Generate predictions based on expertly curated analyses.
Find connections between genes or pathways and disease using Clarivate’s broad portfolio of methods based on approaches using annotated data from knowledge bases and various bioinformatics techniques to make accurate, novel predictions. The analysis results in a prioritization of targets and drugs that can be repositioned into an indication of interest, as well as potential mechanisms of action reconstructed for top candidates.
In the first step of the workflow, predict targets and identify corresponding drugs using pathway-based, network-based and disease similarity-based bioinformatics approaches.
In the second step of the workflow, characterize and triage drugs as repositioning candidates using the commercial/drug development factor assessment that includes safety, pharmacology, formulations, intellectual property, business and other considerations.
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