{"id":289325,"date":"2026-01-08T10:18:55","date_gmt":"2026-01-08T10:18:55","guid":{"rendered":"https:\/\/clarivate.com\/academia-government\/?p=289325"},"modified":"2026-01-09T01:39:57","modified_gmt":"2026-01-09T01:39:57","slug":"professor-zhijian-chens-doctoral-dissertation","status":"publish","type":"post","link":"https:\/\/clarivate.com\/academia-government\/zh\/blog\/professor-zhijian-chens-doctoral-dissertation\/","title":{"rendered":"\u300c\u8afe\u8c9d\u723e\u734e\u98a8\u5411\u7403\u300d2025\u5e74\u5f15\u6587\u6842\u51a0\u734e\u7372\u734e\u8005\u83ef\u4eba\u79d1\u5b78\u5bb6\u9673\u5fd7\u5805\u6559\u6388\u535a\u58eb\u8ad6\u6587"},"content":{"rendered":"<p>9\u670825\u65e5\uff0c\u79d1\u777f\u552f\u5b89\u516c\u4f48\u4e86<strong>2025<\/strong><strong>\u5e74\u5ea6\u5f15\u6587\u6842\u51a0\u734e<\/strong>\u540d\u55ae\uff0c\u4f86\u81ea<strong>8<\/strong><strong>\u500b\u570b\u5bb6<\/strong><strong>\/<\/strong><strong>\u5730\u5340\u7684\u9802\u5c16\u5b78\u8853\u6a5f\u69cb\u7684<\/strong><strong>22<\/strong><strong>\u4f4d\u5091\u51fa\u79d1\u5b78\u5bb6\u7372\u734e<\/strong>\u3002<strong>\u4ed6\u5011\u7684\u7814\u7a76\u6210\u679c\u5177\u6709\u8afe\u8c9d\u723e\u734e\u7d1a\u5225\u7684\u5f71\u97ff\u529b<\/strong>\u3002\u5176\u4e2d\uff0c<strong>\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\u751f\u7269\u91ab\u5b78\u79d1\u5b78<\/strong><strong> George L. MacGregor <\/strong><strong>\u5091\u51fa\u8b1b\u5e2d\u6559\u6388\u9673\u5fd7\u5805\uff08<\/strong><strong>Zhijian &#8216;James&#8217; Chen<\/strong><strong>\uff09<\/strong>\u548c\u5176\u4ed6\u4e8c\u4f4d\u79d1\u5b78\u5bb6\uff0c\u56e0\u5728<strong>\u300c<\/strong>\u00a0<strong>\u95e1\u660e<\/strong><strong> cGAS-STING <\/strong><strong>\u901a\u8def\u9019\u4e00\u56fa\u6709\u514d\u75ab\u7684\u57fa\u672c\u6a5f\u5236<\/strong><strong>\u300d<\/strong> \u7814\u7a76\u9818\u57df\u7684\u7a81\u51fa\u8ca2\u737b\uff0c\u5171\u540c\u7372\u5f97<strong>2025<\/strong><strong>\u5e74\u5ea6<\/strong><strong>\u751f\u7406\u5b78\u6216\u91ab\u5b78\u9818\u57df\u5f15\u6587\u6842\u51a0\u734e<\/strong>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-289326\" src=\"https:\/\/clarivate.com\/academia-government\/wp-content\/uploads\/sites\/3\/2026\/01\/5.png\" alt=\"\" width=\"451\" height=\"227\" srcset=\"https:\/\/clarivate.com\/academia-government\/wp-content\/uploads\/sites\/3\/2026\/01\/5.png 451w, https:\/\/clarivate.com\/academia-government\/wp-content\/uploads\/sites\/3\/2026\/01\/5-300x151.png 300w, https:\/\/clarivate.com\/academia-government\/wp-content\/uploads\/sites\/3\/2026\/01\/5-79x40.png 79w\" sizes=\"auto, (max-width: 451px) 100vw, 451px\" \/><\/p>\n<p>\u9673\u5fd7\u5805\u6559\u6388\/\u5716\u6e90\uff1aCitation Laureates \u5b98\u7db2<\/p>\n<p>&nbsp;<\/p>\n<p>\u9673\u5fd7\u5805\uff08Zhijian &#8216;James&#8217; Chen\uff09\uff0c\u514d\u75ab\u5b78\u5bb6\u3001\u73fe\u4efb\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\u5206\u5b50\u751f\u7269\u5b78\u6559\u6388\u30022005\u5e74\u9673\u5fd7\u5805\u6559\u6388\u6210\u70ba\u7f8e\u570b\u970d\u83ef\u5fb7.\u4f11\u65af\u91ab\u5b78\u7814\u7a76\u6240\u7814\u7a76\u54e1\uff0c2014\u5e74\u7576\u9078\u7f8e\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u9662\u58eb\uff0c2025\u5e74\u7576\u9078\u82f1\u570b\u7687\u5bb6\u5b78\u6703\u5916\u7c4d\u9662\u58eb\u3002\u56e0\u5176\u5091\u51fa\u7684\u79d1\u5b78\u8ca2\u737b\uff0c\u66fe\u7372\u5f97\u5305\u62ec\u7372<strong>\u62c9\u65af\u514b\u57fa\u790e\u91ab\u5b78\u7814\u7a76\u734e<\/strong>\u3001\u7372<strong>\u816b\u7624\u514d\u75ab\u5b78\u754c\u9802\u7d1a\u5927\u734e<\/strong><strong>\u2014\u2014<\/strong><strong>\u5a01\u5ec9<\/strong><strong>\u00b7<\/strong><strong>\u79d1\u5229\u734e<\/strong>\u3001<strong>\u8def\u6613\u838e<\/strong><strong>\u00b7<\/strong><strong>\u683c\u7f85\u65af<\/strong><strong>\u00b7<\/strong><strong>\u970d\u7dad\u8328\u734e\u7b49\u5728\u5167\u7684\u91cd\u8981\u79d1\u5b78\u734e\u9805<\/strong>\u3002<\/p>\n<p>\u9673\u5fd7\u5805\u6559\u63881985\u5e74\u7562\u696d\u65bc\u798f\u5efa\u5e2b\u7bc4\u5927\u5b78\u751f\u7269\u7cfb\uff0c1991\u5e74\u7372\u5f97\u7d10\u7d04\u5dde\u7acb\u5927\u5b78\u6c34\u725b\u57ce\u5206\u6821\u751f\u7269\u5316\u5b78\u535a\u58eb\u5b78\u4f4d\u3002\u5176\u535a\u58eb\u8ad6\u6587\u984c\u76ee\u70ba\uff1a<strong><em>Biochemical and molecular biological studies on the mammalian multiubiquitinating enzyme E2(25K)\u00a0<\/em><\/strong>\uff0c\u8a72\u8ad6\u6587\u6536\u9304\u5728<strong>\u00a0ProQuest <\/strong><strong>\u5168\u7403\u535a\u78a9\u58eb\u8ad6\u6587\u8cc7\u6599\u5eab\uff08<\/strong><strong>ProQuest Dissertations &amp; Theses Global<\/strong><strong>\uff0c\u7c21\u7a31<\/strong><strong> PQDT Global<\/strong><strong>\uff09<\/strong> \u4e2d\uff0c\u4ee5\u4e0b\u662f\u8ad6\u6587\u7684\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8b80\u8005\u53ef\u9ede\u64ca\u9023\u7d50\u67e5\u95b1\u8ad6\u6587\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Biochemical and molecular biological studies on the mammalian multiubiquitinating enzyme E2(25K)<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4f5c\u8005\uff1a<\/strong>Chen, Zhijian (James)<\/p>\n<p><strong>\u5c0e\u5e2b\uff1a<\/strong>Pickart, Cecile M.<\/p>\n<p><strong>\u7562\u696d\u9662\u6821\uff1a<\/strong>State University of New York at Buffalo<\/p>\n<p><strong>\u5b78\u79d1\u5206\u985e\uff1a<\/strong><\/p>\n<p>0487: Biochemistry; 0307: Molecular biology;0306: Biology<\/p>\n<p><strong>\u8ad6\u6587\u9023\u7d50\uff1a<\/strong><\/p>\n<p><a href=\"https:\/\/www.proquest.com\/pqdtglobal\/docview\/303979178\" target=\"_blank\" rel=\"noopener\">https:\/\/www.proquest.com\/pqdtglobal\/docview\/303979178<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>ProQuest Dissertations &amp; Theses Global <\/strong><strong>\u7c21\u4ecb<\/strong><\/p>\n<p>ProQuest \u662f\u7f8e\u570b\u570b\u6703\u5716\u66f8\u9928\u6307\u5b9a\u7684\u6536\u85cf\u5168\u7f8e\u570b\u535a\u78a9\u58eb\u8ad6\u6587\u7684\u6a5f\u69cb\u3002 ProQuest \u5168\u7403\u535a\u78a9\u58eb\u8ad6\u6587\u5168\u6587\u8cc7\u6599\u5eab\uff08ProQuest Dissertations &amp; Theses Global\uff0c\u7c21\u7a31 PQDT Global\uff09\uff0c\u6536\u9304\u4f86\u81ea\u5168\u740360\u591a\u500b\u570b\u5bb6\/\u5730\u53404100\u9918\u6240\u5927\u5b78\u7684\u8d85\u904e400\u842c\u7bc7\u535a\u78a9\u58eb\u5b78\u4f4d\u8ad6\u6587\u5168\u6587\u53ca600\u842c\u7bc7\u6587\u6458\u7d22\u5f15\u8a18\u9304\u3002 \u5167\u5bb9\u8986\u84cb\u79d1\u5b78\u3001\u5de5\u7a0b\u5b78\u3001\u7d93\u6fdf\u8207\u7ba1\u7406\u79d1\u5b78\u3001\u5065\u5eb7\u8207\u91ab\u5b78\u3001\u6b77\u53f2\u5b78\u3001\u4eba\u6587\u53ca\u793e\u6703\u79d1\u5b78\u7b49\u9818\u57df\u3002<\/p>\n<p>\u5b58\u53d6\u7db2\u5740\uff1a<a href=\"https:\/\/www.proquest.com\/pqdtglobal\" target=\"_blank\" rel=\"noopener\">https:\/\/www.proquest.com\/pqdtglobal<\/a><\/p>\n<p>LibGuides: <a href=\"https:\/\/proquest.libguides.com\/pqdt\" target=\"_blank\" rel=\"noopener\">https:\/\/proquest.libguides.com\/pqdt<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>9\u670825\u65e5\uff0c\u79d1\u777f\u552f\u5b89\u516c\u4f48\u4e862025\u5e74\u5ea6\u5f15\u6587\u6842\u51a0\u734e\u540d\u55ae\uff0c\u4f86\u81ea8\u500b\u570b\u5bb6\/\u5730\u5340\u7684\u9802\u5c16\u5b78\u8853\u6a5f\u69cb\u768422\u4f4d\u5091\u51fa\u79d1\u5b78\u5bb6\u7372\u734e\u3002\u4ed6\u5011\u7684\u7814\u7a76\u6210\u679c\u5177\u6709\u8afe\u8c9d\u723e\u734e\u7d1a\u5225\u7684\u5f71\u97ff\u529b\u3002\u5176\u4e2d\uff0c\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\u751f\u7269\u91ab\u5b78\u79d1\u5b78 George L. MacGregor \u5091\u51fa\u8b1b\u5e2d\u6559\u6388\u9673\u5fd7\u5805\uff08Zhijian &#8216;James&#8217; Chen\uff09\u548c\u5176\u4ed6\u4e8c\u4f4d\u79d1\u5b78\u5bb6\uff0c\u56e0\u5728\u300c\u00a0\u95e1\u660e cGAS-STING \u901a\u8def\u9019\u4e00\u56fa\u6709\u514d\u75ab\u7684\u57fa\u672c\u6a5f\u5236\u300d \u7814\u7a76\u9818\u57df\u7684\u7a81\u51fa\u8ca2\u737b\uff0c\u5171\u540c\u7372\u5f972025\u5e74\u5ea6\u751f\u7406\u5b78\u6216\u91ab\u5b78\u9818\u57df\u5f15\u6587\u6842\u51a0\u734e\u3002 &nbsp; \u9673\u5fd7\u5805\u6559\u6388\/\u5716\u6e90\uff1aCitation Laureates \u5b98\u7db2 &nbsp; \u9673\u5fd7\u5805\uff08Zhijian &#8216;James&#8217; Chen\uff09\uff0c\u514d\u75ab\u5b78\u5bb6\u3001\u73fe\u4efb\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\u5206\u5b50\u751f\u7269\u5b78\u6559\u6388\u30022005\u5e74\u9673\u5fd7\u5805\u6559\u6388\u6210\u70ba\u7f8e\u570b\u970d\u83ef\u5fb7.\u4f11\u65af\u91ab\u5b78\u7814\u7a76\u6240\u7814\u7a76\u54e1\uff0c2014\u5e74\u7576\u9078\u7f8e\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u9662\u58eb\uff0c2025\u5e74\u7576\u9078\u82f1\u570b\u7687\u5bb6\u5b78\u6703\u5916\u7c4d\u9662\u58eb\u3002\u56e0\u5176\u5091\u51fa\u7684\u79d1\u5b78\u8ca2\u737b\uff0c\u66fe\u7372\u5f97\u5305\u62ec\u7372\u62c9\u65af\u514b\u57fa\u790e\u91ab\u5b78\u7814\u7a76\u734e\u3001\u7372\u816b\u7624\u514d\u75ab\u5b78\u754c\u9802\u7d1a\u5927\u734e\u2014\u2014\u5a01\u5ec9\u00b7\u79d1\u5229\u734e\u3001\u8def\u6613\u838e\u00b7\u683c\u7f85\u65af\u00b7\u970d\u7dad\u8328\u734e\u7b49\u5728\u5167\u7684\u91cd\u8981\u79d1\u5b78\u734e\u9805\u3002 \u9673\u5fd7\u5805\u6559\u63881985\u5e74\u7562\u696d\u65bc\u798f\u5efa\u5e2b\u7bc4\u5927\u5b78\u751f\u7269\u7cfb\uff0c1991\u5e74\u7372\u5f97\u7d10\u7d04\u5dde\u7acb\u5927\u5b78\u6c34\u725b\u57ce\u5206\u6821\u751f\u7269\u5316\u5b78\u535a\u58eb\u5b78\u4f4d\u3002\u5176\u535a\u58eb\u8ad6\u6587\u984c\u76ee\u70ba\uff1aBiochemical and molecular biological studies on the mammalian multiubiquitinating enzyme E2(25K)\u00a0\uff0c\u8a72\u8ad6\u6587\u6536\u9304\u5728\u00a0ProQuest \u5168\u7403\u535a\u78a9\u58eb\u8ad6\u6587\u8cc7\u6599\u5eab\uff08ProQuest&#8230;<\/p>\n","protected":false},"author":211,"featured_media":289127,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[928],"tags":[1213,1215],"class_list":["post-289325","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academia-government","tag-citation-laureate-award","tag-pqdt-global","clarivate-industry-academia","clarivate-industry-government","clarivate-product-family-proquest","clarivate-product-proquest-dissertations-and-theses"],"acf":[],"lang":"zh","translations":{"zh":289325},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/posts\/289325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/users\/211"}],"replies":[{"embeddable":true,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/comments?post=289325"}],"version-history":[{"count":5,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/posts\/289325\/revisions"}],"predecessor-version":[{"id":289373,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/posts\/289325\/revisions\/289373"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/media\/289127"}],"wp:attachment":[{"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/media?parent=289325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/categories?post=289325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clarivate.com\/academia-government\/wp-json\/wp\/v2\/tags?post=289325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}