{"id":1162,"date":"2020-03-27T00:00:11","date_gmt":"2020-03-26T16:00:11","guid":{"rendered":"https:\/\/clarivate.com\/tw\/2020\/03\/27\/filgotinib%e5%9f%ba%e6%96%bc%e5%a4%9a%e7%a8%ae%e6%bd%9b%e5%9c%a8%e9%81%a9%e6%87%89%e7%97%87%ef%bc%8c%e6%9c%89%e6%9c%9b%e5%8a%a0%e5%85%a5jak%e6%8a%91%e5%88%b6%e5%8a%91%e9%87%8d%e7%a3%85%e4%bf%b1\/?lang=zh-hant"},"modified":"2020-03-27T00:00:11","modified_gmt":"2020-03-26T16:00:11","slug":"filgotinib-looks-to-jak-up-sales-with-multiple-indications","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/zh\/blog\/filgotinib-looks-to-jak-up-sales-with-multiple-indications\/","title":{"rendered":"Filgotinib\u57fa\u65bc\u591a\u7a2e\u6f5b\u5728\u9069\u61c9\u75c7\uff0c\u6709\u671b\u52a0\u5165JAK\u6291\u5236\u5291\u91cd\u78c5\u4ff1\u6a02\u90e8"},"content":{"rendered":"<p><em>\u539f\u6587\u520a\u767b\u65bc\u79d1\u777f\u552f\u5b89\u65d7\u4e0b\u751f\u547d\u79d1\u5b78\u65b0\u805e\u5e73\u53f0\u00a0<a href=\"https:\/\/www.bioworld.com\/articles\/432952-filgotinib-looks-to-jak-up-sales-with-multiple-indications\" target=\"_blank\" rel=\"noopener noreferrer\">BioWorld \u7db2\u7ad9<\/a>\uff0c\u4f5c\u8005\u70ba Brian Orelli<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>\u6839\u64da<a href=\"https:\/\/clarivate.com\/zh-hant\/news\/news-releases-2020-0211\/\">Cortellis Drugs to Watch<\/a>\u7684\u6578\u64da\u5206\u6790\uff0cFilgotinib\uff08GLPG-0634\uff09\u64c1\u6709\u6210\u70ba\u91cd\u78c5\u85e5\u7269\u7684\u6f5b\u529b\uff0c\u5b83\u6709\u671b\u5728\u4e00\u7cfb\u5217\u9069\u61c9\u75c7\u7372\u6279\u4e4b\u5f8c\u9054\u5230\u4ee4\u4eba\u56ae\u5f80\u768410\u5104\u7f8e\u5143\u7684\u5e74\u92b7\u552e\u984d\u3002<\/p>\n<p>Filgotinib\u662f\u4e00\u7a2eJanus kinase 1\uff08JAK1\uff09\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff1bJAK1\u7684\u904e\u5ea6\u6d3b\u5316\/\u5931\u8abf\u80fd\u5920\u5c0e\u81f4\u81ea\u8eab\u514d\u75ab\u53cd\u61c9\u3002\u76ee\u524d\uff0cFilgotinib\u7528\u65bc\u6cbb\u7642\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\u7684\u5206\u5225\u65bc2019\u5e748\u6708\u5728\u6b50\u76df\u30012019\u5e7410\u6708\u5728\u65e5\u672c\u548c2019\u5e7412\u6708\u5728\u7f8e\u570b\u905e\u4ea4\u4e0a\u5e02\u7533\u8acb\uff0c\u4e26\u5148\u5f8c\u9032\u5165\u5be9\u67e5\u968e\u6bb5\u3002\u70ba\u4e86\u78ba\u4fdd\u8a72\u85e5\u80fd\u88abFDA\u5feb\u901f\u6279\u51c6\uff0c\u5409\u5229\u5fb7\u79d1\u5b78\u516c\u53f8\uff08Gilead Sciences Inc.\uff09\u4f7f\u7528\u4e86\u4e00\u5f35\u512a\u5148\u5be9\u67e5\u5238\uff0c\u9019\u5c07\u4f7f\u5be9\u67e5\u6642\u9593\u7e2e\u77ed\u56db\u500b\u6708\u3002<\/p>\n<p>\u4f5c\u70ba\u5409\u5229\u5fb7\u7684\u5408\u4f5c\u5925\u4f34\uff0cGalapagos NV\u548c\u885b\u6750\u5c07\u5728\u5168\u7403\u591a\u500b\u5730\u5340\u92b7\u552eFilgotinib\uff0c\u9032\u8ecd\u5230\u64c1\u64e0\u7684\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\u5e02\u5834\u4e2d\u3002\u9664\u4e86NSAID\uff0c\u985e\u56fa\u9187\u85e5\u7269\u548c\u6539\u5584\u75c5\u60c5\u7684\u6297\u98a8\u6fd5\u85e5\uff08DMARDs\uff09\u5982\u7532\u6c28\u8776\u5464(methotrexate)\u90fd\u6709\u4e86\u5b78\u540d\u85e5\uff0c\u9019\u7247\u7d05\u6d77\u4e2d\u9084\u6709\u591a\u7a2e\u91dd\u5c0d\u4e0d\u540c\u4f5c\u7528\u6a5f\u5236\u7684\u85e5\u7269\uff0c\u5305\u62ecTNF-\u03b1\u6291\u5236\u5291\uff0c\u827e\u4f2f\u7dad\u7684\u5168\u7403\u92b7\u552e\u51a0\u8ecd\u5fa9\u9081\uff08adalimumab\uff09\uff1bBMS\u7684T\u7d30\u80de\u5171\u523a\u6fc0\u8abf\u7bc0\u5291Orencia (abatacept\uff09\uff1bSobi Inc.\u516c\u53f8\u7684IL-1\u62ee\u6297\u5291Kineret\uff08anakinra\uff09\uff0cRegeneron\u548c\u8cfd\u8afe\u83f2\u7684IL-6\u6297\u9ad4Kevzara\uff08sarilumab\uff09, \u7f85\u6c0f\u7684Actemra\uff08tocilizumab\uff09\uff0cBiogen\u8207\u7f85\u6c0f\u7684\u6297CD20\u55ae\u6297\u7f8e\u7f85\u83ef\uff08rituximab\uff09\u4ee5\u53ca\u591a\u500bJAK\u6291\u5236\u5291\uff0c\u5305\u62ec\u8f1d\u745e\u7684Xeljanz\uff08tofacitinib\uff09\uff0c\u79ae\u4f86\u7684Olumiant\uff08baricitinib\uff09\u548c\u827e\u4f2f\u7dad\u7684Rinvoq\uff08upadacitinib\uff09\u3002<\/p>\n<p>\u300c\u5f88\u986f\u7136\uff0c\u6211\u5011\u975e\u5e38\u6e05\u695a\u9019\u662f\u4e00\u500b\u7af6\u722d\u591a\u9ebc\u6fc0\u70c8\u7684\u5e02\u5834\uff0c\u6beb\u7121\u7591\u554f\u3002\u300d\u5409\u5229\u5fb7\u7684\u9996\u5e2d\u5546\u52d9\u5b98Johanna Mercier\u57282019\u5e74\u7b2c\u56db\u5b63\u5ea6\u7684\u96fb\u8a71\u6703\u8b70\u4e2d\u8868\u793a\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>\u60a3\u8005\u4ecd\u76fc\u671b\u6709\u66f4\u591a\u9078\u64c7<\/strong><\/h3>\n<p>\u5118\u7ba1\u5df2\u7d93\u6709\u5f88\u591a\u85e5\u7269\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\uff0c\u4f46\u60a3\u8005\u4f9d\u7136\u5e0c\u671b\u6709\u66f4\u591a\u7684\u9078\u64c7\u3002<\/p>\n<p>\u300c\u554f\u984c\u9084\u6c92\u6709\u89e3\u6c7a\uff0c\u300d\u985e\u98a8\u6fd5\u60a3\u8005\u57fa\u91d1\u6703\uff08Rheumatoid Patient Foundation\uff09\u4e3b\u5e2d\u548c\u5275\u59cb\u4ebaKelly O&#8217;Neill\u5973\u58eb\u544a\u8a34<a href=\"https:\/\/clarivate.com\/cortellis\/zh-hant\/solutions\/bioworld\/\">BioWorld<\/a>\u3002O&#8217;Neill\u76ee\u524d\u7d93\u71df\u8457RA Warrior\u7db2\u7ad9\uff0c\u9084\u5beb\u904e\u4e00\u672c\u95dc\u65bc\u9019\u7a2e\u75be\u75c5\u7684\u66f8\u3002\u5979\u8aaa\uff1a\u300c\u4e00\u65e6\u65b0\u7684\u7642\u6cd5\u8207\u73fe\u6709\u7684\u7a0d\u6709\u4e0d\u540c\uff0c\u6211\u4fbf\u6703\u5efa\u8b70\u6279\u51c6\u5b83\u3002\u300d<\/p>\n<p>O&#8217;Neill\u57282006\u5e74\u88ab\u8a3a\u65b7\u70ba\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\uff0c\u5728\u90a3\u4e4b\u524d\u5979\u5df2\u7d93\u88ab\u4e0d\u65b7\u52a0\u5287\u7684\u75c5\u75c7\u6298\u78e8\u4e86\u9577\u905420\u9918\u5e74\u3002\u76ee\u524d\u5979\u6b63\u5728\u9032\u884c\u7b2c\u4e8c\u7a2eJAK\u6291\u5236\u5291\u7684\u6cbb\u7642\u3002\u5979\u5f37\u8abf\u8aaa\uff0c\u7d04\u6709\u4e09\u5206\u4e4b\u4e00\u7684\u60a3\u8005\u5c0d\u73fe\u6709\u7642\u6cd5\u6c92\u6709\u660e\u986f\u53cd\u61c9\uff0c\u53e6\u6709\u4e09\u5206\u4e4b\u4e00\u60a3\u8005\u50c5\u6709\u90e8\u5206\u53cd\u61c9\uff0c\u5176\u9918\u60a3\u8005\u5c0d\u85e5\u7269\u654f\u611f\uff0c\u4f46\u7642\u6548\u4e5f\u6703\u96a8\u8457\u6642\u9593\u9010\u6f38\u6e1b\u5f31\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>JAK<\/strong><strong>\u6291\u5236\u5291\u7684\u7af6\u722d\u683c\u5c40<\/strong><\/h3>\n<p>Filgotinib\u7684\u4e0a\u5e02\u662f\u57fa\u65bc\u4e00\u7cfb\u5217\u540d\u70baFINCH\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7d50\u679c\u3002\u5728FINCH 1\u7814\u7a76\u4e2d\uff0cFilgotinib\u8207\u7532\u6c28\u8776\u5464\u806f\u7528\uff0c\u5728\u55ae\u7528\u7532\u6c28\u8776\u5464\u61c9\u7b54\u4e0d\u5145\u5206\u7684\u60a3\u8005\u4e2d\u9032\u884c\u4e86\u70ba\u671f12\u5468\u7684\u8a66\u9a57\u3002\u6578\u64da\u986f\u793a\uff0c\u4ee5\u7f8e\u570b\u98a8\u6fd5\u75c5\u5b78\u6703\u768420%\u75be\u75c5\u7de9\u89e3\u91cf\u8868ACR20\u70ba\u6a19\u6e96\uff0c100mg\u5291\u91cf\u7d44\u7684\u53cd\u61c9\u7387\u70ba69.8%\uff0c200mg\u5291\u91cf\u7d44\u70ba76.6%\uff0c\u800c\u55ae\u7528\u7532\u6c28\u8776\u5464\u50c5\u70ba48.9%\u3002\u5728FINCH 2\u7814\u7a76\u4e2d\uff0c\u5728\u5c0d\u751f\u7269\u88fd\u5291DMARDs\u53cd\u61c9\u4e0d\u5145\u5206\u7684\u60a3\u8005\u4e2d\uff0c\u670d\u7528100mg\u548c200mg\u5291\u91cf\u7684Filgotinib\u806f\u5408DMARDs\uff0c\u572812\u5468\u6642\u7684ACR20\u7de9\u89e3\u7387\u5206\u5225\u70ba58%\u548c66%\uff0c\u800c\u55ae\u7528DMARDs\u7684\u7de9\u89e3\u7387\u50c5\u70ba31.1%\u3002\u5728FINCH 3\u7814\u7a76\u4e2d\uff0c\u5728\u672a\u4f7f\u7528\u904e\u7532\u6c28\u8776\u5464\u7684\u60a3\u8005\u968a\u5217\u4e2d\uff0c\u540c\u6642\u670d\u7528100 mg\u6216200 mg\u5291\u91cf\u7684Filgotinib\u806f\u7528\u7532\u6c28\u8776\u5464\uff0c\u572824\u5468\u6642\u5206\u5225\u9054\u5230\u4e8680.2%\u548c81%\u7684\u53cd\u61c9\u7387\uff0c\u800c\u7532\u6c28\u8776\u5464\u55ae\u85e5\u7684\u7de9\u89e3\u7387\u70ba71.4%\u3002<\/p>\n<p>\u300c\u6295\u8cc7\u4eba\u548c\u91ab\u751f\u5c07\u4e0d\u53ef\u907f\u514d\u7684\u5c0d\u81e8\u5e8a\u6578\u64da\u9032\u884c\u5168\u9762\u7684\u6a6b\u5411\u6bd4\u8f03\u3002\u82e5\u8207\u672a\u4f86\u7684\u7af6\u722d\u5c0d\u624b\u2014\u827e\u4f2f\u7dad\u7684JAK1\u6291\u5236\u5291upadacitinib\u76f8\u6bd4\uff0c\u5373\u4f7f\u5728\u9ad8\u5291\u91cf\u7d44\uff0cfilgotinib\u7684\u7642\u6548\u770b\u8d77\u4f86\u4e5f\u4e0d\u90a3\u9ebc\u9a5a\u8c54\uff0c\u5118\u7ba1filgotinib\u7684\u5b89\u5168\u53ef\u80fd\u66f4\u597d\u3002\u300d\u5728FINCH 1\u548cFINCH 3\u81e8\u5e8a\u6578\u64da\u62ab\u9732\u5f8c\uff0c\u4f86\u81eaRBC Capital Markets\u7684\u5206\u6790\u5e2bBrian Abrahams\u5728\u7d66\u5ba2\u6236\u7684\u5831\u544a\u4e2d\u5982\u6b64\u8a55\u8ad6\u3002<\/p>\n<p>\u5409\u5229\u5fb7\u9996\u5e2d\u91ab\u5b78\u5b98Merdad 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