4fe1\u8a17\u3002\u81ea19\u4e16\u7d00\u516c\u53f8\u6210\u7acb\u4ee5\u4f86\u4e00\u76f4\u63a7\u5236\u8457\u8a72\u516c\u53f8\u7684Sackler\u5bb6\u65cf\uff0c\u70ba\u6b64\u5c07\u51fa\u8cc7\u81f3\u5c1130\u5104\u7f8e\u5143\uff0c\u4e26\u6709\u53ef\u80fd\u901a\u904e\u5728\u5176\u4ed6\u570b\u5bb6\u7684\u88fd\u85e5\u696d\u52d9\u7684\u92b7\u552e\u4f86\u9032\u4e00\u6b65\u51fa\u8cc7\u3002<\/p>\n

\u4e00\u4e9b\u5dde\u6aa2\u5bdf\u9577\u8aaa\uff0c\u9019\u8655\u7f70\u529b\u5ea6\u9084\u4e0d\u5920\u3002\u8003\u616e\u5230\u9019\u500b\u5bb6\u65cf\u901a\u904ePurdue\u548c\u75bc\u59cb\u5eb7\u5b9a\uff08Oxycontin\uff09\u7684\u884c\u92b7\u7372\u5f97\u7684\u8ca1\u5bcc\uff0cSackler\u5bb6\u65cf\u61c9\u8a72\u7e73\u7d0d\u66f4\u591a\u7684\u7f70\u6b3e\u3002<\/p>\n

\u611b\u8377\u83ef\u5dde\u516c\u53f8Tom Miller\u8aaa\uff1a\u300c\u6211\u7684\u95dc\u6ce8\u9ede\u5728\u65bcSackler\u5bb6\u65cf\u8981\u652f\u4ed8\u7684\u91d1\u984d\u3002\u300d\u4ed6\u8aaa\uff1a\u300c\u6211\u76f8\u4fe1\u4ed6\u5011\u6709\u80fd\u529b\u3001\u4e5f\u6709\u8cac\u4efb\u652f\u4ed8\u8d85\u51fa\u4ed6\u5011\u5728\u5354\u8b70\u4e2d\u627f\u8afe\u7684\u91d1\u984d\u3002\u300d<\/p>\n

2019\u5e7410\u6708\u521d\uff0cMallinckrodt plc\u7684\u5168\u8cc7\u5b50\u516c\u53f8Mallinckrodt LLC\u548cSpecgx LLC\u8207\u4fc4\u4ea5\u4fc4\u5dde\u7684Cuyahoga\u548cSummit\u7e23\u9054\u6210\u4e86\u548c\u89e3\uff0c\u7d50\u675f\u4e86\u5e7e\u5468\u5f8c\u5c31\u8981\u958b\u5ead\u5be9\u7406\u7684\u6848\u4ef6\u3002Mallinckrodt\u540c\u610f\u652f\u4ed82400\u842c\u7f8e\u5143\u7684\u73fe\u91d1\uff0c\u63d0\u4f9b600\u842c\u7f8e\u5143\u7684\u5b78\u540d\u85e5\uff0c\u4e26\u652f\u4ed850\u842c\u7f8e\u5143\u7528\u65bc\u5404\u90e1\u7e23\u82b1\u8cbb\u7684\u6642\u9593\u548c\u8cbb\u7528\u3002<\/p>\n

\u5e7e\u5929\u5f8c\uff0c\u5f37\u751f\u516c\u53f8\uff08Johnson\uff06Johnson\uff09\u65bc8\u6708\u5e95\u5728\u5967\u514b\u62c9\u8377\u99ac\u5dde\u7684\u4e00\u6b21\u5be9\u5224\u4e2d\u906d\u53d7\u4e865.72\u5104\u7f8e\u5143\u7684\u640d\u5931\uff0c\u8003\u616e\u5230\u4e86\u540c\u4e00\u5730\u9ede\u7684\u985e\u4f3c\u548c\u8feb\u5728\u7709\u776b\u7684\u9ebb\u7169\u5f8c\uff0c\u540c\u610f\u8207Cuyahoga\u548cSummit\u7e23\u9054\u62101000\u842c\u7f8e\u5143\u7684\u548c\u89e3\u5354\u5b9a\u3002\u5f37\u751f\u516c\u53f8\u96d6\u7136\u6c92\u6709\u627f\u8a8d\u8cac\u4efb\uff0c\u4f46\u5b83\u540c\u610f\u8ce0\u511f\u5404\u7e23500\u842c\u7f8e\u5143\u4f5c\u70ba\u6cd5\u5f8b\u548c\u5176\u5b83\u5be9\u5224\u6e96\u5099\u7684\u8cbb\u7528\uff0c\u4e26\u5c07\u5176540\u842c\u7f8e\u5143\u7684\u6148\u5584\u6350\u6b3e\u76f4\u63a5\u7528\u65bc\u9019\u5169\u500b\u7e23\u63d0\u4f9b\u9d09\u7247\u985e\u85e5\u7269\u76f8\u95dc\u5c08\u6848\u7684\u975e\u71df\u5229\u7d44\u7e54\u3002\u5f37\u751f\u516c\u53f8\u7684\u5b98\u54e1\u8868\u793a\uff0c\u8a72\u516c\u53f8\u9858\u610f\u5c0d\u6240\u6709\u7f8e\u570b\u9d09\u7247\u985e\u85e5\u7269\u8a34\u8a1f\u63a1\u53d6\u300c\u9069\u7576\uff0c\u5168\u9762\u7684\u89e3\u6c7a\u65b9\u6848\u300d\u6301\u958b\u653e\u614b\u5ea6\u3002<\/p>\n

\u6700\u5f8c\u5169\u500bTrack 1\u6848\u4ef6\u572810\u6708\u5e95\u7684\u6700\u5f8c\u4e00\u523b\u89e3\u6c7a\u3002\u7e3d\u90e8\u4f4d\u65bc\u8036\u8def\u6492\u51b7\u7684Teva Pharmaceutical Industries Ltd.\u540c\u610f\u5728\u4e09\u5e74\u5167\u5411Cuyahoga\u548cSummit\u7e23\u652f\u4ed82000\u842c\u7f8e\u5143\uff0c\u4e26\u63d0\u4f9b\u50f9\u503c2500\u842c\u7f8e\u5143\u7684Suboxone\uff08\u4e01\u4e19\u8afe\u5561\u7d0d\u6d1b\u916e\uff09\u4f86\u6cbb\u7642\u9d09\u7247\u985e\u85e5\u7269\u6210\u766e\u8005\u3002<\/p>\n

\u5728\u8207\u4fc4\u4ea5\u4fc4\u5dde\u5404\u7e23\u9054\u6210\u7684\u4e00\u9805\u55ae\u7368\u548c\u89e3\u5354\u5b9a\u4e2d\uff0c\u4e09\u500b\u85e5\u54c1\u7d93\u92b7\u5546\uff08AmerisourceBergen\uff0cCardinal Health\u548cMcKesson\uff09\u540c\u610f\u652f\u4ed82.15\u5104\u7f8e\u5143\u3002\u9019\u4e9b\u7d93\u92b7\u5546\u8868\u793a\uff0c\u5118\u7ba1\u4ed6\u5011\u300c\u5f37\u70c8\u8cea\u7591\u5169\u500b\u7e23\u7684\u6307\u63a7\uff0c\u4f46\u4ed6\u5011\u8a8d\u70ba\uff0c\u89e3\u6c7a\u9019\u5834\u5177\u6709\u91cc\u7a0b\u7891\u610f\u7fa9\u7684\u5be9\u5224\uff0c\u662f\u9054\u6210\u5168\u7403\u89e3\u6c7a\u65b9\u6848\u548c\u63d0\u4f9b\u6709\u610f\u7fa9\u7684\u6551\u6fdf\u7684\u91cd\u8981\u4e00\u6b65\u3002\u300d<\/p>\n

 <\/p>\n

\u4e00\u5834\u6fc0\u70c8\u7684\u8cbf\u6613\u6469\u64e6<\/strong><\/h3>\n

\u7f8e\u4e2d\u8cbf\u6613\u6469\u64e6\u57282019\u5e74\u7de9\u6162\u63a8\u9032\uff0c\u6642\u800c\u7206\u767c\uff0c\u6642\u800c\u5e73\u606f\uff0c\u76f4\u523012\u6708\u624d\u9054\u6210\u521d\u6b65\u8cbf\u6613\u5354\u5b9a\u3002\u8a72\u5354\u8b70\u5c1a\u672a\u7c3d\u7f72\uff0c\u5f88\u53ef\u80fd\u662f\u9081\u51fa\u4e86\u89e3\u6c7a\u5169\u570b\u5df2\u5fb5\u6536\u6216\u5a01\u8105\u5fb5\u6536\u7684\u6578\u5341\u5104\u7f8e\u5143\u8cbf\u6613\u95dc\u7a05\u7684\u53ef\u559c\u7684\u7b2c\u4e00\u6b65\u3002\u7136\u800c\uff0c\u4efb\u4f55\u5354\u5b9a\u7684\u9054\u6210\u90fd\u70ba\u6642\u5df2\u665a\uff0c\u7121\u6cd5\u4f7f\u751f\u547d\u79d1\u5b78\u884c\u696d\u514d\u65bc\u906d\u53d7\u6700\u521d\u7684\u640d\u5931\u3002\u00a0\u57282019\u5e74\u671f\u9593\uff0c\u884c\u696d\u89c0\u5bdf\u5bb6\u6ce8\u610f\u5230\uff0c\u4e00\u5ea6\u5145\u88d5\u7684\u4e2d\u570b\u8cc7\u91d1\u6d41\u5165\u7f8e\u570b\u4f01\u696d\u7684\u6e1b\u5c11\uff0c\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u6b78\u56e0\u65bc\u5c0d\u7f8e\u570b\u5916\u570b\u6295\u8cc7\u59d4\u54e1\u6703(Committee on Foreign Investment)\u6d3b\u52d5\u589e\u52a0\u7684\u64d4\u6182\u3002\u77fd\u8c37\u9280\u884c\u66fe\u57289\u6708\u9810\u8a082019\u5e74\u6d41\u5411\u7f8e\u570b\u548c\u6b50\u6d32\u751f\u7269\u88fd\u85e5\u516c\u53f8\u7684\u7e3d\u8cc7\u91d1\u5c07\u6e1b\u5c1127%\u3002\u5c08\u5bb6\u5011\u9084\u5c0d\u4e2d\u570b\u4f9b\u61c9\u7684\u539f\u6599\u85e5\u53ef\u80fd\u51fa\u73fe\u7684\u4e2d\u65b7\u63d0\u51fa\u4e86\u8b66\u544a\uff0c\u539f\u6599\u85e5\u662f\u5168\u7403\u85e5\u54c1\u4f9b\u61c9\u93c8\u4e2d\u7684\u95dc\u9375\u8981\u7d20\u3002<\/p>\n

\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u7f8e\u570b\u751f\u7269\u88fd\u85e5\u884c\u696d\u5df2\u7d93\u6210\u529f\u5730\u9032\u884c\u4e86\u904a\u8aaa\uff0c\u53cd\u5c0d\u5c0d\u4e2d\u570b\u88fd\u9020\u4e26\u5728\u7f8e\u570b\u92b7\u552e\u7684\u91ab\u7642\u76f8\u95dc\u7522\u54c1\u5fb5\u6536\u95dc\u7a05\u3002\u6b64\u5916\uff0c\u4e2d\u570b\u9084\u6c92\u6709\u63a1\u53d6\u4efb\u4f55\u884c\u52d5\u5207\u65b7\u5c0d\u7f8e\u570b\u95dc\u9375\u85e5\u54c1\u7684\u4f9b\u61c9\uff0c\u6bd4\u5982\u6297\u751f\u7d20\uff0c\u4e2d\u570b\u5728\u6297\u751f\u7d20\u65b9\u9762\u626e\u6f14\u8457\u91cd\u8981\u7684\u89d2\u8272\u3002\u5118\u7ba1\u7f8e\u570b\u7e3d\u7d71\u5510\u7d0d\u5fb7\u00b7\u7279\u6717\u666e(Donald Trump)\u5728\u5e73\u5b89\u591c\u5ba3\u4f48\u8207\u7fd2\u8fd1\u5e73\u4e3b\u5e2d\u7684\u4e0b\u4e00\u6b21\u6703\u6664\u5c07\u7c3d\u7f72\u7f8e\u570b\u8cbf\u6613\u5354\u5b9a\u7b2c\u4e00\u968e\u6bb5\uff0c\u4f46\u662f\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\uff0c\u4e0d\u78ba\u5b9a\u6027\u4f9d\u7136\u5b58\u5728\u3002<\/p>\n

\u66f4\u6709\u5e0c\u671b\u7684\u662f\uff0c\u4e2d\u570b\u6d3b\u8e8d\u7684\u570b\u5167\u751f\u547d\u79d1\u5b78\u9818\u57df\u6b63\u5728\u5d1b\u8d77\uff0c\u4ee5\u6eff\u8db3\u570b\u5bb6\u5c0d\u81ea\u4e3b\u5275\u65b0\u85e5\u7269\u7684\u9700\u6c42\uff0c\u4f8b\u5982\u4fe1\u9054\u751f\u7269\u7684Tyvyt (sintilimab)\u548c\u548c\u8a18\u9ec3\u57d4\u7684Elunate (fruquintinib)\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u4e00\u4e9b\u6700\u5177\u5275\u65b0\u6027\u7684\u9805\u76ee\u662f\u5efa\u7acb\u5728\u8207\u7f8e\u570b\u7684\u8de8\u5883\u5408\u4f5c\u95dc\u4fc2\u4e4b\u4e0a\u7684\uff0c\u4f8b\u5982\u5357\u4eac\u50b3\u5947\u751f\u7269\u6280\u8853\u6709\u9650\u516c\u53f8\u8207\u694a\u68ee\u751f\u7269\u6280\u8853\u6709\u9650\u516c\u53f8\uff0c\u4f4d\u65bc\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u7684CASI Pharmaceuticals Inc.\u548c\u5b83\u4f4d\u65bc\u5317\u4eac\u7684\u4e2d\u570b\u5408\u4f5c\u5925\u4f34\u5408\u6e90\u751f\u7269.\u3002\u9019\u5c0d\u642d\u6a94\u662f2018\u5e7412\u6708\u9032\u5165\u81e8\u5e8a\u7684\u5169\u7a2e\u6b63\u5728\u7814\u7a76\u7684CAR-T\u7642\u6cd5\u7684\u806f\u5408\u958b\u767c\u8005\uff0c\u9019\u4f3c\u4e4e\u8868\u660e\uff0c\u5118\u7ba1\u5b58\u5728\u8cbf\u6613\u52d5\u76ea\uff0c\u4f46\u5168\u7403\u751f\u7269\u88fd\u85e5\u5275\u65b0\u6838\u5fc3\u7684\u5408\u4f5c\u7cbe\u795e\u4ecd\u7136\u5f88\u5f37\u3002<\/p>\n

 <\/p>\n

\u84ec\u52c3\u767c\u5c55\u7684\u6cd5\u862d\u5fb7\u65af<\/strong><\/h3>\n

\u5118\u7ba1\u6bd4\u5229\u6642\u570b\u571f\u9762\u7a4d\u5c0f\uff0c\u4f46\u5b83\u4e00\u76f4\u662f\u6b50\u6d32\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u96c6\u7fa4\u4e4b\u4e00\uff0c\u800c2019\u5e74\u5c0d\u8a72\u570b\u7684\u751f\u7269\u6280\u8853\u7522\u696d\u4f86\u8aaa\uff0c\u662f\u683c\u5916\u597d\u7684\u4e00\u5e74\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5c0d\u4e00\u500b\u4fdd\u7559\u8457\u9bae\u660e\u7684\u8a9e\u8a00\u548c\u5730\u5340\u5206\u88c2\u7684\u570b\u5bb6\u4f86\u8aaa\uff0c\u9019\u5c0d\u65bc\u751f\u7269\u6280\u8853\u7522\u54c1\u96c6\u4e2d\u7684\u6cd5\u862d\u5fb7\u65af (Flanders) \u662f\u5f88\u597d\u7684\u4e00\u5e74\u3002\u6cd5\u862d\u5fb7\u65af\u4f4d\u65bc\u6bd4\u5229\u6642\u7684\u5317\u9762\uff0c\u8b1b\u8377\u862d\u8a9e\uff0c\u4eba\u53e3\u8207\u9ebb\u585e\u8af8\u585e\u5dde\u76f8\u4f3c\uff0c\u4f46\u53ea\u6709\u5927\u7d04\u4e00\u534a\u9762\u7a4d\u3002<\/p>\n

\u9577\u671f\u4ee5\u4f86\uff0c\u8a72\u5730\u5340\u7684\u65d7\u8266\u751f\u7269\u6280\u8853\u516c\u53f8\u662f\u7e3d\u90e8\u4f4d\u65bc\u6839\u7279\u7684Ablynx NV\uff0c\u57282018\u5e74\u4ee548\u5104\u7f8e\u5143\u7684\u50f9\u683c\u88ab\u6536\u8cfc\u5f8c\uff0c\u73fe\u5df2\u4f75\u5165\u7e3d\u90e8\u4f4d\u65bc\u5df4\u9ece\u7684\u8cfd\u8afe\u83f2\uff0c\u4f46\u5b83\u4ecd\u662f\u8cfd\u8afe\u83f2\u7814\u767c\u7d44\u7e54\u4e2d\u7684\u91cd\u8981\u7bc0\u9ede\u3002\u6b64\u5916\uff0c\u5176\u7368\u7279\u7684llama\u884d\u751f\u7684\u7d0d\u7c73\u9ad4\u7247\u6bb5\u6297\u9ad4\u5e73\u53f0\u5df2\u65bc2019\u5e742\u6708\u9996\u6b21\u7372\u5f97\u4e86FDA\u7684\u6279\u51c6\uff0c\u7528\u65bcCablivi\uff08caplacizumab-yhdp\uff09\u6cbb\u7642\u7372\u5f97\u6027\u8840\u6813\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u6027\u7d2b\u765c\uff08\u4e00\u7a2e\u7f55\u898b\u7684\u51dd\u8840\u969c\u7919\uff09\u3002\u4f46\u662f\uff0c\u5169\u5bb6\u76f8\u9130\u7684\u516c\u53f8\u5df2\u7d93\u8d85\u8d8a\u4e86Ablynx\uff0c\u4e26\u4e14\u7e7c\u7e8c\u5f37\u52c1\u589e\u9577\u3002\u7e3d\u90e8\u4f4d\u65bcMechelen\u7684Galapagos NV\u516c\u53f8\u4eca\u5e74\u5b8c\u6210\u4e86Filgotinib\u7528\u65bc\u6cbb\u7642\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u7684NDA\u7533\u8acb\u905e\u4ea4\uff0c\u5176\u53e3\u670dJAK1\u6291\u5236\u5291\u8207\u4f4d\u65bc\u52a0\u5ddeFoster City\u7684\u5409\u5229\u5fb7\uff08Gilead Sciences Inc.\uff09\u5408\u4f5c\u3002Galapagos\u5728\u7d93\u6b77\u4e86\u6b77\u53f2\u6027\u7684\u5de8\u984d\u4ea4\u6613\u5f8c\uff0c\u76ee\u524d\u5e02\u503c\u7d04\u70ba135\u5104\u7f8e\u5143\u30027\u6708\u4efd\u8207\u5409\u5229\u5fb7\uff08Gilead\uff09\u9054\u6210\u5354\u8b70\uff0c\u5409\u5229\u5fb7\u9810\u5148\u652f\u4ed8\u4e8639.5\u5104\u7f8e\u5143\uff0c\u4e26\u53e6\u5916\u6295\u8cc7\u4e8611\u5104\u7f8e\u5143\u80a1\u7968\u4ee5\u7372\u5f97\u672a\u4f86\u5341\u5e74Galapagos\u958b\u767c\u51fa\u7684\u6240\u6709\u7522\u54c1\u5728\u6b50\u6d32\u4ee5\u5916\u7684\u6b0a\u76ca\u3002<\/p>\n

\u540c\u6a23\u4f86\u81ea\u6839\u7279\u7684Argenx NV\uff0c2018\u5e7411\u6708\u5728\u5168\u7403\u767c\u884c\u4e865.57\u5104\u7f8e\u5143\u7684\u80a1\u7968\uff0c\u4ee5\u4fdd\u6301\u5176\u81ea\u8eab\u958b\u767c\u7f8a\u99dd\u4f86\u6e90\u6297\u9ad4\u7684\u767c\u5c55\u52e2\u982d\uff0c\u9019\u4e9b\u6297\u9ad4\u7528\u65bc\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u764c\u75c7\u3002\u73fe\u5728\u5b83\u7684\u50f9\u503c\u63a5\u8fd170\u5104\u7f8e\u5143\u3002\u9019\u4e09\u5bb6\u516c\u53f8\u90fd\u662f\u6b50\u6d32\u8fd1\u5e74\u4f86\u8f49\u5411\u7d0d\u65af\u9054\u514b\uff08Nasdaq\uff09\u7684\u4e3b\u8981\u53d7\u76ca\u8005\uff0c\u9019\u8b93\u5b83\u5011\u7372\u5f97\u4e86\u5f88\u9ad8\u7684\u77e5\u540d\u5ea6\u548c\u5927\u91cf\u6d41\u52d5\u6027\u3002\u6bcf\u4e00\u7a2e\u751f\u7269\u6280\u8853\u90fd\u4ee5\u81ea\u5df1\u7684\u65b9\u5f0f\u9ad4\u73fe\u4e86\u751f\u7269\u6280\u8853\u7522\u696d\u5168\u7403\u5316\u7684\u5feb\u901f\u767c\u5c55\u3002\u7d0d\u65af\u9054\u514b\u73fe\u5728\u5c0d\u9ad8\u54c1\u8cea\u7684\u516c\u53f8\u958b\u653e\uff0c\u7121\u8ad6\u5b83\u5011\u4f4d\u65bc\u4f55\u8655\u3002<\/p>\n

 <\/p>\n

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