Accelerate safer, smarter drug discovery

With over 50% of Phase II and III trials failing due to efficacy, and 25% due to safety , it’s never been more critical to reduce risk early.

OFF-X and Cortellis Drug Discovery Intelligence help R&D teams accelerate preclinical decisions and improve their odds of success by anticipating safety issues and validating the right targets earlier.

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A complete intelligence solution for modern drug discovery

Cortellis Drug Discovery Intelligence and OFF-X are built for drug discovery, preclinical and translational professionals who need a holistic, translational approach to optimize early-stage research.

Unlike fragmented alternatives, this combined solution offers broad and deep coverage of biology, pharmacology, chemistry, and toxicity data — integrated across the full drug development lifecycle.

Why combine OFF-X and Cortellis?

With increasing investor pressure and flat success rates, every failed trial costs more. OFF-X and Cortellis give you the insight you need to avoid those failures and the confidence to move faster with less risk.

  • OFF-X equips you to anticipate safety risks for targets and compounds, from discovery to post-market.
  • Cortellis Drug Discovery Intelligence provides rich biological, pharmacological, and competitive insights to drive target selection and compound optimization.
  • Together, they help reduce late-stage failures, prioritize safer, more promising targets, compare experimental data and anticipate adverse events, design smarter early-phase trials.

Explore key features

OFF-X highlights:

  • Safety profiles of 40,000+ drugs and biologics
  • Monitor adverse events daily from regulatory and literature sources
  • Benchmark class effects, analyze pathways, explore population-specific risks

Cortellis Drug Discovery Intelligence highlights:

  • Validate targets using disease association scoring
  • Access biology, chemistry, and pharmacology data in one place
  • Optimize compounds with synthesis tools, IP insights, and biomarker data

OFF-X and Cortellis Drug Discovery Intelligence combined, the platforms cover:

  • 49k+ genes & targets
  • 3m+ curated safety alerts
  • 6500+ diseases
  • 3.1m+ publications and 589k+ patents

Ready to take the next step?

See how OFF-X and Cortellis Drugs Discovery Intelligence can transform your R&D strategy.

Trusted by leading researchers & regulators

The FDA will continue using OFF-X as a solution to identify potential adverse events...

U.S. Food & Drug Administration

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