{"id":1172,"date":"2020-03-04T00:00:32","date_gmt":"2020-03-03T16:00:32","guid":{"rendered":"https:\/\/clarivate.com\/tw\/2020\/03\/04\/%e4%b8%80%e6%ac%a1%e6%b2%bb%e7%99%82%e7%b5%82%e8%ba%ab%e6%9c%89%e6%95%88%ef%bc%8c%e6%9c%89%e6%9c%9b%e6%94%b9%e8%ae%8aa%e5%9e%8b%e8%a1%80%e5%8f%8b%e7%97%85%e6%82%a3%e8%80%85%e6%9c%aa%e4%be%86%e7%9a%84\/?lang=zh-hant"},"modified":"2024-10-24T00:27:42","modified_gmt":"2024-10-24T00:27:42","slug":"therapies-poised-to-reshape-the-treatment-landscape-for-hematologic-disorders","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/zh\/blog\/therapies-poised-to-reshape-the-treatment-landscape-for-hematologic-disorders\/","title":{"rendered":"\u4e00\u6b21\u6cbb\u7642\u7d42\u8eab\u6709\u6548\uff0c\u6709\u671b\u6539\u8b8aA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u672a\u4f86\u7684\u57fa\u56e0\u7642\u6cd5"},"content":{"rendered":"<p><em>\u539f\u6587\u520a\u767b\u65bc\u79d1\u777f\u552f\u5b89\u65d7\u4e0b\u751f\u547d\u79d1\u5b78\u65b0\u805e\u5e73\u53f0\u00a0<a href=\"https:\/\/www.bioworld.com\/articles\/432950-therapies-poised-to-reshape-the-treatment-landscape-for-hematologic-disorders\" target=\"_blank\" rel=\"noopener noreferrer\">BioWorld \u7db2\u7ad9<\/a>\uff0c\u4f5c\u8005\u70ba Peter Winter<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>\u6578\u4ee5\u767e\u842c\u7684\u4eba\u60a3\u6709\u8840\u6db2\u7cfb\u7d71\u75be\u75c5\uff0c\u96a8\u8457\u4eba\u53e3\u9ad8\u9f61\u5316\uff0c\u8a72\u985e\u75be\u75c5\u7684\u767c\u75c5\u7387\u9810\u8a08\u9084\u6703\u589e\u52a0\u3002<\/p>\n<p>\u6839\u64da\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u7684\u5831\u5c0e\uff0c 2019\u5e74FDA\u6838\u51c6\u4e86\u597d\u5e7e\u7a2e\u65b0\u7642\u6cd5\uff0c\u62d3\u5c55\u5df2\u6838\u51c6\u7642\u6cd5\u7684\u65b0\u9069\u61c9\u75c7\uff0c\u7528\u65bc\u6cbb\u7642\u975e\u60e1\u6027\u8840\u6db2\u75c5\u60a3\u8005\u3002\u9019\u4e9b\u7642\u6cd5\u5305\u62ec\u91dd\u5c0d\u942e\u72c0\u7d30\u80de\u75be\u75c5\u7684\u5169\u7a2e\u75be\u75c5\u7de9\u89e3\u7642\u6cd5\uff08disease-modifying\uff09\u548c\u9996\u6b21\u53ef\u6cbb\u7642\u5152\u7ae5\u975c\u8108\u8840\u6813\u6813\u585e\u7684\u6297\u51dd\u5291\u3002<\/p>\n<p>\u800c\u5176\u4e2d\uff0c\u5169\u7a2e\u6f5b\u5728\u7684\u91cd\u78c5\u85e5\u7269 \u2500 \u7528\u65bcA\u578b\u8840\u53cb\u75c5\u6cbb\u7642\u7684 Valrox \uff08valoctocogene roxaparvovec\uff09\u548c\u6162\u6027\u814e\u81df\u75c5\u76f8\u95dc\u6027\u8ca7\u8840\u7684 vadadustat \u2500 \u5247\u6709\u671b\u91cd\u5851\u8840\u6db2\u7cfb\u7d71\u75be\u75c5\u7684\u6cbb\u7642\u524d\u666f\uff0c\u540c\u6642\u540d\u5217\u65bc<a href=\"https:\/\/clarivate.com\/zh-hant\/news\/news-releases-2020-0211\/\">\u300a2020 Cortellis Drugs to Watch\u300b<\/a>\u768411\u7a2e\u52302024\u5e74\u9810\u8a08\u5c07\u5be6\u73fe10\u5104\u7f8e\u5143\u5e74\u92b7\u552e\u984d\u7684\u85e5\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>A<\/strong><strong>\u578b\u8840\u53cb\u75c5<\/strong><\/h3>\n<p>A\u578b\u8840\u53cb\u75c5\uff0c\u4e5f\u7a31\u70ba\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\uff08FVIII\uff09\u7f3a\u4e4f\u75c7\u6216\u7d93\u5178\u8840\u53cb\u75c5\uff0c\u662f\u4e00\u7a2e\u7531\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u7f3a\u5931\u6216\u7f3a\u9677\u5f15\u8d77\u7684\u907a\u50b3\u6027\u75be\u75c5\u3002\u60a3\u6709\u9019\u7a2e\u75be\u75c5\u7684\u4eba\u5373\u4f7f\u53d7\u5230\u8f15\u5ea6\u50b7\u5bb3\u4e5f\u6709\u75db\u82e6\u4e0d\u582a\uff0c\u751a\u81f3\u53ef\u80fd\u6709\u751f\u547d\u5371\u96aa\u51fa\u8840\u4e8b\u4ef6\u7684\u98a8\u96aa\u3002\u6839\u64da\u7f8e\u570b\u75be\u75c5\u7ba1\u5236\u4e2d\u5fc3\uff08CDC\uff09\u7684\u5831\u5c0e\uff0c\u5728\u7f8e\u570b\uff0c\u6bcf5,000\u4f8b\u6d3b\u7522\u80ce\u5152\u4e2d\u5c31\u67091\u4f8b\u80ce\u5152\u60a3\u6709\u8a72\u75c5\uff0c\u8840\u53cb\u75c5\u60a3\u8005\u7e3d\u6578\u7d04\u70ba20,000\u4eba\u3002\u64da\u5168\u7403\u8840\u53cb\u75c5\u767c\u75c5\u7387\u7684\u6e96\u78ba\u6578\u64da\uff0c\u4f30\u8a08\u5168\u7403\u6709\u8d85\u904e40\u842c\u7684\u8840\u53cb\u75c5\u60a3\u8005\u3002<\/p>\n<p>\u91cd\u75c7A\u578b\u8840\u53cb\u75c5\u60a3\u8005\u7d93\u5e38\u6703\u767c\u751f\u81ea\u767c\u6027\u4e14\u75bc\u75db\u7684\u808c\u8089\u6216\u95dc\u7bc0\u90e8\u4f4d\u7684\u51fa\u8840\uff0c\u8a72\u4eba\u7fa4\u7d04\u5360A\u578b\u8840\u53cb\u75c5\u60a3\u8005\u7e3d\u6578\u768443\uff05\u3002\u6b64\u985e\u60a3\u8005\u7684\u6a19\u6e96\u7642\u6cd5\uff08SOC\uff09\u662f\u9810\u9632\u6027\u7684\u9032\u884c\u66ff\u4ee3\u6027\u7684\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u6ce8\u5c04\uff0c\u983b\u7387\u5728\u6bcf\u9031\u975c\u8108\u6ce8\u5c042\u81f33\u6b21\u6216\u6bcf\u5e74\u6ce8\u5c04100\u81f3150\u6b21\u3002\u5118\u7ba1\u63a5\u53d7\u9019\u6a23\u7684\u6cbb\u7642\uff0c\u8a31\u591a\u60a3\u8005\u4ecd\u6703\u767c\u751f\u51fa\u8840\u4e8b\u4ef6\uff0c\u5f15\u767c\u6301\u7e8c\u9032\u5c55\u3001\u7834\u58de\u6027\u7684\u95dc\u7bc0\u640d\u50b7\uff0c\u800c\u9019\u53ef\u80fd\u5c0d\u4ed6\u5011\u7684\u751f\u6d3b\u8cea\u91cf\u7522\u751f\u91cd\u5927\u5f71\u97ff\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u4e00\u52de\u6c38\u9038\u7684\u7642\u6cd5<\/strong><\/h3>\n<p>\u7e3d\u90e8\u4f4d\u65bc\u52a0\u5dde\u8056\u62c9\u6590\u723e\uff08San Rafael, Calif.\uff09\u7684Biomarin\u516c\u53f8\uff08Biomarin Pharmaceutical Inc.\uff09\u5df2\u5411FDA\u63d0\u4ea4\u4e86BLA\uff08\u751f\u7269\u85e5\u4e0a\u5e02\u7533\u8acb\uff09\uff0c\u7528\u65bc\u7533\u8acb\u5176\u91dd\u5c0dA\u578b\u8840\u53cb\u75c5\u6210\u4eba\u60a3\u8005\u7684\u4ee5\u817a\u76f8\u95dc\u75c5\u6bd2 (adeno-associated virus, AAV)\u70ba\u8f09\u9ad4\u7684\u57fa\u56e0\u6cbb\u7642\u85e5\u7269 Valrox \u7642\u6cd5\u4e0a\u5e02\u3002\u8a72\u7642\u6cd5\u7684\u7b56\u7565\u662f\u5c07\u6b63\u5e38\u529f\u80fd\u7684\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u7684\u57fa\u56e0\u905e\u9001\u81f3\u60a3\u8005\u7684\u7d30\u80de\u4e2d\uff0c\u4f7f\u4ed6\u5011\u80fd\u5920\u7522\u751f\u6709\u529f\u80fd\u7684\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u4f86\u66ff\u4ee3\u4e4b\u524d\u7f3a\u5931\u7684\u6216\u6709\u7f3a\u9677\u7684\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u3002\u5982\u679c\u7372\u5f97\u6838\u51c6\uff0cValrox \u5c07\u6210\u70ba\u6cbb\u7642A\u578b\u8840\u53cb\u75c5\u7684\u7b2c\u4e00\u6b3e\u5177\u6709\u6cbb\u7652\u6f5b\u80fd\u7684\u7642\u6cd5\uff0c\u4e00\u6b21\u6ce8\u5c04\u5373\u6d88\u9664\u4e86\u8f38\u8840\u548c\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u66ff\u4ee3\u7642\u6cd5\u7684\u9700\u8981\u3002FDA\u5df2\u65bc2\u6708\u63a5\u53d7\u4e86\u751f\u7269\u85e5\u4e0a\u5e02\u7533\u8acb\u53ca\u512a\u5148\u5be9\u67e5 (Priority review)\uff0c\u4e26\u5c07PDUFA\u65e5\u5b9a\u57288\u670821\u65e5\u3002<\/p>\n<p>FDA\u5df2\u6388\u4e88\u8a72\u7642\u6cd5\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u548c\u5b64\u5152\u85e5\u8cc7\u683c\u3002 EMA\u4e5f\u5df2\u901a\u904e\u52a0\u901f\u8a55\u5be9\u9a57\u8b49\u4e86\u516c\u53f8\u7684\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n<p>\u6839\u64da<a href=\"https:\/\/clarivate.com\/zh-hant\/news\/news-releases-2020-0211\/\">\u300a2020 Cortellis Drugs to Watch\u300b<\/a>\u5206\u6790\uff0c\u9019\u6b21\u4e0a\u5e02\u7533\u8acb\u662f\u57fa\u65bc\u4e00\u9805\u540d\u70baGENEr8-1\u7684\u81e8\u5e8aIII\u671f\u7814\u7a76\u7684\u4e2d\u671f\u6578\u64da\u4ee5\u53ca\u4e00\u9805\u4e09\u5e74\u671f\u7684I \/ II\u671f\u8a66\u9a57\u6578\u64da\u800c\u9032\u884c\u7684\u3002\u5728GENEr8-1\u7814\u7a76\u4e2d\uff0cValrox\u9054\u5230\u4e86\u7f8e\u570b\u548c\u6b50\u76df\u76e3\u7ba1\u5be9\u67e5\u7684\u9810\u5b9a\u6a19\u6e96\uff0c\u5728\u5305\u542b20\u540d\u60a3\u8005\u7684\u5be6\u9a57\u7d44\u4e2d\u67098\u540d\u60a3\u8005\u572823\u81f326\u5468\u6642\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u7684\u6d3b\u6027 (activity of FVIII)\u81f3\u5c11\u9054\u523040 IU \/ dl\uff1b\u6b63\u5728\u9032\u884c\u7684\u8a66\u9a57\u76ee\u7684\u5728\u65bc\u8a55\u4f30Valrox\u662f\u5426\u512a\u65bc\u76ee\u524d\u7684\u6a19\u6e96\u7642\u6cd5\u548c\u9810\u9632\u6027\u7642\u6cd5\u3002I \/ II\u671f\u7814\u7a76\u4e2d\u9ad8\u5291\u91cf\u7d44\u7d50\u679c\u986f\u793a100%\u6d88\u9664\u76ee\u6a19\u95dc\u7bc0\u7684\u51fa\u8840\uff0c\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u7684\u5e73\u5747\u5e74\u4f7f\u7528\u91cf\u6e1b\u5c11\u4e8696\uff05\uff0c\u4e26\u4e14\u6240\u6709\u60a3\u8005\u5747\u672a\u63a5\u53d7\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u9810\u9632\u6027\u6cbb\u7642\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u5c1a\u7121\u8840\u6813\u5f62\u6210\u4e8b\u4ef6\u6216\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u6291\u5236\u5291\u7684\u7522\u751f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u70ba\u60a3\u8005\u5e36\u4f86\u8b8a\u9769<\/strong><\/h3>\n<p>I \/ II\u671f\u7814\u7a76\u9996\u5e2d\u7814\u7a76\u54e1\u548cIII\u671f\u7814\u7a76\u9996\u5e2d\u7814\u7a76\u54e1John Pasi\u6307\u51fa\uff1a\u300c\u5118\u7ba1\u63a1\u7528\u7576\u524d\u7684\u6a19\u6e96\u7642\u6cd5\uff0c\u91cd\u5ea6A\u578b\u8840\u53cb\u75c5\u60a3\u8005\u4ecd\u6703\u767c\u751f\u81e8\u5e8a\u76f8\u95dc\u7684\u51fa\u8840\uff0c\u4e26\u4e14\u53ef\u80fd\u6703\u9650\u5236\u5176\u8eab\u9ad4\u6d3b\u52d5\u3002 Valrax (Valoctocogene roxaparvovec)\u4ee3\u8868\u4e00\u7a2e\u7814\u7a76\u4e2d\u7684\u4e14\u5177\u9769\u547d\u6027\u7684\u7642\u6cd5\uff0c\u53ef\u4ee5\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\uff0c\u5305\u62ec\u51fa\u8840\u3001\u8eab\u9ad4\u6a5f\u80fd\u3001\u751f\u6d3b\u6a5f\u80fd\u3001\u60c5\u7dd2\u3001\u6cbb\u7642\u6642\u7684\u6b35\u616e\u53ca\u6182\u5fc3\u2026\u7b49\u554f\u984c\u3002\u300d<\/p>\n<p>\u4eca\u5e74\u4e00\u6708\u4efd\uff0c\u8a72\u516c\u53f8\u767c\u4f48\u4e86I \/ II\u671f\u7814\u7a76\u7684\u70ba\u671f\u4e09\u5e74\u7684\u8ddf\u8e64\u6578\u64da\uff0c\u7d50\u679c\u986f\u793a6 e<sup>13<\/sup>-vg \/ kg\u5291\u91cf\u7d44\u60a3\u8005\u7d44\u4f7f\u7528\u5916\u6e90\u6027\u56e0\u5b50VIII\u7684\u4e2d\u4f4d\u6578\u5f9e\u6bcf\u5e74\u7684138.5\u6b21\u6ce8\u5c04\u5728\u7b2c\u4e09\u5e74\u7684\u6642\u5019\u6e1b\u70ba0\u6b21\u3002\u5728\u5165\u7d44\u7814\u7a76\u7684\u524d\u4e00\u5e74\uff0c\u6bcf\u4f4d\u53c3\u8207\u8005\u7684\u5e73\u5747\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u6ce8\u5c04\u5e74\u5747\u6b21\u6578\u70ba136.7 + 22.4\uff1b\u5728\u7b2c\u4e09\u5e74\u672b\uff0c\u5916\u6e90\u6027\u56e0\u5b50VIII\u7684\u5e74\u5747\u4f7f\u7528\u6b21\u6578\u4e0b\u964d\u4e8696\uff05\uff0c\u5e73\u5747\u6ce8\u5c04\u6b21\u6578\u70ba5.5 + 9.4\u3002<\/p>\n<p>John Pasi \u5728\u7814\u7a76\u7d50\u679c\u4e2d\u6307\u51fa\uff1a\u300c\u4f5c\u70ba\u4e3b\u6cbb\u91ab\u5e2b\uff0c\u6211\u5c0d\u57fa\u56e0\u6cbb\u7642\u5c0dA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u7684\u751f\u6d3b\u7522\u751f\u986f\u8457\u6539\u5584\u7684\u6f5b\u529b\u611f\u5230\u8208\u596e\u3002\u300d<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u5148\u767c\u512a\u52e2<\/strong><\/h3>\n<p>\u57282020\u5e741\u6708\u7684\u5e74\u5ea6JP Morgan\u91ab\u7642\u4fdd\u5065\u5927\u6703\u4e0a\u7684\u4e00\u6b21\u6f14\u8b1b\u4e2d\uff0cBiomarin\u8463\u4e8b\u9577\u517cCEO \u7684Jean-Jacques Bienaime\u8208\u596e\u5730\u900f\u9732\uff0c\u8a72\u516c\u53f8\u6b63\u5728\u63d0\u9ad8\u5176\u4f4d\u65bc\u52a0\u5ddeNovato\u7684\u5de5\u5ee0\u7684\u751f\u7522\u529b\uff0c\u53ef\u5c07\u7522\u80fd\u63d0\u9ad8\u4e00\u500d\u4ee5\u4e0a\uff0c\u9054\u5230\u6bcf\u5e74\u751f\u752210,000\u5291\u7684\u6c34\u6e96\u3002\u4ed6\u6307\u51fa\uff0c\u7522\u80fd\u63d0\u5347\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u70ba\u516c\u53f8\u5e0c\u671b\u80fd\u5920\u5118\u5feb\u5411\u57fa\u56e0\u6cbb\u7642\u5e02\u5834\u63d0\u4f9b\u670d\u52d9\uff0c\u300c\u5148\u767c\u512a\u52e2\u5728\u57fa\u56e0\u6cbb\u7642\u9818\u57df\u81f3\u95dc\u91cd\u8981\uff0c\u56e0\u70ba\u5728\u67d0\u7a2e\u610f\u7fa9\u4e0a\u6bcf\u7576\u4f60\u6cbb\u597d\u4e00\u4f4d\u60a3\u8005\uff0c\u90a3\u9ebc\u5e02\u5834\u4e0a\u5c31\u6703\u5c11\u4e00\u4f4d\u60a3\u8005\u3002\u300d<\/p>\n<p>\u57fa\u56e0\u7642\u6cd5\u80af\u5b9a\u6709\u5fb9\u5e95\u6539\u8b8aA\u578b\u8840\u53cb\u75c5\u60a3\u8005\u6cbb\u7642\u65b9\u5f0f\u7684\u6f5b\u529b\u3002\u4f46\u662f\uff0c\u6839\u64da\u52a0\u62ff\u5927\u8840\u53cb\u75c5\u5b78\u6703\u7684\u8aaa\u6cd5\uff0c\u300c\u5f9e\u672a\u6709\u5982\u6b64\u591a\u7684\u51dd\u8840\u7642\u6cd5\u8655\u65bc\u958b\u767c\u4e2d\u3002\u9664\u4e86\u6700\u8fd1\u63a8\u51fa\u7684\u5927\u91cf\u7642\u6cd5\u5916\uff0c\u6211\u5011\u77ad\u89e3\u5230\u9084\u6709\u53e6\u591618\u7a2e\u6b63\u5728\u958b\u767c\u4e2d\u6216\u5373\u5c07\u4e0a\u5e02\u7684\u65b0\u7642\u6cd5\uff0c\u5305\u62ec6\u7a2e\u6fc3\u7e2e\u51dd\u8840\u56e0\u5b50\uff0c4\u7a2e\u4f7f\u7528\u6291\u5236\u5291\u6cbb\u7642\u60a3\u8005\u7684\u7e5e\u9053\u7642\u6cd5(bypassing therapies)\uff0c\u5169\u7a2e\u975e\u56e0\u5b50\u985e\u4fc3\u51dd\u85e5\u7269\u548c5\u7a2e\u57fa\u56e0\u6cbb\u7642\u7522\u54c1\u3002\u300d<\/p>\n<p>Cortellis\u7684\u5206\u6790\u8868\u660e\uff0c\u5982\u679c\u7372\u5f97\u6838\u51c6\uff0cValrox\u80af\u5b9a\u6703\u9762\u81e8\u6210\u719f\u7684\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u66ff\u4ee3\u7642\u6cd5\u4ee5\u53ca\u5373\u5c07\u4e0a\u5e02\u7684\u66ff\u4ee3\u7642\u6cd5\u7684\u7af6\u722d\u3002<\/p>\n<p>\u8fd1\u671f\u6838\u51c6\u7684\u7642\u6cd5\uff0c\u4f8b\u5982\u7f85\u6c0f\uff08Roche Holding AG\uff09\u7684Hemlibra\uff08emicizumab\uff09\u548c\u62dc\u8033\uff08Bayer AG\uff09\u7684Jivi\uff08\u91cd\u7d44\u7684\u805a\u4e59\u4e8c\u9187\u5316\u6297\u8840\u53cb\u75c5\u56e0\u5b50\uff09\u6b63\u5728\u8c50\u5bcc\u60a3\u8005\u7684\u9078\u64c7\u3002\u5206\u6790\u6307\u51fa\uff0c\u8840\u53cb\u75c5\u5e02\u5834\u5728\u63a1\u7528\u65b0\u7642\u6cd5\u65b9\u9762\u6bd4\u8f03\u4fdd\u5b88\uff0c\u5982\u679c\u60a3\u8005\u76ee\u524d\u7684\u66ff\u4ee3\u7642\u6cd5\u6548\u679c\u826f\u597d\uff0c\u4ed6\u5011\u53ef\u80fd\u4e0d\u9858\u610f\u4f7f\u7528\u65b0\u7522\u54c1\u3002\u4f46\u4ecd\u5b58\u5728\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u56e0\u70ba\u5927\u7d0475\uff05\u7684A\u578b\u8840\u53cb\u75c5\u60a3\u8005\u5c0d\u5176\u73fe\u6709\u6cbb\u7642\u6c92\u6709\u8db3\u5920\u7684\u53cd\u61c9\uff0c\u6216\u8005\u751a\u81f3\u6839\u672c\u6c92\u6709\u63a5\u53d7\u6cbb\u7642\u3002\u5118\u7ba1\u5168\u4e16\u754c\u7bc4\u570d\u7684\u60a3\u75c5\u7387\u8f03\u4f4e\uff0c\u4f46\u63a1\u7528\u5b64\u5152\u5b9a\u50f9\uff0cA\u578b\u8840\u53cb\u75c5\u4ecd\u662f\u4e00\u500b\u5927\u7684\u5e02\u5834\u3002<\/p>\n<p>\u6b64\u5916\uff0cCortellis\u5206\u6790\u6307\u51fa\uff0cValrox\u81ea\u8eab\u4e26\u975e\u5b8c\u5168\u6c92\u6709\u554f\u984c\u3002\u8a72\u85e5\u7269\u5728III\u671fGENEr8-1\u81e8\u5e8a\u8a66\u9a57\u7684\u6700\u521d\u968a\u5217(cohort)\u4e2d\u672a\u9054\u6a19\uff1a\u572817\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u67093\u4f8b\u60a3\u8005\u9ad4\u5167\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u6d3b\u6027\u672a\u80fd\u9054\u5230\u9ad8\u65bc5 IU \/ dl\u3002\u6574\u500b\u968a\u5217\u7684\u5e73\u5747\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u6d3b\u6027\u548c\u4e2d\u4f4d\u6578\u4e5f\u4f4e\u65bcI \/ II\u671f\u7684\u7d50\u679c\uff0c\u5206\u5225\u70ba33 IU \/ dl\u548c36 IU \/ dl\u3002\u4e00\u65e6\u7372\u5f97\u4e86\u5b8c\u6574\u7684\u6578\u64da\u4e14\u8868\u660e\u7121\u6cd5\u63d0\u9ad8\u75c5\u4eba\u5c0d\u85e5\u7269\u7684\u53cd\u61c9\uff0c\u5247\u53ef\u80fd\u6703\u5f71\u97ff\u6f5b\u5728\u7684\u5546\u696d\u61c9\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Valrox\u53ef\u80fd\u6210\u70ba\u53f2\u4e0a\u6700\u8cb4\u7642\u6cd5<\/strong><\/h3>\n<p>\u53bb\u5e74\u5168\u7403A\u578b\u8840\u53cb\u75c5\u7684\u5e02\u5834\u4f30\u8a08\u63a5\u8fd1100\u5104\u7f8e\u5143\uff0cBienaime\u5728\u4ed6\u7684\u6f14\u8b1b\u4e2d\u8aaa\uff1a\u300c\u4f30\u8a08\u6709121,000\u540d\u60a3\u8005\u5c6c\u4fdd\u96aa\u516c\u53f8\u8986\u84cb\u7684\u7bc4\u570d\u5167\u3002\u5118\u7ba1\u8a72\u57fa\u56e0\u7642\u6cd5\u7684\u5b9a\u50f9\u5c1a\u672a\u78ba\u5b9a\uff0c\u516c\u53f8\u5df2\u7d93\u9032\u884c\u4e86\u5927\u91cf\u4ed8\u8cbb\u8005\u7814\u7a76(payer research)\u3002\u4ed6\u8868\u793a\uff0c\u4ed8\u6b3e\u4eba\u8a8d\u70baA\u578b\u8840\u53cb\u75c5\u7684\u751f\u7406\u77ef\u6b63\u5177\u6709\u5f88\u9ad8\u7684\u50f9\u503c\uff0c\u800c\u4e14\u770b\u4f86\u7f8e\u570b\u7684\u4ed8\u8cbb\u8005\u65cf\u7fa4\u9858\u610f\u63a5\u53d7200\u842c\u81f3300\u842c\u7f8e\u5143\u7684\u50f9\u683c\u3002\u300d<\/p>\n<p>\u9452\u65bcHemlibra\u5728\u9ad4\u5167\u7121\u6291\u5236\u5291\u7684\u6210\u5e74\u60a3\u8005\u4e2d\u7684\u6279\u91cf\u63a1\u8cfc\u50f9\u683c\u5728\u6bcf\u5e7460\u842c\u7f8e\u5143\u81f380\u842c\u7f8e\u5143\u4e4b\u9593\uff0cBiomarin\u7684\u9810\u8a08\u5b9a\u50f9\u5728100\u842c\u7f8e\u5143\u81f3500\u842c\u7f8e\u5143\u4e4b\u9593\u3002\u7531\u65bc\u5230\u4e0a\u5e02\u6642\u5c07\u6703\u6709\u56db\u5e74\u591a\u7684Valrox\u7684\u6578\u64da\uff0c\u50f9\u683c\u53ef\u4ee5\u5b9a\u70baHemlibra\u5e73\u5747\u50f9\u683c\uff08700,000\u7f8e\u5143\uff09\u7684\u56db\u500d\uff0c\u78ba\u5b9a\u5728280\u842c\u7f8e\u5143\u3002\u9019\u5c07\u4f7f\u5176\u6210\u70ba\u6700\u6602\u8cb4\u7684\u4e00\u6b21\u6027\u7642\u6cd5\uff0c\u8d85\u904e\u8afe\u83ef\u516c\u53f8\u7684\u810a\u9ad3\u6027\u808c\u840e\u7e2e\u57fa\u56e0\u7642\u6cd5Zolgensma\uff08onasemnogene abeparvovec-xioi\uff09210\u842c\u7f8e\u5143\u7684\u50f9\u683c\u3002\u8a72\u516c\u53f8\u8868\u793a\uff0c\u9019\u662f\u91dd\u5c0d\u8840\u53cb\u75c5\u7684\u7b2c\u4e00\u6b3e\u57fa\u56e0\u7642\u6cd5\uff0c\u6210\u529f\u6cbb\u7642\u4e00\u4f4d\u5178\u578b\u60a3\u8005\uff0c\u5c07\u6703\u70ba\u91ab\u7642\u4fdd\u5065\u7cfb\u7d71\u7bc0\u7701\u8d85\u904e2000\u842c\u7f8e\u5143\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u5373\u4f7f\u6ef2\u900f\u7387\u4e0d\u9ad8\uff0cValrox\u4ecd\u9810\u671f\u7372\u5f97\u53ef\u89c0\u7684\u6536\u5165\u3002Cortellis\u5206\u6790\u9810\u6e2c\uff0c\u4eca\u5e74Valrox\u7684\u92b7\u552e\u984d\u5c07\u9054\u52301745\u842c\u7f8e\u5143\uff0c\u52302024\u5e74\u5c07\u589e\u9577\u81f312.97\u5104\u7f8e\u5143\u3002\u7136\u800c\uff0c\u5118\u7ba1Biomarin\u6191\u85c9\u5176\u57fa\u56e0\u7642\u6cd5\u8655\u65bc\u9818\u5148\u5730\u4f4d\uff0c\u4f46\u6b63\u5728\u958b\u767c\u7684\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u57fa\u56e0\u7642\u6cd5\u7684\u6f5b\u5728\u7af6\u722d\u8005\u53ef\u80fd\u6703\u524a\u5f31\u8a72\u516c\u53f8\u4e2d\u9577\u671f\u7684\u9810\u6e2c\u92b7\u552e\u984d\u3002Spark Therapeutics\u7684SPK-8011\u65bc2019\u5e742\u6708\u9032\u5165III\u671f\u7814\u7a76\uff0c\u5728\u4e4b\u524d\u7684I \/ II\u671f\u7814\u7a76\u4e2d\u986f\u793a\u8a72\u7642\u6cd5\u53ef\u4f7f\u60a3\u8005\u51fa\u8840\u6642\u9593\u767c\u751f\u7387\u6e1b\u5c1194%\uff0c\u7b2c\u516b\u51dd\u8840\u56e0\u5b50\u6ce8\u5c04\u6e1b\u5c1195%\u3002\u5176\u4ed6\u8655\u65bcI \/ II\u671f\u958b\u767c\u968e\u6bb5\u7684\u76f4\u63a5\u7af6\u722d\u5c0d\u624b\u5305\u62ecUltragenyx Pharmaceutical\u7684DTX-201\uff0cSpark\u7684SPK-8016\uff0c Shire \u7684SHP-654\u548c\u502b\u6566\u5927\u5b78\u5b78\u9662\uff08UCL\uff09\/\u8056\u88d8\u5fb7\u5152\u7ae5\u7814\u7a76\u91ab\u9662\u7684AAV2 \/ 8-HLP-FVIII-V3\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_5813\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-5813\" class=\"wp-image-5813 size-large\" src=\"http:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-sales-forecast-2020-1024x478.jpg\" alt=\"A\u578b\u8840\u53cb\u75c5\u85e5\u7269\u672a\u4f865\u5e74\u92b7\u552e\u9810\u6e2c\uff08Source: Cortellis Competitive Intelligence\uff09\" width=\"640\" height=\"299\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-sales-forecast-2020-1024x478.jpg 1024w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-sales-forecast-2020-300x140.jpg 300w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-sales-forecast-2020-768x358.jpg 768w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-sales-forecast-2020-86x40.jpg 86w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-sales-forecast-2020.jpg 1050w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><p id=\"caption-attachment-5813\" class=\"wp-caption-text\">A\u578b\u8840\u53cb\u75c5\u85e5\u7269\u672a\u4f865\u5e74\u92b7\u552e\u9810\u6e2c\uff08Source: <a href=\"https:\/\/clarivate.com\/cortellis\/zh-hant\/solutions\/competitive-intelligence-and-analytics\/\" target=\"_blank\" rel=\"noopener\">Cortellis Competitive Intelligence<\/a>\uff09<\/p><\/div>\n<p>&nbsp;<\/p>\n<div id=\"attachment_5814\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-5814\" class=\"wp-image-5814 size-large\" src=\"http:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-DTSR-2020-1024x439.jpg\" alt=\"A\u578b\u8840\u53cb\u75c5\u85e5\u7269\u4e0a\u5e02\u6642\u9593\u8207\u6210\u529f\u7387\u9810\u6e2c (Source: Cortellis Analytics - DTSR)\" width=\"640\" height=\"274\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-DTSR-2020-1024x439.jpg 1024w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-DTSR-2020-300x129.jpg 300w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-DTSR-2020-768x329.jpg 768w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-DTSR-2020-93x40.jpg 93w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/Valrox-Cortellis-DTSR-2020.jpg 1228w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><p id=\"caption-attachment-5814\" class=\"wp-caption-text\">A\u578b\u8840\u53cb\u75c5\u85e5\u7269\u4e0a\u5e02\u6642\u9593\u8207\u6210\u529f\u7387\u9810\u6e2c (Source: <a href=\"https:\/\/clarivate.com\/cortellis\/zh-hant\/solutions\/competitive-intelligence-and-analytics\/\" target=\"_blank\" rel=\"noopener\">Cortellis Analytics &#8211; DTSR<\/a>)<\/p><\/div>\n<p>&nbsp;<\/p>\n<h3><strong>\u6162\u6027\u814e\u75c5\u6027\u8ca7\u8840<\/strong><\/h3>\n<p>\u8ca7\u8840\u662f\u6162\u6027\u814e\u81df\u75c5\uff08CKD\uff09\u7684\u8a31\u591a\u4f75\u767c\u75c7\u4e4b\u4e00\uff0c\u96a8\u8457\u814e\u81df\u75be\u75c5\u7684\u9032\u5c55\u800c\u60e1\u5316\uff1b\u5927\u591a\u6578CKD\u9032\u5c55\u70ba\u814e\u8870\u7aed\u7684\u60a3\u8005\u90fd\u60a3\u6709\u56b4\u91cd\u8ca7\u8840\u3002\u64da\u4f30\u8a08\uff0c\u5168\u7403CKD\u60a3\u8005\u7d04\u67092\u5104\u4eba\u3002CKD\u8ca7\u8840\u76ee\u524d\u4f7f\u7528\u53ef\u6ce8\u5c04\u7684\u91cd\u7d44\u4fc3\u7d05\u7d30\u80de\u751f\u6210\u523a\u6fc0\u5291\uff08ESA\uff09\u9032\u884c\u6cbb\u7642\uff0c\u4f46\u5e38\u898b\u8840\u7d05\u86cb\u767d\u53cd\u61c9\u4e0d\u4e00\u81f4\u548c\u5b89\u5168\u6027\u98a8\u96aa\u3002<\/p>\n<p>\u8ffd\u6c42\u66f4\u6709\u6548\uff0c\u66f4\u5b89\u5168\u7684\u7642\u6cd5\u7684\u9700\u6c42\u5f15\u767c\u4e86\u7f3a\u6c27\u8a98\u5c0e\u56e0\u5b50\u812f\u6c28\u91af\u7fa5\u5316\u9176\uff08HIF-PH\uff09\u6291\u5236\u5291\u7684\u767c\u73fe\uff0c\u9019\u662f\u4e00\u985e\u7528\u65bc\u6cbb\u7642CKD\u8ca7\u8840\u7684\u65b0\u578b\u85e5\u7269\u3002\u9019\u4e9b\u85e5\u7269\u901a\u904e\u7a69\u5b9aHIF\u8907\u5408\u7269\u548c\u523a\u6fc0\u5167\u6e90\u6027\u7d05\u8840\u7403\u751f\u6210\u7d20\u7684\u7522\u751f\u800c\u8d77\u4f5c\u7528\uff0c\u5373\u4f7f\u5728\u60a3\u6709\u665a\u671f\u814e\u81df\u75be\u75c5\u7684\u60a3\u8005\u4e2d\u4e5f\u53ef\u8d77\u6548\u3002<\/p>\n<p>\u76ee\u524d\u6709\u5e7e\u7a2eHIF-PH\u9176\u6291\u5236\u5291\u6b63\u5728\u958b\u767c\u4e2d\uff0c\u4ed6\u5011\u7684\u76ee\u6a19\u5e02\u5834\u662f\u4f30\u503c\u70ba35\u5104\u7f8e\u5143\u7684\u814e\u6027\u8ca7\u8840\u5e02\u5834\u3002\u9019\u4e9b\u85e5\u7269\u4e2d\u5305\u62ec\u4f4d\u65bc\u9ebb\u5dde\u528d\u6a4b\u5e02Akebia Therapeutics\u7684vadadustat\uff0c\u8a72\u85e5\u7269\u5df2\u7d93\u9032\u5165\u665a\u671f\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\u30022019\u5e747\u6708\uff0c\u5176\u6230\u7565\u5408\u4f5c\u5925\u4f34\u4e09\u83f1\u7530\u908a\u88fd\u85e5\u516c\u53f8\uff08<a href=\"https:\/\/www.bioworld.com\/articles\/429636-hif-hif-hooray-heartfelt-faith-in-ckd-anemia-class-street-sorts-market-odds\" target=\"_blank\" rel=\"noopener noreferrer\">Mitsubishi Tanabe Pharma Corp.<\/a>\uff09\u5411\u65e5\u672c\u539a\u751f\u52de\u52d5\u7701\u63d0\u4ea4\u4e86\u65b0\u85e5\u7533\u8acb\uff0c\u7533\u8acb\u6838\u51c6\u8a72\u7522\u54c1\u7528\u65bcCKD\u8ca7\u8840\u7684\u6cbb\u7642\u3002<\/p>\n<p>\u8a72\u7533\u8acb\u57fa\u65bc\u56db\u9805\u91dd\u5c0d\u65e5\u672c\u60a3\u8005\u9032\u884c\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u6578\u64da\uff1a\u4e00\u9805\u91dd\u5c0d\u4e0d\u9700\u900f\u6790\u6cbb\u7642CKD\u8ca7\u8840\u7684\u4e3b\u52d5\u5c0d\u7167\u7814\u7a76\uff08J01\uff09\uff0c\u53e6\u4e00\u9805\u91dd\u5c0d\u9700\u900f\u6790\u6cbb\u7642CKD\u8ca7\u8840\u7684\u4e3b\u52d5\u5c0d\u7167\u7814\u7a76\uff08J03\uff09\u548c\u5169\u9805\u8179\u819c\u548c\u8840\u6db2\u900f\u6790\u4f9d\u8cf4\u6027CKD\u8ca7\u8840\u60a3\u8005\u7684\u55ae\u81c2\u7814\u7a76\uff08J02\u548cJ04\uff09\u3002\u5728\u900f\u6790\u548c\u975e\u900f\u6790\u60a3\u8005\u4e2d\uff0c\u4f7f\u7528Vadadustat\u60a3\u8005\u7684\u8840\u7d05\u86cb\u767d\u6c34\u5e73\u4e0d\u905c\u65bc\u967d\u6027\u5c0d\u7167\u85e5Darbepoetin alfa\uff08J01\u548cJ03\u7814\u7a76\uff1b 11.66 vs 11.93 g \/ dL\uff0c10.61 vs 10.65 g \/ dL\uff09\uff0c\u4e26\u5728\u55ae\u81c2\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u6cbb\u7642\u6548\u679c\u3002<\/p>\n<p>\u5982\u679c\u7372\u5f97\u6838\u51c6\uff0c\u8a72\u516c\u53f8\u9810\u8a08\u5c07\u57282020\u5e74\u4e2d\u4e0a\u5e02\uff0c\u4e26\u8a08\u5283\u5728\u7f8e\u570b\u548c\u6b50\u76df\u63d0\u4ea4\u7533\u8acb\uff0c\u9019\u4e9b\u5730\u5340\u5c07\u7531Akebia\u8207\u5927\u585a\u88fd\u85e5\uff08Otsuka Pharmaceutical Co., Ltd.\uff09\u806f\u5408\u92b7\u552e\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>HIF-PH<\/strong><strong>\u6291\u5236\u5291\u7684\u7af6\u722d<\/strong><\/h3>\n<p>\u5728HIF-PH\u6291\u5236\u5291\u672c\u8eab\u9019\u500b\u985e\u5225\u4e2d\uff0c\u7279\u5225\u662f\u4f86\u81eaFibrogen Inc.\u7684Evrenzo\uff08roxadustat\uff09\uff08HIF-PH\u6291\u5236\u5291\u4e2d\u7684first-in-class\u85e5\u7269\uff09\uff0c\u662fvadadustat\u5c07\u9762\u81e8\u7684\u76f4\u63a5\u7af6\u722d\u8005\u3002Fibrogen\u5df2\u8207\u5b89\u65af\u6cf0\u4f86\uff08Astellas Pharma Inc.\uff09\u548c\u963f\u65af\u7279\u6377\u5229\u5eb7\uff08Astrazeneca plc\uff09\u5408\u4f5c\u958b\u767c\u548c\u92b7\u552eEvrenzo\uff0c\u8a72\u85e5\u7269\u5df2\u65bc2019\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5728\u65e5\u672c\uff08\u900f\u6790\u60a3\u8005\uff09\u548c\u4e2d\u570b\uff08\u900f\u6790\u548c\u975e\u900f\u6790\u60a3\u8005\uff09\u7372\u5f97\u4e0a\u5e02\u6838\u51c6\u3002\u9810\u8a08\u8a72\u85e5\u6703\u5728\u77ed\u671f\u5167\u5b8c\u6210\u7b2c\u4e8c\u9805\u91dd\u5c0d\u975e\u900f\u6790\u60a3\u8005\u7684\u95dc\u9375\u6027\u7814\u7a76\uff0c\u5c46\u6642\u5c07\u5728\u65e5\u672c\u905e\u4ea4\u589e\u52a0\u76f8\u95dc\u9069\u61c9\u75c7\u7684\u7533\u8acb\u3002\u6839\u64daCortellis\u7684\u7d00\u9304\uff0c\u5728ALPS\uff08\u975e\u900f\u6790\u76f8\u95dc\uff09\u548cHIMALAYAS\uff08\u900f\u6790\u76f8\u95dc\uff09\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u6578\u64da\u826f\u597d\u7684\u60c5\u6cc1\u4e0b\uff0c\u8a72\u85e5\u7269\u4e5f\u5df2\u5728\u7f8e\u570b\uff08\u91dd\u5c0d\u4ee5\u4e0a\u5169\u7a2e\u60a3\u8005\u4eba\u7fa4\uff09\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8acb\uff0c\u4e26\u6709\u671b\u5728\u4eca\u5e743\u6708\u4efd\u5411\u6b50\u76df\u63d0\u4ea4\u7533\u8acb\u3002<\/p>\n<p>\u5206\u6790\u8868\u660e\uff0cvadadustat\u9084\u5c07\u9762\u81e8\u4f86\u81eaCKD\u4e2d\u5176\u4ed6\u516c\u8a8d\u7642\u6cd5\u7684\u7af6\u722d\uff0c\u4f8b\u5982\u975c\u8108\u6ce8\u5c04\u9435\u5291\u66ff\u4ee3\u985e\u7522\u54c1\u548c\u8f38\u8840\u7642\u6cd5\uff0c\u9019\u4e9b\u7642\u6cd5\u53ef\u8fc5\u901f\u589e\u52a0Hb\u6c34\u5e73\u3002<\/p>\n<p>\u672a\u4f86\u7684\u76f4\u63a5\u7af6\u722d\u4e5f\u5c07\u4f86\u81eaGSK\u7684HIF-PH\u6291\u5236\u5291daprodustat\uff0c\u8a72\u85e5\u5df2\u65bc\u53bb\u5e74(2019) 8\u6708\u5728\u65e5\u672c\u63d0\u4ea4\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n<p>Cortellis\u5206\u6790\u5f15\u7528\u4e862024\u5e74\u7684\u9810\u6e2c\u92b7\u552e\u984d\uff08Cortellis\u5206\u6790\u5c0d\u4e09\u7a2eHIF-PH\u6291\u5236\u52912024\u5e74\u92b7\u552e\u984d\u9032\u884c\u4e86\u9810\u6e2c\uff09\uff0cEvrenzo\u64da\u4f30\u70ba11.88\u5104\u7f8e\u5143\uff0cdaprodustat\u64da\u4f30\u70ba\u70ba2.86\u5104\u7f8e\u5143\u3002\u5c0d\u65bcvadadustat\uff0c\u9810\u8a08\u4eca\u5e74\u7684\u92b7\u552e\u984d\u70ba200\u842c\u7f8e\u5143\uff0c\u52302024\u5e74\u5c07\u589e\u81f315.89\u5104\u7f8e\u5143\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_5815\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-5815\" class=\"wp-image-5815 size-large\" src=\"http:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-sales-forecast-2020-1024x478.png\" alt=\"\u8ca7\u8840\u85e5\u7269\u672a\u4f865\u5e74\u92b7\u552e\u9810\u6e2c (Source: Cortellis Competitive Intelligence)\" width=\"640\" height=\"299\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-sales-forecast-2020-1024x478.png 1024w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-sales-forecast-2020-300x140.png 300w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-sales-forecast-2020-768x358.png 768w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-sales-forecast-2020-86x40.png 86w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-sales-forecast-2020.png 1050w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><p id=\"caption-attachment-5815\" class=\"wp-caption-text\">\u8ca7\u8840\u85e5\u7269\u672a\u4f865\u5e74\u92b7\u552e\u9810\u6e2c (Source: <a href=\"https:\/\/clarivate.com\/cortellis\/zh-hant\/solutions\/competitive-intelligence-and-analytics\/\" target=\"_blank\" rel=\"noopener\">Cortellis Competitive Intelligence<\/a>)<\/p><\/div>\n<p>&nbsp;<\/p>\n<div id=\"attachment_5816\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-5816\" class=\"wp-image-5816 size-large\" src=\"http:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-DTSR-2020-1024x364.jpg\" alt=\"\u8ca7\u8840\u85e5\u7269\u4e0a\u5e02\u6642\u9593\u53ca\u6210\u529f\u7387\u9810\u6e2c (Source: Cortellis Analytics - DTSR)\" width=\"640\" height=\"228\" srcset=\"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-DTSR-2020-1024x364.jpg 1024w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-DTSR-2020-300x107.jpg 300w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-DTSR-2020-768x273.jpg 768w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-DTSR-2020-113x40.jpg 113w, https:\/\/clarivate.com\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2020\/03\/vadadustat-Cortellis-DTSR-2020.jpg 1228w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><p id=\"caption-attachment-5816\" class=\"wp-caption-text\">\u8ca7\u8840\u85e5\u7269\u4e0a\u5e02\u6642\u9593\u53ca\u6210\u529f\u7387\u9810\u6e2c (Source: <a href=\"https:\/\/clarivate.com\/cortellis\/zh-hant\/solutions\/competitive-intelligence-and-analytics\/\" target=\"_blank\" rel=\"noopener\">Cortellis Analytics &#8211; DTSR<\/a>)<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u539f\u6587\u520a\u767b\u65bc\u79d1\u777f\u552f\u5b89\u65d7\u4e0b\u751f\u547d\u79d1\u5b78\u65b0\u805e\u5e73\u53f0\u00a0BioWorld \u7db2\u7ad9\uff0c\u4f5c\u8005\u70ba Peter Winter &nbsp; \u6578\u4ee5\u767e\u842c\u7684\u4eba\u60a3\u6709\u8840\u6db2\u7cfb\u7d71\u75be\u75c5\uff0c\u96a8\u8457\u4eba\u53e3\u9ad8\u9f61\u5316\uff0c\u8a72\u985e\u75be\u75c5\u7684\u767c\u75c5\u7387\u9810\u8a08\u9084\u6703\u589e\u52a0\u3002 \u6839\u64da\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u7684\u5831\u5c0e\uff0c 2019\u5e74FDA\u6838\u51c6\u4e86\u597d\u5e7e\u7a2e\u65b0\u7642\u6cd5\uff0c\u62d3\u5c55\u5df2\u6838\u51c6\u7642\u6cd5\u7684\u65b0\u9069\u61c9\u75c7\uff0c\u7528\u65bc\u6cbb\u7642\u975e\u60e1\u6027\u8840\u6db2\u75c5\u60a3\u8005\u3002\u9019\u4e9b\u7642\u6cd5\u5305\u62ec\u91dd\u5c0d\u942e\u72c0\u7d30\u80de\u75be\u75c5\u7684\u5169\u7a2e\u75be\u75c5\u7de9\u89e3\u7642\u6cd5\uff08disease-modifying\uff09\u548c\u9996\u6b21\u53ef\u6cbb\u7642\u5152\u7ae5\u975c\u8108\u8840\u6813\u6813\u585e\u7684\u6297\u51dd\u5291\u3002 \u800c\u5176\u4e2d\uff0c\u5169\u7a2e\u6f5b\u5728\u7684\u91cd\u78c5\u85e5\u7269 \u2500 \u7528\u65bcA\u578b\u8840\u53cb\u75c5\u6cbb\u7642\u7684 Valrox \uff08valoctocogene roxaparvovec\uff09\u548c\u6162\u6027\u814e\u81df\u75c5\u76f8\u95dc\u6027\u8ca7\u8840\u7684 vadadustat \u2500 \u5247\u6709\u671b\u91cd\u5851\u8840\u6db2\u7cfb\u7d71\u75be\u75c5\u7684\u6cbb\u7642\u524d\u666f\uff0c\u540c\u6642\u540d\u5217\u65bc\u300a2020 Cortellis Drugs to Watch\u300b\u768411\u7a2e\u52302024\u5e74\u9810\u8a08\u5c07\u5be6\u73fe10\u5104\u7f8e\u5143\u5e74\u92b7\u552e\u984d\u7684\u85e5\u7269\u3002 &nbsp; A\u578b\u8840\u53cb\u75c5 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