{"id":1154,"date":"2020-04-24T03:59:08","date_gmt":"2020-04-23T19:59:08","guid":{"rendered":"https:\/\/clarivate.com\/tw\/2020\/04\/24\/%e6%8f%90%e9%ab%98%e7%b5%a6%e8%97%a5%e4%be%bf%e5%88%a9%e6%80%a7%ef%bc%8cozanimod%e3%80%81ofatumumab%e5%8f%8arimegepant%e5%bc%b7%e5%8b%a2%e6%94%bb%e5%85%a5%e5%a4%9a%e7%99%bc%e6%80%a7%e7%a1%ac%e5%8c%96\/?lang=zh-hant"},"modified":"2020-04-24T03:59:08","modified_gmt":"2020-04-23T19:59:08","slug":"cns-drugs-provide-new-delivery-options-cleaner-safety-for-ms-and-migraine","status":"publish","type":"post","link":"https:\/\/clarivate.com\/life-sciences-healthcare\/zh\/blog\/cns-drugs-provide-new-delivery-options-cleaner-safety-for-ms-and-migraine\/","title":{"rendered":"Ozanimod\u3001Ofatumumab\u53caRimegepant\u5f37\u52e2\u653b\u5165\u591a\u767c\u6027\u786c\u5316\u75c7\u548c\u504f\u982d\u75db\u7684\u7af6\u722d"},"content":{"rendered":"

\u539f\u6587\u520a\u767b\u65bc\u79d1\u777f\u552f\u5b89\u65d7\u4e0b\u751f\u547d\u79d1\u5b78\u65b0\u805e\u5e73\u53f0\u00a0BioWorld \u7db2\u7ad9<\/a>\uff0c\u4f5c\u8005\u70ba Karen Carey<\/em><\/p>\n

 <\/p>\n

\u672c\u7bc7\u5c07\u8981\u4ecb\u7d39\u4e09\u7a2e\u6b63\u7b49\u5f85\u85e5\u7269\u76e3\u7ba1\u6a5f\u69cb\u6279\u51c6\u4e0a\u5e02\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08central nervous system, CNS\uff09\u65b0\u85e5\uff0c\u5118\u7ba1\u9019\u4e09\u7a2eCNS\u85e5\u7269\u7684\u7642\u6548\u8207\u76ee\u524d\u5df2\u4e0a\u5e02\u7684\u85e5\u7269\u4e26\u6c92\u6709\u592a\u5927\u4e0d\u540c\uff0c\u4f46\u7531\u65bc\u5177\u6709\u5728\u88fd\u5291\u914d\u65b9\u3001\u7d66\u85e5\u65b9\u5f0f\u4ee5\u53ca\u85e5\u7269\u8cbb\u7528\u652f\u4ed8\u65b9\u652f\u6301\u7b49\u65b9\u9762\u7684\u512a\u52e2\uff0c\u4f7f\u5f97\u9019\u4e09\u7a2e\u85e5\u7269\u6210\u70ba\u591a\u767c\u6027\u786c\u5316\u75c7\uff08multiple sclerosis, MS\uff09\u548c\u504f\u982d\u75db\u5e02\u5834\u4e2d\u4e0d\u5bb9\u5ffd\u8996\u7684\u91cd\u8981\u53c3\u8207\u8005\u3002<\/p>\n

\u9019\u4e09\u7a2eCNS\u85e5\u7269\u5747\u5728 \u79d1\u777f\u552f\u5b89 2020\u6700\u503c\u5f97\u95dc\u6ce8\u7684\u91cd\u78c5\u85e5\u7269\u9810\u6e2c (Drugs to Watch 2020)<\/a> \u4e2d\uff0c\u5176\u4e2d\u5169\u500b\u7528\u65bc\u5fa9\u767c\u6027\u591a\u767c\u6027\u786c\u5316\u75c7\u7684\u85e5\u7269\uff0c\u5206\u5225\u662fBMS\u7684 Ozanimod\uff08RPC-1063\uff09\u548c\u8afe\u83ef\u7684 Ofatumumab\uff08OMB-157\uff09\u3002\u5c0d\u65bc Ozanimod\uff0c\u5982\u679cFDA\u4e0d\u8981\u6c42\u5176\u540c\u985e\u85e5\u7269 Gilenya (fingolimod\uff0c\u8afe\u83ef\uff09\u548c Mayzent (siponimod, Novartis) \u518d\u958b\u5c55\u76f8\u95dc\u7684\u4e00\u7cfb\u5217\u5be6\u9a57\u7814\u7a76\uff0c\u90a3\u9ebcOzanimod\u5c31\u53ef\u80fd\u66f4\u5bb9\u6613\u88ab\u8655\u65b9\u3002\u5c0d\u65bcOfatumumab\uff0c\u8207\u5176\u6700\u5927\u7684\u7af6\u722d\u5c0d\u624bOcrevus (ocrelizumab, Roche)\u76f8\u6bd4\uff0cOfatumumab\u63d0\u4f9b\u4e86\u4e00\u7a2e\u53ef\u4ee5\u5728\u5bb6\u9032\u884c\u76ae\u4e0b\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u800cOcrevus\u5247\u9700\u8981\u5728\u5c08\u696d\u6a5f\u69cb\u6216\u91ab\u9662\u4e2d\u9032\u884c\u8cbb\u7528\u8f03\u9ad8\u7684\u8f38\u6db2\u7d66\u85e5\u3002<\/p>\n

\u5c0d\u65bc\u504f\u982d\u75db\uff0c\u7f8e\u570bBiohaven\u7684Rimegepant<\/a>\u53ef\u80fd\u6210\u70ba\u504f\u982d\u75db\u6025\u6027\u767c\u4f5c\u60a3\u8005\u53ef\u4ee5\u9078\u64c7\u7684\u65b0\u578b\u53e3\u670d\u85e5\u7269\u3002\u7e7c2019\u5e7412\u6708FDA\u6279\u51c6\u4e0a\u5e02\u7684Ubrelvy (ubrogepant,Allergan)\u4e4b\u5f8c\uff0cRimegepant<\/a>\u662f\u7b2c\u4e8c\u500b\u53e3\u670d\u5c0f\u5206\u5b50\u964d\u9223\u7d20\u57fa\u56e0\u76f8\u95dc\u80bd\uff08calcitonin gene-related peptide\uff0cCGRP\uff09\u62ee\u6297\u5291\u985e\u85e5\u7269\u3002\u800c\u57282018\u5e74\uff0c\u5df2\u6709\u4e09\u7a2e\u6ce8\u5c04\u7528CGRP\u985e\u85e5\u7269\u5df2\u7d93\u4e0a\u5e02\u4e86\u3002<\/p>\n

\u5982\u679c\u4e0a\u8ff0\u7684\u4e09\u7a2e\u65b0\u578b\u85e5\u7269\uff08Ozanimod, Ofatumumab\u548cRimegepant\uff09\u5747\u80fd\u7372\u51c6\uff0c\u90a3\u9ebc\u672a\u4f86\u4e94\u5e74\u4e4b\u5167\uff0c\u9019\u4e09\u7a2e\u85e5\u7269\u7684\u5e74\u92b7\u552e\u7e3d\u984d\u5c07\u8d85\u904e10\u5104\u7f8e\u5143\u3002<\/p>\n

 <\/p>\n

\u61c9\u5c0d<\/strong>MS\u7684\u85e5\u7269 \u2014\u00a0<\/strong>Ozanimod\u548cOfatumumab<\/strong><\/h3>\n

\u795e\u7d93\u79d1\u91ab\u751f\u6703\u628aMS\u60a3\u8005\u5206\u70ba3\u7a2e\u985e\u578b\uff1a\u7d0485%\u7684\u60a3\u8005\u5c6c\u65bc\u5fa9\u767c\u7de9\u89e3\u578b\uff0c\u7d0415%\u7684\u60a3\u8005\u5c6c\u65bc\u539f\u767c\u9032\u5c55\u578b\uff0c\u800c\u8d85\u904e\u4e00\u534a\u7684\u5fa9\u767c\u7de9\u89e3\u578b\u60a3\u8005\u5f8c\u671f\u6703\u8f49\u70ba\u7e7c\u767c\u9032\u5c55\u578b\uff08SPMS\uff09\u3002MS\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7d71\u6703\u653b\u64ca\u81ea\u8eab\u795e\u7d93\u5143\u8ef8\u7a81\u5468\u570d\u7684\u9ad3\u9798\uff0c\u7834\u58de\u904b\u52d5\u548c\u611f\u89ba\u529f\u80fd\uff0c\u53ef\u9020\u6210\u7671\u7613\u548c\u8a8d\u77e5\u529f\u80fd\u969c\u7919\u3002\u6839\u64da\u82f1\u570b\u591a\u767c\u6027\u786c\u5316\u75c7\u4fe1\u8a17\u57fa\u91d1\u6703\u7684\u6578\u64da\uff0c\u76ee\u524d\u5168\u7403\u7d04\u6709250\u842cMS\u60a3\u8005\u3002<\/p>\n

\u7f8e\u570b\u57282017\u5e743\u6708\u5c31\u4e0a\u5e02\u4e86\u7528\u65bc\u6cbb\u7642MS\u7684\u85e5\u7269Ocrevus\uff0cOcrevus\u4e0d\u50c5\u53ef\u4ee5\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\u7de9\u89e3\u578bMS\uff0c\u9084\u662f\u7b2c\u4e00\u500b\u53ef\u4ee5\u7528\u65bc\u6cbb\u7642\u539f\u767c\u9032\u5c55\u578bMS\u7684\u85e5\u7269\u3002<\/p>\n

\u795e\u7d93\u5b78\u5bb6Barry Hendin\u5728\u7f8e\u570b\u9cf3\u51f0\u57ce\u64c1\u6709\u81ea\u5df1\u7684\u79c1\u4eba\u8a3a\u6240\uff0c\u4e26\u64d4\u4efb\u73ed\u7d0d\u5927\u5b78\u91ab\u5b78\u4e2d\u5fc3MS\u5c08\u79d1\u9580\u8a3a\u7684\u4e3b\u4efb\uff0c\u4ed6\u8aaa\uff1a\u300c\u57281993\u5e74\u4e4b\u524d\u9084\u6c92\u6709\u6709\u6548\u7de9\u89e3MS\u7684\u85e5\u7269\uff0c\u7b2c\u4e00\u500b\u6709\u6548\u85e5\u7269\u51fa\u73fe\u57281993\u5e74\uff0c\u5f8c\u4f86\u57281990\u5e74\u4ee3\u9678\u7e8c\u5171\u51fa\u73fe\u4e864\u500b\u85e5\u7269\u3002\u800c\u73fe\u5728\u5df2\u7d93\u63a5\u8fd1\u670920\u500b\u85e5\u7269\u4e86\uff0c\u9019\u610f\u5473\u8457\u5c0dMS\u7684\u6cbb\u7642\u6709\u4e86\u5f88\u591a\u53ef\u4f9b\u9078\u64c7\u7684\u85e5\u7269\u3002\u800c\u5c0d\u6211\u4f86\u8aaa\uff0c\u90a3\u771f\u662f\u975e\u540c\u5c0b\u5e38\u3002\u300d<\/p>\n

\u5728Betaseron\u00ae\uff08interferon \u03b2-1b\uff0cBayer\uff09\u4e0a\u5e02\u4e4b\u524d\uff0c\u795e\u7d93\u79d1\u91ab\u751f\u5c0dMS\u7684\u6cbb\u7642\u53ea\u80fd\u662f\u5c0d\u75c7\u6cbb\u7642\uff0c\u5982\u4f7f\u7528\u6297\u75d9\u6523\u85e5\u3001\u6297\u6291\u9b31\u85e5\u548c\u8180\u80f1\u7528\u85e5\u7b49\u53ef\u7528\u7684\u85e5\u7269\u4f86\u61c9\u5c0dMS\u7684\u75c7\u72c0\u3002Barry Hendin\u63d0\u5230\uff0cMS\u7684\u6cbb\u7642\u65b9\u6cd5\u5df2\u7d93\u5f9e\u904e\u53bb\u7642\u6548\u5f31\u3001\u514d\u75ab\u6291\u5236\u80fd\u529b\u4f4e\u7684\u6ce8\u5c04\u85e5\u7269\uff0c\u767c\u5c55\u5230\u5982\u4eca\u7684\u7642\u6548\u9ad8\u540c\u6642\u98a8\u96aa\u4e5f\u9ad8\u7684\u85e5\u7269\u3002<\/p>\n

Ozanimod\u65bc2019\u5e743\u6708\uff0c\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u5206\u5225\u905e\u4ea4\u4e86NDA\u548cMAA\u6587\u4ef6\uff0c\u56e0\u6b64\u6709\u53ef\u80fd\u6210\u70ba\u4e0b\u4e00\u500b\u7372\u51c6\u4e0a\u5e02\u7684\u53e3\u670dMS\u6cbb\u7642\u85e5\u7269\u3002FDA\u66fe\u57282018\u5e742\u6708\u62d2\u7d55\u4e86Ozanimod\u7684NDA\u7533\u8acb\uff0c\u800c\u91cd\u65b0\u905e\u4ea4\u7684NDA\u6587\u4ef6\u88e1\u89e3\u6c7a\u4e86\u5148\u524d\u5b58\u5728\u7684\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u85e5\u7406\u5b78\u554f\u984c\u3002\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u7d10\u6fa4\u897f\u5dde\u7684Celgene\u516c\u53f8\u5ba3\u4f48FDA\u63a5\u53d7\u4e86\u65b0\u7684NDA\u7533\u8acb\uff0c\u4e26\u4e14PDUFA\u65e5\u671f\uff08\u5be9\u67e5\u622a\u6b62\u65e5\u671f\uff09\u5b9a\u70ba2020\u5e743\u670825\u65e5\uff0cCelgene\u5f8c\u4f86\u88abBMS\u4ee5740\u5104\u7f8e\u5143\u6536\u8cfc\u3002EMA\u4e5f\u63a5\u6536\u4e86Ozanimod\u7684MAA\u7533\u8acb\uff0c\u9810\u8a08\u57282020\u4e0a\u534a\u5e74\u6703\u6709\u7d50\u679c\u3002\u64daCortellis\u7684\u5206\u6790\uff0c\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u9810\u8a08\u52302024\u5e74Ozanimod\u7684\u92b7\u552e\u984d\u53ef\u9054\u523016.21\u5104\u7f8e\u5143\u3002<\/p>\n

Ozanimod\u662f\u4e00\u7a2e\u53e3\u670d\u7684\u9798\u6c28\u91871-\u78f7\u9178\u9176\u53d7\u9ad41\uff08sphingosine 1-phosphatase, S1P1\uff09\u548c\u53d7\u9ad45\uff08S1P5\uff09\u6fc0\u52d5\u5291\u3002 \u7533\u8acb\u6587\u4ef6\u4e2d\u5305\u542bSunbeam\u548cRadiance\u5169\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff0c\u9019\u5169\u9805\u8a66\u9a57\u90fd\u5230\u9054\u4e86\u4e3b\u8981\u7d42\u9ede\uff1a\u5c0d\u65bcOzanimod\u548cAvonex<\/a>\uff08interferon\u03b21a\uff0cBiogen\uff09\uff0c\u6cbb\u764212\u500b\u6708\u4e4b\u5f8c\u7684\u5e74\u5fa9\u767c\u7387\uff08ARR\uff09\u5206\u5225\u70ba0.18\u548c0.35\uff0c\u6cbb\u764224\u500b\u6708\u4e4b\u5f8c\u7684ARR\u5206\u5225\u70ba0.17\u548c0.28\u3002<\/p>\n

Ozanimod\u7684\u5b89\u5168\u6027\u6578\u64da\u986f\u793a\u5176\u8207\u5b89\u6170\u5291\u5177\u6709\u76f8\u4f3c\u7684\u5fc3\u81df\u4e8b\u4ef6\uff0c\u9019\u4e00\u9ede\u53ef\u80fd\u6703\u4f7fOzanimod\u82072010\u5e74\u6279\u51c6\u7684\u7b2c\u4e00\u500b\u53ef\u7de9\u89e3\u75c5\u60c5\u7684\u53e3\u670dS1P\u85e5\u7269 \u2014 Gilenya\u5340\u5206\u958b\uff0c\u7b2c\u4e8c\u500b\u7372\u51c6\u7684\u985e\u4f3c\u85e5\u7269Mayzent<\/a>\u4e5f\u4f86\u81eaNovartis\uff0c\u65bc2019\u5e743\u6708\u7372\u51c6\u3002\u5728\u67d0\u4e9b\u60a3\u8005\u4e2d\u89c0\u5bdf\u5230\u7684\u5fc3\u8840\u7ba1\u98a8\u96aa\u662fGilenya\u9700\u8981\u514b\u670d\u7684\u969c\u7919\u4e4b\u4e00\u3002\u800cMayzent<\/a>\u7372\u51c6\u7684\u9069\u61c9\u75c7\u4e0d\u50c5\u6709\u5fa9\u767c\u578bMS\uff0cMayzent<\/a>\u9084\u662f\u7b2c\u4e00\u500b\u7372\u51c6\u7528\u65bc\u6cbb\u7642SPMS\u7684\u85e5\u7269\u3002\u96a8\u5f8c\u4e0d\u4e45\u76842019\u5e744\u6708\uff0c\u53e6\u4e00\u7a2e\u53ef\u4ee5\u540c\u6642\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\u578bMS\u548cSPMS\u7684\u5408\u6210\u6c2f\u53bb\u6c27\u817a\u82f7\u985e\u4f3c\u7269(synthetic chlorinated deoxyadenosine analogue)\u85e5\u7269\uff0cMavenclad<\/a>\uff08cladribine\uff0cMerck\uff09\uff0c\u4e5f\u7372\u51c6\u4e0a\u5e02\u4e86\u3002<\/p>\n

Barry Hendin\u8b1b\u5230\uff0cOzanimod\u548cGilenya\u5177\u6709\u76f8\u4f3c\u7684\u7642\u6548\uff0c\u4f46Mayzent\u548cOzanimod\u986f\u7136\u5177\u6709\u66f4\u9ad8\u7684\u53d7\u9ad4\u7279\u7570\u6027\uff0c\u800cGilenya\u662f\u591a\u7a2e\u53d7\u9ad4S1P1\u3001S1P3\u3001S1P4\u548cS1P5\u7684\u6fc0\u52d5\u5291\u3002<\/p>\n

\u5c0d\u65bcMayzent\u548cGilenya\uff0c\u60a3\u8005\u90fd\u9700\u8981\u63a5\u53d7\u5176\u4ed6\u6aa2\u67e5\u4e4b\u5f8c\u624d\u80fd\u4f7f\u7528\uff0c\u9019\u53ef\u80fd\u6703\u70baOzanimod\u5e36\u4f86\u6a5f\u6703\u3002Gilenya\u8981\u6c42\u5728\u9996\u6b21\u7d66\u85e5\u4e4b\u524d\u548c\u7d66\u85e5\u4e4b\u5f8c\u516d\u500b\u5c0f\u6642\u9032\u884c\u5fc3\u96fb\u5716\u6aa2\u67e5\uff0c\u7528\u4f86\u76e3\u6e2c\u662f\u5426\u6709\u5fc3\u5f8b\u4e0d\u6574\u7684\u8de1\u8c61\u3002Mayzent\u548cGilenya\u4e5f\u90fd\u9700\u8981\u773c\u79d1\u8a55\u4f30\u548c\u8840\u6db2\u6aa2\u67e5\u3002<\/p>\n

Barry Hendin\u4e5f\u63d0\u5230\uff0c\u56e0\u70baOzanimod\u4e0d\u9700\u8981\u505a\u9019\u4e9b\u6aa2\u67e5\uff0c\u6240\u4ee5\u6703\u66f4\u5bb9\u6613\u8655\u65b9\u3002<\/p>\n

\u4f46\u662fOzanimod\u4e5f\u5c07\u9762\u81e8\u4f86\u81ea\u5176\u4ed6\u53e3\u670dMS\u85e5\u7269\u7684\u6fc0\u70c8\u7af6\u722d\uff0c\u5982Tecfidera\uff08dimethyl fumarate\uff0cBiogen\uff09\u3001Aubagio\uff08teriflunomide\uff0cSanofi\uff09\u4ee5\u53caJ&J\u7684\u5c1a\u672a\u7372\u51c6\u7684\u53e3\u670d\u85e5\u7269Ponesimod<\/a>\uff0c\u5176\u4e2dPonesimod<\/a>\u4e0d\u50c5\u8207Gilenya\u5177\u6709\u76f8\u4f3c\u7684\u4f5c\u7528\u6a5f\u5236\u9084\u53ef\u80fd\u5177\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002\u5176\u4ed6\u5177\u6709\u4e0d\u540c\u4f5c\u7528\u6a5f\u5236\u7684\u53e3\u670d\u85e5\u7269\u7af6\u722d\u8005\u9084\u6709Vumerity<\/a>(diroximel fumarate\uff0cBiogen \u548c Alkermes)\u548cMavenclad\uff1bVumerity<\/a>\u00a0\u65bc2019\u5e7410\u6708\u7372FDA\u6279\u51c6\uff0c\u8207Tecfidera\u76f8\u6bd4\uff0cVumerity<\/a>\u00a0\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u6709\u6240\u6539\u5584\uff1b\u800cMavenclad\u5728\u9032\u884c\u6027\u591a\u767c\u6027\u767d\u8cea\u8166\u75c5\u8b8a (progressive multifocal Leukoencephalopathy) \u98a8\u96aa\u65b9\u9762\u512a\u65bcGilenya\u3002<\/p>\n

\u5305\u62ecOfatumumab\u5728\u5167\u7684\u6297CD20\u55ae\u682a\u6297\u9ad4\u4e5f\u53ef\u80fd\u662f\u5f37\u6709\u529b\u7684\u7af6\u722d\u5c0d\u624b\u3002Ofatumumab\u53ef\u4ee5\u8207CD20\u6297\u539f\u4f4d\u9ede\u7d50\u5408\uff0c\u9032\u800c\u6d88\u9664\u53ef\u653b\u64ca\u9ad3\u9798\u7684B\u7d30\u80de\u3002Novartis\u516c\u53f8\u57282015\u5e7412\u6708\u5f9e\u4e39\u9ea5Genmab\u516c\u53f8\u7372\u5f97Ofatumumab\u7684\u6240\u6709\u6b0a\u5229\uff0c\u4e26\u5206\u5225\u57282019\u5e74\u7b2c\u56db\u5b63\u548c2020\u5e74\u4e00\u6708\u5411FDA\u548cEMA\u905e\u4ea4\u4e86\u4e0a\u5e02\u7533\u8acb\u3002\u5982\u80fd\u7372\u51c6\uff0cCortellis\u7684\u4e00\u9805\u5206\u6790\u7d50\u679c\u9810\u8a08\uff0c2024\u5e74\u76ae\u4e0b\u6ce8\u5c04\u7528Ofatumumab\u7684\u92b7\u552e\u984d\u5c07\u9054\u523012.61\u5104\u7f8e\u5143\u3002<\/p>\n

\u5728\u6bd4\u8f03Ofatumumab\u548cOcrevus<\/a>\u6642\uff0cBarry Hendin\u8aaa\uff1a\u300c\u5728\u6211\u770b\u4f86\uff0c\u76ee\u524d\u6c92\u6709\u982d\u5c0d\u982d\u7684\u6bd4\u8f03\u7d50\u679c\u80fd\u8aaa\u660e\u4e00\u500b\u6bd4\u53e6\u4e00\u500b\u66f4\u6709\u6548\uff0c\u5169\u7a2e\u85e5\u7269\u5728\u9ad8\u7642\u6548\u65b9\u9762\u90fd\u8655\u65bc\u540c\u4e00\u7d1a\u5225\uff1b\u4f46\u662f\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u5728\u5927\u898f\u6a21\u4f7f\u7528\u5f8c\uff0c\u53ef\u80fd\u6703\u51fa\u73fe\u4e00\u4e9b\u7d30\u5fae\u7684\u5dee\u7570\u3002\u300d<\/p>\n

\u7136\u800c\u9019\u5169\u7a2e\u85e5\u7269\u6700\u660e\u986f\u7684\u5340\u5225\u662f\u5b83\u5011\u7684\u7d66\u85e5\u65b9\u5f0f\u3002Ocrevus\u9700\u8981\u524d\u5f80\u5c08\u696d\u7684\u6ce8\u5c04\u5ba4\uff0c\u800cOfatumumab\u53ef\u5728\u5bb6\u4e2d\u81ea\u884c\u6ce8\u5c04\u3002<\/p>\n

\u5728Asclepios III\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0cOfatumumab\u8207Aubagio\u76f8\u6bd4\uff0c\u5e74\u5fa9\u767c\u7387\u964d\u4f4e\u4e8650%\u4ee5\u4e0a\uff0c\u4e26\u9054\u5230\u4e86\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5982\u6b98\u75be\u9032\u5c55\u78ba\u8a3a\u7684\u5ef6\u9072\u6642\u9593\u3001\u6e1b\u5c11\u75c5\u7076\u6578\u91cf\u7b49\u3002\u96d6\u7136Aubagio\u662f\u4e00\u500b\u7642\u6548\u8f03\u4f4e\u7684\u5c0d\u7167\u85e5\u7269\uff0c\u4f46Ocrevus\u9084\u662f\u63a1\u7528\u4e86\u7acb\u6bd4\u6276(Rebif\u00ae, interferon\u03b2-1a\uff0cMerck Serono)\u7528\u4f5c\u8a66\u9a57\u7684\u5c0d\u7167\u85e5\u7269\u3002<\/p>\n

Barry Hendin\u8b1b\u5230\uff0c\u300cAubagio\u548c\u7acb\u6bd4\u6276\u90fd\u4e0d\u88ab\u8a8d\u70ba\u662f\u9ad8\u6548\u85e5\u7269\uff0c\u5b83\u5011\u7684\u7642\u6548\u76f8\u4f3c\uff0c\u4e26\u4e14\u90fd\u6eff\u8db3\u4e86FDA\u5c0d\u6709\u6548\u5c0d\u7167\u85e5\u7269\u7684\u8981\u6c42\u3002\u300d<\/p>\n

\u6469\u6839\u5927\u901a\uff08J.P. Morgan\uff09\u7684\u5206\u6790\u5e2bCory Kasimov\u5728\u53bb\u5e7410\u6708\u4efd\u7684\u6587\u7ae0\u4e2d\u5beb\u5230\uff0c\u4ed6\u8a2a\u554f\u904e\u7684\u795e\u7d93\u79d1\u91ab\u751f\u5011\u8a8d\u70baAsclepios III\u671f\u81e8\u5e8a\u8a66\u9a57\u8d85\u51fa\u4e86\u9810\u671f\uff0cOfatumumab\u53ef\u4ee5\u5ab2\u7f8eOcrevus\uff0c\u5546\u54c1\u5316\u65b9\u9762\u7684\u4e3b\u8981\u5dee\u7570\u5728\u65bcOfatumumab\u662f\u6bcf\u6708\u4e00\u6b21\u7684\u76ae\u4e0b\u7d66\u85e5\uff0c\u800cOcrevus\u662f\u6bcf\u516d\u500b\u6708\u7684\u975c\u8108\u6ce8\u5c04\u7d66\u85e5\u3002<\/p>\n

Cory Kasimov\u9084\u63d0\u5230\uff0c\u96d6\u7136Ocrevus\u793e\u5340\u8a3a\u6240\u975c\u8108\u6ce8\u5c04\u7d66\u85e5\u7684\u8cbb\u7528\u5f9e800\u7f8e\u5143\u52301000\u7f8e\u5143\u4e0d\u7b49\uff0c\u5728\u91ab\u9662\u5247\u5f9e3000\u7f8e\u5143\u52304000\u7f8e\u5143\u4e0d\u7b49\u3002\u4f46Ocrevus\u7684\u50f9\u683c\u53ef\u4ee5\u5728\u975c\u8108\u6ce8\u5c04\u6a5f\u69cb\u548c\u85e5\u54c1\u6279\u767c\u5546\u4e4b\u9593\u5354\u8abf\uff0c\u9019\u610f\u5473\u8457\u5728\u652f\u4ed8\u65b9\u7f3a\u5c11\u52d5\u529b\u7684\u60c5\u6cc1\u4e0b\uff0c\u6703\u4fc3\u4f7f\u4e00\u4e9b\u91ab\u751f\u8b93\u4ed6\u5011\u7684\u60a3\u8005\u4e00\u76f4\u4f7f\u7528Ocrevus\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u534a\u6578\u4f7f\u7528Ocrevus\u7684\u60a3\u8005\u6703\u5728Ofatumumab\u4e0a\u5e02\u7684\u4e00\u5e74\u5167\u8f49\u7528Ofatumumab\u3002<\/p>\n

\u300c\u6211\u8a8d\u70ba\u652f\u4ed8\u65b9\u5c07\u626e\u6f14\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\u300d\uff0cBarry Hendin\u8aaa\u5230\u3002<\/p>\n

\u6839\u64da\u8207Novartis\u7684\u5354\u8b70\uff0cGenmab\u516c\u53f8\u6709\u6b0a\u7372\u5f97Ofatumumab\u7684\u6b0a\u5229\u91d1\uff0c\u5305\u62ec\u8a72\u85e5\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u5168\u7403\u6de8\u92b7\u552e\u984d\u768420%\u4ee5\u53ca\u975e\u764c\u75c7\u6cbb\u7642\u5168\u7403\u6de8\u92b7\u552e\u984d\u768410%\u3002\u5728\u7f8e\u570b\u3001\u6b50\u76df\u548c\u5176\u4ed6\u5e7e\u500b\u570b\u5bb6\uff0c\u5546\u54c1\u540d\u70baArzerra<\/a>\u7684Ofatumumab\u5df2\u7d93\u7372\u51c6\u7528\u65bc\u67d0\u4e9b\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u7684\u6cbb\u7642\uff0c\u4f46\u662f\u7531\u65bc\u7af6\u722d\u58d3\u529b\uff0cArzerra<\/a>\u5df2\u7d93\u9000\u51fa\u6216\u6162\u6162\u9000\u51fa\u9664\u7f8e\u570b\u548c\u65e5\u672c\u4ee5\u5916\u7684\u5e02\u5834\u3002<\/p>\n

\u5c0d\u65bc\u5fa9\u767c\u578bMS\u9019\u7a2e30\u5e74\u524d\u9084\u6c92\u6709\u4efb\u4f55\u85e5\u7269\u53ef\u4ee5\u7de9\u89e3\u75c5\u60c5\u7684\u75be\u75c5\uff0c\u76f8\u95dc\u7814\u7a76\u5f9e\u672a\u505c\u6b62\u904e\uff0cOfatumumab\u548cOzanimod\u4eca\u5e74\u4ecd\u7136\u53ef\u80fd\u6703\u70baMS\u60a3\u8005\u7fa4\u9ad4\u63d0\u4f9b\u65b0\u7684\u9078\u64c7\u3002<\/p>\n

\u300c\u6211\u8a8d\u70baMS\u7684\u75be\u75c5\u9032\u5c55\u3001\u81f4\u6b98\u7387\u3001\u6b7b\u4ea1\u7387\u5df2\u7d93\u5927\u5927\u50f9\u683c\u4f4e\u4e86\u300d\uff0c\u540c\u6642\u64d4\u4efb\u7f8e\u570b\u591a\u767c\u6027\u786c\u5316\u75c7\u5354\u6703\u9996\u5e2d\u91ab\u7642\u5b98\u7684Barry Hendin\u8aaa\u5230\uff0c\u300c\u4f46\u9019\u9084\u4e0d\u662f\u6700\u5f8c\u4e00\u6b65\u3002\u6211\u5011\u73fe\u5728\u6b63\u5728\u81f4\u529b\u65bc\u63d0\u9ad8\u6e1b\u5c11\u767c\u708e\u548c\u5fa9\u767c\u9032\u800c\u6e1b\u5c11\u81f4\u6b98\uff0c\u4e0b\u4e00\u6b65\u91dd\u5c0dMS\u5e0c\u671b\u80fd\u6709\u4e00\u4e9b\u4fee\u5fa9\u7684\u65b9\u6cd5\u3002\u300d<\/p>\n

 <\/p>\n

\u504f\u982d\u75db\u7528\u85e5 \u2014\u00a0<\/strong>Rimegepant<\/strong><\/h3>\n

\u672c\u7bc7\u4ecb\u7d39\u7684\u7b2c\u4e09\u500bCNS\u85e5\u7269\u662fRimegepant\uff0c\u57282020\u5e74\u7b2c\u4e00\u5b63\u5ea6\u63a5\u53d7FDA\u7684\u5be9\u8a55\uff0c\u5df2\u65bc2020\u5e742\u6708\u5728\u7f8e\u570b\u7372\u51c6\u3002Rimegepant\u5df2\u65bc2019\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5728\u7f8e\u570b\u905e\u4ea4\u4e86\u7528\u65bc\u6cbb\u7642\u6025\u6027\u504f\u982d\u75db\u7684NDA\u7533\u8acb\uff0c\u4e26\u4f7f\u7528\u4e86\u512a\u5148\u5be9\u8a55\u3002Biohaven\u57282016\u5e74\u5f9eBMS\u624b\u4e2d\u7372\u5f97\u4e86Rimegepant\u7684\u5168\u7403\u6b0a\u5229\u3002\u6839\u64daCortellis\u7684\u5206\u6790\uff0c\u5982\u679cRimegepant\u7372\u51c6\uff0c\u5373\u4f7f\u6703\u8207Ubrelvy\u548c\u5176\u4ed6\u985e\u5225\u7684\u53e3\u670d\u85e5\u7269\u5c55\u958b\u7af6\u722d\uff0c\u5982FDA\u57282019\u5e7410\u6708\u6279\u51c6\u76845-HT 1f\u53d7\u9ad4\u6fc0\u52d5\u5291Reyvow\uff08lasmiditan\uff0cEli Lilly\uff09\uff0c2024\u5e74Rimegepant\u7684\u92b7\u552e\u984d\u4ecd\u6709\u671b\u589e\u81f310.3\u5104\u7f8e\u5143\u3002Rimegepant\u5176\u4ed6\u7684\u6f5b\u5728\u7af6\u722d\u5c0d\u624b\u9084\u5305\u62ecTrokendi XR\uff08topiramate\uff0cSupernus\uff09\u548c\u4fdd\u59a5\u9069\uff08\u8089\u6bd2\u687f\u83cc\u6bd2\u7d20A\u578b\uff0cAllergan\uff09\u3002<\/p>\n

Frederick Godley\u662f\u504f\u982d\u75db\u5354\u6703\uff08AMD\uff09\u7684\u4e3b\u5e2d\u548c\u5275\u59cb\u4eba\uff0c\u8a72\u5354\u6703\u4f4d\u65bc\u7f8e\u570b\u7f85\u5fb7\u5cf6\u7684\u5317\u91d1\u65af\u9813\uff0c\u662f\u5728\u4e00\u7fa4\u8033\u9f3b\u5589\u79d1\u91ab\u751f\u7684\u4e00\u9805\u6709\u8da3\u7684\u767c\u73fe\u7684\u57fa\u790e\u4e0a\u5275\u7acb\u7684\uff1a\u9019\u7fa4\u91ab\u751f\u767c\u73fe\u4f86\u5c31\u8a3a\u7684\u60a3\u8005\u4e2d\uff0c\u7d04\u670918%\u7684\u60a3\u8005\u901a\u904e\u7be9\u67e5\u767c\u73fe\u60a3\u6709\u504f\u982d\u75db\uff0c\u800c\u504f\u982d\u75db\u662f\u4e00\u7a2e\u6703\u4f7f\u4eba\u8870\u5f31\u7684\u982d\u75db\u75c7\u72c0\uff0c\u5e38\u4f34\u6709\u5641\u5fc3\u3001\u5614\u5410\u548c\u5c0d\u5149\u3001\u8072\u97f3\u548c\u6c23\u5473\u7684\u654f\u611f\u3002<\/p>\n

\u504f\u982d\u75db\u6709\u53ef\u80fd\u662f\u7531\u96e2\u5b50\u901a\u9053\u50b3\u5c0e\u7387\u7684\u6539\u8b8a\u5f15\u8d77\u7684\uff0c\u5f9e\u800c\u6703\u5c0e\u81f4\u5927\u8166\u76ae\u5c64\u64f4\u6563\u6291\u5236\u3001\u4e09\u53c9\u795e\u7d93\u6fc0\u6d3b\u3001\u4e09\u53c9\u795e\u7d93\u8840\u7ba1\u7cfb\u7d71\u91cb\u653eCGRP\u7b49\u4e00\u7cfb\u5217\u7684\u53cd\u61c9\u3002\u5728\u7f8e\u570b\u6709\u8d85\u904e2500\u842c\u4eba\u60a3\u6709\u504f\u982d\u75db\uff0cWHO\u5247\u628a\u504f\u982d\u75db\u5217\u70ba\u5c0e\u81f4\u50b7\u6b98\u7684\u56db\u5927\u795e\u7d93\u75be\u75c5\u4e4b\u4e00\u3002<\/p>\n

Alicia Torborg\u672c\u4f86\u662fFrederick Godley\u7684\u4e00\u4f4d\u60a3\u8005\uff0c\u73fe\u5728\u64d4\u4efb\u504f\u982d\u75db\u5354\u6703\u7684\u57f7\u884c\u7e3d\u76e3\u3002\u5728Alicia Torborg\u5c0f\u6642\u5019\uff0c\u5979\u7684\u504f\u982d\u75db\u5c31\u6703\u6bcf\u9031\u767c\u4f5c\u4e00\u6b21\uff0c\u96d6\u7136\u5728\u5979\u5341\u5e7e\u6b72\u7684\u6642\u5019\u504f\u982d\u75db\u6d88\u5931\u4e86\uff0c\u4f46\u5728\u5979\u61f7\u5b55\u671f\u9593\u4ee5\u53ca\u56db\u5341\u591a\u6b72\u7684\u6642\u5019\u53c8\u56de\u4f86\u4e86\uff0cAlicia Torborg\u8aaa\uff1a\u300c\u5f8c\u4f86\u5fa9\u767c\u7684\u504f\u982d\u75db\u5f88\u4e0d\u4e00\u6a23\uff0c\u6c92\u6709\u90a3\u9ebc\u56b4\u91cd\uff0c\u6211\u6c92\u6709\u7d93\u6b77\u904e\u90a3\u7a2e\u6233\u773c\u822c\u7684\u5287\u75db\uff0c\u4f46\u662f\u6211\u9019\u7a2e\u75bc\u75db\u6703\u6301\u7e8c\u6578\u6708\u3002\u300d<\/p>\n

Alicia Torborg\u5617\u8a66\u4e86\u5f9e\u7528\u65bc\u5fc3\u81df\u5230\u7672\u7647\u767c\u4f5c\u7684\u5404\u7a2e\u85e5\u7269\uff0c\u653e\u68c4\u4e86\u904b\u52d5\u7684\u611b\u597d\uff0c\u770b\u4e86\u5305\u62ec\u810a\u690e\u6309\u6469\u5e2b\u3001\u91dd\u7078\u5e2b\u3001\u4e2d\u91ab\u5e2b\u3001\u9806\u52e2\u7642\u6cd5\u91ab\u751f\u3001\u795e\u7d93\u79d1\u91ab\u751f\u5728\u5167\u7684\u8a31\u591a\u4e0d\u540c\u7684\u91ab\u751f\uff0c\u6700\u5f8c\u770b\u4e86\u8033\u9f3b\u5589\u91ab\u751f\u4f86\u6aa2\u67e5\u904e\u654f\u3002<\/p>\n

triptans\u662f\u7b2c\u4e00\u985e\u5c08\u9580\u8a2d\u8a08\u7528\u4f86\u6cbb\u7642\u504f\u982d\u75db\u7684\u85e5\u7269\uff0c\u5305\u62ec1995\u5e74\u4e0a\u5e02\u7684Imitrex\uff08sumatriptan\uff0cGSK\uff09\u3001\u5f8c\u7e8c\u4e0a\u5e02\u7684Zomig\uff08zolmitriptan\uff0cAmneal Pharmaceuticals\uff09\u548cMaxalt<\/a>(rizatriptan, Merck)\u3002triptan\u985e\u85e5\u7269\u53ef\u4ee5\u8207\u8840\u6e05\u7d20\u53d7\u9ad4\u7d50\u5408\uff0c\u9032\u800c\u963b\u65b7CGRP\u795e\u7d93\u905e\u8cea\u7684\u91cb\u653e\u3002\u76ee\u524d\u5df2\u6709\u5f88\u591atriptan\u985e\u7684\u985e\u65b0\u85e5\u4e0a\u5e02\uff0c\u5305\u62ecOnzetra Xsail<\/a>(sumatriptan, Currax)\u3001Rizaport<\/a>(rizatriptan\u53e3\u6eb6\u819c, Intelgenx)\u548cZosano pharma\u7684zolmitriptan\u8cbc\u7247\u3002<\/p>\n

\u300ctriptan\u985e\u85e5\u7269\u78ba\u5be6\u662f\u4e00\u7a2e\u5275\u65b0\u7684\u4e5f\u662f\u4e3b\u8981\u7684\u7528\u85e5\uff0c\u4f46\u5b83\u4e0d\u662f\u5c0d\u6240\u6709\u60a3\u8005\u90fd\u9069\u7528\u3002\u9996\u5148triptan\u985e\u85e5\u7269\u5927\u7d04\u53ea\u5c0d60%\u7684\u60a3\u8005\u6709\u6548\uff0c\u53e6\u5916triptan\u985e\u6709\u4e00\u4e9b\u7981\u5fcc\u75c7\uff0c\u5982\u679c\u60a3\u8005\u6709\u4efb\u4f55\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u5fc3\u7d5e\u75db\u3001\u4e2d\u98a8\u6216\u4e0d\u53d7\u63a7\u7684\u9ad8\u8840\u58d3\uff0c\u5c31\u4e0d\u80fd\u518d\u4f7f\u7528triptan\u985e\u85e5\u7269\u300d\uff0cFrederick Godley\u8aaa\u3002<\/p>\n

2018\u5e74FDA\u6279\u51c6\u4e86\u7b2c\u4e00\u6279\u53ef\u4ee5\u963b\u65b7CGRP\u7684\u55ae\u682a\u6297\u9ad4\u6ce8\u5c04\u7528\u85e5\u7269\uff0c\u5206\u5225\u662fEmgality\u3001Aimovig\u548cAjovy\u3002Aimovig<\/a> (erenumab-aooe, Amgen)\u53ef\u8207CGRP\u53d7\u9ad4\u7d50\u5408\u4ee5\u963b\u6b62\u5176\u6d3b\u5316\uff0cEmgality<\/a> (galcanezumab-gnlm\uff0cEli Lilly)\u548cAjovy<\/a> (fremanezumab-vfrm\uff0cTeva)\u5247\u662f\u53ef\u4ee5\u963b\u65b7CGRP\u7684\u914d\u9ad4\u8207\u53d7\u9ad4\u7d50\u5408\u3002\u9019\u985e\u85e5\u7269\u7684\u95dc\u9375\u512a\u52e2\u662f\u53ef\u4ee5\u5c0d\u6162\u6027\u504f\u982d\u75db\u60a3\u8005\u9032\u884c\u9810\u9632\u6027\u4f7f\u7528\u3002<\/p>\n

Frederick Godley\u8b1b\u5230\uff1a\u300c\u9019\u4e9b\u85e5\u7269\u975e\u5e38\u4e86\u4e0d\u8d77\uff0c\u5b83\u5011\u6c92\u6709\u85e5\u7269\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4e5f\u975e\u5e38\u6709\u6548\u3002\u56e0\u70baCGRP\u53ef\u4ee5\u8aaa\u662f\u795e\u7d93\u4e4b\u9593\u7684\u4e2d\u7e7c\u7ad9\uff0c\u6240\u4ee5\u5982\u679c\u4f60\u80fd\u963b\u6b62\u9019\u7a2e\u4fe1\u865f\u50b3\u5c0e\u5230\u4e0b\u4e00\u7ad9\uff0c\u90a3\u5f8c\u7e8c\u75bc\u75db\u4fe1\u865f\u5c31\u6703\u6e1b\u5f31\u3002\u300d<\/p>\n

Alicia Torborg\u5df2\u7d93\u5617\u8a66\u4e86\u5169\u7a2eCGRP\u6ce8\u5c04\u7528\u85e5\u7269\uff0c\u5176\u4e2d\u4e00\u7a2e\u4e0d\u8d77\u4f5c\u7528\u3002\u800c\u5f9e\u4f7f\u7528\u7b2c\u4e8c\u7a2e\u85e5\u7269\u958b\u59cb\u5230\u73fe\u5728\u5df2\u7d93\u6709\u4e5d\u500b\u6708\u4e86\uff0cAlicia Torborg\u8868\u793a\u5979\u7684\u504f\u982d\u75db\u4ecd\u7136\u6703\u767c\u4f5c\uff0c\u4f46\u6301\u7e8c\u6642\u9593\u4e0d\u50cf\u4ee5\u524d\u90a3\u9ebc\u9577\u4e86\u3002<\/p>\n

Frederick Godley\u5728\u81ea\u5df1\u7684\u7528\u85e5\u5be6\u8e10\u4e2d\u767c\u73fe\u4e86\u4e00\u4e9b\u6709\u8da3\u7684\u73fe\u8c61\uff0c\u4ed6\u767c\u73fe\u9019\u985e\u85e5\u7269\u9084\u53ef\u4ee5\u7528\u65bc\u6cbb\u7642\u9762\u90e8\u548c\u9f3b\u7ac7\u58d3\u529b\u6027\u75bc\u75db\uff0c\u4e26\u4e14\u9019\u985e\u85e5\u7269\u4e5f\u4e0d\u662f\u5b8c\u5168\u6c92\u6709\u526f\u4f5c\u7528\uff0c\u67d0\u4e9b\u60a3\u8005\u6703\u51fa\u73fe\u4fbf\u79d8\u548c\u812b\u9aee\u3002<\/p>\n

\u73fe\u5728\u53c8\u51fa\u73fe\u4e86Rimegepant\u548c\u5176\u4ed6\u53e3\u670d\u5c0f\u5206\u5b50CGRP\u53d7\u9ad4\u62ee\u6297\u5291\u985e\u85e5\u7269\u3002CGRP\u662f\u4e00\u7a2e\u5728\u5916\u5468\u548c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u90fd\u6709\u8868\u9054\u7684\u591a\u80bd\uff0c\u4f46\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u9019\u4e00\u985e\u7684\u53e3\u670d\u85e5\u7269\u662f\u5426\u80fd\u7a7f\u904e\u8840\u8166\u969c\u58c1\u3002<\/p>\n

SVB Leerink\u7684\u5206\u6790\u5e2bMarc Goodman\u5728\u4e00\u4efd\u7814\u7a76\u5831\u544a\u4e2d\u63d0\u5230\uff0c\u6ce8\u5c04\u85e5\u7269\u5728\u504f\u982d\u75db\u9818\u57df\u5e36\u4f86\u4e86\u6cbb\u7642\u6a21\u5f0f\u7684\u8f49\u8b8a\uff0c\u4f46\u5f88\u591a\u91cd\u8981\u7684\u610f\u898b\u9818\u8896\uff08KOL\uff09\u8868\u793a\u4ed6\u5011\u4e5f\u671f\u76fc\u53ef\u4ee5\u8a66\u7528\u7d66\u85e5\u65b9\u4fbf\u3001\u5b89\u5168\u6027\u826f\u597d\u7684\u53e3\u670dCGRP\u85e5\u7269\uff0cUbrelvy\u548cRimegepant\u90fd\u53ef\u4ee5\u6210\u70ba\u50f9\u503c\u5de8\u5927\u7684\u85e5\u7269\u3002<\/p>\n

\u9664\u4e86\u53ef\u7528\u65bc\u6cbb\u7642\u6025\u6027\u504f\u982d\u75db\u4ee5\u5916\uff0cRimegepant\u9084\u53ef\u4ee5\u586b\u88dc\u6162\u6027\u504f\u982d\u75db\u6cbb\u7642\u7684\u7a7a\u767d\uff0c\u4e26\u70ba\u90a3\u4e9b\u4e0d\u80fd\u4f7f\u7528triptan\u985e\u85e5\u7269\u7684\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u7528\u85e5\u9078\u64c7\uff0c\u53e6\u5916\u6839\u64da\u9810\u8a08\u65bc2020\u5e74\u7b2c\u4e00\u5b63\u516c\u4f48\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0cRimegepant\u9084\u6709\u53ef\u80fd\u7528\u65bc\u9810\u9632\u6027\u6cbb\u7642\u3002<\/p>\n

Frederick Godley\u9084\u8b1b\u5230\uff0c\u5305\u62ecRimegepant\u5728\u5167\u7684\u6b64\u985e\u53e3\u670d\u5c0f\u5206\u5b50CGRP\u53d7\u9ad4\u62ee\u6297\u5291\u985e\u85e5\u7269\u5728\u526f\u4f5c\u7528\uff08\u5982\u53e3\u4e7e\u3001\u5641\u5fc3\u3001\u75b2\u52de\u3001\u982d\u6688\u548c\u55dc\u7761\u7b49\uff09\u65b9\u9762\u7684\u8868\u73fe\uff0c\u4e26\u4e0d\u6bd4\u5b89\u6170\u5291\u5dee\uff0c\u9019\u610f\u5473\u8457\u6b64\u985e\u85e5\u7269\u53ef\u80fd\u7528\u65bc\u4e00\u4e9b\u96e3\u4ee5\u78ba\u5b9a\u7684\u504f\u982d\u75db\u60a3\u8005\u7684\u8a3a\u65b7\u3002\u5982\u679c\u60a3\u8005\u5c0d\u85e5\u7269\u6709\u6240\u53cd\u61c9\uff0c\u4f60\u53ef\u80fd\u6703\u66f4\u6709\u4fe1\u5fc3\u78ba\u8a3a\u60a3\u8005\u60a3\u6709\u504f\u982d\u75db\uff0c\u540c\u6642\u53c8\u4e0d\u6703\u7d66\u60a3\u8005\u5e36\u4f86\u5f88\u5927\u7684\u98a8\u96aa\u3002<\/p>\n

Rimegepant\u7684NDA\u7533\u8acb\u6587\u4ef6\u542b\u6709\u5169\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u5169\u9805\u8a66\u9a57\u4e2d\u8a66\u9a57\u7d44\u7528\u85e5\u5f8c\u5169\u5c0f\u6642\u5be6\u73fe\u7121\u75bc\u75db\u611f\u7684\u6bd4\u4f8b\u5206\u5225\u70ba19.2%\u548c19.6%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u5206\u5225\u70ba14.2%\u548c12%\u3002\u5728\u504f\u982d\u75db\u75c7\u72c0\u6700\u56b4\u91cd\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u8a66\u9a57\u7d44\u5be6\u73fe\u7121\u75bc\u75db\u611f\u7684\u6bd4\u4f8b\u5206\u5225\u70ba36.6%\u548c37.6%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u5206\u5225\u70ba27.7%\u548c25.2%\u3002\u5c0d\u65bcRimegepant\u7684\u53e3\u8154\u5d29\u89e3\u5291\u578b\uff08Zydis ODT\uff09\uff1a\u8a66\u9a57\u7d44\u548c\u5b89\u6170\u5291\u7d44\u5169\u5c0f\u6642\u5be6\u73fe\u7121\u75bc\u75db\u611f\u7684\u6bd4\u4f8b\u5206\u5225\u70ba21.2%\u548c10.9%\uff1b\u504f\u982d\u75db\u75c7\u72c0\u6700\u56b4\u91cd\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u8a66\u9a57\u7d44\u548c\u5b89\u6170\u5291\u7d44\u5be6\u73fe\u7121\u75bc\u75db\u611f\u7684\u6bd4\u4f8b\u5206\u5225\u70ba35.1%\u548c26.8%\u3002<\/p>\n

\u4e5f\u6709\u4eba\u64d4\u5fc3\u6b64\u985e\u85e5\u7269\u7684\u809d\u6bd2\u6027\u554f\u984c\uff0c\u56e0\u70baMerck\u516c\u53f8\u7684CGRP\u62ee\u6297\u5291Telcagepant<\/a>\u5c31\u662f\u7531\u65bc\u809d\u6bd2\u6027\u7684\u554f\u984c\u800c\u7d42\u6b62\u4e86\u7814\u7a76\uff0c\u4f46Biohaven\u516c\u53f8\u63d0\u4f9b\u7684II\u671f\u548cIII\u671f\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0c\u5728\u6bcf\u5929\u90fd\u6703\u4f7f\u7528Rimegepant\u7684\u53d7\u8a66\u8005\u4f7f\u7528\u85e5\u7269\u4e00\u5e74\u5f8c\uff0c\u6c92\u6709\u767c\u73fe\u809d\u81df\u7570\u5e38\u7684\u8de1\u8c61\u3002<\/p>\n

Ubrelvy\u7684\u85e5\u54c1\u8aaa\u660e\u66f8\u5141\u8a31\u56b4\u91cd\u809d\u529f\u80fd\u548c\u56b4\u91cd\u814e\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\u5728\u9996\u6b21\u53e3\u670d50mg\u5291\u91cf\u5169\u5c0f\u6642\u5f8c\uff0c\u53ef\u518d\u6b21\u7528\u85e5\u3002Frederick Godley\u8aaa\uff1a\u300c\u6211\u5011\u8a8d\u70ba\u9019\u7a2e\u8868\u8ff0\u53ef\u80fd\u9810\u793a\u8457Rimegepant\u4e5f\u53ef\u4ee5\u7372\u51c6\u975e\u5e38\u6709\u5229\u7684\u8aaa\u660e\u66f8\u8868\u8ff0\uff0c\u56e0\u70ba\u6839\u64da\u76f8\u7576\u6578\u91cf\u7684\u5177\u9ad4\u6848\u4f8b\uff0c\u6211\u5011\u53ef\u4ee5\u8b49\u660e\u81e8\u5e8a\u6578\u64da\u986f\u793aRimegepant\u6bd4Ubrelvy\u6709\u66f4\u591a\u7684\u300e\u985e\u4f3c\u5b89\u6170\u5291\u300f\u6a23\u7684\u6578\u64da\u3002\u300d<\/p>\n

Frederick Godley\u9084\u8b1b\u5230\uff1a\u300c\u5118\u7ba1\u5982\u6b64\uff0c\u9084\u662ftriptan\u985e\u85e5\u7269\u7684\u6548\u679c\u66f4\u597d\uff1b\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0cRimegepant\u4e00\u985e\u7684\u53e3\u670dCGRP\u62ee\u6297\u5291\u85e5\u7269\u7684\u6cbb\u7642\u7372\u76ca\u662f5%\u52307.56%\uff0c\u6578\u64da\u662f\u4e0d\u5bb9\u6a02\u89c0\u7684\uff1b\u800c100mg\u7684sumatriptan\u7528\u85e5\u5f8c\u5169\u5c0f\u6642\u5be6\u73fe\u7121\u75bc\u75db\u611f\u7684\u6bd4\u4f8b\u662f35%\u3002\u300d<\/p>\n

\u7136\u800c\uff0cRimegepant\u4e00\u985e\u7684\u53e3\u670dCGRP\u62ee\u6297\u5291\u85e5\u7269\u9084\u662f\u53ef\u4ee5\u6eff\u8db3\u4e00\u4e9b\u7279\u6b8a\u60a3\u8005\u7684\u91cd\u8981\u9700\u6c42\u7684\uff0c\u5982\u4e0d\u80fd\u4f7f\u7528triptan\u985e\u85e5\u7269\u7684\u60a3\u8005\u4ee5\u53ca\u66f4\u559c\u6b61\u53e3\u670d\u7d66\u85e5\u800c\u975e\u6ce8\u5c04\u7d66\u85e5\u7684\u60a3\u8005\u3002<\/p>\n

\u300c\u4f60\u4e0d\u77e5\u9053\u6709\u9019\u4e9b\u85e5\u7269\u6211\u662f\u591a\u9ebc\u7684\u8208\u596e\uff0c\u6211\u5e0c\u671b\u4fdd\u96aa\u80fd\u5920\u8986\u84cb\u9019\u4e9b\u85e5\u7269\uff0c\u4e5f\u5e0c\u671b\u88fd\u85e5\u516c\u53f8\u80fd\u70ba\u85e5\u7269\u652f\u4ed8\u63d0\u4f9b\u4e00\u4e9b\u652f\u63f4\u300d\uff0cAlicia Torborg\u8aaa\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u539f\u6587\u520a\u767b\u65bc\u79d1\u777f\u552f\u5b89\u65d7\u4e0b\u751f\u547d\u79d1\u5b78\u65b0\u805e\u5e73\u53f0\u00a0BioWorld \u7db2\u7ad9\uff0c\u4f5c\u8005\u70ba Karen Carey   \u672c\u7bc7\u5c07\u8981\u4ecb\u7d39\u4e09\u7a2e\u6b63\u7b49\u5f85\u85e5\u7269\u76e3\u7ba1\u6a5f\u69cb\u6279\u51c6\u4e0a\u5e02\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08central nervous system, CNS\uff09\u65b0\u85e5\uff0c\u5118\u7ba1\u9019\u4e09\u7a2eCNS\u85e5\u7269\u7684\u7642\u6548\u8207\u76ee\u524d\u5df2\u4e0a\u5e02\u7684\u85e5\u7269\u4e26\u6c92\u6709\u592a\u5927\u4e0d\u540c\uff0c\u4f46\u7531\u65bc\u5177\u6709\u5728\u88fd\u5291\u914d\u65b9\u3001\u7d66\u85e5\u65b9\u5f0f\u4ee5\u53ca\u85e5\u7269\u8cbb\u7528\u652f\u4ed8\u65b9\u652f\u6301\u7b49\u65b9\u9762\u7684\u512a\u52e2\uff0c\u4f7f\u5f97\u9019\u4e09\u7a2e\u85e5\u7269\u6210\u70ba\u591a\u767c\u6027\u786c\u5316\u75c7\uff08multiple sclerosis, MS\uff09\u548c\u504f\u982d\u75db\u5e02\u5834\u4e2d\u4e0d\u5bb9\u5ffd\u8996\u7684\u91cd\u8981\u53c3\u8207\u8005\u3002 \u9019\u4e09\u7a2eCNS\u85e5\u7269\u5747\u5728 \u79d1\u777f\u552f\u5b89 2020\u6700\u503c\u5f97\u95dc\u6ce8\u7684\u91cd\u78c5\u85e5\u7269\u9810\u6e2c (Drugs to Watch 2020) \u4e2d\uff0c\u5176\u4e2d\u5169\u500b\u7528\u65bc\u5fa9\u767c\u6027\u591a\u767c\u6027\u786c\u5316\u75c7\u7684\u85e5\u7269\uff0c\u5206\u5225\u662fBMS\u7684 Ozanimod\uff08RPC-1063\uff09\u548c\u8afe\u83ef\u7684 Ofatumumab\uff08OMB-157\uff09\u3002\u5c0d\u65bc Ozanimod\uff0c\u5982\u679cFDA\u4e0d\u8981\u6c42\u5176\u540c\u985e\u85e5\u7269 Gilenya (fingolimod\uff0c\u8afe\u83ef\uff09\u548c Mayzent (siponimod, Novartis) \u518d\u958b\u5c55\u76f8\u95dc\u7684\u4e00\u7cfb\u5217\u5be6\u9a57\u7814\u7a76\uff0c\u90a3\u9ebcOzanimod\u5c31\u53ef\u80fd\u66f4\u5bb9\u6613\u88ab\u8655\u65b9\u3002\u5c0d\u65bcOfatumumab\uff0c\u8207\u5176\u6700\u5927\u7684\u7af6\u722d\u5c0d\u624bOcrevus (ocrelizumab, Roche)\u76f8\u6bd4\uff0cOfatumumab\u63d0\u4f9b\u4e86\u4e00\u7a2e\u53ef\u4ee5\u5728\u5bb6\u9032\u884c\u76ae\u4e0b\u7d66\u85e5\u7684\u65b9\u5f0f\uff0c\u800cOcrevus\u5247\u9700\u8981\u5728\u5c08\u696d\u6a5f\u69cb\u6216\u91ab\u9662\u4e2d\u9032\u884c\u8cbb\u7528\u8f03\u9ad8\u7684\u8f38\u6db2\u7d66\u85e5\u3002…<\/p>\n","protected":false},"author":2,"featured_media":1155,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_links_to":"","_links_to_type":0,"footnotes":""},"categories":[1668],"tags":[1741],"class_list":["post-1154","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life-sciences-healthcare","tag-drugs-to-watch-2020"],"acf":[],"lang":"zh","translations":{"zh":1154},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/1154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/comments?post=1154"}],"version-history":[{"count":0,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/posts\/1154\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media\/1155"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/media?parent=1154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/categories?post=1154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clarivate.com\/life-sciences-healthcare\/wp-json\/wp\/v2\/tags?post=1154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}