Smarter target choices start with OFF-X

OFF-X is a powerful translational safety intelligence platform that helps researchers uncover the safety liabilities of targets and drugs faster and with greater confidence.

Drug discovery remains high-risk, and safety is still a leading cause of failure:

  • 88% of drugs entering clinical development will never be approved
  • ~25% of Phase II and III failures are due to safety concerns
  • Poor target selection causes over half of trial failures
  • In the U.S. alone, adverse drug reactions are among the top 10 causes of death, with over 100,000 deaths annually

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Why choose OFF-X?

Unexpected target-related safety issues are a leading cause of R&D attrition.

OFF-X empowers you to make confident early-stage decisions with consolidated and curated safety intelligence across the drug development life cycle.

Top benefits:

  • Identify adverse events linked to drug targets
  • Benchmark safety profiles across related targets or drug classes
  • Explore off-target effects based on secondary pharmacology
  • Align with regulators using FDA-trusted intelligence

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Explore key features

Comparative target safety profiles

Explore toxicity risks across 15,600 targets using curated safety alerts and preclinical/clinical data

Visual safety mapping

Use interactive signaling pathways to analyze safety impact of genes upstream or downstream of your target

Daily updated, manually curated alerts

Over 3 million safety alerts, drawn from literature, regulatory filings, RWD (FAERS, JADER), and more

Diverse data coverage

Covers small molecules, biologics, gene/cell therapies, ADCs, and mRNA — across populations, conditions, and modalities

See how OFF-X suits your role

Fact sheet
Translational safety intelligence
Pre-clinical fact sheet
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Fact sheet
Translational safety intelligence
Clinical fact sheet
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Fact sheet
Translational safety intelligence
Pharmacovigilance fact sheet
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Trusted by leading researchers and regulators

The FDA will continue using OFF-X as a solution to identify potential adverse events...

U.S. Food & Drug Administration

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The platform covers:

3m+
curated safety and toxicity alerts
15k
targets and genes
39k+
drugs and biologics
14k
adverse events and toxicity endpoints

New: OFF-X is getting even more powerful with pathway maps to accelerate target safety assessments

  • Visualize target risk via interactive pathway maps
  • Get one-click comparisons of safety profiles for all targets in each pathway
  • Conduct more granular system organ class-level assessments
  • Unlock biological context and causality insights faster than ever

Save time assessing target safety and confidently inform go/no-go decisions with OFF-X.

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